Superior antibody and membrane protein-specific T-cell responses to CoronaVac by intradermal versus intramuscular routes in adolescents DOI Creative Commons
Jaime S. Rosa Duque, Samuel M. S. Cheng, Carolyn A. Cohen

et al.

World Journal of Pediatrics, Journal Year: 2023, Volume and Issue: 20(4), P. 353 - 370

Published: Dec. 12, 2023

Abstract Background Optimising the immunogenicity of COVID-19 vaccines to improve their protection against disease is necessary. Fractional dosing by intradermal (ID) administration has been shown be equally immunogenic as intramuscular (IM) for several vaccines, but ID inactivated whole severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at full dose unknown. This study (NCT04800133) investigated superiority antibody and T-cell responses full-dose CoronaVac over IM in adolescents. Methods Participants aged 11–17 years received two doses or vaccine, followed 3rd 13–42 days later. Humoral cellular outcomes were measured post-dose (IM-CC versus ID-CC) 3 (IM-CCC ID-CCC). Doses administered 173 104 adolescents, respectively. Results Spike protein (S) immunoglobulin G (IgG), S-receptor-binding domain (RBD) IgG, S IgG Fcγ receptor IIIa (FcγRIIIa)-binding, SNM [sum individual (S), nucleocapsid (N), membrane (M) peptide pool]-specific interleukin-2 (IL-2) + CD4 , SNM-specific IL-2 CD8 S-specific N-specific M-specific fulfilled superior non-inferior criteria ID-CC compared IM-CC, whereas avidity was inferior. For ID-CCC, S-RBD surrogate virus neutralisation test, 90% plaque reduction titre (PRNT90), PRNT50, avidity, FcγRIIIa-binding, interferon-γ IM-CCC. The estimated vaccine efficacies 49%, 52%, 66% 79% ID-CC, IM-CCC groups reported more local, mild adverse reactions. Conclusion first demonstrate SARS-CoV-2 vaccination serves basis future research vaccines. Graphical abstract

Language: Английский

Lifting Universal Masking in Schools — Covid-19 Incidence among Students and Staff DOI Open Access
Tori L. Cowger, Eleanor J. Murray, Jaylen Clarke

et al.

New England Journal of Medicine, Journal Year: 2022, Volume and Issue: 387(21), P. 1935 - 1946

Published: Nov. 9, 2022

In February 2022, Massachusetts rescinded a statewide universal masking policy in public schools, and many school districts lifted requirements during the subsequent weeks. greater Boston area, only two — neighboring Chelsea sustained through June 2022. The staggered lifting of provided an opportunity to examine effect policies on incidence coronavirus disease 2019 (Covid-19) schools.

Language: Английский

Citations

99

Trends in Acute Care Use for Mental Health Conditions Among Youth During the COVID-19 Pandemic DOI Open Access

Lindsay Overhage,

Ruth Hailu,

Alisa B. Busch

et al.

JAMA Psychiatry, Journal Year: 2023, Volume and Issue: 80(9), P. 924 - 924

Published: July 12, 2023

Importance

Understanding how children's utilization of acute mental health care changed during the COVID-19 pandemic is critical for directing resources.

Objective

To examine youth use (emergency department [ED], boarding, and subsequent inpatient care) second year pandemic.

Design, Setting, Participants

This cross-sectional analysis national, deidentified commercial insurance claims ED hospital took place between March 2019 February 2022. Among 4.1 million enrollees aged 5 to 17 years, 614 16 815 had at least 1 visit in baseline (March 2019-February 2020) 2 2021-February 2022), respectively.

Exposure

The

Main outcomes measures

relative change from was determined (1) fraction with or more visits; (2) percentage visits resulting psychiatry admission; (3) mean length psychiatric stay following visit; (4) frequency prolonged boarding (≥2 midnights) a medical unit before admission an unit.

Results

Of enrollees, 51% were males 41% 13 years (vs 5-12 years) 88 665 visits. Comparing 2, there 6.7% increase any (95% CI, 4.7%-8.8%). adolescent females, larger (22.1%; 95% 19.2%-24.9%). that resulted increased by 8.4% 5.5%-11.2%). Mean 3.8% 1.8%-5.7%). episodes 76.4% 71.0%-81.0%).

Conclusions relevance

Into pandemic, notably among awaiting care. Interventions are needed child capacity reduce strain on system.

Language: Английский

Citations

45

Patterns of Social Determinants of Health and Child Mental Health, Cognition, and Physical Health DOI Creative Commons
Yunyu Xiao, J. John Mann, Julian Chun‐Chung Chow

et al.

JAMA Pediatrics, Journal Year: 2023, Volume and Issue: 177(12), P. 1294 - 1294

Published: Oct. 16, 2023

Importance Social determinants of health (SDOH) influence child health. However, most previous studies have used individual, small-set, or cherry-picked SDOH variables without examining unbiased computed patterns from high-dimensional factors to investigate associations with mental health, cognition, and physical Objective To identify estimate their children’s mental, cognitive, developmental outcomes. Design, Setting, Participants This population-based cohort study included children aged 9 10 years at baseline caregivers enrolled in the Adolescent Brain Cognitive Development (ABCD) Study between 2016 2021. The ABCD includes 21 sites across 17 states. Exposures Eighty-four neighborhood-level, geocoded spanning 7 domains SDOH, including bias, education, infrastructure, natural environment, socioeconomic status, social context, crime drugs, were studied. Hierarchical agglomerative clustering was patterns. Main Outcomes Measures Associations (internalizing externalizing behaviors) suicidal behaviors, cognitive function (performance, reading skills), (body mass index, exercise, sleep disorder) estimated using mixed-effects linear logistic regression models. Results Among 504 (baseline median [SD] age, 9.9 [0.6] years; 5510 boys [52.5%] 4994 girls [47.5%]; 229 Asian [2.2%], 1468 Black [14.0%], 2128 Hispanic [20.3%], 5565 White [53.0%], 1108 multiracial [10.5%]), 4 identified: pattern 1, affluence (4078 [38.8%]); 2, high-stigma environment (2661 [25.3%]); 3, high deprivation (2653 4, drug sales, low population density (1112 [10.6%]). distinctly associated Children exposed (SDOH 3) showed worst profiles, manifesting more internalizing (β = 0.75; 95% CI, 0.14-1.37) 1.43; 0.83-2.02) problems, lower performance, adverse Conclusions shows that an quantitative analysis multidimensional can permit determination how are outcomes relative other categories. These findings suggest need determine whether improvement conditions enhance

Language: Английский

Citations

34

COVID-19-related financial strain and adolescent mental health DOI Creative Commons
Stirling T. Argabright, Kate T. Tran,

Elina Visoki

et al.

The Lancet Regional Health - Americas, Journal Year: 2022, Volume and Issue: 16, P. 100391 - 100391

Published: Nov. 16, 2022

The COVID-19 pandemic and associated responses have induced a host of crises worldwide, including an economic recession global mental health crisis. specific effects on youth are understudied. We aimed to examine the mechanisms by which pandemic-related financial strain may affect in diverse sample American adolescents.We analyzed data from Adolescent Brain Cognitive Development Study (ABCD Study®), large, longitudinal study US adolescents collected before during (N = 9,720, mean age 12.9 years, 18.2% Black). Linear mixed-effects models tested associations (parent-reported household wage loss youth-reported stress) with depressive symptomatology over time, covarying for multiple confounders pre-pandemic socioeconomic status psychopathology, environmental factors. Longitudinal mediation analyses examined potential leading health.Financial was highly prevalent, especially among low-income participants, >70% total reporting lost wages. Both subjective stress were time (Estimate 0.04, P 0.014; Estimate 0.17, < 0.001; respectively). association between robust addition 0.16, 0.001). family-level (family conflict) individual-level (financial factors mediated relationship symptomatology.The (and worldwide it) taken significant toll health. In families that wages, familial time. Findings highlight as key driver burden identify critical targets intervention mitigate risks periods crises.This supported National Institute Mental Health [grant numbers K23MH120437 (RB), R01MH117014 (TMM)]; Lifespan Children's Hospital Philadelphia Penn Medicine, University Pennsylvania.

Language: Английский

Citations

37

Mental Well-Being Among Adversity-Exposed Adolescents During the COVID-19 Pandemic DOI Creative Commons
Julia H. Raney, Shayna Weinstein, Kyle T. Ganson

et al.

JAMA Network Open, Journal Year: 2024, Volume and Issue: 7(3), P. e242076 - e242076

Published: March 13, 2024

Importance Further research is needed to understand factors associated with well-being during the COVID-19 pandemic among adolescents who have experienced adverse childhood experiences (ACEs). Objective To explore improved mental health ACEs. Design, Setting, and Participants This cross-sectional study used data from baseline (2016-2018) sixth (March 2021) COVID Rapid Response Research (RRR) surveys of Adolescent Brain Cognitive Development study, which includes 21 sites across US. Adolescents aged 11 15 years completed RRR measures were included. Data analyses conducted June August 2023. Exposures School-based (eg, in-person school) 8 coping behaviors exercise). Main Outcomes Measures The primary outcomes adolescent-reported positive affect (PA) perceived stress (PS). stratified by no ACEs, low-to-intermediate ACEs (1-3), high (≥4). Linear regressions estimated associations between health, adjusting for potential confounders. Unstandardized beta coefficients (B) compared equality tests. Results 4515 in this (mean [SD] age, 13.3 [0.88] years; 51% [95% CI, 50% 53%] female) racially ethnically diverse (American Indian/Alaska Native, 2% 3%]; Asian, 8% 7% 9%]; Black, 11% 10% 12%]; Latino or Hispanic, 17% 15% 18%]; White, 61% 60% 63%]; other, 1% 0% 2%]). For youths caring one’s body (PA B = 4.02 1.39 6.66]; PS −0.92 −1.84 0.00]), exercising 3.19 0.46 5.92]; −1.41 −2.40 −0.43]), engaging healthy 4.07 1.28 6.84]; −1.01 −1.98 −0.05]) higher PA lower scores. In-person schooling had a greater impact on scores (B 5.55 2.08 9.01]) than 1.27 0.27 2.27]). Conclusions Relevance These findings suggest that several (caring body, exercising, behaviors) significantly demonstrated especially when they reported schooling. Future studies should build these identify clinical school-based protective ACE risk.

Language: Английский

Citations

5

COVID-19 Policies, Pandemic Disruptions, and Changes in Child Mental Health and Sleep in the United States DOI Creative Commons
Yunyu Xiao, Timothy T. Brown, Lonnie R. Snowden

et al.

JAMA Network Open, Journal Year: 2023, Volume and Issue: 6(3), P. e232716 - e232716

Published: March 13, 2023

Importance The adverse effects of COVID-19 containment policies disrupting child mental health and sleep have been debated. However, few current estimates correct biases these potential effects. Objectives To determine whether financial school disruptions related to unemployment rates were separately associated with perceived stress, sadness, positive affect, COVID-19–related worry, sleep. Design, Setting, Participants This cohort study was based on the Adolescent Brain Cognitive Development Study Rapid Response Release used data collected 5 times between May December 2020. Indexes state-level (restrictive, supportive) county-level plausibly address confounding through 2-stage limited information maximum likelihood instrumental variables analyses. Data from 6030 US children aged 10 13 years included. analysis conducted 2021 January 2023. Exposures Policy-induced (lost wages or work due economic impact); policy-induced (switches online partial in-person schooling). Main Outcomes Measures Perceived stress scale, National Institutes Health (NIH)–Toolbox NIH-Toolbox (latency, inertia, duration). Results In this study, included in sample (weighted median [IQR] age, [12-13] years; 2947 [48.9%] females, 273 [4.5%] Asian children, 461 [7.6%] Black 1167 [19.4%] Hispanic 3783 [62.7%] White 347 [5.7%] other multiracial ethnicity). After imputing missing data, experiencing disruption a 205.2% [95% CI, 52.9%-509.0%] increase 112.1% 22.2%-268.1%] 32.9% 3.5%-53.4%] decrease 73.9 13.2-134.7] percentage-point moderate-to-extreme worry. There no association health. Neither nor Conclusions Relevance our knowledge, presents first bias-corrected linking policy-related outcomes. School did not affect indices children’s These findings suggest public policy should consider impact families pandemic measures, part protect until vaccines antiviral drugs become available.

Language: Английский

Citations

12

The mutual overlapping impact of stress and infection on mental health problems in adolescents and youths during and after COVID-19 pandemic in China DOI
Mao‐Sheng Ran, Cong Wang, Jia Cai

et al.

Journal of Affective Disorders, Journal Year: 2023, Volume and Issue: 347, P. 500 - 508

Published: Dec. 7, 2023

Language: Английский

Citations

11

Utilization of Mental Health Services by Low-Income Children in the United States: A Multiple Disadvantage Model DOI
Tyrone C. Cheng, Celia C. Lo

Journal of Poverty, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17

Published: Jan. 24, 2025

Language: Английский

Citations

0

Trends in Emergency Department, Primary Care, and Behavioral Health Use for Pediatric Mental Health Conditions in Virginia before and during the COVID-19 pandemic DOI Creative Commons
Jennifer Hinesley, Bergen B. Nelson, Jacqueline Britz

et al.

BMC Primary Care, Journal Year: 2025, Volume and Issue: 26(1)

Published: Feb. 26, 2025

Pediatric emergency department (ED) visits for mental health are costly and often preventable. Access to primary care behavioral providers can improve reduce unnecessary ED visits. Quantitative analysis of the Virginia All-Payers Claims Database assess outpatient children adolescents up age 21 years between 2016 2021. We determined proportion seen by or one week year before an visit, how many had follow-up within two months after. Results: From 2021, pediatric dropped 14%, but rose 10.6%, suicidality tripled (301 929, p < 0.001). Only 5% youth with a visit 7 days prior, 18% saw provider. During pandemic, prior-year cases declined (68.1–61.8%, 0.0001). Follow-ups 60 (mental health: 40.0–34.2%; suicidality: 37.5–33.5%), slightly improved (32.2–37.1%), stayed stable (64.1–63.0%). The crisis has worsened since pandemic. There were substantial missed opportunities prevention intervention prior following suicidality.

Language: Английский

Citations

0

Successful Interventions to Improve Pediatric Vaccine Uptake in Hesitant Cohorts: A Scoping Review DOI Open Access

Kristen Sibson,

Abbigail Shrontz,

Jordan Jones

et al.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: May 19, 2025

Language: Английский

Citations

0