Long-term symptoms after SARS-CoV-2 infection in a cohort of people living with HIV DOI Creative Commons
Melania Degli Antoni, Giovanni Maifredi,

Samuele Storti

et al.

Infection, Journal Year: 2024, Volume and Issue: unknown

Published: May 3, 2024

Abstract Background Our Hospital in Northern Italy assists 3817 people living with HIV (PLWH) and has faced the impact of COVID-19. Little is known about infection on risk post-COVID-19 conditions (PCCs) onset. We aim to assess incidence PCC PLWH factors associated its occurrence. Methods performed a retrospective, observational study including all > 18 years registered Brescia Health Protection Agency database, assessing SARS-CoV-2 burden, vaccination status, socio-demographic, viro-immunological parameters from February 2020 until May 2022. Persistence self-reported symptoms (clustered into gastrointestinal, respiratory, osteo-muscular, neuro-behavioral symptoms) was evaluated after 3 months by telephone-administered questionnaire. estimated associations between variables outcomes through univariate multivariable logistic models. Results In period, 653 were diagnosed (17.1%). observed 19 (2.9%) reinfections, 71 (10.9%) hospitalizations, (0.5%) deaths. interviewed 510/653 (78%), 178 (PCCs prevalence 34.9%; CI 95% 30.7–39.2) reported persistent symptoms. Asthenia/fatigue most symptom (60/178), followed muscular pain (54/178). multivariate regression model, there lower PCCs males respect females (adjusted OR = 0.64; 0.99–3.66), while hospitalization during acute an increased 1.9; 0.99–3.66). Notably, no variable modified Conclusions highlights substantial among PLWH, three post-SARS-CoV-2 infection, independent features or status.

Language: Английский

Long COVID science, research and policy DOI Creative Commons
Ziyad Al‐Aly, Hannah Davis, Lisa McCorkell

et al.

Nature Medicine, Journal Year: 2024, Volume and Issue: 30(8), P. 2148 - 2164

Published: Aug. 1, 2024

Long COVID represents the constellation of post-acute and long-term health effects caused by SARS-CoV-2 infection; it is a complex, multisystem disorder that can affect nearly every organ system be severely disabling. The cumulative global incidence long around 400 million individuals, which estimated to have an annual economic impact approximately $1 trillion-equivalent about 1% economy. Several mechanistic pathways are implicated in COVID, including viral persistence, immune dysregulation, mitochondrial dysfunction, complement endothelial inflammation microbiome dysbiosis. devastating impacts on individual lives and, due its complexity prevalence, also has major ramifications for systems economies, even threatening progress toward achieving Sustainable Development Goals. Addressing challenge requires ambitious coordinated-but so far absent-global research policy response strategy. In this interdisciplinary review, we provide synthesis state scientific evidence assess human health, systems, economy metrics, forward-looking roadmap.

Language: Английский

Citations

106
Long COVID: a clinical update DOI
Trisha Greenhalgh, Manoj Sivan,

Alice Perlowski

et al.

The Lancet, Journal Year: 2024, Volume and Issue: 404(10453), P. 707 - 724

Published: July 31, 2024

Language: Английский

Citations

85
The impact of COVID-19 vaccination prior to SARS-CoV-2 infection on prevalence of long COVID among a population-based probability sample of Michiganders, 2020-2022 DOI
Colleen L. MacCallum‐Bridges, Jana L. Hirschtick, Akash J. Patel

et al.

Annals of Epidemiology, Journal Year: 2024, Volume and Issue: 92, P. 17 - 24

Published: Feb. 19, 2024

Language: Английский

Citations

9
Effectiveness of BNT162b2 XBB vaccine in the US Veterans Affairs Healthcare System DOI Creative Commons
Aisling R. Caffrey, Haley J. Appaneal,

Vrishali V. Lopes

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 7, 2024

ABSTRACT Data evaluating effectiveness of XBB.1.5-adapted vaccines against JN.1-related endpoints are scarce. We performed a nationwide test-negative case-control study within the US Veterans Affairs Healthcare System to estimate vaccine (VE) BNT162b2 compared not receiving an XBB any kind COVID-19 hospitalization, emergency department or urgent care visits (ED/UC), and outpatient visits. Between September 25, 2023 January 31, 2024, was 24–35% during period JN.1 predominance 50–61% across all outcomes. VE 60 days vaccination likely 32% (95% confidence interval 3-52%) 41% (23–54%) ED/UC visits, 31% (1–52%) Corresponding 62% (44–74%), 52% (37–63%), 50% (25–66%) by setting, respectively. These data underscore importance strain match maximize public health impact vaccination.

Language: Английский

Citations

9
Long COVID’s Impact on Patients, Workers, & Society: A review DOI Creative Commons
Kevin T. Kavanagh,

Lindsay E. Cormier,

Christine Pontus

et al.

Medicine, Journal Year: 2024, Volume and Issue: 103(12), P. e37502 - e37502

Published: March 22, 2024

The incidence of long COVID in adult survivors an acute SARS-CoV-2 infection is approximately 11%. Of those afflicted, 26% have difficulty with day-to-day activities. majority COIVD cases occur after mild or asymptomatic infection. Children can spread infections and also develop long-term neurological, endocrine (type I diabetes), immunological sequelae. Immunological hypofunction exemplified by the recent large outbreaks respiratory syncytial virus streptococcal infections. Neurological manifestations are associated anatomical brain damage demonstrated on scans autopsy studies. prefrontal cortex particularly susceptible. Common symptoms include fog, memory loss, executive dysfunction, personality changes. impact society has been profound. Fewer than half previously employed adults who working full-time, 42% patients reported food insecurity 20% difficulties paying rent. Vaccination not only helps prevent severe COVID-19, but numerous studies found beneficial effects preventing mitigating COVID. There evidence that vaccination lessen Physical occupational therapy help regain function, approach must be "low slow." Too much physical mental activity result post-exertional malaise set back recovery process days weeks. complexity presentations coupled rampant organized disinformation, caused significant segments public to ignore sound health advice. Further research needed regarding treatment effective communication.

Language: Английский

Citations

8
Vaccination and the risk of post-acute sequelae after COVID-19 in the Omicron-predominant period DOI
Kyungmin Huh, Young‐Eun Kim,

Gi Hwan Bae

et al.

Clinical Microbiology and Infection, Journal Year: 2024, Volume and Issue: 30(5), P. 666 - 673

Published: Feb. 6, 2024

Language: Английский

Citations

7
The Potential Role of Viral Persistence in the Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) DOI Creative Commons
Lorenzo Lupi, Adriana Vitiello,

Cristina Parolin

et al.

Pathogens, Journal Year: 2024, Volume and Issue: 13(5), P. 388 - 388

Published: May 8, 2024

The infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated not only with the development of disease but also long-term symptoms or post-acute sequelae SARS-CoV-2 (PASC). Multiple lines evidence support that some viral antigens and RNA can persist for up to 15 months in multiple organs body, often after apparent clearance from upper system, possibly leading persistence symptoms. Activation immune system observed a prolonged time, providing indirect elements infection. In gastrointestinal tract, could stimulate shaping local microbiota potential systemic effects. All these interactions need be investigated, taking into account predisposing factors, multiplicity pathogenic mechanisms, stratifying populations vulnerable individuals, particularly women, children, immunocompromised where may present additional challenges.

Language: Английский

Citations

7
Characteristics and predictors of Long Covid in children: a 3-year prospective cohort study DOI Creative Commons
Anna Camporesi, Rosa Morello,

Anna Rocca

et al.

EClinicalMedicine, Journal Year: 2024, Volume and Issue: 76, P. 102815 - 102815

Published: Sept. 5, 2024

Language: Английский

Citations

7
Who develops long COVID? Longitudinal pre-pandemic predictors of long COVID and symptom clusters in a representative Dutch population DOI Creative Commons
Isabel Slurink, Sophie C.M. van den Houdt, Gaëtan Mertens

et al.

International Journal of Infectious Diseases, Journal Year: 2024, Volume and Issue: 144, P. 107048 - 107048

Published: April 10, 2024

Prior studies show that long COVID has a heterogeneous presentation. Whether specific risk factors are related to subclusters of remains unknown. This study aimed determine pre-pandemic predictors and symptom clustering.

Language: Английский

Citations

6
Effectiveness of BNT162b2 XBB vaccine in the US Veterans Affairs Healthcare System DOI Creative Commons
Aisling R. Caffrey, Haley J. Appaneal,

Vrishali V. Lopes

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Nov. 2, 2024

Data evaluating effectiveness of XBB.1.5-adapted vaccines against JN.1-related endpoints are scarce. This nationwide test-negative case-control study within the US Veterans Affairs Healthcare System aims to estimate vaccine (VE) BNT162b2 compared not receiving an XBB any kind COVID-19 hospitalization, emergency department or urgent care visits (ED/UC), and outpatient visits. Between September 25, 2023 January 31, 2024, was 24-35% during a period JN.1 predominance 50-61% across all outcomes. VE 60 days vaccination likely 32% (95% confidence interval 3-52%) 41% (23-54%) ED/UC visits, 31% (1-52%) Corresponding 62% (44-74%), 52% (37-63%), 50% (25-66%) by setting, respectively. Here, we show importance strain match maximize public health impact vaccination.

Language: Английский

Citations

6