The effect of exercise on GDF‐15 levels in individuals with prediabetes: A randomized controlled trial

Journal of Diabetes Investigation, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Growth differentiation factor-15 (GDF-15) is an inflammatory cytokine that increases in prediabetes and known for its anorexigenic effects. This study aims to evaluate the effects of a 12-week exercise program on GDF-15 individuals with prediabetes. In this multicenter, parallel-group, randomized-controlled trial, 64 patients aged 18-60 diagnosed were randomized 1:1 ratio into group (E) control (C). Additionally, 32 who planned start metformin included (M). Participants engaged aerobic at 50-70% their maximum heart rate 60 min, 3 days week. Serum levels evaluated beginning end 12th The mean age 91 participants completed was 46.13 ± 8.52 years, 23.1% male. Basal similar among groups (E = 668.6 415.1, C 651.8 352.5, M 603.6 387.2, P 0.47). At week, lower E compared C, while higher 383.1 215.6, 556.4 285.6, 810.8 498.0, < 0.001). inter-group comparisons, no significant change observed between 0th weeks, decreased (P 0.001) increased It determined prediabetes, GDF-15, which serves both as biomarker metabolic disorder has negative regulatory effect appetite, 12 weeks administration.

Language: Английский

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Prediabetes remission to reduce the global burden of type 2 diabetes

Trends in Endocrinology and Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Prediabetes is a highly prevalent and increasingly common condition affecting significant proportion of the global population. The heterogeneous nature prediabetes presents challenge in identifying individuals who particularly benefit from lifestyle or other therapeutic interventions aiming at preventing type 2 diabetes (T2D) associated comorbidities. phenotypic characteristics risk for are with both specific profiles progression differential potential to facilitate remission reduce future T2D. This review examines current definition prevalence evaluates alarming increase burden

Language: Английский

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The Role of the Planetary Diet in Managing Metabolic Syndrome and Cardiovascular Disease: A Narrative Review

Nutrients, Journal Year: 2025, Volume and Issue: 17(5), P. 862 - 862

Published: Feb. 28, 2025

Introduction: The planetary health diet, introduced by the EAT-Lancet Commission, aims to address global and sustainability challenges promoting a plant-based diet with reduced consumption of animal-sourced foods. This not only contributes environmental but also offers significant benefits, including prevention management abdominal obesity, carbohydrate metabolism disorders, dyslipidemia, elevated blood pressure. These metabolic disorders are components syndrome, cluster risk factors for cardiovascular disease. Objectives: narrative review gather most recent findings on impact individual syndrome treatment Methods: available research topic was identified via searches in PubMed, Scopus, Google Scholar. Results: Abdominal major factor range chronic diseases, can be effectively mitigated adhering dietary patterns, which have been shown reduce waist circumference improve overall cardiometabolic health. Furthermore, plays crucial role reducing type-2 diabetes improving glycemic control, specific such as whole grains fiber, demonstrating positive effects glucose levels. is additionally associated favorable lipid profiles, lower levels LDL cholesterol total cholesterol, critical atherosclerosis diseases. Conclusions: multiple benefits highlight that may an effective strategy managing preventing However, further needed confirm its long-term efficacy applicability across diverse populations.

Language: Английский

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Lifestyle Interventions for Treatment and Remission of Type 2 Diabetes and Prediabetes in Adults: Implications for Clinicians

American Journal of Lifestyle Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

This review is based on a presentation at the 2024 Annual Meeting of American College Lifestyle Medicine (ACLM), which showcased ACLM's first clinical practice guideline Interventions for Treatment and Remission Type 2 Diabetes Prediabetes in Adults. Our goal to offer pragmatic implications everyday patient care, including case presentations showing how recommendations (key action statements) can be implemented. The target audience any clinician or healthcare professional community outpatient setting involved managing non-pregnant adults with T2D, prediabetes history gestational diabetes mellitus (GDM). Unique features ACLM include placing lifestyle interventions as foundation T2D management prevention, offering strategies sustained behavior change, emphasizing all six pillars medicine: plant-predominant nutrition, regular physical activity, restorative sleep, stress reduction, social connectedness, avoiding risky substances. not intended substitute full guideline, should read before doing recommended actions.

Language: Английский

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Spatiotemporal Immunomodulation and Biphasic Osteo‐Vascular Aligned Electrospun Membrane for Diabetic Periosteum Regeneration

Advanced Science, Journal Year: 2023, Volume and Issue: 10(36)

Published: Nov. 16, 2023

Abstract Under diabetic conditions, blood glucose fluctuations and exacerbated immunopathological inflammatory environments pose significant challenges to periosteal regenerative repair strategies. Responsive immune regulation in damaged tissues is critical for the microenvironment, osteogenesis, angiogenesis stabilization. Considering high‐glucose microenvironment of such acute injury sites, a functional glucose‐responsive immunomodulation‐assisted regeneration composite material—PLA（Polylactic Acid）/COLI(Collagen I）/Lipo(Liposome）‐APY29 (PCLA)—is constructed. Aside from stimulating osteogenic differentiation, owing presence surface self‐assembled type I collagen scaffolds, PCLA can directly respond focal area microenvironments. The scaffolds trigger release APY29‐loaded liposomes, shifting macrophages toward M2 phenotype, inhibiting cytokines, improving bone promoting differentiation angiogenesis. Bioinformatics analyses show that enhances by signal pathway regulating polarization direction angiogenic gene expression. In calvarial defect model rats, induce macrophage improve significantly accelerating repair. Overall, scaffold material regulates immunity fluctuating microenvironments, achieves relatively stable favorable facilitates effective design functionalized biomaterials therapy patients with diabetes.

Language: Английский

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Serum 25(OH)D Concentration, Vitamin D Supplementation, and Risk of Cardiovascular Disease and Mortality in Patients with Type 2 Diabetes or Prediabetes: a Systematic Review and Dose–Response Meta-Analysis

American Journal of Clinical Nutrition, Journal Year: 2023, Volume and Issue: 118(3), P. 697 - 707

Published: July 18, 2023

Language: Английский

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Effectiveness of a Nutrition Education Program for Patients with Type 2 Diabetes Mellitus

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(5), P. 2114 - 2114

Published: March 4, 2024

Diabetes is a metabolic disease that major health problem globally. Dietary interventions contribute to the management of and improvement in patients’ quality life. The aim present study was assess effects nutrition lifestyle education intervention on sample patients with diabetes. duration 3 months, it focused promotion Mediterranean diet through information pamphlets, plans healthy guidelines, which were provided addition standard medical treatment. Patients enrolled outpatient clinic University Hospital Larissa (Greece). Anthropometric biochemical parameters recorded at baseline follow-up using standardized equipment methods. improved body mass index, composition, fasting glucose, postprandial triglycerides, HDL/LDL cholesterol cholesterol. For smoking status, alcohol consumption physical activity categorization, but not other two indices. results this show patient should be according nutritional recommendations for T2DM plus more individually structured intervention. It therefore necessary direct attention doctors need continuous detailed discussions relation both standards benefits brings. Patients, their part, commit following an appropriate, diet.

Language: Английский

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The promise of CRISPR/Cas9 technology in diabetes mellitus therapy: How gene editing is revolutionizing diabetes research and treatment

Journal of Diabetes and its Complications, Journal Year: 2023, Volume and Issue: 37(8), P. 108524 - 108524

Published: June 3, 2023

Language: Английский

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Glucagon-like peptide-1 receptor agonist and new-onset diabetes in overweight/obese individuals with prediabetes: A systematic review and meta-analysis of randomized trials

Diabetes & Metabolic Syndrome Clinical Research & Reviews, Journal Year: 2024, Volume and Issue: 18(6), P. 103069 - 103069

Published: June 1, 2024

Language: Английский

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Associations of Diabetes and Prediabetes With Mortality and Life Expectancy in China: A National Study

Diabetes Care, Journal Year: 2024, Volume and Issue: 47(11), P. 1969 - 1977

Published: Sept. 10, 2024

OBJECTIVE To investigate the excess mortality and life-years lost associated with diabetes prediabetes in China. RESEARCH DESIGN AND METHODS This national cohort study enrolled 135,405 participants aged 18 years or older from general population Cox proportional hazards regression models were used to estimate adjusted rate ratio (RR). The life table method was expectancy. RESULTS Among participants, 10.5% had 36.2% 2013. During a median follow-up of 6 years, 5517 deaths recorded, including 1428 2300 among people prediabetes, respectively. Diabetes significantly increased risk all-cause (diabetes: RR, 1.61 [95% CI 1.49, 1.73]; prediabetes: 1.08 1.01, 1.15]), cardiovascular disease 1.59 1.41, 1.78]; 1.10 1.00, 1.21]) mortality. Additionally, risks death resulting cancer, respiratory disease, liver diabetic ketoacidosis coma. Compared normoglycemia, expectancy those shorter, on average, by 4.2 0.7 at age 40 magnitude associations varied residence. CONCLUSIONS In this study, reduced cause-specific risks. disparities between different ages residences have implications for prevention treatment programs.

Language: Английский

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