Journal of Clinical Medicine,
Journal Year:
2025,
Volume and Issue:
14(11), P. 3721 - 3721
Published: May 26, 2025
Exposure
to
microplastics
(MPs)
in
biological
systems
can
lead
particle
toxicity,
oxidative
stress,
and
inflammatory
changes,
potentially
contributing
cancer
development,
digestive
disorders,
respiratory
issues,
fertility
problems.
Traditional
cigarette
users
are
particularly
vulnerable,
as
MPs
have
been
detected
99%
of
filters,
exposing
smokers
these
particles
through
inhalation
ingestion.
This
narrative
review
aims
analyze
the
sources,
health
implications,
biochemical
impact
derived
from
consumption.
A
literature
search
was
conducted
using
databases
such
PubMed,
Scopus,
Google
Scholar,
applying
strict
inclusion
criteria:
peer-reviewed
studies
published
between
2010
2025
keywords
“microplastics”,
“smoking”,
“tobacco”,
“oxidative
stress”,
“pro-inflammatory
cytokines”,
“cell
viability”,
“regulatory
policies”,
“health
effects”.
Findings
indicate
that
present
samples
blood
(77%
cases),
placenta
(75%),
lung
tissue
(88%),
feces
(100%),
demonstrating
systemic
human
exposure.
The
environmental
implications
improper
disposal
further
exacerbate
global
microplastic
crisis.
highlights
potential
mitigation
strategies
reduce
cigarette-derived
microplastics.
Microorganisms,
Journal Year:
2025,
Volume and Issue:
13(1), P. 114 - 114
Published: Jan. 8, 2025
Bisphenol
A,
an
endocrine-disrupting
compound,
is
widely
used
in
the
industrial
production
of
plastic
products.
Despite
increasing
concerns
about
its
harmful
effects
on
human
health,
animals,
and
environment,
use
BPA
has
been
banned
only
infant
products,
cellular
processes
are
not
fully
understood.
To
investigate
impact
eukaryotic
cells,
we
analyzed
proteome
changes
wild-type
PDR5-deleted
S.
cerevisiae
strains
exposed
to
different
doses
using
sample
multiplexing-based
proteomics.
We
found
that
ABC
multidrug
transporter
Pdr5
plays
important
role
protecting
yeast
cells
from
toxicity,
with
absence
significantly
sensitizing
BPA.
inhibited
growth
a
dose-dependent
manner,
more
pronounced
effect
cells.
Proteomic
analysis
revealed
induces
widespread
protein
abundance,
including
upregulation
metabolic
pathways
such
as
arginine
biosynthesis
downregulation
mitochondrial
proteins.
Additionally,
observed
markers
stress
induced
by
identifying
multiple
stress-induced
proteins
were
upregulated
this
compound.
As
affected
have
shown
be
evolutionarily
conserved,
these
insights
can
advance
our
understanding
BPA's
broader
health.
Processes,
Journal Year:
2025,
Volume and Issue:
13(2), P. 502 - 502
Published: Feb. 11, 2025
The
presence
of
microplastics
in
the
environment
has
increased
due
to
anthropogenic
activities;
it
is
estimated
that
15
million
kilograms
plastic
waste
accumulate
ocean
annually.
Pollution
permeates
every
inch
from
food
chain
water
bottles
floating
on
surface.
This
monolith
pollution
made
up
all
kinds
marine
debris
and
contains
1.8
trillion
pieces
plastic,
covering
an
area
twice
size
Texas.
objective
this
review
show
advances
study
emerging
problems,
specifically
soil
their
potential
effects
health.
In
addition,
have
synergy
with
residual
contaminants
exist
such
as
textile
waste,
organic
matter,
pathogens,
etc.
causes
damage
aquatic
organisms
makes
nutrient
transfer
more
complex
many
these
species.
There
a
report
estimates
liabilities
related
will
cost
industry
100,000
dollars
lawsuits
for
damages
losses,
which
20,000
occur
United
States.
can
generate
indicators
current
effect
public
policies
try
control
growth
pollutant
environment.
It
important
discuss
routes
generation
microplastics,
distribution,
cosmetics
involved
fast
fashion
glitter
evaluate
physical,
chemical,
biological,
toxicological
environment,
proposing
path
future
be
followed
regarding
research
topic.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(7), P. 2899 - 2899
Published: March 22, 2025
The
inevitable
exposure
of
humans
to
micro/nanoplastics
has
become
a
pressing
global
environmental
issue,
with
growing
concerns
regarding
their
impact
on
health.
While
the
direct
effects
human
health
remain
largely
unknown,
increasing
attention
is
being
given
potential
role
as
carriers
pollutants
and
organic
substances.
This
study
investigates
toxicity
500
nm
polystyrene
nanoplastics
(NPs)
hepatocytes
(HepG2)
in
vitro,
both
alone
combination
cadmium
(Cd),
hazardous
heavy
metal
prevalent
pollutant.
One-hour
100
µg/mL
NPs
causes
significant
increase
ROS
production
(+25%
compared
control)
but
cell
viability
remains
unaffected
even
at
concentrations
much
higher
than
levels.
Interestingly,
significantly
reduce
Cd
cytotoxicity
LC50
(cell
control:
55.4%
for
50
µM
Cd,
66.9%
+
10
NPs,
68.4%
NPs).
Additionally,
do
not
alter
cellular
lipid
content
after
short-term
(24
h).
However,
when
fatty
acids
are
added
medium,
appear
sequester
acids,
reducing
availability
impairing
uptake
by
cells
dose-dependent
manner.
We
confirmed
Dynamic
Light
Scattering
Scanning
Electron
Microscopy
interaction
between
free
acids.
Although
exhibited
minimal
our
experimental
model,
collectively
findings
suggest
that
predicting
extremely
challenging,
due
specific
components
biological
matrix.
Archives of Toxicology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 19, 2025
Abstract
Microplastic
particles
(MPs)
are
ubiquitous
environmental
pollutants
that
can
remain
in
ecosystems
for
prolonged
periods.
Plastic
materials
undergo
various
degradation
processes
driven
by
chemical,
physical,
and
biological
factors
alter
their
size,
shape,
composition,
bioavailability.
The
gastrointestinal
tract
is
the
primary
pathway
through
which
MPs
absorbed,
raising
concerns
as
they
transport
harmful
microorganisms
into
body.
Despite
widespread
presence,
effects
of
exposure
to
vehicle
toxins
still
not
well
understood.
In
this
study,
we
rigorously
simulated
photoaging
polystyrene
two
distinct
sizes
(1
µm
5
µm)
confirmed
capacity
adsorb
benzo[a]pyrene,
a
known
carcinogen.
Moreover,
explored
capabilities
these
analyzed
genotoxic
on
liver
cells
under
gastric
digestion
conditions.
Our
findings
reveal
enriched
with
BaP
release
toxic
compound
when
ingested
exposed
juices,
markedly
increasing
toxicity
compared
individual
components.
This
research
underscores
alarming
potential
exacerbate
risks
associated
human
health.
Toxics,
Journal Year:
2025,
Volume and Issue:
13(5), P. 353 - 353
Published: April 29, 2025
Hepatocarcinogenesis
is
linked
to
environmental
factors,
with
microplastics
(MPs)
emerging
as
a
global
concern
that
may
contribute
liver
injury.
However,
the
impact
of
MPs
on
early
stages
hepatocarcinogenesis
has
been
largely
ignored.
Here
we
investigated
long-term
MP
exposure
formation
preneoplastic
lesions
during
induced
by
diethylnitrosamine
(DEN)
in
rats.
Rats
were
injected
DEN
induce
lesions,
and
then
they
orally
administered
1
µm
0.5
mg/kg
body
weight
per
day
for
20
weeks.
The
results
revealed
did
not
glutathione
S-transferase
placental
form
(GST-P)-positive
foci
these
animals,
thereby
indicating
non-carcinogenicity.
resulted
1-fold
increase
both
number
size
GST-P-positive
rats
initiated
compared
those
treated
alone.
Accordingly,
led
0.61-fold
index
proliferating
cell
nuclear
antigen
(PCNA)-positive
cells
DEN-initiated
when
treatment
In
addition,
composition
gut
microbiota
was
significantly
altered,
accompanied
various
levels
short-chain
fatty
acids.
Our
suggest
can
promote
pre-neoplastic
lesion
DEN-induced
increased
proliferation
well
alterations
acid
levels.
This
highlights
potential
health
risks
associated
MPs.
