Myopia control using a modified optical defocus soft contact lens in schoolchildren—A 12‐month randomised double masked control trial

Ophthalmic and Physiological Optics, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Defocus Incorporated Soft Contact (DISC) lenses with +2.50 D myopic defocus reduced myopia progression by 25% in a previous randomised clinical trial (RCT). The current study aimed to evaluate if stronger defocus, +3.50 variable (DISC3.5plus), could slow compared single vision (SV) soft contact 12-month RCT. Conducted from December 2018 January 2021, the RCT randomly assigned children wear DISC3.5plus (n = 87) or SV 80) lenses. Myopia and axial elongation were between two groups. Analyses performed for both enrolled completed participants. For all participants, group had significantly less (mean difference: -0.15 ± 0.07 D, p 0.02) 0.04 0.02 0.04) than at 6 months but not 12 (myopia progression: 0.11; elongation: 0.13). 33) (0.25 0.001) (0.19 0.09 0.049) 40), (6 months: 0.16; 0.32). In 2020, coronavirus pandemic disturbed lens-wearing patterns. slowed participants over months. hindered longer term efficacy follow-up sample size; thus, further investigation more is needed confirm sustained treatment effects.

Language: Английский

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ZEISS Young Investigator Award in myopia research and Josh Wallman Memorial Lecture. Understanding Myopia Development.

Ophthalmic and Physiological Optics, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

Abstract In this paper, three key questions regarding our understanding of myopia are addressed: predictors onset, the mechanism underlying its development and potential treatments to slow progression. To explore these aspects, first, a non‐invasive biomarker using chicken model was investigated. A strong correlation found between both increased ultraviolet (UV) fundus reflectivity thinning retinal nerve fibre layer (RNFL). Through electron microscopy, it observed that, within hours vision deprivation, significant myelin sheaths around large axons in RNFL occurred, accompanied by an increase UV reflectivity—changes that took place even before eye elongation. These findings suggest early degradation contributes may serve as predictive animal model. However, prediction onset humans remains challenging. investigate further, visual stimuli affecting emmetropic myopic eyes differently were examined. The results indicated have weaker responses positive defocus short‐term stimulation simulated chromatic aberrations when compared with eyes, suggesting possible impairment signalling pathways responsible for detecting blur defocus. terms treatment, reading text inverted contrast (bright letters on dark background) induced axial length shortening choroidal thickening eyes. Furthermore, repeated exposure digitally shown reduce thickness effectively human subjects. align from models indicate approach strategy control. more research is necessary establish effective control intervention suitable children adolescents.

Language: Английский

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The impact of the COVID 19 pandemic on myopia prevalence in 5 year old Israeli children

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 23, 2025

Language: Английский

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Global burden of blindness and vision loss among children and adolescents: A systematic analysis for the Global Burden of Disease Study 2021

Asia-Pacific Journal of Ophthalmology, Journal Year: 2025, Volume and Issue: unknown, P. 100200 - 100200

Published: April 1, 2025

This study investigates the global burden of vision impairment caused by refraction disorders, near loss, and other loss among children adolescents from 1990 to 2021. The analysis is categorized globally sex, age, socio-demographic index (SDI), with a focus on predicting trends 2035. Data were obtained Global Burden Disease Study We reported prevalence disability-adjusted life-years (DALYs) due globally. Then, we described DALYs numbers rate SDI age. Next, analyzed relationship between SDI. Finally, bayesian age-period-cohort (BAPC) model was used predict 2022 2035 sex for disorders had statistically significant trend reduction in four age groups positively associated increasing groups, negatively BAPC indicates that age-specific both men women will remain downward until 2035, while continues rise. findings underscore there are extensive variations based type impairment, group, Policies should be tailored specific types order effectively alleviate burden.

Language: Английский

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Comparison of myopia progression among Chinese schoolchildren before and during COVID-19 pandemic: a meta-analysis

International Ophthalmology, Journal Year: 2023, Volume and Issue: 43(10), P. 3911 - 3921

Published: June 30, 2023

Language: Английский

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Associations of Near Work, Time Outdoors, and Sleep Duration With Myopic Regression 5 Years After SMILE and FS-LASIK: A Cross-sectional Study

Journal of Refractive Surgery, Journal Year: 2024, Volume and Issue: 40(1)

Published: Jan. 1, 2024

Purpose: To investigate the association of near work, time outdoors, and sleep duration with myopic regression 5 years after small incision lenticule extraction (SMILE) femtosecond laser–assisted in situ keratomileusis (FS-LASIK) . Methods: This cross-sectional study included patients who received SMILE or FS-LASIK at Beijing Tongren Hospital ago. The underwent ophthalmic examinations including visual acuity, intraocular pressure, subjective refraction, slit-lamp examination, keratometry, corneal topography, optical coherence tomography, fundus examination from January 2020 to March 2023. Fluorescein break-up was measured Ocular Surface Disease Index questionnaire completed exclude dry eye. A self-administered used collect data on work exposure, physical activities, duration. Results: total 323 eyes were analysis, a 5-year incidence rate FSLASIK 16.1%. After adjusted for all confounders, more than 8 hours/day revealed significant (odds ratio: 2.461; 95% CI: 1.143 5.298, P = .021), particularly younger adults, women, high myopia treatment. between restricted women (near significant). However, no associations observed continuous outdoors regression. Conclusions: Excessive exposure associated greater FS-LASIK. It is crucial maintain good behavior care preventing FS-LASIK, especially myopia. [ J Refract Surg 2024;40(1):e10–e19.]

Language: Английский

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Key strategies to reduce the global burden of myopia: consensus from the international myopia summit

British Journal of Ophthalmology, Journal Year: 2025, Volume and Issue: unknown, P. bjo - 326643

Published: Feb. 19, 2025

In this paper, we describe key strategies to guide global collaborative efforts further reduce the burden of myopia and myopia-related visual impairment. A modified Delphi method was applied as an iterative multistage process collect expert stakeholders’ opinions extract consensus regarding diagnosis, prevention control. Anonymous pre-meeting preparation rounds, structured discussions for prioritisation development areas were performed. Consensus reached on three collaborate complement existing frameworks: (1) Myopia defined not only a refractive error but also disease with phenotypic features allowing risk stratification significant (2) addition preventive strategies, focus is needed preventing progression high (HM). (3) treating pathologic (PM), that is, end-stage irreversible conclusion, workgroup suggests global, strategy across public health, healthcare advocacy sectors support in reducing impairment from myopia. Complementary health efforts, additional defining emphasis associated HM PM should be considered.

Language: Английский

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Trend Analysis of Global, Regional, and National Burdens of Visual Impairment Due to Refraction Disorders from 1990 to 2021: Findings from the Global Burden of Disease Study 2021

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 26, 2025

Purpose To estimate the global, regional, and national burden of vision impairment due to refraction disorders (RD) from 1990 2021 based on sex, age, Socio-demographic Index (SDI), predict future disease trends.Methods This retrospective demographic analysis utilized data Global Burden Disease (GBD) database. Prevalence, years lived with disability (YLDs), age-standardized prevalence rates (ASPR), YLDs (ASYR) RD were analyzed assess temporal, sex-specific trends. We calculated Average Annual Percentage Change (AAPC) determine changes in used Bayesian Age-Period-Cohort (BAPC) model forecast 2020 2035.Results ASPR ASYR declined 2021, AAPC is -3.76 (95% confidence interval [CI]: -4.20~-3.32) − 0.26 CI: -0.28~-0.25), respectively. In global was 159,765,917 uncertainty [UI]: 142,526,915 ~ 178,698,348). The slightly higher females than males, a among middle-aged elderly populations. There slight negative correlation regional (r≈-0.32, P < 0.001), South Asia exhibiting highest (3,398/100,000 people [95% UI: 2992 3860]). predicted increase, while expected decrease 2022 2035.Conclusion has increased past 30 continue increasing over next 15 years. heavier females, middle-aged,

Language: Английский

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A clearer vision: unveiling the importance of cycloplegic refraction and the pseudomyopia prevalence in Chinese preschoolers

BMC Ophthalmology, Journal Year: 2024, Volume and Issue: 24(1)

Published: Aug. 12, 2024

This study aimed to investigate the difference between cycloplegic and noncycloplegic refraction evaluate pseudomyopia prevalence in Chinese preschool children during outbreak of COVID-19.

Language: Английский

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Myopia control strategies: A systematic review and meta‐meta‐analysis

Ophthalmic and Physiological Optics, Journal Year: 2024, Volume and Issue: 45(1), P. 160 - 176

Published: Nov. 12, 2024

Abstract Purpose To summarise pooled estimates of the efficacies various myopia control interventions, as drawn from published meta‐analyses. Method PubMed, SCOPUS and Web Science were searched inception to February 2024 for systematic reviews meta‐analyses reporting treatment effects strategies. The qualities included assessed using 16‐item A MeaSurement Tool Assess Reviews ( AMSTAR ) 2. An intervention was defined having a clinically significant effect if it resulted in change spherical equivalent refraction (SER) ≥0.50 D/year or axial length (AL) ≤−0.18 mm/year. Results total 38 studies identified. overall respective changes SER AL, mean difference (95% CI) high‐concentration (≥0.5%) atropine 0.67 D (0.58–0.77) −0.24 mm (−0.36 −0.11); moderate‐concentration (>0.05% <0.5%) 0.48 (0.34–0.62) −0.23 (−0.27 −0.19); low‐concentration (0.01%, 0.025%, 0.05%) 0.33 (0.23–0.43) −0.14 (−0.19 −0.09); orthokeratology −0.47 (−0.66 −0.28); peripheral plus soft contact lenses 0.30 (0.18–0.42) −0.35 (−0.62 −0.08); spectacles 0.77 (0.40–1.14) −0.43 (−0.78 multifocal 0.21 (0.11–0.31); repeated low‐level red light therapy 0.55 (0.46–0.65) −0.25 (−0.29 −0.20); outdoor time 0.17 (0.16–0.18) −0.04 (−0.06 −0.01). Conclusion High moderate concentrations atropine, orthokeratology, demonstrated on slowing AL elongation, while high progression.

Language: Английский

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