Tea polyphenol nano-crosslinked dynamical hyaluronic acid-based hydrogel for diabetic wound healing

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 136856 - 136856

Published: Oct. 1, 2024

Language: Английский

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Novel Detection and Progression Markers for Diabetes Based on Continuous Glucose Monitoring Data Dynamics

The Journal of Clinical Endocrinology & Metabolism, Journal Year: 2024, Volume and Issue: 110(1), P. 254 - 262

Published: May 29, 2024

Static measures of continuous glucose monitoring (CGM) data, such as time spent in specific ranges (70-180 mg/dL or 70-140 mg/dL), do not fully capture the dynamic nature blood glucose, particularly subtle gradual deterioration glycemic control over individuals with early-stage type 1 diabetes. Develop a diabetes diagnostic tool based on 2 markers CGM dynamics: entropy rate (ER) and Poincaré plot (PP) ellipse area (S). A total 5754 daily profiles from 843 1, diabetes, healthy without islet autoantibody status were used to compute individual markers: ER (in bits per transition; BPT) probability matrices describing transitions between 8 states, S (mg2/dL2) PP ellipses using standard descriptors. The Youden index was determine "optimal" cut-points for health vs (case 1); 2); low high immunological risk 3). markers' discriminative power assessed through under receiver operating characteristics curves (AUC). Optimal cutoff points determined each 3 cases. discriminated case AUC = 0.98 (95% CI, 0.97-0.99) 0.99 0.99-1.00), respectively (cutoffs ERcase1 0.76 BPT, Scase1 1993.91 mg2/dL2), 0.81 0.77-0.84) 0.72-0.81), (ERcase2 1.00 Scase2 5112.98 0.72 0.58-0.86), 0.66 0.47-0.86), (ERcase3 0.52 Scase3 923.65 mg2/dL2). dynamics can be an alternative fasting plasma tolerance testing identify at higher progressing

Language: Английский

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The role of the Mediterranean diet in prediabetes management and prevention: a review of molecular mechanisms and clinical outcomes

Food and Agricultural Immunology, Journal Year: 2024, Volume and Issue: 35(1)

Published: Sept. 10, 2024

Language: Английский

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Association of neutrophil-to-lymphocyte ratio with all-cause and cardiovascular mortality in CVD patients with diabetes or pre-diabetes

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 17, 2024

The neutrophil-to-lymphocyte ratio (NLR), a simple marker of systemic inflammation, is crucial in the progression cardiovascular diseases (CVD). Its predictive value for all-cause and mortality CVD patients with diabetes or pre-diabetes remains unclear. We analyzed 3,780 from National Health Nutrition Examination Survey (2001-2018). Kaplan-Meier survival curves, weighted Cox proportional hazards models, restricted cubic spline (RCS) analyses were used to assess relationship between NLR risk. RCS revealed U-shaped association mortality, an inflection point at 1.776. For < 1.776, risk decreased by 13% per unit increase (HR: 0.87, 95% CI: 0.76-0.98). ≥ increased 15% 1.15, 1.10-1.26). A positive linear was found 17% 1.17, 1.10-1.25). No significant interactions observed stratified analyses. Our study pre-diabetes.

Language: Английский

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Prediabetes is associated with elevated risk of clinical outcomes even without progression to diabetes

Diabetologia, Journal Year: 2024, Volume and Issue: 68(2), P. 357 - 366

Published: Nov. 12, 2024

Language: Английский

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