Marine Omega‐3 Supplementation and Cardiovascular Disease: An Updated Meta‐Analysis of 13 Randomized Controlled Trials Involving 127 477 Participants DOI Creative Commons
Yang Hu, Frank B. Hu, JoAnn E. Manson

et al.

Journal of the American Heart Association, Journal Year: 2019, Volume and Issue: 8(19)

Published: Sept. 30, 2019

Background Whether marine omega‐3 supplementation is associated with reduction in risk of cardiovascular disease (CVD) remains controversial. Methods and Results This meta‐analysis included study‐level data from 13 trials. The outcomes interest myocardial infarction, coronary heart (CHD) death, total CHD, stroke, CVD CVD, major vascular events. unadjusted rate ratios were calculated using a fixed‐effect meta‐analysis. A meta‐regression was conducted to estimate the dose–response relationship between dosage each prespecified outcome. During mean treatment duration 5.0 years, 3838 infarctions, 3008 CHD deaths, 8435 events, 2683 strokes, 5017 15 759 16 478 events documented. In analysis excluding REDUCE‐IT (Reduction Cardiovascular Events Icosapent Ethyl‐Intervention Trial), significantly lower infarction (rate ratio [RR] [95% CI]: 0.92 [0.86, 0.99]; P =0.020), death (RR 0.98]; =0.014), 0.95 [0.91, =0.008), 0.93 [0.88, =0.013), 0.97 [0.94, =0.015). Inverse associations for all strengthened after including while introducing statistically significant heterogeneity. Statistically linear relationships found analyses without REDUCE‐IT. Conclusions Marine lowers even exclusion Risk reductions appeared be linearly related dose.

Language: Английский

Heart Disease and Stroke Statistics—2019 Update: A Report From the American Heart Association DOI Creative Commons
Emelia J. Benjamin, Paul Muntner, Álvaro Alonso

et al.

Circulation, Journal Year: 2019, Volume and Issue: 139(10)

Published: Jan. 31, 2019

Language: Английский

Citations

8010
Heart Disease and Stroke Statistics—2020 Update: A Report From the American Heart Association DOI Creative Commons
Salim S. Virani, Álvaro Alonso, Emelia J. Benjamin

et al.

Circulation, Journal Year: 2020, Volume and Issue: 141(9)

Published: Jan. 29, 2020

The American Heart Association, in conjunction with the National Institutes of Health, annually reports on most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, diet, weight) factors (cholesterol, blood pressure, glucose control) that contribute health. Statistical Update presents latest data a range major clinical circulatory disease conditions (including congenital rhythm disorders, subclinical atherosclerosis, coronary failure, valvular venous peripheral artery disease) associated outcomes quality care, procedures, economic costs).The through its Statistics Committee, continuously monitors evaluates sources stroke United States provide current information available annual Update. 2020 is product full year's worth effort by dedicated volunteer clinicians scientists, committed government professionals, Association staff members. This edition includes monitoring benefits population, metrics assess monitor healthy diets, an enhanced focus social determinants health, global burden further evidence-based approaches changing behaviors, implementation strategies, implications Association's Impact Goals.Each 26 chapters focuses different topic statistics.The represents critical resource for lay public, policy makers, media clinicians, healthcare administrators, researchers, advocates, others seeking best these conditions.

Language: Английский

Citations

7738
2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk DOI Open Access

François Mach,

Colin Baigent, Alberico L. Catapano

et al.

European Heart Journal, Journal Year: 2019, Volume and Issue: 41(1), P. 111 - 188

Published: Aug. 31, 2019

The ESC/EAS Guidelines represent the views of ESC and EAS, were produced after careful consideration scientific medical knowledge, evidence available at time their publication.The EAS is not responsible in event any contradiction, discrepancy, and/or ambiguity between other official recommendations or guidelines issued by relevant public health authorities, particular relation to good use healthcare therapeutic strategies.Health professionals are encouraged take fully into account when exercising clinical judgment, as well determination implementation preventive, diagnostic, strategies; however, do override, way whatsoever, individual responsibility make appropriate accurate decisions each patient's condition consultation with that patient and, where necessary, caregiver.Nor exempt from taking full updated competent order manage case light scientifically accepted data pursuant respective ethical professional obligations.It also professional's verify applicable rules regulations relating drugs devices prescription.

Language: Английский

Citations

6897
Heart Disease and Stroke Statistics—2021 Update DOI Creative Commons
Salim S. Virani, Álvaro Alonso, Hugo J. Aparicio

et al.

Circulation, Journal Year: 2021, Volume and Issue: 143(8)

Published: Jan. 27, 2021

The American Heart Association, in conjunction with the National Institutes of Health, annually reports most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, diet, weight) factors (cholesterol, blood pressure, glucose control) that contribute health. Statistical Update presents latest data on a range major clinical circulatory disease conditions (including congenital rhythm disorders, subclinical atherosclerosis, coronary failure, valvular venous peripheral artery disease) associated outcomes quality care, procedures, economic costs).The through its Statistics Committee, continuously monitors evaluates sources stroke United States provide current information available annual Update. 2021 is product full year's worth effort by dedicated volunteer clinicians scientists, committed government professionals, Association staff members. This edition includes monitoring benefits population, an enhanced focus social determinants health, adverse pregnancy outcomes, vascular contributions brain global burden further evidence-based approaches changing disease.Each 27 chapters focuses different topic statistics.The represents critical resource for lay public, policy makers, media clinicians, care administrators, researchers, advocates, others seeking best these conditions.

Language: Английский

Citations

4712
2021 ESC Guidelines on cardiovascular disease prevention in clinical practice DOI Open Access
Frank L.J. Visseren,

François Mach,

Yvo M. Smulders

et al.

European Heart Journal, Journal Year: 2021, Volume and Issue: 42(34), P. 3227 - 3337

Published: Aug. 30, 2021

The ESC Guidelines represent the views of and were produced after careful consideration scientific medical knowledge evidence available at time their publication.The is not responsible in event any contradiction, discrepancy and/or ambiguity between other official recommendations or guidelines issued by relevant public health authorities, particular relation to good use healthcare therapeutic strategies.Health professionals are encouraged take fully into account when exercising clinical judgment, as well determination implementation preventive, diagnostic strategies; however, do override, way whatsoever, individual responsibility make appropriate accurate decisions each patient's condition consultation with that patient and, where necessary, caregiver.Nor exempt from taking full updated competent order manage case light scientifically accepted data pursuant respective ethical professional obligations.It also professional's verify applicable rules regulations relating drugs devices prescription.

Language: Английский

Citations

4289
Heart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association DOI Creative Commons

Connie W. Tsao,

Aaron W. Aday, Zaid Almarzooq

et al.

Circulation, Journal Year: 2022, Volume and Issue: 145(8)

Published: Jan. 26, 2022

The American Heart Association, in conjunction with the National Institutes of Health, annually reports most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, diet, weight) factors (cholesterol, blood pressure, glucose control) that contribute health. Statistical Update presents latest data on a range major clinical circulatory disease conditions (including congenital rhythm disorders, subclinical atherosclerosis, coronary failure, valvular venous peripheral artery disease) associated outcomes quality care, procedures, economic costs).

Language: Английский

Citations

4265
Heart Disease and Stroke Statistics—2023 Update: A Report From the American Heart Association DOI Creative Commons

Connie W. Tsao,

Aaron W. Aday, Zaid Almarzooq

et al.

Circulation, Journal Year: 2023, Volume and Issue: 147(8)

Published: Jan. 25, 2023

Background: The American Heart Association, in conjunction with the National Institutes of Health, annually reports most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, diet, weight) factors (cholesterol, blood pressure, glucose control) that contribute health. Statistical Update presents latest data on a range major clinical circulatory disease conditions (including congenital rhythm disorders, subclinical atherosclerosis, coronary failure, valvular venous peripheral artery disease) associated outcomes quality care, procedures, economic costs). Methods: through its Epidemiology Prevention Statistics Committee, continuously monitors evaluates sources stroke United States provide current information available annual review published literature year before writing. 2023 is product full year’s worth effort 2022 by dedicated volunteer clinicians scientists, committed government professionals, Association staff members. strives further understand help heal problems inflicted structural racism, public crisis can significantly damage mental perpetuate disparities access education, income, housing, several other vital healthy lives. This edition includes additional COVID-19 (coronavirus 2019) publications, as well monitoring benefits population, an enhanced focus equity across key domains. Results: Each chapters focuses different topic statistics. Conclusions: represents critical resource for lay public, policymakers, media clinicians, care administrators, researchers, advocates, others seeking best these conditions.

Language: Английский

Citations

4232
2019 ESC/EAS guidelines for the management of dyslipidaemias: Lipid modification to reduce cardiovascular risk DOI
François Mach,

Colin Baigent,

Alberico L. Catapano

et al.

Atherosclerosis, Journal Year: 2019, Volume and Issue: 290, P. 140 - 205

Published: Aug. 31, 2019

Language: Английский

Citations

4175
Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia DOI Open Access
Deepak L. Bhatt, Philippe Gabríel Steg, Michael Miller

et al.

New England Journal of Medicine, Journal Year: 2018, Volume and Issue: 380(1), P. 11 - 22

Published: Nov. 10, 2018

Patients with elevated triglyceride levels are at increased risk for ischemic events. Icosapent ethyl, a highly purified eicosapentaenoic acid ethyl ester, lowers levels, but data needed to determine its effects on

Language: Английский

Citations

2673
DNA methylation GrimAge strongly predicts lifespan and healthspan DOI Creative Commons
Ake T. Lu,

Austin Quach,

James G. Wilson

et al.

Aging, Journal Year: 2019, Volume and Issue: 11(2), P. 303 - 327

Published: Jan. 21, 2019

It was unknown whether plasma protein levels can be estimated based on DNA methylation (DNAm) levels, and if so, how the resulting surrogates consolidated into a powerful predictor of lifespan. We present here, seven DNAm-based estimators proteins including those plasminogen activator inhibitor 1 (PAI-1) growth differentiation factor 15. The lifespan, DNAm GrimAge (in units years), is composite biomarker estimator smoking pack-years. Adjusting for chronological age generated novel measure epigenetic acceleration, AgeAccelGrim.Using large scale validation data from thousands individuals, we demonstrate that stands out among existing clocks in terms its predictive ability time-to-death (Cox regression P=2.0E-75), time-to-coronary heart disease P=6.2E-24), time-to-cancer (P= 1.3E-12), strong relationship with computed tomography fatty liver/excess visceral fat, age-at-menopause (P=1.6E-12). AgeAccelGrim strongly associated host age-related conditions comorbidity count (P=3.45E-17). Similarly, age-adjusted PAI-1 are lifespan (P=5.4E-28), 7.3E-56) type 2 diabetes (P=2.0E-26). These biomarkers show expected lifestyle factors healthy diet educational attainment.Overall, these to find many applications human anti-aging studies.

Language: Английский

Citations

1662