Superior antibody and membrane protein-specific T-cell responses to CoronaVac by intradermal versus intramuscular routes in adolescents DOI Creative Commons
Jaime S. Rosa Duque, Samuel M. S. Cheng, Carolyn A. Cohen

et al.

World Journal of Pediatrics, Journal Year: 2023, Volume and Issue: 20(4), P. 353 - 370

Published: Dec. 12, 2023

Abstract Background Optimising the immunogenicity of COVID-19 vaccines to improve their protection against disease is necessary. Fractional dosing by intradermal (ID) administration has been shown be equally immunogenic as intramuscular (IM) for several vaccines, but ID inactivated whole severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at full dose unknown. This study (NCT04800133) investigated superiority antibody and T-cell responses full-dose CoronaVac over IM in adolescents. Methods Participants aged 11–17 years received two doses or vaccine, followed 3rd 13–42 days later. Humoral cellular outcomes were measured post-dose (IM-CC versus ID-CC) 3 (IM-CCC ID-CCC). Doses administered 173 104 adolescents, respectively. Results Spike protein (S) immunoglobulin G (IgG), S-receptor-binding domain (RBD) IgG, S IgG Fcγ receptor IIIa (FcγRIIIa)-binding, SNM [sum individual (S), nucleocapsid (N), membrane (M) peptide pool]-specific interleukin-2 (IL-2) + CD4 , SNM-specific IL-2 CD8 S-specific N-specific M-specific fulfilled superior non-inferior criteria ID-CC compared IM-CC, whereas avidity was inferior. For ID-CCC, S-RBD surrogate virus neutralisation test, 90% plaque reduction titre (PRNT90), PRNT50, avidity, FcγRIIIa-binding, interferon-γ IM-CCC. The estimated vaccine efficacies 49%, 52%, 66% 79% ID-CC, IM-CCC groups reported more local, mild adverse reactions. Conclusion first demonstrate SARS-CoV-2 vaccination serves basis future research vaccines. Graphical abstract

Language: Английский

Trajectories and correlates of mental health among urban, school-age children during the COVID-19 pandemic: a longitudinal study DOI Creative Commons
Rachel Oblath,

Rohan Dayal,

J. Krystel Loubeau

et al.

Child and Adolescent Psychiatry and Mental Health, Journal Year: 2024, Volume and Issue: 18(1)

Published: March 14, 2024

The COVID-19 pandemic posed numerous obstacles to psychosocial wellbeing for children. We conducted a longitudinal study evaluate child mental health and social risks during the pandemic. Participants were 172 caregivers of children aged 6-11 years old who attended well visits within 6 months before onset at an urban safety net hospital in US. Prepandemic data was extracted from electronic medical record, surveys administered three time points between August 2020 July 2021. measured symptoms with Pediatric Symptom Checklist-17, (e.g., food housing insecurity) THRIVE questionnaire, school modality (in-person, hybrid, remote). Compared pre-pandemic, had significantly higher PSC-17 total scores (overall symptoms) (total burden risks) all mid-pandemic waves. Using mixed models accounting time, risks, modality, both (B = 0.37, SE 0.14, p < 0.01) associated - 1.95, 0.63, 0.01). Children attending in-person fewer than those remote or hybrid school. Mental remained fifteen after compared prepandemic. In-person attendance appeared protective against persistently elevated symptoms.

Language: Английский

Citations

1

Resilience throughout and beyond COVID-19: a longitudinal analysis DOI Creative Commons

Roselyn Thom,

John R. Best,

Anna MacLellan

et al.

Psychology Health & Medicine, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 13

Published: Nov. 20, 2024

Defined as the ability to adapt adversity with a positive and stable mindset, resilience should be an important factor in coping long-term evolving setbacks such COVID-19 pandemic. Although negative mental health impacts of pandemic are well-documented, course during recovery periods remains understudied. This study examined trajectories among respondents Canadian Personal Impacts Survey (PICS) who provided data for at least two timepoints (

Language: Английский

Citations

1

Psychological research of the children with chronic kidney disease and their guardians during the COVID-19 pandemic DOI Creative Commons

Hua-Ying Xiong,

Gaofu Zhang,

Li Wang

et al.

Frontiers in Public Health, Journal Year: 2022, Volume and Issue: 10

Published: Oct. 17, 2022

Background There is great mental stress due to the coronavirus disease 2019 (COVID-19) pandemic. However, there are no detailed psychological studies of children with chronic kidney (CKD) and their guardians during COVID-19 Objective This study explores pressure on CKD guardians. Methods An online survey was conducted at 20 largest pediatric nephropathy departments in China, including Rutter Parent Questionnaire, Self-rating Anxiety Scale (SAS), Depression (SDS). Overall, 885 (589 associated 296 control group) completed together Results statistical difference between regarding behavior scores abnormal behaviors. Nevertheless, might aggravate anxiety depression both groups ( p &lt; 0.05). We confirmed that group were significantly higher than those The lower annual income more likely experience Furthermore, whose older 11 years old be anxious who 6–11 old. Besides, watched news for 30–60 min daily less have 10 subgroup results showed gender, time watching news, guardians, children's age most critical factors influencing guardians' burden. Conclusion severe behavior, adolescents' pressure, low household income, panic about pandemic may main reasons

Language: Английский

Citations

6

A meta-analysis of COVID-19 vaccines acceptance among black/African American DOI Creative Commons
Rezaul Karim Ripon,

Umma Motahara,

Adiba Alam

et al.

Heliyon, Journal Year: 2022, Volume and Issue: 8(12), P. e12300 - e12300

Published: Dec. 1, 2022

The COVID-19 pandemic had harmed Black/African Americans disproportionately. Mortality and morbidity can reduce by increasing vaccination acceptability availability. We conducted a meta-analysis of 20 studies that show the prevalence who embrace between 2020 September, 2022. Investigations before after availability vaccines found vaccinations effective. heterogeneity was examined using stratified analyses, meta-regression approach, sensitivity analysis in R programming language. This showed overall vaccine hesitancy among is 35% (95% CI: 26%–45%). That means 65% Black African received without any hesitancy. According to correlation analysis, there negative relationship (r = -0.392, P 0.021) survey year. Evidence suggests ethnic health disparities were for lower socioeconomic status. Some initiatives address disparities, while ethnicity not consistently been focus. Only prevent like infectious diseases. Policy makers educators should concern on acceptance or related programs American.

Language: Английский

Citations

6

Superior antibody and membrane protein-specific T-cell responses to CoronaVac by intradermal versus intramuscular routes in adolescents DOI Creative Commons
Jaime S. Rosa Duque, Samuel M. S. Cheng, Carolyn A. Cohen

et al.

World Journal of Pediatrics, Journal Year: 2023, Volume and Issue: 20(4), P. 353 - 370

Published: Dec. 12, 2023

Abstract Background Optimising the immunogenicity of COVID-19 vaccines to improve their protection against disease is necessary. Fractional dosing by intradermal (ID) administration has been shown be equally immunogenic as intramuscular (IM) for several vaccines, but ID inactivated whole severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at full dose unknown. This study (NCT04800133) investigated superiority antibody and T-cell responses full-dose CoronaVac over IM in adolescents. Methods Participants aged 11–17 years received two doses or vaccine, followed 3rd 13–42 days later. Humoral cellular outcomes were measured post-dose (IM-CC versus ID-CC) 3 (IM-CCC ID-CCC). Doses administered 173 104 adolescents, respectively. Results Spike protein (S) immunoglobulin G (IgG), S-receptor-binding domain (RBD) IgG, S IgG Fcγ receptor IIIa (FcγRIIIa)-binding, SNM [sum individual (S), nucleocapsid (N), membrane (M) peptide pool]-specific interleukin-2 (IL-2) + CD4 , SNM-specific IL-2 CD8 S-specific N-specific M-specific fulfilled superior non-inferior criteria ID-CC compared IM-CC, whereas avidity was inferior. For ID-CCC, S-RBD surrogate virus neutralisation test, 90% plaque reduction titre (PRNT90), PRNT50, avidity, FcγRIIIa-binding, interferon-γ IM-CCC. The estimated vaccine efficacies 49%, 52%, 66% 79% ID-CC, IM-CCC groups reported more local, mild adverse reactions. Conclusion first demonstrate SARS-CoV-2 vaccination serves basis future research vaccines. Graphical abstract

Language: Английский

Citations

3