Gold nanoparticles-mediated photothermal and photodynamic therapies for cancer

International Journal of Pharmaceutics, Год журнала: 2024, Номер 655, С. 124057 - 124057

Опубликована: Март 27, 2024

Язык: Английский

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Applications of Microwaves in Medicine

IEEE Journal of Microwaves, Год журнала: 2022, Номер 3(1), С. 134 - 169

Опубликована: Дек. 19, 2022

Advances and updates in medical applications utilizing microwave techniques technologies are reviewed this paper. The article aims to provide an overview of enablers for their recent progress. emphasis focuses on the microwaves, following order, 1) signal data communication implants wearables through human body, 2) electromagnetic energy transfer tissues, 3) noninvasive, remote or in situ physical biochemical sensing, 4) therapeutic purposes by changing tissue properties with controlled thermal effects. For wireless power transfer, implant wearable discussed categories pacemakers, endoscopic capsules, brain interfaces, intraocular, cardiac intracranial pressure sensors, neurostimulators, endoluminal implants, artificial retina, smart lenses, cochlear implants. noninvasive vital sign radar, biological cell probing, magnetic resonance imaging, biochemical, blood glucose, hydration biomarker sensing introduced. uses, developments ablation, balloon angioplasty, hyperthermia reviewed. scopes mainly concentrate research development efforts past 20 years. Recent review articles specific topics cited accomplishment highlights trends deliberated. At end article, a brief history IEEE Microwave Theory Techniques Society (MTT-S) Biological Effects Medical Applications committee contributions its members promotion advancement fields chronicled.

Язык: Английский

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From Localized Mild Hyperthermia to Improved Tumor Oxygenation: Physiological Mechanisms Critically Involved in Oncologic Thermo-Radio-Immunotherapy

Cancers, Год журнала: 2023, Номер 15(5), С. 1394 - 1394

Опубликована: Фев. 22, 2023

(1) Background: Mild hyperthermia (mHT, 39-42 °C) is a potent cancer treatment modality when delivered in conjunction with radiotherapy. mHT triggers series of therapeutically relevant biological mechanisms, e.g., it can act as radiosensitizer by improving tumor oxygenation, the latter generally believed to be commensurate result increased blood flow, and positively modulate protective anticancer immune responses. However, extent kinetics flow (TBF) changes oxygenation are variable during after application mHT. The interpretation these spatiotemporal heterogeneities currently not yet fully clarified. (2) Aim methods: We have undertaken systematic literature review herein provide comprehensive insight into potential impact on clinical benefits therapeutic modalities such radio- immuno-therapy. (3) Results: mHT-induced increases TBF multifactorial differ both spatially time. In

Язык: Английский

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Advances in screening hyperthermic nanomedicines in 3D tumor models

Nanoscale Horizons, Год журнала: 2024, Номер 9(3), С. 334 - 364

Опубликована: Янв. 1, 2024

Integrating the advances of emerging hyperthermia techniques with 3D tumor models and non-invasive temperature control systems can contribute to identifying top-performing hyperthermic nanomedicines in preclinical evaluation stages.

Язык: Английский

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Nanoparticle-mediated thermal Cancer therapies: Strategies to improve clinical translatability

Journal of Controlled Release, Год журнала: 2024, Номер 372, С. 751 - 777

Опубликована: Июль 4, 2024

Despite significant advances, cancer remains a leading global cause of death. Current therapies often fail due to incomplete tumor removal and nonspecific targeting, spurring interest in alternative treatments. Hyperthermia, which uses elevated temperatures kill cells or boost their sensitivity radio/chemotherapy, has emerged as promising alternative. Recent advancements employ nanoparticles (NPs) heat mediators for selective cell destruction, minimizing damage healthy tissues. This approach, known NP hyperthermia, falls into two categories: photothermal (PTT) magnetothermal (MTT). PTT utilizes NPs that convert light heat, while MTT magnetic activated by alternating fields (AMF), both achieving localized damage. These methods offer advantages like precise minimal invasiveness, reduced systemic toxicity. However, the efficacy hyperthermia depends on many factors, particular, properties, microenvironment (TME), TME-NP interactions. Optimizing this treatment requires accurate monitoring strategies, such nanothermometry biologically relevant screening models can better mimic physiological features human body. review explores state-of-the-art NP-mediated discussing available nanomaterials, strengths weaknesses, characterization methods, future directions. Our particular focus lies preclinical techniques, providing an updated perspective relevance journey towards clinical trials.

Язык: Английский

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Preclinical Development of Magnetic Nanoparticles for Hyperthermia Treatment of Pancreatic Cancer

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер 17(2), С. 2924 - 2939

Опубликована: Янв. 2, 2025

Pancreatic ductal adenocarcinoma (PDAC) is a very challenging disease with poor prognosis. It characterized by dense desmoplastic stroma that hampers drug penetration and limits the effectiveness of conventional chemotherapy (CT). As an alternative, combination CT hyperthermia (HT) has been proposed as innovative treatment modality for PDAC. In previous works, we reported on development iron oxide magnetic nanoparticles (MNPs) that, when exposed to time-varying fields, exhibit strong HT responses inhibited growth pancreatic cancers. We report here advances toward clinical use these MNPs intratumorally administered sterile fluid (the "NoCanTher ThermoTherapy" or "NTT" Agent) alongside intravenous standard-of-care drugs (gemcitabine nab-paclitaxel) vitro cell viability assays show low doses highly synergistic, particularly in BxPC-3 line. vivo, biodistribution showed NTT Agent remained mainly within tumor, concentrated around areas high stromal component. Moreover, combined CT/HT shows clear advantages over alone terms reduction tumor volume, suggesting potential direct effect disruption interstitial facilitate access malignant cells. These studies have led approval commencement investigational study at Vall d'Hebron University Hospital (Barcelona, Spain) patients locally advanced

Язык: Английский

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Safety of Gold Nanoparticles: From In Vitro to In Vivo Testing Array Checklist

Pharmaceutics, Год журнала: 2023, Номер 15(4), С. 1120 - 1120

Опубликована: Март 31, 2023

In recent years, gold nanoparticles (AuNPs) have aroused the interest of many researchers due to their unique physicochemical and optical properties. AuNPs are being explored in a variety biomedical fields, either diagnostics or therapy, particularly for localized thermal ablation cancer cells after light irradiation. Besides promising therapeutic potential AuNPs, safety constitutes highly important issue any medicine medical device. For this reason, present work, production characterization properties morphology coated with two different materials (hyaluronic oleic acids (HAOA) bovine serum albumin (BSA)) were firstly performed. Based on above importantly referred issue, vitro developed was evaluated healthy keratinocytes, human melanoma, breast, pancreatic glioblastoma cells, as well three-dimensional skin model. Ex vivo biosafety assays using, respectively, red blood Artemia salina also carried out. HAOA-AuNPs selected acute toxicity biodistribution studies Balb/c mice. Histopathological analysis showed no significant signs tested formulations. Overall, several techniques order characterize evaluate safety. All these results support use applications.

Язык: Английский

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Autophagy inhibition mediated via an injectable and NO-releasing hydrogel for amplifying the antitumor efficacy of mild magnetic hyperthermia

Bioactive Materials, Год журнала: 2024, Номер 39, С. 336 - 353

Опубликована: Май 25, 2024

While mild hyperthermia holds great potential in the treatment of solid tumors, thermal stress-triggered self-repairing autophagy significantly compromises its efficacy. To circumvent this obstacle, an injectable hydrogel (NO-Gel) composed thermosensitive poly(ethylene glycol)-polypeptide copolymers modified with abundant NO donors on their side chains is developed. Meanwhile, ferrimagnetic Zn

Язык: Английский

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Efficient drug delivery to hypoxic tumors using thermosensitive liposomes with encapsulated anti-cancer drug under high intensity pulsed ultrasound

International Journal of Mechanical Sciences, Год журнала: 2022, Номер 237, С. 107818 - 107818

Опубликована: Окт. 3, 2022

Язык: Английский

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Wireless sequential dual light delivery for programmed PDT in vivo

Light Science & Applications, Год журнала: 2024, Номер 13(1)

Опубликована: Май 15, 2024

Abstract Using photodynamic therapy (PDT) to treat deep-seated cancers is limited due inefficient delivery of photosensitizers and low tissue penetration light. Polymeric nanocarriers are widely used for photosensitizer delivery, while the self-quenching encapsulated would impair PDT efficacy. Furthermore, generated short-lived reactive oxygen spieces (ROS) can hardly diffuse out nanocarriers, resulting in Therefore, a smart nanocarrier system which be degraded by light, followed activation potentially overcome these limitations enhance A light-sensitive polymer encapsulating (RB-M) was synthesized. An implantable wireless dual wavelength microLED device delivers two light wavelengths sequentially developed programmatically control release loaded photosensitizer. Two transmitter coils with matching resonant frequencies allow connected LEDs emit different independently. Optimal irradiation time, dose, RB-M concentration were determined using an agent-based digital simulation method. In vitro vivo validation experiments orthotopic rat liver hepatocellular carcinoma disease model confirmed that rupture sequential dose strategy resulted successful at reduced clinically significant event enhances treatment safety.

Язык: Английский

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