Journal of Social Work Practice in the Addictions, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17
Published: April 16, 2025
Language: Английский
BMJ evidence-based medicine, Journal Year: 2023, Volume and Issue: 29(3), P. 142 - 146
Published: Sept. 25, 2023
Language: Английский
Citations
42
European Journal of Pediatrics, Journal Year: 2024, Volume and Issue: 183(4), P. 1543 - 1553
Published: Jan. 27, 2024
Abstract This review summarizes current knowledge on post-acute sequelae of COVID-19 (PASC) and post-COVID-19 condition (PCC) in children adolescents. A literature was performed to synthesize information from clinical studies, expert opinions, guidelines. PASC also termed Long COVID — at any age comprise a plethora unspecific symptoms present later than 4 weeks after confirmed or probable infection with severe respiratory syndrome corona virus type 2 (SARS-CoV-2), without another medical explanation. PCC adolescents defined by the WHO as occurring within 3 months acute coronavirus disease 2019 (COVID-19), lasting least months, limiting daily activities. Pediatric mostly manifest mild courses majority cases remit few months. However, can last for more 1 year may result significant disability. Frequent include fatigue, exertion intolerance, anxiety. Some patients postural tachycardia (PoTS), small number fulfill criteria myalgic encephalomyelitis/chronic fatigue (ME/CFS). To date, no diagnostic marker has been established, differential diagnostics remains challenging. Therapeutic approaches appropriate self-management well palliation non-pharmaceutical pharmaceutical strategies. Conclusion : pediatrics heterogenous severity duration. stepped, interdisciplinary, individualized approach is essential management. Current health care structures have be adapted, research extended meet psychosocial needs young people similar conditions. What Known: • Post-acute (COVID-19) lead activity limitation reduced quality life. belongs large group syndromes (PAIS). Specific biomarkers causal treatment options are not yet available. New: In February 2023, case definition post provided World Health Organization (WHO), indicating duration Interdisciplinary collaborations necessary established worldwide offer harmonized, multimodal diagnosis management PASC/PCC
Language: Английский
Citations
20
EClinicalMedicine, Journal Year: 2024, Volume and Issue: 68, P. 102436 - 102436
Published: Feb. 1, 2024
BackgroundPost Coronavirus disease (COVID) and other post-viral infection syndromes present an overlap of pathogenesis, onset, progression, symptom profile. We aimed to systematically describe studies on conditions determine the entity post COVID compared in children.MethodsWe conducted a systematic search Embase, MEDLINE, Cochrane Library, GoogleScholar databases (January 1946–3 November 2023), according Preferred Reporting Items for Systematic reviews Meta-Analyses (PRISMA) guidelines. The main outcomes were differences condition duration, type, development chronic symptoms. This review was registered PROSPERO (CRD42023401789).Findings35/5051 included, with 42,934 children, adolescents young adults (0–20 years old) overall. Twenty-eight focused symptoms, followed by five papers Respiratory Syncytial Virus (RSV) Rhinovirus, one study Epstein–Barr (EBV), gastrointestinal viruses. Studies mainly reported data older children/adolescents, describing long-lasting including fatigue, neurologic, cardiorespiratory, musculoskeletal, mental health, maximum described symptoms duration eighteen months, average follow-up seven months. 30 (93.8%) 10,473/28,474 patients (36.8%). Recovery achieved 18,001/28,474 cases (63.2%). EBV persistent fatigue similar (6 46% chronic). RSV Rhinovirus done children under three years, recurrent wheezing (up 3 years).InterpretationPost-viral shared feature between conditions. A better understanding as unique condition, sharing features syndromes, is needed. healthcare burden socio-economic consequences their families warrant further investigation appropriate management plans. foremost requirement establishment consistent shareable definitions, well consensus outcomes, effectively evaluate quantify different viral infections.FundingEU Horizon, EDCTP, NIH.
Language: Английский
Citations
16
Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 28(10), P. 4261 - 4271
Published: July 19, 2023
Language: Английский
Citations
30
Annals of Clinical and Translational Neurology, Journal Year: 2023, Volume and Issue: 10(8), P. 1338 - 1352
Published: June 15, 2023
To determine the prevalence and natural history of post-acute COVID-19 objective cognitive impairment function, their relationship to demographic, clinical factors, sequelae (PASC), biomarkers.A total 128 patients (age = 46 ± 15; 42% women, acute disease severity: not hospitalized: 38.6% mild: 0-1 symptoms, 52% 2+ symptoms; 9.4% hospitalized) completed standard cognition, olfaction, mental health examinations 2-, 4-, 12-month post diagnosis. Over same time frame, WHO-defined PASC was determined. Blood cytokines, peripheral neurobiomarkers, kynurenine pathway (KP) metabolites were measured. Objective function demographically/practice corrected, determined using evidence-based Global Deficit Score method detect at least mild (GDS > 0.5). Linear mixed effect regression models with (month diagnosis) evaluated relationships cognition.Across study period, moderate ranged from 16% 26%, 46.5% impaired once. Impairment associated poorer work capacity (p < 0.05), 2-month objectively tested anosmia 0.05). 0.01) without disability 0.03) severity. KP measures showed prolonged activation (2 8 months) 0.0001) linked IFN-beta in those PASC. Of blood analytes, only (elevated quinolinic acid, 3-hydroxyanthranilic kynurenine, kynurenine/tryptophan ratio) 0.001) performance greater likelihood impairment. PASC, independent abnormal 0.03).The relates thereby enabling biomarker therapeutic possibilities.
Language: Английский
Citations
28
SAGE Open Medicine, Journal Year: 2023, Volume and Issue: 11
Published: Jan. 1, 2023
This review proposes a model of Long-COVID where the constellation symptoms are in fact genuinely experienced persistent physical that usually functional nature and therefore potentially reversible, is, is somatic symptom disorder. First, we describe what currently known about children adults. Second, examine reported “Long-Pandemic” effects create risk for similar to develop non-COVID-19 patients. Third, was somatization disorder before COVID-19 pandemic, suggest by analogy, may best be conceptualized as one these disorders, with predisposing, precipitating, perpetuating factors. Fourth, phenomenon mass sociogenic (functional) illness, concept nocebo effects, compatible descriptions. Fifth, current theoretical mechanism underlying Bayesian predictive coding perception. accounts moderators can make inferences functionally inaccurate explain how understand common Finally, discuss implications this framework improved public health messaging during recommendations management healthcare systems. We argue approach has induced fear population, including from constant disabling theorizing irreversible tissue damage cause Long-COVID. created self-fulfilling prophecy inducing very factors syndrome. introduce term “Pandemic-Response Syndrome” previously labeled alternative perspective aims stimulate research serve lesson learned avoid repeat performance future.
Language: Английский
Citations
23
EClinicalMedicine, Journal Year: 2024, Volume and Issue: 74, P. 102756 - 102756
Published: July 27, 2024
Language: Английский
Citations
12
European Journal of Pediatrics, Journal Year: 2024, Volume and Issue: 183(3), P. 1107 - 1112
Published: Jan. 2, 2024
Abstract Countries in Europe and around the world have taken varying approaches to their policies on COVID-19 vaccination for children. The low risk of severe illness from means that even small risks warrant careful consideration. Vaccination appears result a decreased including paediatric multi-system inflammatory syndrome known be associated with COVID-19. These already significantly emergence Omicron variant its subvariants, due widespread population immunity through previous infection. There is relatively high myocarditis following second doses mRNA vaccines adolescent males, although general course this condition mild. Conclusion : only provides transient reduction transmission. Currently, insufficient evidence exists determine impact post-acute COVID syndromes children, which are uncommon. What Known: • Vaccines against reduced morbidity mortality world. Whilst countries universally recommended adults continue recommend them vulnerable populations, there has been more variability recommendations New: In setting near universal existing infection, majority initial benefit protecting eroded. children low, but an important consideration given modest benefits.
Language: Английский
Citations
10
Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)
Published: July 12, 2023
Post coronavirus disease-19 (post COVID-19) is mainly studied in clinical populations and less known about post COVID-19 a young general population. The aim of the study to investigate prevalence symptoms its potential risk factors adults. Participants from Swedish population-based birth cohort BAMSE were included (n = 2022, mean age 26.5 years). was assessed through questionnaire defined as after confirmed (registry-based or self-reported positive test) lasting for ≥ 2 months. In total, 681 participants had COVID-19. Among them, 112 (16.5%) fulfilled definition (17.8% females, 14.5% males, p 0.26). most common altered smell taste (68.8%), dyspnea (33.7%) fatigue (30.4%). Overall, no major identified except being bedbound during However, asthma rhinitis associated with symptom dyspnea, migraine taste, lower self-rated health fatigue. conclusion, are common, also among adults Although not life-threatening, it could have considerable impact on public due high long-term symptoms.
Language: Английский
Citations
17
Virology Journal, Journal Year: 2024, Volume and Issue: 21(1)
Published: Jan. 11, 2024
Abstract Background Previous meta-analyses estimating the prevalence of post-COVID-19 condition (PCC) were confounded by lack negative control groups. This may result in an overestimation those experiencing PCC, as these symptoms are non-specific and common general population. In this study, we aimed to compare burden persistent among COVID-19 survivors relative COVID-19-negative controls. Methods A systematic literature search was conducted using following databases (PubMed, Web Science, Scopus) until July 2023 for comparative studies that examined survivors. Given many overlap with post-hospitalization syndrome post-intensive care syndrome, included hospitalized patients non-COVID-19 non-hospitalized healthy controls reported outcomes after at least 3 months since infection. The results meta-analysis odds ratios a 95% confidence interval based on random effects model. Results Twenty articles study. Our analysis symptomatology compared revealed majority not related infection appeared equally prevalent both cohorts. However, had higher occurrence certain like anosmia, ageusia, fatigue, dyspnea, brain fog ( P < 0.05). Particularly, anosmia ageusia showed substantially elevated group 11.27 9.76, respectively, 0.05. contrast, other indications did demonstrate significantly tested symptoms. Conclusions from hospitalization causes unrelated commonly Although exhibited controls, post-viral illnesses. Therefore, be unique SARS-CoV-2. Future including well-matched groups when investigating warranted draw firm conclusion.
Language: Английский
Citations
7