JAMA Pediatrics,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 14, 2024
Importance
Glucagon-like
peptide
1
receptor
agonists
(GLP1R)
are
increasingly
being
used
for
the
treatment
of
obesity
in
adolescents.
It
is
currently
unknown
whether
GLP1R
associated
with
suicidal
ideation
or
attempts
this
population.
Objective
To
investigate
association
between
initiation
and
adolescents
obesity.
Design,
Setting,
Participants
Retrospective
propensity
score–matched
cohort
study
using
electronic
health
records
from
TriNetX
global
federated
network
December
2019
June
2024.
The
analysis
included
data
120
care
organizations,
mainly
USA.
were
aged
12
to
18
years
a
diagnosis
evidence
an
antiobesity
prescription
lifestyle
intervention
without
within
following
year.
Cohorts
balanced
baseline
demographic
characteristics,
psychiatric
medications
comorbidities,
diagnoses
socioeconomic
status
access
score
matching.
Exposure
Initial
(study
cohort)
(control
cohort).
Main
Outcomes
Measures
Incidence
based
on
International
Statistical
Classification
Diseases
Related
Health
Problems,
Tenth
Revision
codes
recorded
patient
during
months
follow-up.
Diagnoses
upper
respiratory
tract
infections
(URTI)
as
negative
control
outcomes,
gastrointestinal
symptoms
(GI)
positive
outcomes.
Results
A
total
4052
concomitant
identified
50
112
cohort.
Propensity
matching
resulted
3456
participants
each
Prescription
was
33%
reduced
risk
over
follow-up
(1.45%
vs
2.26%;
hazard
ratio
[HR],
0.67;
95%
CI,
0.47-0.95;
P
=
.02)
higher
rate
GI
(6.9%
5.4%;
HR,
1.41;
1.12-1.78;
.003)
but
no
difference
rates
URTI
diagnoses.
Conclusions
Relevance
In
study,
prescribed
had
lower
incidence
compared
matched
patients
not
who
treated
intervention.
These
results
suggest
favorable
safety
profile
detected
reduction
HRs
among
suggests
potential
avenues
future
research.
JAMA,
Journal Year:
2023,
Volume and Issue:
329(17), P. 1469 - 1469
Published: May 2, 2023
There
has
been
increasing
concern
about
the
burden
of
mental
health
problems
among
youth,
especially
since
COVID-19
pandemic.
Trends
in
health-related
emergency
department
(ED)
visits
are
an
important
indicator
unmet
outpatient
needs.To
estimate
annual
trends
ED
US
children,
adolescents,
and
young
adults
between
2011
2020.Data
from
to
2020
National
Hospital
Ambulatory
Medical
Care
Survey,
cross-sectional
national
probability
sample
survey
EDs,
was
used
examine
for
youths
aged
6
24
years
(unweighted
=
49
515).Mental
included
associated
with
psychiatric
or
substance
use
disorders
were
identified
by
International
Classification
Diseases-Ninth
Revision,
Clinical
Modification
(ICD-9-CM;
2011-2015)
ICD-10-CM
(2016-2020)
discharge
diagnosis
codes
reason-for-visit
(RFV)
codes.
We
estimated
proportion
pediatric
2020.
Subgroup
analyses
performed
demographics
broad
diagnoses.
Multivariable-adjusted
logistic
regression
factors
independently
controlling
period
effects.From
2020,
weighted
number
increased
4.8
million
(7.7%
all
visits)
7.5
(13.1%
average
percent
change
8.0%
(95%
CI,
6.1%-10.1%;
P
<
.001).
Significant
linearly
seen
adults,
greatest
increase
adolescents
across
sex
race
ethnicity.
While
types
significantly
increased,
suicide-related
demonstrated
0.9%
4.2%
(average
change,
23.1%
[95%
19.0%-27.5%];
.001).Over
last
10
years,
reasons
approximately
doubled,
including
a
5-fold
visits.
These
findings
underscore
urgent
need
improve
crisis
service
capacity
people,
children
experiencing
suicidal
symptoms.
PEDIATRICS,
Journal Year:
2023,
Volume and Issue:
151(3)
Published: Feb. 15, 2023
To
identify
potential
differential
changes
in
youth
suicide
deaths
associated
with
the
coronavirus
disease
(COVID-19)
pandemic
to
better
inform
prevention
strategies.
American Journal of Psychiatry,
Journal Year:
2022,
Volume and Issue:
179(6), P. 422 - 433
Published: May 23, 2022
Suicide
rates
among
ethnoracially
minoritized
youth
(i.e.,
of
color)
peak
before
the
age
30,
and
striking
disparities
in
access
to
mental
health
services
have
been
identified
this
group.
However,
suicide
prevention
strategies
yet
fully
address
structural
racism
as
a
mechanism
producing
risk,
protective
factors,
quality
effective
intervention
for
color.
Such
an
approach
is
critical
provide
more
culturally
responsive
care.
Through
adapted
socio-ecological
model,
authors
propose
Structural
Racism
Prevention
Systems
Framework
illustrate
pathways
through
which
impacts
color
United
States.
The
contextualize
impact
three
key
settings
where
occurs:
services,
schools,
interface
between
crisis
care
law
enforcement.
posit
that
attention
must
be
paid
intersection
mutually
reinforcing,
interdependent
systems
rather
than
isolation.
then
recommendations
prevention,
including
macro-level
interventions
improve
societal
conditions,
research
inform
solutions,
training
approaches
institutional
racism,
clinical
racial
trauma
on
youths
families.
BMJ,
Journal Year:
2023,
Volume and Issue:
unknown, P. e070630 - e070630
Published: April 24, 2023
Abstract
Suicide
is
the
fourth
leading
cause
of
death
among
young
people
worldwide
and
third
those
in
US.
This
review
outlines
epidemiology
suicide
suicidal
behavior
people.
It
discusses
intersectionality
as
an
emerging
framework
to
guide
research
on
prevention
highlights
several
clinical
community
settings
that
are
prime
targets
for
implementation
effective
treatment
programs
interventions
aimed
at
rapidly
reducing
rate
provides
overview
current
approaches
screening
assessment
risk
commonly
used
tools
measures.
universal,
selective,
indicated
evidence
based
focused
components
psychosocial
with
strongest
risk.
Finally,
strategies
considers
future
directions
questions
challenging
field.
PEDIATRICS,
Journal Year:
2022,
Volume and Issue:
149(2)
Published: Jan. 3, 2022
BACKGROUND
The
coronavirus
disease
2019
(COVID-19)
pandemic
created
high
levels
of
psychological
distress
and
may
have
increased
suicide
risk.
METHODS
We
used
the
4-item
Ask
Suicide-Screening
Questions
(ASQ)
to
assess
risk
among
all
patients
12
24
years
age
at
a
children’s
hospital.
compared
demographics,
encounter
type
(telehealth
or
face-to-face
[F2F]),
screening
results
from
April
June
2020
(T2)
those
(T1).
RESULTS
Fewer
were
seen
T2
than
T1
(17
986
vs
863).
A
greater
proportion
visits
by
telehealth
(0%
43%).
rate
positive
screens
was
higher
in
(12.2%
11.1%,
adjusted
odds
ration
[aOR],
1.24;
95%
confidence
interval
[CI],
1.15–1.35).
screen
for
older
(aOR
1.12
years;
CI,
1.10–1.14),
female
(aOR,
2.23;
2.00–2.48),
with
public
versus
private
insurance
1.88;
1.72–2.07),
lower
Black
White
0.85;
0.77–0.95).
Rates
highest
inpatients
(20.0%),
intermediate
emergency
department
(14.4%),
lowest
outpatient
clinics
(9.9%)
(P
<
.05).
CONCLUSIONS
adolescents
rose
pandemic’s
early
months
differences
related
sociodemographics
visit
type.
Changes
health
care
delivery
highlight
complexities
assessing
responding
mental
needs
adolescents.
Additional
research
might
determine
effects
methods
patient
populations
on
results.
JAMA Psychiatry,
Journal Year:
2024,
Volume and Issue:
81(6), P. 595 - 595
Published: March 20, 2024
Suicide
rates
in
the
US
increased
by
35.6%
from
2001
to
2021.
Given
that
most
individuals
die
on
their
first
attempt,
earlier
detection
and
intervention
are
crucial.
Understanding
modifiable
risk
factors
is
key
effective
prevention
strategies.
JAMA Network Open,
Journal Year:
2023,
Volume and Issue:
6(2), P. e2255986 - e2255986
Published: Feb. 15, 2023
Screening
adolescents
in
emergency
departments
(EDs)
for
suicidal
risk
is
a
recommended
strategy
suicide
prevention.
Comparing
screening
measures
on
predictive
validity
could
guide
ED
clinicians
choosing
tool.To
compare
the
Ask
Suicide-Screening
Questions
(ASQ)
instrument
with
Computerized
Adaptive
Screen
Suicidal
Youth
(CASSY)
prediction
of
behavior
among
seen
EDs,
across
demographic
and
clinical
strata.The
Emergency
Department
Study
Teens
at
Risk
Suicide
prospective,
random-series,
multicenter
cohort
study
that
recruited
adolescents,
oversampled
those
psychiatric
symptoms,
who
presented
to
from
July
24,
2017,
through
October
29,
2018,
3-month
follow-up
assess
occurrence
behavior.
The
included
14
pediatric
members
Pediatric
Care
Applied
Research
Network
1
Indian
Health
Service
ED.
Statistical
analysis
was
performed
May
2021
January
2023.This
used
model
outcomes.
primary
outcome
attempt
(SA),
secondary
suicide-related
visits
or
hospital
within
3
months
baseline;
both
were
assessed
by
an
interviewer
blinded
baseline
information.
ASQ
4-item
questionnaire
surveys
ideation
lifetime
SAs.
A
positive
response
nonresponse
any
item
indicates
risk.
CASSY
computerized
adaptive
tool
always
includes
items
mean
8
additional
items.
CASSY's
continuous
predicted
probability
SA.Of
6513
available,
4050
enrolled,
3965
completed
assessments,
2740
(1705
girls
[62.2%];
[SD]
age
enrollment,
15.0
[1.7]
years;
469
Black
participants
[17.1%],
678
Hispanic
[24.7%],
1618
White
[59.1%])
screenings
follow-ups.
showed
similar
sensitivity
(0.951
[95%
CI,
0.918-0.984]
vs
0.945
0.910-0.980]),
specificity
(0.588
0.569-0.607]
0.643
0.625-0.662]),
value
(0.127
0.109-0.146]
0.144
0.123-0.165]),
negative
(both
0.995
0.991-0.998],
respectively).
Area
under
receiver
operating
characteristic
curve
findings
patients
physical
symptoms
(ASQ,
0.88
0.81-0.95]
CASSY,
0.94
0.91-0.96]).
Among
better
than
(0.72
0.68-0.77]
0.57
0.55-0.59],
respectively).This
suggests
are
appropriate
universal
EDs.
For
small
subset
shows
greater
validity.
JAMA Network Open,
Journal Year:
2022,
Volume and Issue:
5(7), P. e2219934 - e2219934
Published: July 1, 2022
Racial,
ethnic,
and
sex
disparities
for
concussion
incidence
suicide
attempts
in
youth
have
been
reported,
but
data
on
the
interaction
of
these
variables
a
large
national
set
are
lacking.
Understanding
how
race
ethnicity
interact
with
to
influence
could
yield
critical
information
sociocultural
impact
brain
injury
mental
health
US
youth.To
examine
associations
history,
ethnicity,
reported
among
adolescents.This
population-based
cross-sectional
cohort
study
used
from
Youth
Risk
Behavior
Surveillance
System
(YRBSS)
survey
respondents
between
2017
2019.
Data
were
analyzed
May
2021
January
2022.Respondents
sport-
or
recreation-related
(yes
no),
depression
attempt
no)
over
previous
12
months,
along
(categorized
as
American
Indian
Alaska
Native,
Asian,
Black,
Hispanic/Latino,
multiracial,
Native
Hawaiian
other
Pacific
Islander,
White),
(male
female).Two
Chi-Square
Automatic
Interaction
Detection
(CHAID)
decision
tree
models
built.
The
first
was
history
(SA-DEP),
second
without
(SA-NO
DEP).
CHAID
uses
risk
factors
(eg,
number
concussions,
sex)
divide
sample
into
series
subgroups
that
nested
within
each
other.
ratios
(RRs)
95%
CIs
calculated
subgroup
provide
effect
estimates.A
total
28
442
youths
aged
up
18
years
(mean
[SD]
age,
14.6
[3.0]
years;
14
411
[50.7%]
female)
responded
survey.
trees
revealed
complex
race,
sex,
attempting
suicide,
which
differed
by
(overall
accuracy,
84.4%-97.9%).
Overall,
variable
most
strongly
associated
SA
(adjusted
odds
ratio,
11.24;
CI,
10.27-12.29).
Concussion
SA-DEP
(RR,
1.31;
1.20-1.51;
P
<
.001).
multiracial
increased
compared
others
1.59;
1.38-1.84;
Hispanic/Latino
SA-NO
DEP
1.89;
1.54-2.32;
.001)
remaining
population.These
findings
suggest
clinicians
should
consider
when
evaluating
role
youth.
Journal of the American Medical Informatics Association,
Journal Year:
2023,
Volume and Issue:
30(8), P. 1408 - 1417
Published: April 11, 2023
Abstract
Objectives
Suicide
presents
a
major
public
health
challenge
worldwide,
affecting
people
across
the
lifespan.
While
previous
studies
revealed
strong
associations
between
Social
Determinants
of
Health
(SDoH)
and
suicide
deaths,
existing
evidence
is
limited
by
reliance
on
structured
data.
To
resolve
this,
we
aim
to
adapt
suicide-specific
SDoH
ontology
(Suicide-SDoHO)
use
natural
language
processing
(NLP)
effectively
identify
individual-level
SDoH-related
social
risks
from
death
investigation
narratives.
Materials
Methods
We
used
latest
National
Violent
Death
Report
System
(NVDRS),
which
contains
267
804
victim
data
2003
2019.
After
adapting
Suicide-SDoHO,
developed
transformer-based
model
circumstances
crises
in
applied
our
retrospectively
annotate
narratives
whose
crisis
variables
were
not
coded
NVDRS.
The
rates
calculated
as
percentage
group’s
total
population
with
present.
Results
Suicide-SDoHO
57
fine-grained
hierarchical
structure.
Our
classifier
achieves
AUCs
0.966
0.942
for
classifying
crises,
respectively.
Through
trend
analysis,
observed
that
everyone
equally
affected
risks.
For
economic
stability
crisis,
result
showed
significant
increase
rate
2007–2009,
parallel
Great
Recession.
Conclusions
This
first
study
curating
using
showcased
can
classify
through
NLP
approaches.
hope
will
facilitate
understanding
inform
effective
prevention
strategies.
Youth & Society,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 18, 2025
Previous
studies
have
well-documented
that
adverse
childhood
experiences
(ACEs)
are
associated
with
negative
health
outcomes,
including
suicidal
thoughts
and
behaviors.
As
historically
marginalized
groups
long
experienced
poorer
socio-emotional
outcomes
due
to
systemic
institutional
racism,
racial
stress,
related
factors,
surprisingly
little
is
known
about
how
ACEs
matter
across
racial/ethnic
adolescent
groups.
This
study
aims
fill
this
gap
by
analyzing
data
from
the
2022
Florida
Youth
Substance
Abuse
Survey
(FYSAS).
Utilizing
logistic
regression
models,
we
investigate
influence
Results
reveal
a
significant
link
between
these
indicating
higher
ACE
scores
correlate
increased
risk
of
attempts.
Racial/ethnic
variations
in
effects
on
suicidality
observed
among
non-Hispanic
Black
Hispanic/Latinx
youth.
We
also
find
despite
generally
experiencing
fewer
ACEs,
Asian
American
youth
were
nearly
30%
more
likely
than
White