Rising Concern About the Carcinogenetic Role of Micro-Nanoplastics DOI Open Access
Lorenzo Ruggieri, Ottavia Amato, Cristina Marrazzo

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 26(1), P. 215 - 215

Published: Dec. 30, 2024

In recent years, awareness regarding micro-nanoplastics’ (MNPs) potential effects on human health has progressively increased. Despite a large body of evidence the origin and distribution MNPs in environment, their impact remains to be determined. this context, there is major need address carcinogenic risks, since could hypothetically mediate direct indirect effects, latter mediated by particle-linked chemical carcinogens. Currently, field scarce heterogeneous, but reported increased incidence malignant tumors among younger populations, together with ubiquitous environmental abundance MNPs, are rising global concern possible role development progression cancer. review, we provide an overview currently available eco-toxicology, as well methods for identification characterization MNP particulates health-associated focus addition, suggest routes future research order unravel carcinogenetic exposure understand prognostic preventive implications intratumoral MNPs.

Language: Английский

Microplastics in coastal and marine environments: A critical issue of plastic pollution on marine organisms, seafood contaminations, and human health implications DOI Creative Commons

Rebecca Muniz,

Md Saydur Rahman

Journal of Hazardous Materials Advances, Journal Year: 2025, Volume and Issue: unknown, P. 100663 - 100663

Published: Feb. 1, 2025

Language: Английский

Citations

1
Microplastics in the Human Body: Exposure, Detection, and Risk of Carcinogenesis: A State-of-the-Art Review DOI Open Access

Eliasz Dzierżyński,

Piotr Gawlik, Damian Puźniak

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(21), P. 3703 - 3703

Published: Nov. 1, 2024

Humans cannot avoid plastic exposure due to its ubiquitous presence in the natural environment. The waste generated is poorly biodegradable and exists form of MPs, which can enter human body primarily through digestive tract, respiratory or damaged skin accumulate various tissues by crossing biological membrane barriers. There an increasing amount research on health effects MPs. Most literature reports focus impact plastics respiratory, digestive, reproductive, hormonal, nervous, immune systems, as well metabolic MPs accumulation leading epidemics obesity, diabetes, hypertension, non-alcoholic fatty liver disease. xenobiotics, undergo ADMET processes body, i.e., absorption, distribution, metabolism, excretion, are not fully understood. Of particular concern carcinogenic chemicals added during manufacturing adsorbed from environment, such chlorinated paraffins, phthalates, phenols, bisphenols, be released when absorbed body. continuous increase NMP has accelerated SARS-CoV-2 pandemic there was a need use single-use products daily life. Therefore, urgent diagnose problems related MP detection.

Language: Английский

Citations

5
Preserving brain health by minimizing microplastic output from resin histology DOI

Tia Tedford

Journal of Histotechnology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 3

Published: Jan. 7, 2025

With an increasing concentration of microplastics (MPs) in every biome, laboratories with a focus on creating histology slides from resin-embedded specimens could be partially responsible for expanding the emission microscopic resinous particles into environment. current research elucidating harmful health impacts MPs, releasing them incautiously is arguably unethical and, near future, plausibly illegal. The Orthopedic Bioengineering Research Laboratory (OBRL) Colorado, state known not only its natural beauty but also number legislative amendments aimed at reducing plastic pollution. department OBRL has chosen to self-regulate due importance protecting and Because virtually molecule ever created still existence, greater need MP mitigation become apparent. Remediation specifically important findings indicating negative neurodevelopment, neuronal organelle function, mental health, increased risk dementia.

Language: Английский

Citations

0
Plastics in dermatology: A review and solutions DOI Creative Commons
Eugene Tan,

Susanne Saha,

Dennis Niebel

et al.

Journal of the European Academy of Dermatology and Venereology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Abstract Hazards to human and planetary health are present at every stage of the plastic life cycle, yet production is projected triple by 2060. This review focuses on three key areas: cycle plastic, impact microplastics their associated chemicals, along with recommendations reduce use. In dermatology, micro‐ nanoplastics especially problematic as they in over 90% personal care products. They have been detected utero, absorbed through skin found lungs gastrointestinal tract. Numerous vitro animal studies substantiated negative but gaps remain regards effect health. spite this limitation, we evidence date offer evidence‐based which can production, enhance outcomes promote environmental justice.

Language: Английский

Citations

0
FGF1 alleviates polystyrene nanoplastics-induced neuroinflammation through the suppression of lipophagy DOI
Bo Qian,

Chen-Qiang Wang,

Zou Su

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 302, P. 140531 - 140531

Published: Jan. 30, 2025

Language: Английский

Citations

0
Effects of microplastics on the immune system: How much should we worry? DOI Creative Commons
Claudia Vanetti,

Martina Broggiato,

Stefania Pezzana

et al.

Immunology Letters, Journal Year: 2025, Volume and Issue: 272, P. 106976 - 106976

Published: Feb. 1, 2025

Plastics are everywhere. It is widely recognized that they represent a global problem, the extent of which yet to be defined. Humans broadly exposed plastics, whose effects and consequences poorly characterized so far. The main route exposure via alimentary respiratory intake. pollutions may come from both: water food contamination itself, their packaging. smaller sizes (i.e. microplastics <150 µm - MPs) considered most pervasive living organisms and, therefore, potentially harmful. As humans occupy one apex positions chain, we bioaccumulation biomagnification MPs. In fact, MPs commonly found in human stools blood. However, there no data available on ability accumulate produce detrimental biological systems. Even though plastics pollution studied mammals, including humans, appear have inflammatory effects, rather concerning as many etiologies disease based pro-inflammatory status.

Language: Английский

Citations

0
Inhalation of nanoplastics in the mouse model: Tissue bio-distribution and effects on the olfactory system DOI Creative Commons

G. M. Prosperi,

Natalia Marchetti,

Alessandro D’Elia

et al.

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 968, P. 178853 - 178853

Published: Feb. 18, 2025

The impact of plastic fragments on human health is currently under investigation, with nanoplastics (NPs) being particularly concerning due to their small size. This allows them be inhaled, pass through blood barriers, and reach various organs. In this study, we evaluated the effects airborne NPs mouse olfactory system, which a primary target inhalation. Adult mice were exposed an aerosol solution containing synthetic polystyrene (PS-NPs) labelled red fluorophore for 5 h day over 7 days. Biodistribution analysis revealed that PS-NPs accumulated in tissues, such as brain, lung, adipose tissue, testicles, but cleared after one month. study first investigate inhaled bulb (OB) subventricular neurogenesis adult mice. We observed long-term impairments discrimination, decreased neuronal functionality, pro-inflammatory activation microglia OB following exposure. Surprisingly, noted compensatory increase neurogenesis, although insufficient counteract olfaction impairment induced by PS-NPs. These results provide novel insights into potential neurotoxic emphasize importance assessing occupational environmental exposure these pollutants.

Language: Английский

Citations

0
Microplastics in the marine environment: Impacts, identification and treatments DOI
Maria da Luz Fernandes,

Luiz Leite,

Martim Costa

et al.

Bioresource Technology Reports, Journal Year: 2025, Volume and Issue: unknown, P. 102073 - 102073

Published: Feb. 1, 2025

Language: Английский

Citations

0
La paradoja del plástico en la salud: herramienta vital, contaminante letal DOI Open Access

Félix Sanz del Castillo,

Andrés Giglio, Andrés Ferre

et al.

SciComm Report, Journal Year: 2025, Volume and Issue: 5(1), P. 1 - 12

Published: Feb. 27, 2025

El uso de plásticos en la atención salud plantea una paradoja crítica, mientras facilita médica, pero su eliminación inadecuada amenaza humana y planetaria. Existe un impacto ambiental el sector salud, destacando que hasta 83% los residuos hospitalarios a nivel global pueden ser plásticos, con efectos nocivos para como cáncer, afecciones cardiovasculares enfermedades respiratorias. En Chile, solo 2% se reciclan, 98% dispone vertederos. La presencia microplásticos fluidos tejidos humanos, sangre bulbo olfatorio, expone gravedad del problema. exposición prolongada asocia patologías oncológicas, respiratorias, comprometiendo principio ético “no hacer daño”. Por lo anterior, existe necesidad integrar estrategias sostenibles gestión hospitalarios, implementación equipos “Green Teams” reducir insumos desechables, reutilizar materiales fomentar reciclaje. adhesión 233 instituciones Red Global Hospitales Verdes Saludables marca avance, persisten desafíos educación profesionales políticas efectivas. este contexto, enfermería posiciona actor clave liderar cambio, dada capacidad intervención directa clínica, formación académica residuos. sostenibilidad debe eje central transformación proponiendo mallas curriculares fortalecimiento investigación local formulación públicas. Este enfoque asegura equilibrio entre calidad pacientes protección planeta, garantizando futuro más saludable todos.

Citations

0
Environmental factors trigger pubertal development DOI

Sofia Malave-Ortiz,

C. C. Grant,

Natalie D. Shaw

et al.

Current Opinion in Pediatrics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Purpose of review We provide an overview the secular trend earlier pubertal development, why there is a growing concern that environmental factors may be to blame, and how these influence developing reproductive axis. Recent findings highlight recent work suggesting that, in addition activating sex steroid receptors, compounds neuropeptide receptors and/or epigenetic regulators. describe studies linking air pollution, metals, endocrine disrupting (EDCs), short sleep duration, early life adversity, stress timing. Summary Pubertal timing tightly controlled by genetic, epigenetic, factors. While animal epidemiological have pointed several potential factors, additional necessary identify critical levels developmental windows exposure as well mechanistic underpinnings.

Language: Английский

Citations

0