Are Brain and Cognitive Reserve Shaped by Early Life Circumstances? DOI Creative Commons
Susanne R. de Rooij

Frontiers in Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: June 16, 2022

When growing older, many people are faced with cognitive deterioration, which may even amount to a form of dementia at some point in time. Although neuropathological signs disorders can often be demonstrated brains patients, the degree clinical symptoms present does mostly not accurately reflect neuropathology that is present. Sometimes existent pathology goes without any obvious presentation. An explanation for this phenomenon found concept reserve capacity. Reserve capacity refers ability brain effectively buffer changes associated normal aging processes and cope pathological damage. A larger has been suggested increase resilience against age-associated deterioration disorders. Traditionally, division made between reserve, based on morphological characteristics brain, functional brain. The review discusses premises shaped by prenatal early postnatal factors. Evidence accumulating circumstances during first 1,000 days life utmost importance lifelong health an individual. Cognitive also have their origin potentially important pathway environment affects risk neurodegenerative diseases developmental programming basic idea behind explained overview studies support presented. concluded discussion potential mechanisms, synthesis evidence relevance future directions field origins

Language: Английский

Associations Between Neighborhood Disadvantage, Resting-State Functional Connectivity, and Behavior in the Adolescent Brain Cognitive Development Study: The Moderating Role of Positive Family and School Environments DOI
Divyangana Rakesh, Caio Seguin, Andrew Zalesky

et al.

Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Journal Year: 2021, Volume and Issue: 6(9), P. 877 - 886

Published: March 23, 2021

Language: Английский

Citations

139
Socioeconomic status and the developing brain – A systematic review of neuroimaging findings in youth DOI
Divyangana Rakesh, Sarah Whittle

Neuroscience & Biobehavioral Reviews, Journal Year: 2021, Volume and Issue: 130, P. 379 - 407

Published: Aug. 30, 2021

Language: Английский

Citations

135
Racial Disparities in Adversity During Childhood and the False Appearance of Race-Related Differences in Brain Structure DOI

Nathalie M. Dumornay,

Lauren A. M. Lebois, Kerry J. Ressler

et al.

American Journal of Psychiatry, Journal Year: 2023, Volume and Issue: 180(2), P. 127 - 138

Published: Feb. 1, 2023

Objective: Black Americans in the United States are disproportionately exposed to childhood adversity compared with White Americans. Such disparities may contribute race-related differences brain structures involved regulating emotional response stress, such as amygdala, hippocampus, and prefrontal cortex (PFC). The authors investigated neuroanatomical consequences of racial adversity. Methods: sample included 7,350 American 1,786 children (ages 9–10) from Adolescent Brain Cognitive Development Study (public data release 2.0). Structural MRI data, parent child self-reports adversity-related measures, U.S. Census neighborhood were used investigate relationship between exposure structure. Results: experienced more traumatic events, family conflict, material hardship on average children, their parents or caregivers had lower educational attainment, income, unemployment those children. showed PFC gray matter volumes but not also varied metrics adversity, income being most common predictor volume differences. Accounting for attenuated magnitude some volume. Conclusions: results suggest that key regions associated threat-related processes. alterations these linked cognitive-affective dysfunction observed disorders posttraumatic stress disorder. More granular assessments structural inequities across racial/ethnic identities needed a thorough understanding impact brain. Together, present findings provide insight into potential systemic contributors disparate rates psychiatric disease among individuals States.

Language: Английский

Citations

86
Socioeconomic status, BMI, and brain development in children DOI Creative Commons
Evan Dennis, Peter Manza, Nora D. Volkow

et al.

Translational Psychiatry, Journal Year: 2022, Volume and Issue: 12(1)

Published: Jan. 24, 2022

Low socioeconomic status (SES) in childhood is associated with deficits executive function and changes cortical morphology. Furthermore, rates of obesity are greater among low SES children also alterations impaired neurocognition, specifically the domain function. To investigate influence BMI on relationships between both neurocognition brain morphology, we used data from Adolescent Brain Cognitive Development (ABCD) study to construct multiple linear regression models conduct mediation analyses. Overall, as measured by household income, highest level parental education, area deprivation, was lower BMI, total prefrontal volume, better performance assessments Mediation analysis indicated that had a significant indirect effect associations deprivation volumes. played mediating role composite neurocognitive scores, which were driven tasks working memory cognitive flexibility, but not control. These findings suggest should be considered future studies investigating relationship poor neurodevelopmental outcomes.

Language: Английский

Citations

80
Task fMRI paradigms may capture more behaviorally relevant information than resting-state functional connectivity DOI Creative Commons
Weiqi Zhao, Carolina Makowski, Donald J. Hagler

et al.

NeuroImage, Journal Year: 2023, Volume and Issue: 270, P. 119946 - 119946

Published: Feb. 17, 2023

Characterizing the optimal fMRI paradigms for detecting behaviorally relevant functional connectivity (FC) patterns is a critical step to furthering our knowledge of neural basis behavior. Previous studies suggested that FC derived from task paradigms, which we refer as task-based FC, are better correlated with individual differences in behavior than resting-state but consistency and generalizability this advantage across conditions was not fully explored. Using data three tasks Adolescent Brain Cognitive Development Study ® (ABCD), tested whether observed improvement behavioral prediction power can be attributed changes brain activity induced by design. We decomposed time course each into model fit (the fitted condition regressors single-subject general linear model) residuals, calculated their respective compared performance these estimates original FC. The residual at predicting measure cognitive ability or two measures on tasks. superior content-specific insofar it only probed similar constructs predicted interest. To surprise, parameters, beta regressors, were equally if more predictive all measures. These results showed afforded largely driven associated Together previous studies, findings highlighted importance design eliciting meaningful activation patterns.

Language: Английский

Citations

79
State-level macro-economic factors moderate the association of low income with brain structure and mental health in U.S. children DOI Creative Commons
David G. Weissman, Mark L. Hatzenbuehler, Mina Cikara

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: May 2, 2023

Abstract Macrostructural characteristics, such as cost of living and state-level anti-poverty programs relate to the magnitude socioeconomic disparities in brain development mental health. In this study we leveraged data from Adolescent Brain Cognitive Development (ABCD) 10,633 9-11 year old youth (5115 female) across 17 states. Lower income was associated with smaller hippocampal volume higher internalizing psychopathology. These associations were stronger states living. However, high that provide more generous cash benefits for low-income families, reduced by 34%, association family resembled lowest We observed similar patterns State-level may be confounded other factors related neurodevelopment robust controls numerous social, economic, political characteristics. findings suggest macrostructural including generosity policies, are potentially relevant addressing relationship low

Language: Английский

Citations

78
Childhood socioeconomic status and the pace of structural neurodevelopment: accelerated, delayed, or simply different? DOI Creative Commons
Divyangana Rakesh, Sarah Whittle, Margaret A. Sheridan

et al.

Trends in Cognitive Sciences, Journal Year: 2023, Volume and Issue: 27(9), P. 833 - 851

Published: May 11, 2023

Socioeconomic status (SES) is associated with children's brain and behavioral development. Several theories propose that early experiences of adversity or low SES can alter the pace neurodevelopment during childhood adolescence. These make contrasting predictions about whether adverse are accelerated delayed neurodevelopment. We contextualize these within context normative development cortical subcortical structure review existing evidence on structural to adjudicate between competing hypotheses. Although none fully consistent observed SES-related differences in development, suggests trajectories more a simply different developmental pattern than an acceleration

Language: Английский

Citations

73
Building towards an adolescent neural urbanome: Expanding environmental measures using linked external data (LED) in the ABCD study DOI Creative Commons

Carlos Cardenas‐Iniguez,

Jared N. Schachner, Ka I Ip

et al.

Developmental Cognitive Neuroscience, Journal Year: 2024, Volume and Issue: 65, P. 101338 - 101338

Published: Jan. 4, 2024

Many recent studies have demonstrated that environmental contexts, both social and physical, an important impact on child adolescent neural behavioral development. The adoption of geospatial methods, such as in the Adolescent Brain Cognitive Development (ABCD) Study, has facilitated exploration many contexts surrounding participants' residential locations without creating additional burdens for research participants (i.e., youth families) neuroscience studies. However, number linked databases increases, developing a framework considers various domains related to environments external their home becomes crucial. Such needs identify structural contextual factors may yield inequalities children's built natural environments; these differences may, turn, result downstream negative effects children from historically minoritized groups. In this paper, we develop – which describe "adolescent urbanome" use it categorize newly geocoded information incorporated into ABCD Study by Linked External Data (LED) Environment & Policy Working Group. We also highlight relationships between measures possible applications Neural Urbanome. Finally, provide recommendations considerations regarding responsible communication data, highlighting potential harm groups through misuse.

Language: Английский

Citations

18
Adolescent Brain Cognitive Development (ABCD) study Linked External Data (LED): Protocol and practices for geocoding and assignment of environmental data DOI Creative Commons
Chun Fan, Andrew T. Marshall, Harry R. Smolker

et al.

Developmental Cognitive Neuroscience, Journal Year: 2021, Volume and Issue: 52, P. 101030 - 101030

Published: Nov. 8, 2021

Our brain is constantly shaped by our immediate environments, and while some effects are transient, have long-term consequences. Therefore, it critical to identify which environmental risks evident impact on development. To expand understanding of the context each child, Adolescent Brain Cognitive Development (ABCD) Study® incorporates use geospatial location data capture a range individual, neighborhood, state level based child's residential in order elucidate physical contexts today's youth growing up. We review major considerations types geocoded information incorporated Linked External Data Environmental (LED) workgroup built natural constructs existing future ABCD Study releases. Understanding furthers consortium's mission understand factors that may influence individual differences development, providing opportunity inform public policy health organization guidelines for child adolescent health.

Language: Английский

Citations

100
Similar but distinct – Effects of different socioeconomic indicators on resting state functional connectivity: Findings from the Adolescent Brain Cognitive Development (ABCD) Study® DOI Creative Commons
Divyangana Rakesh, Andrew Zalesky, Sarah Whittle

et al.

Developmental Cognitive Neuroscience, Journal Year: 2021, Volume and Issue: 51, P. 101005 - 101005

Published: Aug. 14, 2021

Early socioeconomic status (SES) has consistently been associated with child health and cognitive outcomes, in addition to alterations brain function connectivity. The goal of the present study was probe effects different facets SES (parent education, income, neighborhood disadvantage), that likely represent varying aspects environment, on resting state functional connectivity (rsFC). We investigated this question a large sample 9475 children (aged 9-10 years) from Adolescent Brain Cognitive Development (ABCD) Study. Specifically, we analyzed association between household income-to-needs ratio) disadvantage, system-level rsFC using within-sample split-half replication. then tested whether associations were unique each measure, disadvantage had interactive rsFC. measures both common distinct rsFC, sensory-motor systems (e.g., sensorimotor network) networks front-parietal particularly implicated. Further, network less pronounced presence high income-to-needs. Findings demonstrate have interacting highlighting importance considering indicators when studying brain.

Language: Английский

Citations

78