World Journal of Pediatrics,
Journal Year:
2023,
Volume and Issue:
20(4), P. 353 - 370
Published: Dec. 12, 2023
Abstract
Background
Optimising
the
immunogenicity
of
COVID-19
vaccines
to
improve
their
protection
against
disease
is
necessary.
Fractional
dosing
by
intradermal
(ID)
administration
has
been
shown
be
equally
immunogenic
as
intramuscular
(IM)
for
several
vaccines,
but
ID
inactivated
whole
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
at
full
dose
unknown.
This
study
(NCT04800133)
investigated
superiority
antibody
and
T-cell
responses
full-dose
CoronaVac
over
IM
in
adolescents.
Methods
Participants
aged
11–17
years
received
two
doses
or
vaccine,
followed
3rd
13–42
days
later.
Humoral
cellular
outcomes
were
measured
post-dose
(IM-CC
versus
ID-CC)
3
(IM-CCC
ID-CCC).
Doses
administered
173
104
adolescents,
respectively.
Results
Spike
protein
(S)
immunoglobulin
G
(IgG),
S-receptor-binding
domain
(RBD)
IgG,
S
IgG
Fcγ
receptor
IIIa
(FcγRIIIa)-binding,
SNM
[sum
individual
(S),
nucleocapsid
(N),
membrane
(M)
peptide
pool]-specific
interleukin-2
(IL-2)
+
CD4
,
SNM-specific
IL-2
CD8
S-specific
N-specific
M-specific
fulfilled
superior
non-inferior
criteria
ID-CC
compared
IM-CC,
whereas
avidity
was
inferior.
For
ID-CCC,
S-RBD
surrogate
virus
neutralisation
test,
90%
plaque
reduction
titre
(PRNT90),
PRNT50,
avidity,
FcγRIIIa-binding,
interferon-γ
IM-CCC.
The
estimated
vaccine
efficacies
49%,
52%,
66%
79%
ID-CC,
IM-CCC
groups
reported
more
local,
mild
adverse
reactions.
Conclusion
first
demonstrate
SARS-CoV-2
vaccination
serves
basis
future
research
vaccines.
Graphical
abstract
New England Journal of Medicine,
Journal Year:
2022,
Volume and Issue:
387(21), P. 1935 - 1946
Published: Nov. 9, 2022
In
February
2022,
Massachusetts
rescinded
a
statewide
universal
masking
policy
in
public
schools,
and
many
school
districts
lifted
requirements
during
the
subsequent
weeks.
greater
Boston
area,
only
two
—
neighboring
Chelsea
sustained
through
June
2022.
The
staggered
lifting
of
provided
an
opportunity
to
examine
effect
policies
on
incidence
coronavirus
disease
2019
(Covid-19)
schools.
JAMA Psychiatry,
Journal Year:
2023,
Volume and Issue:
80(9), P. 924 - 924
Published: July 12, 2023
Importance
Understanding
how
children's
utilization
of
acute
mental
health
care
changed
during
the
COVID-19
pandemic
is
critical
for
directing
resources.
Objective
To
examine
youth
use
(emergency
department
[ED],
boarding,
and
subsequent
inpatient
care)
second
year
pandemic.
Design,
Setting,
Participants
This
cross-sectional
analysis
national,
deidentified
commercial
insurance
claims
ED
hospital
took
place
between
March
2019
February
2022.
Among
4.1
million
enrollees
aged
5
to
17
years,
614
16
815
had
at
least
1
visit
in
baseline
(March
2019-February
2020)
2
2021-February
2022),
respectively.
Exposure
The
Main
outcomes
measures
relative
change
from
was
determined
(1)
fraction
with
or
more
visits;
(2)
percentage
visits
resulting
psychiatry
admission;
(3)
mean
length
psychiatric
stay
following
visit;
(4)
frequency
prolonged
boarding
(≥2
midnights)
a
medical
unit
before
admission
an
unit.
Results
Of
enrollees,
51%
were
males
41%
13
years
(vs
5-12
years)
88
665
visits.
Comparing
2,
there
6.7%
increase
any
(95%
CI,
4.7%-8.8%).
adolescent
females,
larger
(22.1%;
95%
19.2%-24.9%).
that
resulted
increased
by
8.4%
5.5%-11.2%).
Mean
3.8%
1.8%-5.7%).
episodes
76.4%
71.0%-81.0%).
Conclusions
relevance
Into
pandemic,
notably
among
awaiting
care.
Interventions
are
needed
child
capacity
reduce
strain
on
system.
JAMA Pediatrics,
Journal Year:
2023,
Volume and Issue:
177(12), P. 1294 - 1294
Published: Oct. 16, 2023
Importance
Social
determinants
of
health
(SDOH)
influence
child
health.
However,
most
previous
studies
have
used
individual,
small-set,
or
cherry-picked
SDOH
variables
without
examining
unbiased
computed
patterns
from
high-dimensional
factors
to
investigate
associations
with
mental
health,
cognition,
and
physical
Objective
To
identify
estimate
their
children’s
mental,
cognitive,
developmental
outcomes.
Design,
Setting,
Participants
This
population-based
cohort
study
included
children
aged
9
10
years
at
baseline
caregivers
enrolled
in
the
Adolescent
Brain
Cognitive
Development
(ABCD)
Study
between
2016
2021.
The
ABCD
includes
21
sites
across
17
states.
Exposures
Eighty-four
neighborhood-level,
geocoded
spanning
7
domains
SDOH,
including
bias,
education,
infrastructure,
natural
environment,
socioeconomic
status,
social
context,
crime
drugs,
were
studied.
Hierarchical
agglomerative
clustering
was
patterns.
Main
Outcomes
Measures
Associations
(internalizing
externalizing
behaviors)
suicidal
behaviors,
cognitive
function
(performance,
reading
skills),
(body
mass
index,
exercise,
sleep
disorder)
estimated
using
mixed-effects
linear
logistic
regression
models.
Results
Among
504
(baseline
median
[SD]
age,
9.9
[0.6]
years;
5510
boys
[52.5%]
4994
girls
[47.5%];
229
Asian
[2.2%],
1468
Black
[14.0%],
2128
Hispanic
[20.3%],
5565
White
[53.0%],
1108
multiracial
[10.5%]),
4
identified:
pattern
1,
affluence
(4078
[38.8%]);
2,
high-stigma
environment
(2661
[25.3%]);
3,
high
deprivation
(2653
4,
drug
sales,
low
population
density
(1112
[10.6%]).
distinctly
associated
Children
exposed
(SDOH
3)
showed
worst
profiles,
manifesting
more
internalizing
(β
=
0.75;
95%
CI,
0.14-1.37)
1.43;
0.83-2.02)
problems,
lower
performance,
adverse
Conclusions
shows
that
an
quantitative
analysis
multidimensional
can
permit
determination
how
are
outcomes
relative
other
categories.
These
findings
suggest
need
determine
whether
improvement
conditions
enhance
The Lancet Regional Health - Americas,
Journal Year:
2022,
Volume and Issue:
16, P. 100391 - 100391
Published: Nov. 16, 2022
The
COVID-19
pandemic
and
associated
responses
have
induced
a
host
of
crises
worldwide,
including
an
economic
recession
global
mental
health
crisis.
specific
effects
on
youth
are
understudied.
We
aimed
to
examine
the
mechanisms
by
which
pandemic-related
financial
strain
may
affect
in
diverse
sample
American
adolescents.We
analyzed
data
from
Adolescent
Brain
Cognitive
Development
Study
(ABCD
Study®),
large,
longitudinal
study
US
adolescents
collected
before
during
(N
=
9,720,
mean
age
12.9
years,
18.2%
Black).
Linear
mixed-effects
models
tested
associations
(parent-reported
household
wage
loss
youth-reported
stress)
with
depressive
symptomatology
over
time,
covarying
for
multiple
confounders
pre-pandemic
socioeconomic
status
psychopathology,
environmental
factors.
Longitudinal
mediation
analyses
examined
potential
leading
health.Financial
was
highly
prevalent,
especially
among
low-income
participants,
>70%
total
reporting
lost
wages.
Both
subjective
stress
were
time
(Estimate
0.04,
P
0.014;
Estimate
0.17,
<
0.001;
respectively).
association
between
robust
addition
0.16,
0.001).
family-level
(family
conflict)
individual-level
(financial
factors
mediated
relationship
symptomatology.The
(and
worldwide
it)
taken
significant
toll
health.
In
families
that
wages,
familial
time.
Findings
highlight
as
key
driver
burden
identify
critical
targets
intervention
mitigate
risks
periods
crises.This
supported
National
Institute
Mental
Health
[grant
numbers
K23MH120437
(RB),
R01MH117014
(TMM)];
Lifespan
Children's
Hospital
Philadelphia
Penn
Medicine,
University
Pennsylvania.
JAMA Network Open,
Journal Year:
2024,
Volume and Issue:
7(3), P. e242076 - e242076
Published: March 13, 2024
Importance
Further
research
is
needed
to
understand
factors
associated
with
well-being
during
the
COVID-19
pandemic
among
adolescents
who
have
experienced
adverse
childhood
experiences
(ACEs).
Objective
To
explore
improved
mental
health
ACEs.
Design,
Setting,
and
Participants
This
cross-sectional
study
used
data
from
baseline
(2016-2018)
sixth
(March
2021)
COVID
Rapid
Response
Research
(RRR)
surveys
of
Adolescent
Brain
Cognitive
Development
study,
which
includes
21
sites
across
US.
Adolescents
aged
11
15
years
completed
RRR
measures
were
included.
Data
analyses
conducted
June
August
2023.
Exposures
School-based
(eg,
in-person
school)
8
coping
behaviors
exercise).
Main
Outcomes
Measures
The
primary
outcomes
adolescent-reported
positive
affect
(PA)
perceived
stress
(PS).
stratified
by
no
ACEs,
low-to-intermediate
ACEs
(1-3),
high
(≥4).
Linear
regressions
estimated
associations
between
health,
adjusting
for
potential
confounders.
Unstandardized
beta
coefficients
(B)
compared
equality
tests.
Results
4515
in
this
(mean
[SD]
age,
13.3
[0.88]
years;
51%
[95%
CI,
50%
53%]
female)
racially
ethnically
diverse
(American
Indian/Alaska
Native,
2%
3%];
Asian,
8%
7%
9%];
Black,
11%
10%
12%];
Latino
or
Hispanic,
17%
15%
18%];
White,
61%
60%
63%];
other,
1%
0%
2%]).
For
youths
caring
one’s
body
(PA
B
=
4.02
1.39
6.66];
PS
−0.92
−1.84
0.00]),
exercising
3.19
0.46
5.92];
−1.41
−2.40
−0.43]),
engaging
healthy
4.07
1.28
6.84];
−1.01
−1.98
−0.05])
higher
PA
lower
scores.
In-person
schooling
had
a
greater
impact
on
scores
(B
5.55
2.08
9.01])
than
1.27
0.27
2.27]).
Conclusions
Relevance
These
findings
suggest
that
several
(caring
body,
exercising,
behaviors)
significantly
demonstrated
especially
when
they
reported
schooling.
Future
studies
should
build
these
identify
clinical
school-based
protective
ACE
risk.
JAMA Network Open,
Journal Year:
2023,
Volume and Issue:
6(3), P. e232716 - e232716
Published: March 13, 2023
Importance
The
adverse
effects
of
COVID-19
containment
policies
disrupting
child
mental
health
and
sleep
have
been
debated.
However,
few
current
estimates
correct
biases
these
potential
effects.
Objectives
To
determine
whether
financial
school
disruptions
related
to
unemployment
rates
were
separately
associated
with
perceived
stress,
sadness,
positive
affect,
COVID-19–related
worry,
sleep.
Design,
Setting,
Participants
This
cohort
study
was
based
on
the
Adolescent
Brain
Cognitive
Development
Study
Rapid
Response
Release
used
data
collected
5
times
between
May
December
2020.
Indexes
state-level
(restrictive,
supportive)
county-level
plausibly
address
confounding
through
2-stage
limited
information
maximum
likelihood
instrumental
variables
analyses.
Data
from
6030
US
children
aged
10
13
years
included.
analysis
conducted
2021
January
2023.
Exposures
Policy-induced
(lost
wages
or
work
due
economic
impact);
policy-induced
(switches
online
partial
in-person
schooling).
Main
Outcomes
Measures
Perceived
stress
scale,
National
Institutes
Health
(NIH)–Toolbox
NIH-Toolbox
(latency,
inertia,
duration).
Results
In
this
study,
included
in
sample
(weighted
median
[IQR]
age,
[12-13]
years;
2947
[48.9%]
females,
273
[4.5%]
Asian
children,
461
[7.6%]
Black
1167
[19.4%]
Hispanic
3783
[62.7%]
White
347
[5.7%]
other
multiracial
ethnicity).
After
imputing
missing
data,
experiencing
disruption
a
205.2%
[95%
CI,
52.9%-509.0%]
increase
112.1%
22.2%-268.1%]
32.9%
3.5%-53.4%]
decrease
73.9
13.2-134.7]
percentage-point
moderate-to-extreme
worry.
There
no
association
health.
Neither
nor
Conclusions
Relevance
our
knowledge,
presents
first
bias-corrected
linking
policy-related
outcomes.
School
did
not
affect
indices
children’s
These
findings
suggest
public
policy
should
consider
impact
families
pandemic
measures,
part
protect
until
vaccines
antiviral
drugs
become
available.
BMC Primary Care,
Journal Year:
2025,
Volume and Issue:
26(1)
Published: Feb. 26, 2025
Pediatric
emergency
department
(ED)
visits
for
mental
health
are
costly
and
often
preventable.
Access
to
primary
care
behavioral
providers
can
improve
reduce
unnecessary
ED
visits.
Quantitative
analysis
of
the
Virginia
All-Payers
Claims
Database
assess
outpatient
children
adolescents
up
age
21
years
between
2016
2021.
We
determined
proportion
seen
by
or
one
week
year
before
an
visit,
how
many
had
follow-up
within
two
months
after.
Results:
From
2021,
pediatric
dropped
14%,
but
rose
10.6%,
suicidality
tripled
(301
929,
p
<
0.001).
Only
5%
youth
with
a
visit
7
days
prior,
18%
saw
provider.
During
pandemic,
prior-year
cases
declined
(68.1–61.8%,
0.0001).
Follow-ups
60
(mental
health:
40.0–34.2%;
suicidality:
37.5–33.5%),
slightly
improved
(32.2–37.1%),
stayed
stable
(64.1–63.0%).
The
crisis
has
worsened
since
pandemic.
There
were
substantial
missed
opportunities
prevention
intervention
prior
following
suicidality.