Clinical state and future directions of stem cell therapy in stroke rehabilitation DOI
Pardes Habib, Gary K. Steinberg

Experimental Neurology, Journal Year: 2024, Volume and Issue: 385, P. 115132 - 115132

Published: Dec. 30, 2024

Language: Английский

Advances in mesenchymal stem cell-centered stem cell therapy in the treatment of hypoxic-ischemic injury DOI

Lixin Qi,

Lei Hu, Rongyi Qian

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 143, P. 113430 - 113430

Published: Oct. 21, 2024

Language: Английский

Citations

1
Current Stem Cell-Based Clinical Trials and Protective Phenotypic Conversion Cell Therapies Against Ischemic stroke DOI
Masato Kanazawa, Masahiro Hatakeyama, Itaru Ninomiya

et al.

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 308 - 315

Published: Jan. 1, 2024

Language: Английский

Citations

0
Glial cell transplant for brain diseases: the supportive saviours? DOI Creative Commons
Katrina Albert,

Gundars Goldsteins,

Sara Kälvälä

et al.

Translational Medicine Communications, Journal Year: 2024, Volume and Issue: 9(1)

Published: July 13, 2024

Abstract The incidence of brain diseases in humans is increasing as we experience a worldwide ageing the population. Treatment for such still only symptomatic there are almost no disease-modifying therapies available. Further, since treatment often starts when symptoms appear which at late stage pathology, need treatments that will create new cells or restore function to living cells. Cell transplant therapy, where neuronal progenitor derived from stem transplanted brain, has seen experimental success. And though been some clinical progress, available therapy. While through years research focused on neurons, it now shifting so-called support glia. In neurodegenerative and stroke, glia play roles pathogenesis disease. Therefore, replacing them enhancing their functions ultimately save neurons avenue gained traction recent years. this review, present current state-of-the-art transplantation cells, feasibility upcoming directions field.

Language: Английский

Citations

0
Regenerative stem cell therapy for stroke in Europe (RESSTORE): a multicenter randomized controlled efficacy clinical trial DOI Creative Commons
Loïc Legris,

Anaïck Moisan,

Assia Jaillard

et al.

Frontiers in Stroke, Journal Year: 2024, Volume and Issue: 3

Published: Sept. 27, 2024

Introduction Encouraging the activation of brain repair mechanisms and fostering spontaneous functional recovery in stroke patients hold great promise for alleviating global burden this condition allowing an extended therapeutic time window. Cell-based regenerative therapy (with mesenchymal stem/stromal cells, such as adipose-derived stem cells [ADSCs]) is particularly attractive considering its excellent safety profile, low immunogenicity after allogeneic application, well-established benefits on animal models. This study aims to assess efficacy effects intravenous (IV) infusion freshly cultured ADSCs ischemic stroke. Population methods RESSTORE a multicentric, randomized 1:1 controlled double-blind clinical trial. Eighty will be enrolled nine French centers. The main inclusion criteria are ≥18 years age, acute hemispheric stroke, National Institutes Health Stroke Scale (NIHSS) score ≥7, including motor subscore ≥3. According previous dose-escalation trial data, maximum tolerated dose 3 million ADSCs/kg was selected. IV performed within 10 days following onset, with follow-up over 2 years. Outcomes primary endpoint NIHSS subscore, computed sum upper limb, lower hand scores, measured 6 months onset recovery. secondary outcomes occurrence death/serious adverse events, scores (the detailed Montreal Cognitive Assessment modified Rankin Aphasia Handicap Scores, Depression Intensity Circles Fatigue etc.), immune monitoring (for first 30 patients), multimodal biomarkers derived from diffusion magnetic resonance imaging. Discussion may provide some evidence allogenic subacute that help design larger international

Language: Английский

Citations

0
Efficacy and Safety of Stem-Cell Therapy for Acute and Subacute Ischemic Stroke: Improving Long-Term Outcomes - A Systematic Review and Meta-Analysis DOI
Toshiya Osanai, Soichiro Takamiya, Yasuhiro Morii

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0
Stem Cell Therapy for Stroke: Mechanisms and Functional Recovery DOI Creative Commons
Hongjian Pu

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

Stem cell therapy has emerged as a promising approach for enhancing recovery following stroke, leading cause of disability worldwide. This chapter provides comprehensive overview the mechanisms through which stem exerts its effects on brain repair and functional recovery. We explore several types cells, including mesenchymal neural induced pluripotent their potential to promote neurogenesis, angiogenesis, synaptic plasticity. Additionally, we discuss paracrine highlighting role in modulating inflammation reducing apoptosis. Preclinical studies clinical trials are reviewed evaluate efficacy safety different therapies. Furthermore, address challenges limitations currently hindering translation into routine practice, such optimal delivery methods, immune rejection, ethical considerations. By elucidating underlying summarizing latest research advancements, this aims provide valuable insights viable treatment strategy stroke patients, contributing improved quality life.

Language: Английский

Citations

0
Clinical state and future directions of stem cell therapy in stroke rehabilitation DOI
Pardes Habib, Gary K. Steinberg

Experimental Neurology, Journal Year: 2024, Volume and Issue: 385, P. 115132 - 115132

Published: Dec. 30, 2024

Language: Английский

Citations

0