Circulation,
Journal Year:
2019,
Volume and Issue:
140(2)
Published: June 3, 2019
As
early
and
effective
antiretroviral
therapy
has
become
more
widespread,
HIV
transitioned
from
a
progressive,
fatal
disease
to
chronic,
manageable
marked
by
elevated
risk
of
chronic
comorbid
diseases,
including
cardiovascular
diseases
(CVDs).
Rates
myocardial
infarction,
heart
failure,
stroke,
other
CVD
manifestations,
pulmonary
hypertension
sudden
cardiac
death,
are
significantly
higher
for
people
living
with
than
uninfected
control
subjects,
even
in
the
setting
viral
suppression
therapy.
These
risks
generally
persist
after
demographic
clinical
factors
accounted
may
be
partly
attributed
inflammation
immune
dysregulation.
Data
on
long-term
outcomes
limited
relatively
recent
epidemiological
transition
disease.
Therefore,
our
understanding
pathogenesis,
prevention,
treatment
relies
large
observational
studies,
randomized
controlled
trials
therapies
that
underpowered
detect
end
points,
small
interventional
studies
examining
surrogate
points.
The
purpose
this
document
is
provide
thorough
review
existing
evidence
HIV-associated
CVD,
particular
atherosclerotic
(including
infarction
stroke)
as
well
pragmatic
recommendations
how
approach
prevention
absence
large-scale
trial
data.
This
statement
intended
clinicians
caring
HIV,
individuals
translational
researchers
interested
CVD.
European Heart Journal,
Journal Year:
2020,
Volume and Issue:
42(5), P. 373 - 498
Published: July 17, 2020
Supplementary
Table
9,
column
'Edoxaban',
row
'eGFR
category',
'95
mL/min'
(page
15).
The
cell
should
be
coloured
green
instead
of
yellow.
It
also
read
60
mginstead
mg
(use
with
caution
in
'supranormal'
renal
function).In
the
above-indicated
cell,
a
footnote
has
been
added
to
state:
Edoxaban
used
patients
high
creatinine
clearance
only
after
careful
evaluation
individual
thromboembolic
and
bleeding
risk.Supplementary
'Dose
reduction
selected
patients'
16).
reduced
30
once
daily
if
any
following:
15-50
mL/min,
body
weight
<60
kg,
concomitant
use
dronedarone,
erythromycin,
ciclosporine
or
ketokonazoleinstead
daily,
edoxaban
15mg
30-50
us
verapamil
quinidine
dronedarone.
Oncotarget,
Journal Year:
2017,
Volume and Issue:
9(6), P. 7204 - 7218
Published: Dec. 14, 2017
//
Linlin
Chen
1,
*
,
Huidan
Deng
Hengmin
Cui
2
Jing
Fang
Zhicai
Zuo
Junliang
Yinglun
Li
Xun
Wang
and
Ling
Zhao
1
College
of
Veterinary
Medicine,
Sichuan
Agricultural
University,
Wenjiang,
Chengdu
611130,
China
Key
Laboratory
Animal
Diseases
Environmental
Hazards
Province,
Agriculture
These
authors
contributed
equally
to
this
work
Correspondence
to:
Cui,
email:
[email protected]
Keywords:
inflammation;
inflammatory
signaling
pathways;
chemokines;
cytokines;
organ
diseases
Received:
April
19,
2017
Accepted:
November
03,
Published:
December
14,
2017
ABSTRACT
Inflammation
is
a
biological
response
the
immune
system
that
can
be
triggered
by
variety
factors,
including
pathogens,
damaged
cells
toxic
compounds.
factors
may
induce
acute
and/or
chronic
responses
in
heart,
pancreas,
liver,
kidney,
lung,
brain,
intestinal
tract
reproductive
system,
potentially
leading
tissue
damage
or
disease.
Both
infectious
non-infectious
agents
cell
activate
trigger
pathways,
most
commonly
NF-κB,
MAPK,
JAK-STAT
pathways.
Here,
we
review
within
organs,
focusing
on
etiology
inflammation,
mechanisms,
resolution
organ-specific
responses.
Circulation,
Journal Year:
2022,
Volume and Issue:
145(18)
Published: April 1, 2022
The
"2022
AHA/ACC/HFSA
Guideline
for
the
Management
of
Heart
Failure"
replaces
"2013
ACCF/AHA
and
"2017
ACC/AHA/HFSA
Focused
Update
2013
Failure."
2022
guideline
is
intended
to
provide
patient-centric
recommendations
clinicians
prevent,
diagnose,
manage
patients
with
heart
failure.
Journal of Hypertension,
Journal Year:
2023,
Volume and Issue:
41(12), P. 1874 - 2071
Published: June 24, 2023
Document
Reviewers:
Luis
Alcocer
(Mexico),
Christina
Antza
(Greece),
Mustafa
Arici
(Turkey),
Eduardo
Barbosa
(Brazil),
Adel
Berbari
(Lebanon),
Luís
Bronze
(Portugal),
John
Chalmers
(Australia),
Tine
De
Backer
(Belgium),
Alejandro
de
la
Sierra
(Spain),
Kyriakos
Dimitriadis
Dorota
Drozdz
(Poland),
Béatrice
Duly-Bouhanick
(France),
Brent
M.
Egan
(USA),
Serap
Erdine
Claudio
Ferri
(Italy),
Slavomira
Filipova
(Slovak
Republic),
Anthony
Heagerty
(UK),
Michael
Hecht
Olsen
(Denmark),
Dagmara
Hering
Sang
Hyun
Ihm
(South
Korea),
Uday
Jadhav
(India),
Manolis
Kallistratos
Kazuomi
Kario
(Japan),
Vasilios
Kotsis
Adi
Leiba
(Israel),
Patricio
López-Jaramillo
(Colombia),
Hans-Peter
Marti
(Norway),
Terry
McCormack
Paolo
Mulatero
Dike
B.
Ojji
(Nigeria),
Sungha
Park
Priit
Pauklin
(Estonia),
Sabine
Perl
(Austria),
Arman
Postadzhian
(Bulgaria),
Aleksander
Prejbisz
Venkata
Ram
Ramiro
Sanchez
(Argentina),
Markus
Schlaich
Alta
Schutte
Cristina
Sekib
Sokolovic
(Bosnia
and
Herzegovina),
Jonas
Spaak
(Sweden),
Dimitrios
Terentes-Printzios
Bruno
Trimarco
Thomas
Unger
(The
Netherlands),
Bert-Jan
van
den
Born
Anna
Vachulova
Agostino
Virdis
Jiguang
Wang
(China),
Ulrich
Wenzel
(Germany),
Paul
Whelton
Jiri
Widimsky
(Czech
Jacek
Wolf
Grégoire
Wuerzner
(Switzerland),
Eugene
Yang
Yuqing
Zhang
(China).
The Lancet,
Journal Year:
2020,
Volume and Issue:
396(10250), P. 565 - 582
Published: Aug. 1, 2020
Clinicians
can
encounter
sex
and
gender
disparities
in
diagnostic
therapeutic
responses.
These
are
noted
epidemiology,
pathophysiology,
clinical
manifestations,
disease
progression,
response
to
treatment.
This
Review
discusses
the
fundamental
influences
of
as
modifiers
major
causes
death
morbidity.
We
articulate
how
genetic,
epigenetic,
hormonal
biological
influence
physiology
disease,
social
constructs
affect
behaviour
community,
clinicians,
patients
health-care
system
interact
with
pathobiology.
aim
guide
clinicians
researchers
consider
their
approach
diagnosis,
prevention,
treatment
diseases
a
necessary
step
towards
precision
medicine,
which
will
benefit
men's
women's
health.
New England Journal of Medicine,
Journal Year:
2020,
Volume and Issue:
382(25), P. 2441 - 2448
Published: May 1, 2020
There
is
concern
about
the
potential
of
an
increased
risk
related
to
medications
that
act
on
renin-angiotensin-aldosterone
system
in
patients
exposed
coronavirus
disease
2019
(Covid-19),
because
viral
receptor
angiotensin-converting
enzyme
2
(ACE2).We
assessed
relation
between
previous
treatment
with
ACE
inhibitors,
angiotensin-receptor
blockers,
beta-blockers,
calcium-channel
or
thiazide
diuretics
and
likelihood
a
positive
negative
result
Covid-19
testing
as
well
severe
illness
(defined
intensive
care,
mechanical
ventilation,
death)
among
who
tested
positive.
Using
Bayesian
methods,
we
compared
outcomes
had
been
treated
these
untreated
patients,
overall
those
hypertension,
after
propensity-score
matching
for
receipt
each
medication
class.
A
difference
at
least
10
percentage
points
was
prespecified
substantial
difference.Among
12,594
were
Covid-19,
total
5894
(46.8%)
positive;
1002
(17.0%)
illness.
history
hypertension
present
4357
(34.6%),
whom
2573
(59.1%)
test;
634
(24.6%)
no
association
any
single
class
test.
None
examined
associated
increase
positive.We
found
test
five
common
classes
antihypertensive
medications.
Circulation Research,
Journal Year:
2020,
Volume and Issue:
127(1), P. 4 - 20
Published: June 18, 2020
Accompanying
the
aging
of
populations
worldwide,
and
increased
survival
with
chronic
diseases,
incidence
prevalence
atrial
fibrillation
(AF)
are
rising,
justifying
term
global
epidemic.
This
multifactorial
arrhythmia
is
intertwined
common
concomitant
cardiovascular
which
share
classical
risk
factors.
Targeted
prevention
programs
largely
missing.
Prevention
needs
to
start
at
an
early
age
primordial
interventions
population
level.
The
public
health
dimension
AF
motivates
research
in
modifiable
factors
improved
precision
prediction
management.
In
this
review,
we
summarize
current
knowledge
attempt
untangle
these
multifaceted
associations
from
epidemiological
perspective.
We
discuss
disease
trends,
preventive
opportunities
offered
by
underlying
disorders,
developments
diagnosis
prediction,
prognostic
implications
its
complications.
Finally,
review
technological
(eg,
eHealth)
methodological
(artificial
intelligence)
advances
their
relevance
for
future
