Published: Jan. 1, 2024
Language: Английский
Translational Neurodegeneration, Journal Year: 2024, Volume and Issue: 13(1)
Published: Feb. 27, 2024
The aetiologies and origins of neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's (PD), amyotrophic lateral sclerosis (ALS) Huntington's (HD), are complex multifaceted. A growing body evidence suggests that the gut microbiome plays crucial roles in development progression diseases. Clinicians have come to realize therapeutics targeting potential halt This narrative review examines alterations AD, PD, ALS HD, highlighting close relationship between brain Processes mediate microbiome-brain communication including immunological, vagus nerve circulatory pathways, evaluated. Furthermore, we summarize for diseases modify its metabolites, diets, probiotics prebiotics, microbial antibacterials faecal transplantation. Finally, current challenges future directions discussed.
Language: Английский
Citations
22
The Egyptian Journal of Internal Medicine, Journal Year: 2025, Volume and Issue: 37(1)
Published: Jan. 24, 2025
Abstract This narrative review explores the relationship between air pollution and neurodegenerative diseases (NDs). Historically, has been linked primarily to respiratory cardiovascular issues, but recent evidence suggests that it may also impact neurological health. With global increase in diseases, understanding environmental risk factors become crucial. The synthesizes findings from studies, highlighting potential role of pollutants—particularly fine particulate matter (PM2.5), ozone, nitrogen dioxide (NO2), heavy metals—in onset progression NDs. Key mechanisms under investigation include brain inflammation microglial activation, which are believed contribute processes. Animal human studies have shown correlations exposure increased cognitive decline disorders. Research indicates exacerbate neuroinflammation cause white abnormalities, disrupt neural communication function. Additionally, emerging like residential greenness climate action could mitigate some these adverse effects. Despite advancements, significant knowledge gaps remain, particularly regarding long-term chronic specific molecular pathways involved. shows need for further research clarify develop targeted interventions. Addressing pollution’s on requires comprehensive public health strategies, including stricter regulations awareness, alongside continued into preventive therapeutic measures.
Language: Английский
Citations
4
Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 469, P. 133944 - 133944
Published: March 2, 2024
Language: Английский
Citations
15
The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 914, P. 169883 - 169883
Published: Jan. 5, 2024
Language: Английский
Citations
13
Journal of Parkinson s Disease, Journal Year: 2024, Volume and Issue: 14(3), P. 363 - 381
Published: April 9, 2024
The brain- and body-first models of Lewy body disorders predict that aggregated alpha-synuclein pathology usually begins in either the olfactory system or enteric nervous system. In both scenarios seems to arise structures are closely connected outside world. Environmental toxicants, including certain pesticides, industrial chemicals, air pollution therefore plausible trigger mechanisms for Parkinson’s disease dementia with bodies. Here, we propose toxicants inhaled through nose can lead pathological changes subsequently spread give rise a brain-first subtype disease. Similarly, ingested pass gut cause then extends via parasympathetic sympathetic pathways ultimately produce subtype. resulting be tracked by development symptoms, clinical assessments, vivo imaging, examination. integration environmental exposures into generates testable hypotheses, on prevalence conditions, their future incidence, imaging patterns, signatures. proposed link, though, has limitations leaves many questions unanswered, such as role skin, influence microbiome, effects ongoing exposures. Despite these limitations, interaction exogenous factors may explain mysteries open door toward ultimate goal –prevention.
Language: Английский
Citations
12
npj Parkinson s Disease, Journal Year: 2024, Volume and Issue: 10(1)
Published: Jan. 17, 2024
Abstract Inconsistent findings exist regarding the potential association between polluted air and Parkinson’s disease (PD), with unclear insights into role of inherited sensitivity. This study sought to explore link various pollutants PD risk, investigating whether genetic susceptibility modulates these associations. The population-based involved 312,009 initially PD-free participants complete genotyping data. Annual mean concentrations PM 2.5 , 10 NO 2 x were estimated, a polygenic risk score (PRS) was computed assess individual risks for PD. Cox proportional models employed calculate hazard ratios (HR) 95% confidence intervals (CI) associations ambient pollutants, incident Over median 12.07-year follow-up, 2356 cases (0.76%) observed. Compared lowest quartile pollution, highest quartiles pollution showed HRs CIs 1.247 (1.089–1.427) 1.201 (1.052–1.373) incidence, respectively. Each μg/m 3 increase in yielded elevated 1.089 (1.026–1.155) 1.363 (1.043–1.782), Individuals significant exposure had development (HR: 2.748, CI: 2.145–3.520). Similarly, those substantial over twice as likely develop compared minimal-risk counterparts 2.414, 1.912–3.048). Findings suggest that contaminants heightens particularly individuals genetically predisposed high susceptibility.
Language: Английский
Citations
11
Nature Aging, Journal Year: 2025, Volume and Issue: unknown
Published: March 21, 2025
Abstract Previous studies have indicated increased dementia risk associated with fine particulate matter (PM 2.5 ) exposure; however, the findings are inconsistent. In this systematic review, we assessed association between long-term PM exposure and outcomes using Burden of Proof meta-analytic framework, which relaxes log-linear assumptions to better characterize relative functions quantify unexplained between-study heterogeneity (PROSPERO, ID CRD42023421869). Here report a meta-analysis 28 longitudinal cohort published up June 2023 that investigated outcomes. We derived risk–outcome scores (ROSs), highly conservative measures effect size evidence strength, mapped onto 1–5-star rating from ‘weak and/or inconsistent evidence’ ‘very strong consistent evidence’. identified significant nonlinear relationship dementia, minimum 14% averaged across levels 4.5 26.9 µg m −3 (the 15th 85th percentile range included studies), reference 2.0 ( n = 49, ROS 0.13, two stars). found Alzheimer’s disease 12, 0.32, three stars) but not vascular dementia. Our highlight potential impact air pollution on brain aging.
Language: Английский
Citations
1
Environment International, Journal Year: 2024, Volume and Issue: 188, P. 108739 - 108739
Published: May 11, 2024
Protective associations of greenspace with Parkinson's disease (PD) have been observed in some studies. Visual exposure to seems be important for the proposed pathways underlying these associations. However, most studies use overhead-view measures (e.g., satellite imagery, land-classification data) that do not capture street-view and cannot distinguish between specific types. We aimed evaluate hospitalizations a PD diagnosis code (PD-involved hospitalization).
Language: Английский
Citations
7
Environmental Science and Pollution Research, Journal Year: 2024, Volume and Issue: 31(6), P. 9091 - 9105
Published: Jan. 6, 2024
Language: Английский
Citations
4
The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 905, P. 166941 - 166941
Published: Sept. 15, 2023
Language: Английский
Citations
10