Schizophrenia Research, Journal Year: 2025, Volume and Issue: 278, P. 119 - 127
Published: March 31, 2025
Language: Английский
Trends in Cognitive Sciences, Journal Year: 2023, Volume and Issue: 27(9), P. 833 - 851
Published: May 11, 2023
Socioeconomic status (SES) is associated with children's brain and behavioral development. Several theories propose that early experiences of adversity or low SES can alter the pace neurodevelopment during childhood adolescence. These make contrasting predictions about whether adverse are accelerated delayed neurodevelopment. We contextualize these within context normative development cortical subcortical structure review existing evidence on structural to adjudicate between competing hypotheses. Although none fully consistent observed SES-related differences in development, suggests trajectories more a simply different developmental pattern than an acceleration
Language: Английский
Citations
70
Health Affairs, Journal Year: 2023, Volume and Issue: 42(5), P. 702 - 709
Published: May 1, 2023
The Area Deprivation Index (ADI), popularized by the Neighborhood Atlas, is a multifaceted proxy measure for assessing socioeconomic disadvantage that captures social risk factors are not available in typical clinical registries and related to adverse health outcomes. In applying ADI New York State, we found downstate regions (New City its suburbs) were as deprived or more than other thirteen of seventeen variables (all but ones measured dollars), Atlas–computed overall deprivation was much less areas. Numerous census block groups with high home values (indicating low deprivation) accompanied had scores computed Atlas same contiguous deciles values. We concluded mainly representative median value. This can be especially problematic when considering quality assessment, funding, resource allocation large variations cost living, it may result underresourcing disadvantaged communities housing prices. conclude would accurate comparing if standardized before computing index.
Language: Английский
Citations
57
JAMA Neurology, Journal Year: 2023, Volume and Issue: 80(9), P. 903 - 903
Published: July 19, 2023
Residence in a disadvantaged neighborhood may be associated with an increased risk for cognitive impairment and dementia but is understudied nationally representative populations.
Language: Английский
Citations
34
JAMA Pediatrics, Journal Year: 2023, Volume and Issue: 177(12), P. 1294 - 1294
Published: Oct. 16, 2023
Importance Social determinants of health (SDOH) influence child health. However, most previous studies have used individual, small-set, or cherry-picked SDOH variables without examining unbiased computed patterns from high-dimensional factors to investigate associations with mental health, cognition, and physical Objective To identify estimate their children’s mental, cognitive, developmental outcomes. Design, Setting, Participants This population-based cohort study included children aged 9 10 years at baseline caregivers enrolled in the Adolescent Brain Cognitive Development (ABCD) Study between 2016 2021. The ABCD includes 21 sites across 17 states. Exposures Eighty-four neighborhood-level, geocoded spanning 7 domains SDOH, including bias, education, infrastructure, natural environment, socioeconomic status, social context, crime drugs, were studied. Hierarchical agglomerative clustering was patterns. Main Outcomes Measures Associations (internalizing externalizing behaviors) suicidal behaviors, cognitive function (performance, reading skills), (body mass index, exercise, sleep disorder) estimated using mixed-effects linear logistic regression models. Results Among 504 (baseline median [SD] age, 9.9 [0.6] years; 5510 boys [52.5%] 4994 girls [47.5%]; 229 Asian [2.2%], 1468 Black [14.0%], 2128 Hispanic [20.3%], 5565 White [53.0%], 1108 multiracial [10.5%]), 4 identified: pattern 1, affluence (4078 [38.8%]); 2, high-stigma environment (2661 [25.3%]); 3, high deprivation (2653 4, drug sales, low population density (1112 [10.6%]). distinctly associated Children exposed (SDOH 3) showed worst profiles, manifesting more internalizing (β = 0.75; 95% CI, 0.14-1.37) 1.43; 0.83-2.02) problems, lower performance, adverse Conclusions shows that an quantitative analysis multidimensional can permit determination how are outcomes relative other categories. These findings suggest need determine whether improvement conditions enhance
Language: Английский
Citations
32
JAMA Network Open, Journal Year: 2023, Volume and Issue: 6(6), P. e2320276 - e2320276
Published: June 27, 2023
Importance Lower neighborhood and household socioeconomic status (SES) are associated with negative health outcomes altered brain structure in children. It is unclear whether such findings extend to white matter via what mechanisms. Objective To assess how SES independently children’s microstructure examine obesity cognitive performance (reflecting environmental sensory stimulation) plausible mediators. Design, Setting, Participants This cross-sectional study used baseline data from participants the Adolescent Brain Cognitive Development (ABCD) study. Data were collected at 21 US sites, school-based recruitment was represent population. Children aged 9 11 years their parents or caregivers completed assessments between October 1, 2016, 31, 2018. After exclusions, 8842 of 875 children ABCD included analyses. analysis conducted July December 19, 2022. Exposures Neighborhood disadvantage derived area deprivation indices participants’ primary residence. Household factors total income highest parental educational attainment. Main Outcomes Measures A restriction spectrum imaging (RSI) model quantify restricted normalized directional (RND; reflecting oriented myelin organization) isotropic (RNI; glial neuronal cell bodies) diffusion 31 major tracts. The RSI measurements scanner harmonized. Obesity assessed through body mass index (BMI; calculated as weight kilograms divided by height meters squared), age- sex-adjusted BMI z scores, waist circumference, cognition National Institutes Health Toolbox Cognition Battery. Analyses adjusted for age, sex, pubertal development stage, intracranial volume, mean head motion, twin siblingship. Results Among children, 4543 (51.4%) boys, (SD) age 9.9 (0.7) years. Linear mixed-effects models revealed that greater lower RSI-RND left superior longitudinal fasciculus (β = −0.055; 95% CI, −0.081 −0.028) forceps −0.040; −0.067 −0.013). attainment bilateral (eg, right hemisphere: β 0.053; 0.025-0.080) corticospinal pyramidal tract 0.042; 0.015-0.069). Structural equation score higher disadvantage: −0.012; −0.016 −0.009) −0.004; −0.006 −0.001) partially accounted associations RSI-RND. RSI-RNI most tracts inferior fasciculus: −0.042 [95% −0.073 −0.012]; anterior thalamic radiations: −0.045 −0.075 −0.014]), had similar primarily frontolimbic fornix: 0.046 0.019-0.074]; 0.045 0.018-0.072]). −0.048; −0.077 −0.020). Greater these 0.015; 0.011-0.020). Findings robust sensitivity analyses corroborated using tensor imaging. Conclusions Relevance In this study, both contexts suggested possible mediators associations. Future research on may benefit considering multiple perspectives.
Language: Английский
Citations
24
Developmental Review, Journal Year: 2024, Volume and Issue: 73, P. 101135 - 101135
Published: June 12, 2024
Early environmental experiences influence children's cognitive and neural development. In particular, stimulation, defined as inputs that engage the senses provide learning opportunities for children, fosters acquisition of knowledge across various domains. Low levels stimulation in early life may restrict opportunities, contributing to lasting consequences development later academic occupational achievement. This review delves into role related performance, available tools measuring settings, offers insights future research directions. addition, variability often linked differences socioeconomic status, create disparities access enriching foundation learning. We therefore briefly status also leverage evidence from intervention studies illustrate importance outcomes. Investigating on brain behavior is crucial developing effective strategies foster healthy all children unlocking their full potential.
Language: Английский
Citations
14
Molecular Psychiatry, Journal Year: 2024, Volume and Issue: 29(10), P. 3268 - 3286
Published: April 24, 2024
The environment influences brain and mental health, both detrimentally beneficially. Existing research has emphasised the individual psychosocial 'microenvironment'. Less attention been paid to 'macroenvironmental' challenges, including climate change, pollution, urbanicity, socioeconomic disparity. Notably, implications of pollution on health have only recently gained prominence. With advent large-scale big-data cohorts an increasingly dense mapping macroenvironmental parameters, we are now in a position characterise relation between macroenvironment, brain, behaviour across different geographic cultural locations globally. This review synthesises findings from recent epidemiological neuroimaging studies, aiming provide comprehensive overview existing evidence macroenvironment structure functions with particular emphasis its for illness. We discuss putative underlying mechanisms address most common exposures macroenvironment. Finally, identify critical areas future enhance our understanding aetiology illness inform effective interventions healthier environments promotion.
Language: Английский
Citations
13
Advanced Science, Journal Year: 2024, Volume and Issue: 11(11)
Published: Jan. 2, 2024
Abstract The rise of new media has greatly changed the lifestyles, leading to increased time on these platforms and less spent reading. This shift particularly profound impacts early adolescents, who are in a critical stage brain development. Previous studies have found associations between screen use mental health, but it remains unclear whether is direct cause outcomes. Here, Adolescent Brain Cognitive Development (ABCD) dataset utlized examine causal relationships results revealed adverse effects language ability specific behaviors while reading positive their volume frontal temporal regions. Interestingly, identified as result, rather than cause, certain such rule‐breaking aggressive behaviors. Furthermore, analysis uncovered an indirect influence use, mediated by changes habits, These findings provide evidence for influences development highlight importance monitoring related habit change children.
Language: Английский
Citations
12
Human Brain Mapping, Journal Year: 2024, Volume and Issue: 45(5)
Published: April 1, 2024
Abstract There remains little consensus about the relationship between sex and brain structure, particularly in early adolescence. Moreover, few pediatric neuroimaging studies have analyzed both gender as variables of interest—many which included small sample sizes relied on binary definitions gender. The current study examined diversity with a continuous felt‐gender score categorized based X Y allele frequency large children ages 9–11 years old ( N = 7195). Then, statistical model‐building approach was employed to determine whether independently or jointly relate morphology, including subcortical volume, cortical thickness, gyrification, white matter microstructure. Additional sensitivity analyses found that male versus female differences gyrification were largely accounted for by total rather than per se. model sex, but not diversity, best‐fitting 60.1% gray regions 61.9% after adjusting volume. proportion variance negligible all cases. While models explained greater amount regions, alone significant predictor its own any examined. Overall, these findings demonstrate at old, accounts while is directly associated neurostructural diversity.
Language: Английский
Citations
9
Psychological Medicine, Journal Year: 2025, Volume and Issue: 55
Published: Jan. 1, 2025
Abstract Background Recent research has demonstrated that domains of social determinants health (SDOH) (e.g. air pollution and context) are associated with psychosis. However, SDOHs have often been studied in isolation. This study investigated distinct exposure profiles, estimated their associations persistent distressing psychotic-like experiences (PLE), evaluated whether involvement physical activity partially explains this association. Methods Analyses included 8,145 young adolescents from the Adolescent Brain Cognitive Development Study. Data baseline three follow-ups were included. Area-level geocoded variables spanning various SDOH, including socioeconomic status, education, crime, built environment, context, clustered using a self-organizing map method to identify profiles. Generalized linear mixed modeling tested association between profiles PLE activities (i.e. team individual sports), adjusting for individual-level covariates age, sex, race/ethnicity, highest level parent family-relatedness, sites. Results Five identified. Compared reference Profile 1 (suburban affluent areas), 3 (rural areas low walkability high ozone), 4 (urban SES deprivation, pollution) greater PLE. Team sports mediated 6.14% 3. Conclusions found neighborhoods characterized by rural urban concentrations, crime Findings suggest social-environmental factors may differentially impact development
Language: Английский
Citations
1