5. Facilitating Positive Health Behaviors and Well-being to Improve Health Outcomes: Standards of Care in Diabetes—2025

Diabetes Care, Journal Year: 2024, Volume and Issue: 48(Supplement_1), P. S86 - S127

Published: Dec. 9, 2024

The American Diabetes Association (ADA) "Standards of Care in Diabetes" includes the ADA's current clinical practice recommendations and is intended to provide components diabetes care, general treatment goals guidelines, tools evaluate quality care. Members ADA Professional Practice Committee, an interprofessional expert committee, are responsible for updating Standards annually, or more frequently as warranted. For a detailed description standards, statements, reports, well evidence-grading system full list Committee members, please refer Introduction Methodology. Readers who wish comment on invited do so at professional.diabetes.org/SOC.

Language: Английский

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Enhancing the Design of Nutrient Clinical Trials for Disease Prevention—A Focus on Vitamin D: A Systematic Review

Nutrition Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

This systematic review (SR) highlights principles for nutrient clinical trials and explore the diverse physiological functions of vitamin D beyond its traditional role in musculoskeletal system related to study designs. Thousands published research articles have investigated benefits (a example taken this SR) system, including immune, pulmonary, cardiovascular systems; pregnancy; autoimmune disorders; cancer. They illustrated D's molecular mechanisms, interactions, genomic nongenomic actions. SR was designed identify shortcomings designs, statistical methods, data interpretation that led inconsistent findings D-related publications. also examples insights into avoiding design errors future studies, randomized controlled (RCTs). The adheres latest PRISMA statement, guidelines, PICOS process. Inappropriate or flawed designs were frequent trials. Major failures discussed here include too short duration, inadequate infrequent doses, insufficient power, failure measure baseline achieved levels, recruiting D-sufficient participants. These misleading interpretations. Thus, conclusions from such studies should not be generalized used recommendations, policymaking. Adequately powered epidemiological RCTs with sufficient duration individuals deficiency reported favorable outcomes, enriching literature, enabling understand physiology mechanisms. Proper rigorous methodologies cautious outcomes are crucial advancing field. apply only D, but other micro-nutrients nutraceutical research. Adhering them enhances credibility reliability trials, SRs, meta-analysis outcomes. emphasizes importance focused, hypothesis-driven, well-designed, statistically nutrients, conducted index deficient participants, avoidance errors. Findings incorporated practice, policymaking, public health improving nation reducing healthcare costs.

Language: Английский

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Vitamin D and major chronic diseases

Trends in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: 35(12), P. 1050 - 1061

Published: May 31, 2024

Language: Английский

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Association between vitamin D status and cardiometabolic risk factors in adults with type 2 diabetes in Shenzhen, China

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 14, 2024

Background Evidence of vitamin D status and cardiometabolic health in adults with type 2 diabetes mellitus (T2DM) is still limited. This study aimed to investigate the association between risk factors among T2DM Shenzhen, China. Methods cross-sectional included 164 (aged ≥18 years) who were hospitalized at Peking University Shenzhen Hospital from March 1, 2023, May 31, 2023. Serum 25-hydroxyvitamin [25(OH)D] concentration, active marker D, three major including blood pressure (BP), glucose metabolism-related indicators, lipid profiles collected. Vitamin deficiency (VDD) was defined as 25(OH)D < 20 ng/mL. Correlation, Regression, Logistic analysis applied verify serum VDD, 11 factors. Results Median concentration 21.78 [interquartile range (IQR)=17.51-28.05] The prevalence VDD 40.24%. significantly negatively correlated diastolic BP (DBP) glycated hemoglobin A1c (HbA1c) rather than systolic BP, plasma glucose, C-peptide, both correlation linear regression analysis. Furthermore, adjusted odd ratio for poor DBP control (≥90 mmHg) patients 3.164 (95% confidence interval=1.303, 7.683; P =0.011) compared those without VDD. Conclusion In China, highly prevalent associated greater cardiovascular factors, especially increased chances uncontrolled DBP. These findings suggest that levels should be monitored patients, high

Language: Английский

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Association of serum vitamin D and the risk of cardiovascular diseases among diabetic patients: A systematic review and meta-analysis

Clinical Nutrition ESPEN, Journal Year: 2024, Volume and Issue: 62, P. 66 - 75

Published: May 15, 2024

Language: Английский

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Vitamin D and Type 2 Diabetes Mellitus: Molecular Mechanisms and Clinical Implications—A Narrative Review

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2153 - 2153

Published: Feb. 27, 2025

Vitamin D has been widely studied for its implications on type 2 diabetes mellitus, a chronic condition characterized by insulin resistance, inflammation, and metabolic dysfunction. This review explores the molecular mechanisms underpinning vitamin D's effects glucose metabolism, adipogenesis, while assessing potential clinical applications in diabetes. In 1,25-dihydroxyvitamin D3 form, modulates various processes, affecting proinflammatory cytokines activating AMPK pathway, inhibiting mTOR signaling, promoting adipocyte differentiation. These enhance sensitivity reduce key contributors to this context, progression of prediabetes linked D, which limits pathological increases likelihood restoring normal state, crucial progression. Moreover, reported developing 15%, particularly doses higher than traditional recommendations bone health. Despite promising evidence, discrepancies study designs, serum measurements, population-specific factors highlight need standardized methodologies personalized approaches. conclusion, complementary therapeutic treating diabetes, revealing gaps research, such as optimal dosing long-term across populations. Future studies should integrate insights into practice optimize impact

Language: Английский

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Non-linear Association Between Serum 25-hydroxyvitamin D Levels and Cardiovascular Outcomes: Evidence from NHANES and Mendelian Randomization Analysis

Nutrition Metabolism and Cardiovascular Diseases, Journal Year: 2025, Volume and Issue: unknown, P. 104155 - 104155

Published: May 1, 2025

Language: Английский

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Comprehensive assessment on the association of dietary vitamins with all-cause and cardiovascular mortality among individuals with prediabetes: evidence from NHANES 1999–2018

Food & Function, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

: Prediabetes has become a global health issue, and currently, the relationship between vitamin levels mortality in prediabetes remains unclear. This study aims to investigate association of eleven vitamins all-cause cardiovascular disease (CVD) patients.

Language: Английский

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Vitamin D Enhancement of Adipose Biology: Implications on Obesity-Associated Cardiometabolic Diseases

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 586 - 586

Published: Feb. 6, 2025

Vitamin D is activated into 1α,25(OH)2D through two hydroxylation steps that are primarily catalyzed by 25-hydroxylase in the liver and 1α-hydroxylase kidneys. The active form of vitamin regulates myriads cellular functions its nuclear receptor, receptor (VDR). metabolizing enzymes VDR expressed adipose tissues multiple aspects biology including recruitment differentiation stem cells adipocytes metabolic, endocrine, immune properties. Obesity associated with low status, which thought to be explained sequestration large mass as well dysregulated metabolism. Low status obesity may negatively impact leading tissue dysfunctions, major pathological factors for cardiometabolic diseases obesity. In this review, current understanding metabolism molecular mechanisms actions, focusing on D–VDR regulation their implications obesity-associated diseases, discussed. Whether improving leads reductions adiposity risks also

Language: Английский

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The Optimal Protective 25-Hydroxyvitamin D Level for Different Health Outcomes in Adults: A Brief Summary of Dose–Response Meta-Analyses

Metabolites, Journal Year: 2025, Volume and Issue: 15(4), P. 264 - 264

Published: April 10, 2025

Vitamin D is very important for bone metabolism as well the prevention of various diseases, such type 2 diabetes, cardiovascular disease and different types cancer. Although vitamin deficiency widespread an public health problem, there exists controversy in scientific community, with no established standard definition adequate deficient status. To add new information on this topic, aim brief opinion paper to identify discuss optimal 25(OH)D concentration (range) a reduction risk outcomes by summarizing dose-response reporting meta-analyses.

Language: Английский

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