Self-reported long COVID-19 symptoms are rare among vaccinated healthcare workers DOI Creative Commons
Salma AlBahrani, Ali Albarrak,

Nawal AlGubaisi

et al.

Journal of Infection and Public Health, Journal Year: 2023, Volume and Issue: 16(8), P. 1276 - 1280

Published: June 5, 2023

COVID-19 pandemic adversely affected healthcare workers (HCWs). Here, we evaluate the occurence of long-COVID-19 symtoms among HCWs. This is a questionnaire-based study HCWs who had in two medical centers Saudi Arabia and were mostly vaccinated. The included 243 with mean age (+ SD) 36.1 7.6) years. Of them, 223 (91.8%) three doses vaccine, 12 (4.9%) four doses, 5 (2.1%) doses. most common symptoms at start illness cough (180, 74.1%), shortness breath (124, 51%), muscle ache (117, 48.1%), headache (113, 46.5%), sore throat (111, 45.7%), diarrhea (109, 44.9%) loss taste (108, 44.4%). Symptoms lasted for< one week 117 (48.1%),> and< 1 month 89 (36.6%),> 2 months 3 9 (3.7%), and> 15 (6.2%). main present> hair (8, 3.3%), (5, 2.1%), 2.1%). A binomial regression analysis showed no relationship between persistence for> other demographic or clinical characteristics. low rate long-COVID> during Omicron-wave vaccinated significant comorbidities. Furhter studies are needed to examine effect different vaccines on

Language: Английский

Long COVID: a clinical update DOI
Trisha Greenhalgh, Manoj Sivan,

Alice Perlowski

et al.

The Lancet, Journal Year: 2024, Volume and Issue: 404(10453), P. 707 - 724

Published: July 31, 2024

Language: Английский

Citations

85
Clinical phenotypes and quality of life to define post-COVID-19 syndrome: a cluster analysis of the multinational, prospective ORCHESTRA cohort DOI Creative Commons
Elisa Gentilotti, Anna Górska, Adriana Tami

et al.

EClinicalMedicine, Journal Year: 2023, Volume and Issue: 62, P. 102107 - 102107

Published: July 21, 2023

Lack of specific definitions clinical characteristics, disease severity, and risk preventive factors post-COVID-19 syndrome (PCS) severely impacts research discovery new therapeutics drugs.This prospective multicenter cohort study was conducted from February 2020 to June 2022 in 5 countries, enrolling SARS-CoV-2 out- in-patients followed at 3-, 6-, 12-month diagnosis, with assessment biochemical features, antibody (Ab) response, Variant Concern (VoC), physical mental quality life (QoL). Outcome interest identification protective PCS by phenotype, setting, severity disease, treatment, vaccination status. We used SF-36 questionnaire assess evolution QoL index during follow-up unsupervised machine learning algorithms (principal component analysis, PCA) explore symptom clusters. Severity defined phenotype QoL. also generalized linear models analyse the impact on associated factors. CT registration number: NCT05097677.Among 1796 patients enrolled, 1030 (57%) suffered least one 12-month. PCA identified 4 phenotypes: chronic fatigue-like (CFs: fatigue, headache memory loss, 757 patients, 42%), respiratory (REs: cough dyspnoea, 502, 23%); pain (CPs: arthralgia myalgia, 399, 22%); neurosensorial (NSs: alteration taste smell, 197, 11%). Determinants phenotypes were different (all comparisons p < 0.05): being female increased CPs, NSs, CFs; pulmonary diseases REs; neurological symptoms diagnosis REs, oxygen therapy CFs gastrointestinal CFs. Early treatment infection monoclonal Ab phenotypes), corticosteroids for mild/severe cases (NSs), (CPs) less likely be 0.05). Highest reduction detected REs CPs (43.57 43.86 vs 57.32 PCS-negative controls, 0.001). Female sex (p 0.001), = 0.034) renal complications 0.002) acute increase severe (QoL <50). Vaccination early reduced 0.01 0.03, respectively).Our provides evidence suggesting that can classified QoL, underlying possible pathogenic mechanisms. each PCS. These results might help designing pathogenesis studies selecting high-risk inclusion therapeutic management trials.The received funding Horizon ORCHESTRA project, grant 101016167; Netherlands Organisation Health Research Development (ZonMw), 10430012010023; Inserm, REACTing (REsearch & ACtion emergING infectious diseases) consortium French Ministry Health, PHRC 20-0424.

Language: Английский

Citations

60
Cardiovascular autonomic dysfunction in post-COVID-19 syndrome: a major health-care burden DOI
Artur Fedorowski,

Alessandra Fanciulli,

Satish R. Raj

et al.

Nature Reviews Cardiology, Journal Year: 2024, Volume and Issue: 21(6), P. 379 - 395

Published: Jan. 2, 2024

Language: Английский

Citations

55
The effectiveness of COVID-19 vaccine in the prevention of post-COVID conditions: a systematic literature review and meta-analysis of the latest research DOI Creative Commons
Alexandre R. Marra, Takaaki Kobayashi, Gustavo Yano Callado

et al.

Antimicrobial Stewardship & Healthcare Epidemiology, Journal Year: 2023, Volume and Issue: 3(1)

Published: Jan. 1, 2023

We performed a systematic literature review and meta-analysis on the effectiveness of coronavirus disease 2019 (COVID-19) vaccination against post-COVID conditions (long COVID) among fully vaccinated individuals.Systematic review/meta-analysis.We searched PubMed, Cumulative Index to Nursing Allied Health, EMBASE, Cochrane Central Register Controlled Trials, Scopus, Web Science from December 1, 2019, June 2, 2023, for studies evaluating COVID-19 vaccine (VE) individuals who received two doses vaccine. A condition was defined as any symptom that present four or more weeks after infection. calculated pooled diagnostic odds ratio (DOR) (95% confidence interval) between unvaccinated individuals. Vaccine estimated 100% x (1-DOR).Thirty-two with 775,931 evaluated effect conditions, which, twenty-four were included in meta-analysis. The DOR 0.680 CI: 0.523-0.885) an VE 32.0% (11.5%-47.7%). 36.9% (23.1%-48.2%) those before infection 68.7% (64.7%-72.2%) three stratified analysis demonstrated no protection infection.Receiving complete prior contracting virus resulted significant reduction throughout study period, including during Omicron era. increase when supplementary administered.

Language: Английский

Citations

45
Multidisciplinary Center Care for Long COVID Syndrome–A Retrospective Cohort Study DOI Open Access
Joseph I. Bailey,

Bianca Lavelle,

Janet L. Miller

et al.

The American Journal of Medicine, Journal Year: 2023, Volume and Issue: 138(1), P. 108 - 120

Published: May 22, 2023

Language: Английский

Citations

36
The impact of COVID-19 vaccination prior to SARS-CoV-2 infection on prevalence of long COVID among a population-based probability sample of Michiganders, 2020-2022 DOI
Colleen L. MacCallum‐Bridges, Jana L. Hirschtick, Akash J. Patel

et al.

Annals of Epidemiology, Journal Year: 2024, Volume and Issue: 92, P. 17 - 24

Published: Feb. 19, 2024

Language: Английский

Citations

9
Association of vaccine status, reinfections, and risk factors with Long COVID syndrome DOI Creative Commons
María Elena Romero-Ibarguengoitia,

Juan Francisco Rodríguez-Torres,

Arnulfo Garza-Silva

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Feb. 2, 2024

Abstract The COVID-19 pandemic had a profound global impact, characterized by high fatality rate and the emergence of enduring consequences known as Long COVID. Our study sought to determine prevalence COVID syndrome within population Northeastern Mexico, correlating it with patients' comorbidities, number reinfection, vaccination status. Employing an observational cross-sectional approach, we administered comprehensive questionnaire covering medical history, demographics, status, COVID-related symptoms, treatment. participant cohort included 807 patients, average age 41.5 (SD 13.6) years, women accounting 59.3% cohort. follow-up was 488 (IQR 456) days. One hundred sixty-eight subjects (20.9%) met criteria. more prevalent when reinfections (p = 0.02) less frequent they complete scheme 0.05). Through logistic regression, found that male gender (OR 0.5, p ≤ 0.001), blood types AB− 0.48, 0.003) O− 0.27, 0.001) in comparison A+ two doses vaccines 006) be protective factors against COVID; while higher BMI 1.04, 0.005) risk factor. We saw different vaccinated patients specific types, being female were associated increased having long-COVID.

Language: Английский

Citations

8
Nirmatrelvir/ritonavir and risk of long COVID symptoms: a retrospective cohort study DOI Creative Commons

Seth Congdon,

Zev Narrowe,

Nang Yone

et al.

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Nov. 11, 2023

Abstract We conducted a retrospective cohort study to assess whether treatment with nirmatrelvir/ritonavir was associated reduced risk of long COVID. enrolled 500 adults confirmed SARS-CoV-2 who were eligible for nirmatrelvir/ritonavir; 250 took and did not. The primary outcome the development one or more eleven prespecified COVID symptoms, assessed through structured telephone interview four months after positive test. Multivariable logistic regression models controlled age, sex, race/ethnicity, chronic conditions, COVID-19 vaccination status. found that participants no less likely develop compared those not take medication (44% vs. 49.6%, p = 0.21). Taking lower odds two brain fog (OR 0.58, 95% CI 0.38–0.88) chest pain/tightness 0.51, 0.28–0.91). Our finding developing is different from prior studies obtained data only electronic medical records.

Language: Английский

Citations

19
Cardiorespiratory dysautonomia in post‐COVID‐19 condition: Manifestations, mechanisms and management DOI Creative Commons
Artur Fedorowski, Monika Fagevik Olsén,

Frida Nikesjö

et al.

Journal of Internal Medicine, Journal Year: 2023, Volume and Issue: 294(5), P. 548 - 562

Published: May 15, 2023

A significant proportion of COVID-19 patients experience debilitating symptoms for months after the acute infection. According to recent estimates, approximately 1 out 10 convalescents reports persistent health issues more than 3 initial recovery. This 'post-COVID-19 condition' may include a large variety from almost all domains and organs, some it mean prolonged sick-leave, homestay strongly limited activities daily life. In this narrative review, we focus on signs post-COVID-19 condition in adults - particularly those associated with cardiovascular respiratory systems, such as postural orthostatic tachycardia syndrome or airway disorders explore evidence chronic autonomic dysfunction potential underlying mechanism. The most plausible hypotheses regarding cellular molecular mechanisms behind wide spectrum observed lingering viruses, inflammation, impairment oxygen sensing systems circulating antibodies directed blood pressure regulatory components are discussed. addition, an overview currently available pharmacological non-pharmacological treatment options is presented.

Language: Английский

Citations

15
Visual analysis of hotspots and trends in long COVID research based on bibliometric DOI Creative Commons
Zongqiang Lai,

Tao Pu,

Jun Li

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(2), P. e24053 - e24053

Published: Jan. 1, 2024

After severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, a series of symptoms may persist for long time, which is now called COVID. It was found that COVID can affect all patients with COVID-19. Therefore, has become hot topic. In this study, we used the WOS database as sample data source to conduct bibliometric and visual analysis 1765 articles over past three years through VOSviewer R package. The results show countries/authors in Europe United States America contribute most articles, their cooperation also active. Keyword co-occurrence identified four clusters, important topics including mechanism, clinical symptoms, epidemiological characteristics, management/treatment Themes such "cognitive impairment", "endothelial dysfunction", "diagnosis", "biomarkers" are likely be focus new attention coming period. addition, put forward possible research opportunities on researchers practitioners facilitate future research.

Language: Английский

Citations

4