The global prevalence of depression, anxiety, and sleep disorder among patients coping with Post COVID-19 syndrome (long COVID): a systematic review and meta-analysis

BMC Psychiatry, Journal Year: 2024, Volume and Issue: 24(1)

Published: Feb. 6, 2024

Post COVID-19 syndrome, also known as "Long COVID," is a complex and multifaceted condition that affects individuals who have recovered from SARS-CoV-2 infection. This systematic review meta-analysis aim to comprehensively assess the global prevalence of depression, anxiety, sleep disorder in coping with syndrome.

Language: Английский

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Post-Acute Sequelae After Severe Acute Respiratory Syndrome Coronavirus 2 Infection by Viral Variant and Vaccination Status: A Multicenter Cross-Sectional Study

Clinical Infectious Diseases, Journal Year: 2023, Volume and Issue: 77(2), P. 194 - 202

Published: March 11, 2023

Disentangling the effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants and vaccination on occurrence post-acute sequelae SARS-CoV-2 (PASC) is crucial to estimate reduce burden PASC.We performed a cross-sectional analysis (May/June 2022) within prospective multicenter healthcare worker (HCW) cohort in north-eastern Switzerland. HCWs were stratified by viral variant status at time their first positive nasopharyngeal swab. without swab with negative serology served as controls. The sum 18 self-reported PASC symptoms was modeled univariable multivariable negative-binomial regression analyze association mean symptom number status.Among 2912 participants (median age: 44 years; 81.3% female), significantly more frequent after wild-type infection (estimated number: 1.12; P < .001; median since infection: 18.3 months), Alpha/Delta (0.67 symptoms; 6.5 Omicron BA.1 infections (0.52 = .005; 3.1 months) versus uninfected controls (0.39 symptoms). After infection, estimated 0.36 for unvaccinated individuals 0.71 1-2 vaccinations (P .028) 0.49 ≥3 prior .30). Adjusting confounders, only (adjusted rate ratio [aRR]: 2.81; 95% confidence interval [CI]: 2.08-3.83) (aRR: 1.93; CI: 1.10-3.46) associated outcome.Previous pre-Omicron strongest risk factor among our HCWs. Vaccination before not clear protective effect against this population.

Language: Английский

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Prevalence and Associated Factors of Post-COVID-19 Syndrome in a Brazilian Cohort after 3 and 6 Months of Hospital Discharge

International Journal of Environmental Research and Public Health, Journal Year: 2023, Volume and Issue: 20(1), P. 848 - 848

Published: Jan. 2, 2023

(1) Objectives: To evaluate the frequency and factors associated with Post-COVID-19 Syndrome (PCS) in COVID-19 survivors after 3 6 months of hospital discharge; (2) Methods: We conducted a cohort study patients who were hospitalized referral public Brasília, Federal District, Brazil. After discharge, answered questionnaire about PCS symptoms. Poisson regression robust variance was used to estimate crude adjusted prevalence ratios (PR aPR) PCS. (3) Results: The 81% 61% respectively. main symptoms discharge hair loss (44%), fatigue (42%), memory (39%); while months, they (29%) (27%). In multivariate analysis, factor female gender (aPR): 1.28 (1.16–1.41) 1.60 (1.34–1.90), Hypercholesterolemia also aPR 1.15 (1.04–1.27). obesity [aPR: 1.22 (1.03–1.45)] pronation (1.06–1.25)] relevant factors. (4) Conclusions: high had moderate severe forms disease. Memory most persistent symptom. Our data pointed gender, hypercholesterolemia, obesity, during hospitalization as PCS-associated risk

Language: Английский

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Psychophysical assessment of olfactory and gustatory function in post‐mild COVID‐19 patients: A matched case‐control study with 2‐year follow‐up

International Forum of Allergy & Rhinology, Journal Year: 2023, Volume and Issue: 13(10), P. 1864 - 1875

Published: March 5, 2023

The aim of this study was to psychophysically evaluate the prevalence smell and taste dysfunction 2 years after mildly symptomatic severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection compared that observed at 1-year follow-up while considering background chemosensory in no-coronavirus disease 2019 (COVID-19) population.This is a prospective case-control on 93 patients with polymerase chain reaction (PCR)-positive SARS-CoV-2 matched controls. Self-reported olfactory gustatory assessed by 22-item Sino-Nasal-Outcome Test (SNOT-22), item "Sense or taste." Psychophysical orthonasal retronasal function performance were estimated using extended Sniffin' Sticks test battery, 20 powdered tasteless aromas, strips test, respectively. Nasal trigeminal sensitivity sniffing 70% solution acetic acid.The two psychophysical assessments took place median 409 days (range, 366-461 days) 765 739-800 from first SARS-CoV-2-positive swab, At 2-year follow-up, cases exhibited decrease (27.9% vs. 42.0%; absolute difference, -14.0%; 95% confidence interval [CI], -21.8% -2.6%; p = 0.016) (14.0% 25.8%; -11.8%; CI, -24.2% 0.6%; 0.098). Subjects prior COVID-19 more likely than controls have an 10.8 %; 17.2%; 5.2% 28.8%) but not 9.7%; 4.3%; -5.8% 14.4% 0.496) still infection. Overall, 3.2% anosmic infection.Although proportion subjects recovered long-lasting smell/taste 1 year COVID-19, significant excess when

Language: Английский

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Long-term systemic and mucosal SARS-CoV-2 IgA response and its association with persistent smell and taste disorders

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: March 8, 2023

Current approved COVID-19 vaccines, notably mRNA and adenoviral vectored technologies, still fail to fully protect against infection transmission of various SARS-CoV-2 variants. The mucosal immunity at the upper respiratory tract represents first line defense viruses such as is thus critical develop vaccine blocking human-to-human transmission.We measured systemic Immunoglobulin A (IgA) response in serum saliva from 133 healthcare workers Percy teaching military hospital following a mild (SARS-CoV-2 Wuhan strain, n=58) or not infected (n=75), after vaccination (Vaxzevria®/Astrazeneca and/or Comirnaty®/Pfizer).While anti-SARS-CoV-2 Spike IgA lasted up 16 months post-infection, had mostly fallen baseline level 6 post-infection. Vaccination could reactivate generated by prior infection, but failed induce significant itself. Early post-COVID-19 anti-Spike-NTD titer correlated with seroneutralization titers. Interestingly, its counterpart positively persistent smell taste disorders more than one year COVID-19.As breakthrough infections have been levels, other platforms inducing better are needed control future. Our results encourage further studies explore prognosis potential predicting disorders.

Language: Английский

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The immune mechanism of the nasal epithelium in COVID-19–related olfactory dysfunction

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: July 17, 2023

During the first waves of coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome 2 (SARS-CoV-2) infection, olfactory dysfunction (OD) was reported as a frequent clinical sign. The nasal epithelium is one front-line protections against viral infections, and immune responses mucosa may be associated with OD. Two mechanisms underlying OD occurrence in COVID-19 have been proposed: infection sustentacular cells inflammatory reaction epithelium. former triggers latter likely prolongs These two alternative act parallel; more important for because are to entry point SARS-CoV-2 than neurons susceptible early injury. Furthermore, abundantly express transmembrane protease, serine (TMPRSS2) play major role has revealed crucial roles cells. This review aims elucidate how contribute COVID-19–related Understanding aid development improved medical treatments

Language: Английский

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The relationship between the phenotype of long COVID symptoms and one-year psychosocial outcomes: an exploratory clustering analysis

Psychology Health & Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17

Published: Feb. 17, 2025

The impact of Coronavirus Disease 2019 (COVID-19) is not limited to acute symptoms; it also extends post-infection sequelae, such as long COVID and post-COVID conditions. These conditions are characterized by various symptoms, malaise, fatigue, cognitive dysfunction, considered reflect different underlying pathologies. Using a cluster analysis, we hypothesized that may have psychosocial outcomes depending on the phenotype. This study based COVID-19 RECOVERY STUDY II (CORES II) conducted in 20 centers Japan. CORES included patients aged years older who were hospitalized discharged alive between April September 2021. In II, information collected at hospitalization was followed an investigation one year after diagnosis into physical mental health, patients' social circumstances. Long symptoms month infection, well-being, including anxiety, depression, post-traumatic stress disorder, quality life (QOL), onset assessed via questionnaires provided diagnosis. We performed analysis symptoms. compared status clusters. identified five clusters 746 patients. severe multi-organ olfactory gustatory disturbances, shortness breath, muscle weakness, hair loss. dysfunction large number with malaise more likely poor onset. addition, disturbance appeared second highest depression anxiety scores cluster. results obtained five-symptom suggest phenotype disturbances has consequences. Patients these phenotypes require extensive follow-ups interventions.

Language: Английский

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Optimization of a panel of behavioral tests for use in containment using a golden Syrian hamster model

Journal of Virological Methods, Journal Year: 2025, Volume and Issue: unknown, P. 115132 - 115132

Published: March 1, 2025

Golden Syrian hamsters are an often-overlooked model in behavioral testing. While previously utilized for research examining circadian rhythms and mammalian reproduction, they less common than murine models both infectious disease studies. However, coronavirus disease-19 (COVID-19) quickly pushed hamster modeling to the forefront due its myriad of advantages over mice recapitulating human pathology transmission. At least 10% COVID-19 survivors suffer from post-acute sequelae (PASC), a collection some 200 with neurologic (neuro-PASC) presenting potentially debilitating symptomology. This presents clear need small animal that recapitulates ability assess any potential long term neurological changes. We adapted optimized panel tests accepted utilizing golden use within biocontainment facilities. Our includes grip strength, Porsolt forced swim, novel object recognition testing measure muscle fatigue or weakness, depression, memory loss cognitive impairment, respectively. Apart severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), this is applicable other pathogens cause sequelae, such as Nipah eastern equine encephalitis viruses, systems require hamsters. In manuscript, we detail methods each these three tests, how interpret analyze resulting data, emphasize additional factors consideration. also provide baseline data male female

Language: Английский

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SARS-CoV-2-induced Sensory Perturbations: A Narrative Review of Clinical Phenotypes, Molecular Pathologies, and Possible Interventions

Brain Behavior & Immunity - Health, Journal Year: 2025, Volume and Issue: unknown, P. 100983 - 100983

Published: March 1, 2025

The acute and post-acute sequelae of SARS-CoV-2 infection have been great clinical interest since the inception COVID-19 pandemic. Despite a high prevalence individuals with persistent symptoms, wholistic view effects on special sensory systems is lacking. Considering significant impact normal function quality life, goal this review to highlight unresolved issues related SARS-CoV-2-associated insults nervous system. In narrative review, we discuss epidemiology SARS-CoV-2-induced perturbations, underlying pathological mechanisms, possible therapeutic strategies across olfactory, gustatory, somatosensory, visual, auditory systems. Examined literature included studies human biospecimens, human-derived cell lines, naturally susceptible animal models, which highlighted evidence functional disruption in all was associated inflammation olfactory epithelium/bulb, somatosensory ganglia, gustatory systems, long-term transcriptional perturbations central system peripheral system, detectable degeneration/apoptosis visual Few proposed evidence-based for attenuating specific abnormalities after infection. While some extent more thoroughly investigated from symptomatology, behavioral molecular perspectives, there still an unmet need development therapeutics treat COVID-induced impairment these Further, additional attention must be placed COVID-associated lack detailed mechanistic investigations into their pathogenesis.

Language: Английский

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Noninvasive Diagnostic Method to Objectively Measure Olfaction and Diagnose Smell Disorders by a Molecularly Targeted Fluorescence Imaging Agent

Journal of Nuclear Medicine, Journal Year: 2024, Volume and Issue: 65(8), P. 1293 - 1300

Published: July 3, 2024

Despite the recent advances in understanding mechanisms of olfaction, no tools are currently available to noninvasively identify loss smell. Because substantial increase patients presenting with coronavirus disease 2019–related smell, pandemic has highlighted urgent need develop quantitative methods. Methods: Our group investigated use a novel fluorescent probe named Tsp1a-IR800_P as tool diagnose targets sodium channel 1.7, which plays critical role olfaction by aiding signal propagation olfactory bulb. Results: Intuitively, we have identified that conditions leading including chronic inflammation and 2019, correlate downregulation 1.7 expression epithelium, both at transcript protein levels. We demonstrated lower fluorescence emissions significantly smell live animals—thus representing potential for its semiquantitative assessment. Currently methods rely on delayed subjective behavioral studies. Conclusion: This method could aid improving preclinical clinical studies providing way objectively therefore development therapeutic interventions.

Language: Английский

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