Air Pollution and the Risk of Parkinson's Disease: A Review

Movement Disorders, Journal Year: 2022, Volume and Issue: 37(5), P. 894 - 904

Published: Jan. 19, 2022

Parkinson's disease, as well other neurodegenerative disorders, are primarily characterized by pathological accumulation of proteins, inflammation, and neuron loss. Although there some known genetic risk factors, most cases cannot be explained genetics alone. Therefore, it is important to determine the environmental factors that confer mechanisms which they act. Recent epidemiological studies have found exposure air pollution associated with an increased for development although not all results uniform. The variability between these likely due differences in what components measured, timing methods used exposures, correction variables. There several potential could act increase including direct neuronal toxicity, induction systemic inflammation leading central nervous system alterations gut physiology microbiome. Taken together, emerging factor disease. A number been implicated promotes neuropathology providing biological plausibility, relevant disorders such Alzheimer's This field its early stages, but a better understanding how exposures influence pathogenesis neurodegeneration essential reducing incidence disease finding disease-modifying therapies. © 2022 International Parkinson Movement Disorder Society.

Language: Английский

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Semiconducting MOFs on ultraviolet laser-induced graphene with a hierarchical pore architecture for NO2 monitoring

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: May 30, 2023

Due to rapid urbanization worldwide, monitoring the concentration of nitrogen dioxide (NO2), which causes cardiovascular and respiratory diseases, has attracted considerable attention. Developing real-time sensors detect parts-per-billion (ppb)-level NO2 remains challenging due limited sensitivity, response, recovery characteristics. Herein, we report a hybrid structure Cu3HHTP2, 2D semiconducting metal-organic frameworks (MOFs), laser-induced graphene (LIG) for high-performance sensing. The unique hierarchical pore architecture LIG@Cu3HHTP2 promotes mass transport gas molecules takes full advantage large surface area porosity MOFs, enabling highly sensitive responses NO2. Consequently, shows one fastest lowest limit detection at room temperature compared with state-of-the-art sensors. Additionally, by employing LIG as growth platform, flexibility patterning strategies are achieved, main challenges MOF-based electronic devices. These results provide key insight into applying MOFtronics healthcare

Language: Английский

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Parkinson’s Disease is Predominantly a Genetic Disease

Journal of Parkinson s Disease, Journal Year: 2024, Volume and Issue: 14(3), P. 467 - 482

Published: March 26, 2024

The discovery of a pathogenic variant in the alpha-synuclein (SNCA) gene Contursi kindred 1997 indisputably confirmed genetic cause subset Parkinson’s disease (PD) patients. Currently, variants one seven established PD genes or strongest known risk factor gene, GBA1, are identified ∼15% patients unselected for age at onset and family history. In this Debate article, we highlight multiple avenues research that suggest an important - some cases even predominant role genetics aetiology, including familial clustering, high rates monogenic selected populations, complete penetrance with certain forms. At first sight, steep increase prevalence exceeding other neurodegenerative diseases may argue against etiology. Notably, principal contribution is conferred by LRRK2 GBA1 and, both cases, characterized overall late age-related penetrance. addition, polygenic plays considerable PD. However, it likely that, majority patients, complex interplay aging, genetic, environmental, epigenetic factors leads to development.

Language: Английский

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Parkinson’s Disease Is Predominantly an Environmental Disease

Journal of Parkinson s Disease, Journal Year: 2024, Volume and Issue: 14(3), P. 451 - 465

Published: Jan. 12, 2024

Parkinson’s disease is the world’s fastest growing brain disorder, and exposure to environmental toxicants principal reason. In this paper, we consider alternative, but unsatisfactory, explanations for its rise, including improved diagnostic skills, aging populations, genetic causes. We then detail three that are likely among main causes of disease— certain pesticides, solvent trichloroethylene, air pollution. All ubiquitous, many affect mitochondrial functioning, all can access humans via various routes, inhalation ingestion. reach hopeful conclusion most thus preventable help create a world where increasingly rare.

Language: Английский

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Role of the Exposome in Neurodegenerative Disease: Recent Insights and Future Directions

Annals of Neurology, Journal Year: 2024, Volume and Issue: 95(4), P. 635 - 652

Published: Feb. 27, 2024

Neurodegenerative diseases are increasing in prevalence and place a significant burden on society. The causes multifactorial complex, evidence suggests dynamic interplay between genes the environment, emphasizing importance of identifying understanding role lifelong exposures, known as exposome, nervous system. This review provides an overview recent advances toward defining neurodegenerative disease exposomes, focusing Parkinson's disease, amyotrophic lateral sclerosis, Alzheimer's disease. We present current state field based emerging data, elaborate key themes potential mechanisms, conclude with limitations future directions. ANN NEUROL 2024;95:635-652.

Language: Английский

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Preventing Parkinson’s Disease: An Environmental Agenda

Journal of Parkinson s Disease, Journal Year: 2021, Volume and Issue: 12(1), P. 45 - 68

Published: Oct. 29, 2021

Fueled by aging populations and continued environmental contamination, the global burden of Parkinson's disease (PD) is increasing. The disease, or more appropriately diseases, have multiple genetic influences but no approved modifying therapy. Additionally, efforts to prevent this debilitating been limited. As numerous contaminants (e.g., pesticides, metals, industrial chemicals) are implicated in PD, prevention possible. To reduce we compiled preclinical clinical research priorities that highlight both prediction primary prevention. Though not exhaustive, "PD agenda" builds upon many years our colleagues proposes next steps through lens modifiable risk factors. agenda identifies ten specific areas further inquiry considers funding policy changes will be necessary help world's fastest growing brain disease.

Language: Английский

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Air Pollution–Related Neurotoxicity Across the Life Span

The Annual Review of Pharmacology and Toxicology, Journal Year: 2022, Volume and Issue: 63(1), P. 143 - 163

Published: Aug. 27, 2022

Air pollution is a complex mixture of gases and particulate matter, with adsorbed organic inorganic contaminants, to which exposure lifelong. Epidemiological studies increasingly associate air multiple neurodevelopmental disorders neurodegenerative diseases, findings supported by experimental animal models. This breadth neurotoxicity across these central nervous system diseases likely reflects shared vulnerability their inflammatory oxidative stress–based mechanisms corresponding ability produce brain metal dyshomeo-stasis. Future research define the responsible contaminants underlying this critical understanding protecting public health.

Language: Английский

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Role of Nrf2 in Parkinson’s Disease: Toward New Perspectives

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: June 24, 2022

Parkinson's disease (PD) is one of the most common and chronic degenerative diseases in central nervous system. The main pathology PD formation progressive loss dopaminergic neurons substantia nigra α-synuclein-rich Lewy bodies. pathogenesis not caused by any single independent factor. diversity these factors PD, such as iron accumulation, oxidative stress, neuroinflammation, mitochondrial dysfunction, age, environment, heredity, makes research progress slow. Nrf2 has been well-known to be closely associated with could regulate induced development. activation protect slow down progression PD. This review summarized role pathway on Regulation might promising strategies prevent treat

Language: Английский

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Linking environmental risk factors with epigenetic mechanisms in Parkinson’s disease

npj Parkinson s Disease, Journal Year: 2023, Volume and Issue: 9(1)

Published: Aug. 25, 2023

Abstract Sporadic Parkinson’s disease (PD) is a progressive neurodegenerative disease, with complex risk structure thought to be influenced by interactions between genetic variants and environmental exposures, although the full aetiology unknown. Environmental factors, including pesticides, have been reported increase of developing disease. Growing evidence suggests epigenetic changes are key mechanisms which these factors act upon gene regulation, in disease-relevant cell types. We present systematic review critically appraising summarising current body relationship PD inform future research this area. Epigenetic studies relevant animal models yielded promising results, however, humans just emerging. While published currently relatively limited, importance field for elucidation molecular pathogenesis opens clear avenues research. Carefully designed epidemiological carried out patients hold great potential uncover regulatory mechanisms. Therefore, advance burgeoning field, we recommend broadening scope investigations include more increasing sample sizes, focusing on types, recruiting diverse cohorts.

Language: Английский

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Residential greenness, air pollution and incident neurodegenerative disease: A cohort study in China

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 878, P. 163173 - 163173

Published: March 31, 2023

Language: Английский

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