Journal of Clinical Medicine,
Journal Year:
2020,
Volume and Issue:
10(1), P. 15 - 15
Published: Dec. 23, 2020
Background:
The
landscape
of
attitudes,
legal
status
and
patterns
use
cannabis
is
rapidly
changing
in
the
United
States
elsewhere.
Therefore,
primary
aim
this
narrative
review
to
provide
a
concise
overview
literature
on
comorbidity
disorder
(CUD)
with
other
substance
psychiatric
disorders,
information
accurately
guide
future
directions
for
field.
Methods:
A
PubMed
was
conducted
studies
relating
use,
CUD,
co-occurring
disorder.
To
an
representative
data,
focused
national-level,
population-based
work
from
National
Epidemiologic
Survey
Alcohol
Related
Conditions
(NESARC)
Drug
Use
Health
(NSDUH)
surveys.
Considering
laws,
recent
(past
five-year)
were
addressed.
Results:
strong
body
shows
associations
between
CUD
drug
psychosis,
mood
anxiety
personality
disorders.
strongest
evidence
potential
causal
relationship
exists
psychotic
While
some
directionality
results
are
inconsistent.
Studies
have
established
higher
rates
among
those
but
little
about
specifics
understood.
Conclusions:
Although
general
population
increasingly
perceives
be
harmless
substance,
empirical
that
associated
both
comorbid
illness.
However,
there
mixed
regarding
role
etiology,
course,
prognosis
across
all
categories
Future
research
should
expand
existing
representative,
longitudinal
order
better
understand
acute
long-term
effects
Neuropsychopharmacology,
Journal Year:
2017,
Volume and Issue:
43(1), P. 195 - 212
Published: Aug. 30, 2017
This
review
provides
an
overview
of
the
changing
US
epidemiology
cannabis
use
and
associated
problems.
Adults
adolescents
increasingly
view
as
harmless,
some
can
without
harm.
However,
potential
problems
include
harms
from
prenatal
exposure
unintentional
childhood
exposure;
decline
in
educational
or
occupational
functioning
after
early
adolescent
use,
adulthood,
impaired
driving
vehicle
crashes;
disorders
(CUD),
withdrawal,
psychiatric
comorbidity.
Evidence
suggests
national
increases
potency,
adults,
increased
CUD,
cannabis-related
emergency
room
visits,
fatal
crashes.
Twenty-nine
states
have
medical
marijuana
laws
(MMLs)
these,
8
recreational
(RMLs).
Many
studies
indicate
that
MMLs
their
specific
provisions
did
not
increase
use.
more
limited
literature
led
to
exposures,
adult
CUD.
Ecological-level
suggest
substitution
for
opioids,
also
possibly
medications.
Much
remains
be
determined
about
trends
role
RMLs
these
trends.
The
public,
health
professionals,
policy
makers
would
benefit
education
risks
such
risks,
increases.
JAMA Psychiatry,
Journal Year:
2019,
Volume and Issue:
77(2), P. 165 - 165
Published: Nov. 13, 2019
Little
is
known
about
changes
in
marijuana
use
and
cannabis
disorder
(CUD)
after
recreational
legalization
(RML).To
examine
the
associations
between
RML
enactment
use,
frequent
CUD
United
States
from
2008
to
2016.This
survey
study
used
repeated
cross-sectional
data
National
Survey
on
Drug
Use
Health
(2008-2016)
conducted
among
participants
age
groups
of
12
17,
18
25,
26
years
or
older.Multilevel
logistic
regression
models
were
fit
obtain
estimates
before-vs-after
respondents
states
enacting
compared
other
states.Self-reported
past-month
users,
past-year
CUD,
users.The
included
505
796
consisting
51.51%
females
77.24%
older.
Among
total,
65.43%
white,
11.90%
black,
15.36%
Hispanic,
7.31%
race/ethnicity.
aged
17
years,
increased
2.18%
2.72%
enactment,
a
25%
higher
increase
than
that
for
same
group
did
not
enact
(odds
ratio
[OR],
1.25;
95%
CI,
1.01-1.55).
users
this
group,
22.80%
27.20%
(OR,
1.27;
1.01-1.59).
Unmeasured
confounders
would
need
be
more
prevalent
risk
by
1.08
1.11
times
explain
observed
results,
indicating
results
are
sensitive
omitted
variables.
No
found
25
years.
older,
5.65%
7.10%
1.28;
1.16-1.40),
2.13%
2.62%
1.24;
1.08-1.41),
0.90%
1.23%
1.36;
1.08-1.71);
these
robust
unmeasured
confounding.
enactment.This
study's
findings
suggest
although
advanced
social
justice
goals,
small
post-RML
adults
older
potential
public
health
concern.
To
undertake
prevention
efforts,
further
studies
warranted
assess
how
increases
occur
identify
subpopulations
may
especially
vulnerable.
The American Journal of Drug and Alcohol Abuse,
Journal Year:
2019,
Volume and Issue:
45(6), P. 644 - 663
Published: Oct. 11, 2019
Background:
The
past
decade
has
seen
unprecedented
shifts
in
the
cannabis
policy
environment,
and
public
health
impacts
of
these
changes
will
hinge
on
how
they
affect
patterns
use
harms
associated
with
other
substances.Objectives:
To
review
existing
research
state
substance
use,
emphasizing
studies
using
methods
for
causal
inference
highlighting
gaps
our
understanding
evolving
markets.Methods:
Narrative
quasi-experimental
medical
laws
(MCLs)
recreational
(RCLs)
disorders,
as
well
or
from
alcohol,
opioids,
tobacco.Results:
Research
suggests
MCLs
increase
adult
but
not
adolescent
provisions
less
regulated
supply
may
disorders.
These
reduce
some
opioid-related
harms,
while
their
alcohol
tobacco
remain
uncertain.
RCLs
is
just
emerging,
findings
suggest
little
impact
prevalence
potential
increases
college
student
unknown
effects
use.Conclusions:
influence
advanced
importance
heterogeneity
policies,
populations,
market
dynamics,
relate
to
often
ignore
factors.
Understanding
requires
greater
attention
differences
short-
versus
long-term
laws,
nuances
policies
consumption,
careful
consideration
appropriate
control
groups.
The Lancet Public Health,
Journal Year:
2018,
Volume and Issue:
3(7), P. e341 - e350
Published: July 1, 2018
BackgroundInterest
in
the
use
of
cannabis
and
cannabinoids
to
treat
chronic
non-cancer
pain
is
increasing,
because
their
potential
reduce
opioid
dose
requirements.
We
aimed
investigate
people
living
with
who
had
been
prescribed
opioids,
including
reasons
for
perceived
effectiveness
cannabis;
associations
between
amount
pain,
mental
health,
use;
effect
on
severity
interference
over
time;
opioid-sparing
effects
cannabis.MethodsThe
Pain
Opioids
IN
Treatment
study
a
prospective,
national,
observational
cohort
opioids.
Participants
were
recruited
through
community
pharmacies
across
Australia,
completed
baseline
interviews,
followed
up
phone
interviews
or
self-complete
questionnaires
yearly
4
years.
Recruitment
took
place
from
August
13,
2012,
April
8,
2014.
asked
about
lifetime
past
year
conditions,
duration
self-efficacy,
whether
was
neuropathic,
12-month
use,
number
days
used
month,
current
depression
generalised
anxiety
disorder.
also
estimated
daily
oral
morphine
equivalent
doses
logistic
regression
cross-sectional
frequency
lagged
mixed-effects
models
examine
temporal
outcomes.Findings1514
participants
interview
included
Aug
20,
14,
Cannabis
common,
by
4-year
follow-up,
295
(24%)
pain.
Interest
using
increased
364
(33%)
(at
baseline)
723
(60%)
years).
At
compared
no
we
found
that
greater
score
(risk
ratio
1·14,
95%
CI
1·01–1·29,
less
frequent
1·17,
1·03–1·32,
near-daily
use),
(1·21,
1·09–1·35;
1·03–1·26),
lower
self-efficacy
scores
(0·97,
0·96–1·00;
0·98,
0·96–1·00),
disorder
(1·07,
1·03–1·12;
1·10,
1·06–1·15).
evidence
relationship
interference,
reduced
rates
discontinuation.InterpretationCannabis
common
but
improved
patient
outcomes.
People
managing
there
exerted
an
effect.
As
medicinal
purposes
increases
globally,
it
important
large
well
designed
clinical
trials,
which
include
complex
comorbidities,
are
conducted
determine
efficacy
pain.FundingNational
Health
Medical
Research
Council
Australian
Government.
The American Journal of Drug and Alcohol Abuse,
Journal Year:
2019,
Volume and Issue:
45(6), P. 623 - 643
Published: March 14, 2019
Background:
Due
to
significant
comorbidity
and
impairment
associated
with
cannabis
use
disorder,
understanding
time
trends
in
disorder
is
an
important
public
health
priority.Objectives:
To
identify
overall,
by
sociodemographic
subgroup.Methods:
Narrative
review
of
published
findings
on
disorders
data
from
repeated
cross-sectional
US
general
population
surveys.
In
addition,
National
Epidemiologic
Survey
Alcohol
Related
Conditions
(NESARC;
2002–2002)
NESARC-III
(2012–2013)
data,
logistic
regression
was
used
examine
whether
differed
between
subgroups
adults.Results:
The
showed
that
adults,
increased
over
the
past
decade
overall
within
(gender,
age,
race/ethnicity,
income,
education,
marital
status,
urbanicity,
region,
pregnancy
disability
status),
greater
increases
men
disabled
adults.
Most
sources
also
indicated
disorders.
New
analysis
significantly
adult
(p
≤
.0001);
young
adults
<
.05);
Blacks
(vs.
Whites,
p
.01);
low
income
groups
.001);
never-married
.0001),
urban
residents
.05).
adolescents,
generally
decreased,
although
recent
were
observed
older
non-White
adolescents.Conclusion:
Cannabis
are
increasing
specific
at
higher
risk,
may
be
some
adolescent
subgroups.
Studies
should
determine
mechanisms
for
differential
provide
information
policymakers
enable
informed
decisions
legalization
service
planning.
Addiction,
Journal Year:
2018,
Volume and Issue:
113(6), P. 1003 - 1016
Published: Feb. 22, 2018
Abstract
Aims
To
conduct
a
systematic
review
and
meta‐analysis
of
studies
in
order
to
estimate
the
effect
US
medical
marijuana
laws
(MMLs)
on
past‐month
use
prevalence
among
adolescents.
Methods
A
total
2999
papers
from
17
literature
sources
were
screened
systematically.
Eleven
studies,
developed
four
ongoing
large
national
surveys,
meta‐analyzed.
Estimates
MML
effects
any
included
obtained
comparisons
pre–post
changes
states
non‐MML
over
comparable
time‐periods.
These
estimates
standardized
entered
into
model
with
fixed‐effects
for
each
study.
Heterogeneity
study
by
data
survey
was
tested
an
omnibus
F
‐test.
additional
outcomes,
provisions
(e.g.
dispensaries)
demographic
subgroups
abstracted
summarized.
Key
methodological
modeling
characteristics
also
described.
Preferred
Reporting
Items
Systematic
Reviews
Meta‐Analyses
(PRISMA)
guidelines
followed.
Results
None
11
found
significant
compared
contemporaneous
The
yielded
non‐significant
pooled
(standardized
mean
difference)
−0.003
(95%
confidence
interval
=
−0.012,
+0.007).
Four
pre‐MML
differences
all
higher
rates
passage.
Additional
tests
specific
provisions,
outcomes
generally
results,
although
limited
heterogeneity
may
warrant
further
Conclusions
Synthesis
current
evidence
does
not
support
hypothesis
that
until
2014
have
led
increases
adolescent
prevalence.
Limited
exists
MMLs
other
patterns
use,
within
particular
population
provisions.