Optimal dietary patterns for healthy aging

Nature Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

As the global population ages, it is critical to identify diets that, beyond preventing noncommunicable diseases, optimally promote healthy aging. Here, using longitudinal questionnaire data from Nurses' Health Study (1986–2016) and Professionals Follow-Up (1986–2016), we examined association of long-term adherence eight dietary patterns ultraprocessed food consumption with aging, as assessed according measures cognitive, physical mental health, well living 70 years age free chronic diseases. After up 30 follow-up, 9,771 (9.3%) 105,015 participants (66% women, mean = 53 (s.d. 8)) achieved For each pattern, higher was associated greater odds aging its domains. The ratios for highest quintile versus lowest ranged 1.45 (95% confidence interval (CI) 1.35–1.57; healthful plant-based diet) 1.86 CI 1.71–2.01; Alternative Healthy Eating Index). When threshold shifted 75 years, Index diet showed strongest an ratio 2.24 2.01–2.50). Higher intakes fruits, vegetables, whole grains, unsaturated fats, nuts, legumes low-fat dairy products were linked whereas trans sodium, sugary beverages red or processed meats (or both) inversely associated. Our findings suggest that rich in foods, moderate inclusion animal-based may enhance overall guiding future guidelines. In two cohorts followed associations different aging—encompassing health—were studied, identifying constituents lesser

Language: Английский

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BioClocks UK: driving robust cycles of discovery to impact

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2025, Volume and Issue: 380(1918)

Published: Jan. 23, 2025

Chronobiology is a multidisciplinary field that extends across the tree of life, transcends all scales biological organization, and has huge translational potential. For UK to harness opportunities presented within applied chronobiology, we need build our network outwards reach stakeholders can directly benefit from discoveries. In this article, discuss importance rhythms health, society, economy environment, with particular focus on circadian rhythms. We subsequently introduce vision objectives BioClocks UK, newly formed research network, whose mission stimulate researcher interactions sustain discovery-impact cycles between chronobiologists, wider communities multiple industry sectors. This article part Theo Murphy meeting issue ‘Circadian in infection immunity’.

Language: Английский

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Short sleep and insomnia are associated with accelerated epigenetic age

Psychosomatic Medicine, Journal Year: 2023, Volume and Issue: 86(5), P. 453 - 462

Published: Aug. 18, 2023

Short sleep and insomnia are each associated with a greater risk of age-related disease, which suggests that insufficient may accelerate biological aging. We examine whether short alone or together relates to epigenetic age among older adults.

Language: Английский

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Anxiety, depression, and insomnia among nurses during the full liberalization of COVID-19: a multicenter cross-sectional analysis of the high-income region in China

Frontiers in Public Health, Journal Year: 2023, Volume and Issue: 11

Published: June 26, 2023

Introduction Frontline nurses fighting against the epidemic were under great psychological stress. However, there is a lack of studies assessing prevalence rates anxiety, depression, and insomnia among frontline after full liberalization COVID-19 in China. This study demonstrates impact on issues rate associated factors depressive symptoms, nurses. Methods A total 1766 completed self-reported online questionnaire by convenience sampling. The survey included six main sections: 9-item Patient Health Questionnaire (PHQ-9), 7-item Generalized Anxiety Disorder (GAD-7), Insomnia Severity Index (ISI), 10-item Perceived Stress Scale (PSS-10), sociodemographic information, work information. Multiple logistic regression analyses applied to identify potential significantly for issues. methods compliant with STROBE checklist. Results 90.83% infected COVID-19, 33.64% had while COVID-19. overall anxiety was 69.20%, 62.51%, 76.78%, respectively. revealed that job satisfaction, attitude toward current pandemic management, perceived stress insomnia. Conclusions highlighted suffering from varying degrees during Early detection mental health preventive promotive interventions should be implemented according prevent more serious

Language: Английский

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Associations between actigraphy-measured sleep duration, continuity, and timing with mortality in the UK Biobank

SLEEP, Journal Year: 2023, Volume and Issue: 47(3)

Published: Dec. 8, 2023

To examine the associations between sleep duration, continuity, timing, and mortality using actigraphy among adults. Data were from a cohort of 88 282 adults (40-69 years) in UK Biobank that wore wrist-worn triaxial accelerometer for 7 days. Actigraphy data processed to generate estimates duration other characteristics including wake after onset (WASO), number 5-minute awakenings, midpoint onset/wake-up least active 5 hours (L5). linked outcomes with follow-up October 31, 2021. We implemented Cox models (hazard ratio, confidence intervals [HR, 95% CI]) quantify mortality. Models adjusted demographics, lifestyle factors, medical conditions. Over an average 6.8 years 2973 deaths occurred (1700 cancer, 586 CVD deaths). Overall was significantly associated risk all-cause (p < 0.01), cancer = 0.03) For example, when compared durations 7.0 hrs/d, hrs/d 29% higher (HR: 1.29 [1.09, 1.52]). WASO awakenings not Individuals L5 early or late midpoints (<2:30 ≥ 3:30) had ~20% mortality, those intermediate (3:00-3:29; p ≤ 0.01; e.g. HR 3:30: 1.19 [1.07, 1.32]). Shorter both timing risk. These findings reinforce importance public health efforts promote healthy patterns

Language: Английский

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Impact of sleep disturbance in shift workers on hippocampal volume and psychomotor speed

SLEEP, Journal Year: 2024, Volume and Issue: 47(9)

Published: April 25, 2024

Shift work interferes with circadian rhythms, affecting sleep quality and cognitive function. Poor in shift worker (SW)s can impair psychomotor performance due to fatigue sleepiness, increasing the risk of errors, accidents, reduced productivity. Given potential for atrophic changes hippocampus disturbances, our study investigates how poor correlates hippocampal structural alterations impacts among SWs.

Language: Английский

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Mental Health, Mentalising and Empathy in Australian Healthcare Workers During COVID-19: A Cross-Sectional Study

Psychological Reports, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 23, 2025

Since the outbreak of a Coronavirus Disease (COVID-19), healthcare workers have consistently exhibited increased stress, anxiety and depression. However, no study to date, has yet examined whether these symptoms are associated with social cognitive skills, known be paramount in delivering high quality patient care. This cross-sectional aimed investigate depression were related both empathy mentalising who worked during COVID-19 Australia. Participants an average age 31.9 years ( N = 177). completed Depression, Anxiety Stress Scale-21 (DASS-21), Interpersonal Reactivity Index (IRI) Reading Mind The Eyes Test (RMET) between May 24th June 21st, 2021. We found that higher stress levels improved abilities understanding others’ emotions mental states, showing affective engaging imaginative thinking. Conversely, was linked reduced states this cohort. No other significant associations observed. Our findings suggest organisational initiatives needed deliver targeted interventions specialised programs support skills workers. Future studies longitudinal designs better characterise health-social cognition disentangle its directionality.

Language: Английский

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Alterations in Pregnenolone and Testosterone Levels in Male Shift Workers

International Journal of Environmental Research and Public Health, Journal Year: 2023, Volume and Issue: 20(4), P. 3195 - 3195

Published: Feb. 11, 2023

Steroid hormone levels are closely related to the endogenous circadian rhythm induced by sleep-wake and dark-light cycles. Shift work that disrupts may influence of steroid hormones. The association between shift alterations in female sex has been studied, but little is known about testosterone its precursor pregnenolone male workers. present study investigated serum a group daytime All participants were sampled at beginning morning shift. Lower total found workers compared Variations have consequences for well-being, they might produce hormones downstream cascade, such as testosterone. low demonstrate perturbative effect on levels, which be independent and/or synthesis.

Language: Английский

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Vegetarian diet and healthy aging among Chinese older adults: a prospective study

npj Aging, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 1, 2025

Language: Английский

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Sex-specific risk factor awareness, covert misogyny and long-term cardiovascular risk management: Pilot study

Medicinska istrazivanja, Journal Year: 2025, Volume and Issue: 58(1), P. 25 - 32

Published: Jan. 1, 2025

INTRODUCTION: Health literacy is a cornerstone of prevention, while sex specific prevention cardiovascular disease, leading cause death women worldwide, remains less addressed and still more matter local cultural habits than guideline-directed management. METHODS: A validated multiple-choice questionnaire (MCQ) designed to both educate patients help the healthcare team learn about their traditional modern risk factors (RF) management, including opting for comprehensive personalized long term follow up (FU) was offered all in-patients. RESULTS: Out 130 hospitalized at our department (Jan 1, 2024 - Feb 24, 2024) who were fill in MCQ, 37.7% accepted do so, 11.5% excluded on ethical grounds. Women (49%) older men, had significant burden RF possessed higher levels knowledge interest RFs sexes, men especially those declined participate without clear reason even stated having no female relatives' profiles. Men, unlike women, showed particular tech-savvy options FU, although they equally use hand-held devices. CONCLUSION: These results confirm findings obtained from similar study conducted an all-female sample same setting year ago. However, surprising hostility exhibited towards junior mid-career which absent when approached by senior male member team. This confirms that misogyny needs be actively suppressed.

Language: Английский

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