World Journal of Pediatrics,
Journal Year:
2023,
Volume and Issue:
20(4), P. 353 - 370
Published: Dec. 12, 2023
Abstract
Background
Optimising
the
immunogenicity
of
COVID-19
vaccines
to
improve
their
protection
against
disease
is
necessary.
Fractional
dosing
by
intradermal
(ID)
administration
has
been
shown
be
equally
immunogenic
as
intramuscular
(IM)
for
several
vaccines,
but
ID
inactivated
whole
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
at
full
dose
unknown.
This
study
(NCT04800133)
investigated
superiority
antibody
and
T-cell
responses
full-dose
CoronaVac
over
IM
in
adolescents.
Methods
Participants
aged
11–17
years
received
two
doses
or
vaccine,
followed
3rd
13–42
days
later.
Humoral
cellular
outcomes
were
measured
post-dose
(IM-CC
versus
ID-CC)
3
(IM-CCC
ID-CCC).
Doses
administered
173
104
adolescents,
respectively.
Results
Spike
protein
(S)
immunoglobulin
G
(IgG),
S-receptor-binding
domain
(RBD)
IgG,
S
IgG
Fcγ
receptor
IIIa
(FcγRIIIa)-binding,
SNM
[sum
individual
(S),
nucleocapsid
(N),
membrane
(M)
peptide
pool]-specific
interleukin-2
(IL-2)
+
CD4
,
SNM-specific
IL-2
CD8
S-specific
N-specific
M-specific
fulfilled
superior
non-inferior
criteria
ID-CC
compared
IM-CC,
whereas
avidity
was
inferior.
For
ID-CCC,
S-RBD
surrogate
virus
neutralisation
test,
90%
plaque
reduction
titre
(PRNT90),
PRNT50,
avidity,
FcγRIIIa-binding,
interferon-γ
IM-CCC.
The
estimated
vaccine
efficacies
49%,
52%,
66%
79%
ID-CC,
IM-CCC
groups
reported
more
local,
mild
adverse
reactions.
Conclusion
first
demonstrate
SARS-CoV-2
vaccination
serves
basis
future
research
vaccines.
Graphical
abstract
Child and Adolescent Psychiatry and Mental Health,
Journal Year:
2024,
Volume and Issue:
18(1)
Published: March 14, 2024
The
COVID-19
pandemic
posed
numerous
obstacles
to
psychosocial
wellbeing
for
children.
We
conducted
a
longitudinal
study
evaluate
child
mental
health
and
social
risks
during
the
pandemic.
Participants
were
172
caregivers
of
children
aged
6-11
years
old
who
attended
well
visits
within
6
months
before
onset
at
an
urban
safety
net
hospital
in
US.
Prepandemic
data
was
extracted
from
electronic
medical
record,
surveys
administered
three
time
points
between
August
2020
July
2021.
measured
symptoms
with
Pediatric
Symptom
Checklist-17,
(e.g.,
food
housing
insecurity)
THRIVE
questionnaire,
school
modality
(in-person,
hybrid,
remote).
Compared
pre-pandemic,
had
significantly
higher
PSC-17
total
scores
(overall
symptoms)
(total
burden
risks)
all
mid-pandemic
waves.
Using
mixed
models
accounting
time,
risks,
modality,
both
(B
=
0.37,
SE
0.14,
p
<
0.01)
associated
-
1.95,
0.63,
0.01).
Children
attending
in-person
fewer
than
those
remote
or
hybrid
school.
Mental
remained
fifteen
after
compared
prepandemic.
In-person
attendance
appeared
protective
against
persistently
elevated
symptoms.
Psychology Health & Medicine,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 13
Published: Nov. 20, 2024
Defined
as
the
ability
to
adapt
adversity
with
a
positive
and
stable
mindset,
resilience
should
be
an
important
factor
in
coping
long-term
evolving
setbacks
such
COVID-19
pandemic.
Although
negative
mental
health
impacts
of
pandemic
are
well-documented,
course
during
recovery
periods
remains
understudied.
This
study
examined
trajectories
among
respondents
Canadian
Personal
Impacts
Survey
(PICS)
who
provided
data
for
at
least
two
timepoints
(
Frontiers in Public Health,
Journal Year:
2022,
Volume and Issue:
10
Published: Oct. 17, 2022
Background
There
is
great
mental
stress
due
to
the
coronavirus
disease
2019
(COVID-19)
pandemic.
However,
there
are
no
detailed
psychological
studies
of
children
with
chronic
kidney
(CKD)
and
their
guardians
during
COVID-19
Objective
This
study
explores
pressure
on
CKD
guardians.
Methods
An
online
survey
was
conducted
at
20
largest
pediatric
nephropathy
departments
in
China,
including
Rutter
Parent
Questionnaire,
Self-rating
Anxiety
Scale
(SAS),
Depression
(SDS).
Overall,
885
(589
associated
296
control
group)
completed
together
Results
statistical
difference
between
regarding
behavior
scores
abnormal
behaviors.
Nevertheless,
might
aggravate
anxiety
depression
both
groups
(
p
<
0.05).
We
confirmed
that
group
were
significantly
higher
than
those
The
lower
annual
income
more
likely
experience
Furthermore,
whose
older
11
years
old
be
anxious
who
6–11
old.
Besides,
watched
news
for
30–60
min
daily
less
have
10
subgroup
results
showed
gender,
time
watching
news,
guardians,
children's
age
most
critical
factors
influencing
guardians'
burden.
Conclusion
severe
behavior,
adolescents'
pressure,
low
household
income,
panic
about
pandemic
may
main
reasons
Heliyon,
Journal Year:
2022,
Volume and Issue:
8(12), P. e12300 - e12300
Published: Dec. 1, 2022
The
COVID-19
pandemic
had
harmed
Black/African
Americans
disproportionately.
Mortality
and
morbidity
can
reduce
by
increasing
vaccination
acceptability
availability.
We
conducted
a
meta-analysis
of
20
studies
that
show
the
prevalence
who
embrace
between
2020
September,
2022.
Investigations
before
after
availability
vaccines
found
vaccinations
effective.
heterogeneity
was
examined
using
stratified
analyses,
meta-regression
approach,
sensitivity
analysis
in
R
programming
language.
This
showed
overall
vaccine
hesitancy
among
is
35%
(95%
CI:
26%–45%).
That
means
65%
Black
African
received
without
any
hesitancy.
According
to
correlation
analysis,
there
negative
relationship
(r
=
-0.392,
P
0.021)
survey
year.
Evidence
suggests
ethnic
health
disparities
were
for
lower
socioeconomic
status.
Some
initiatives
address
disparities,
while
ethnicity
not
consistently
been
focus.
Only
prevent
like
infectious
diseases.
Policy
makers
educators
should
concern
on
acceptance
or
related
programs
American.
World Journal of Pediatrics,
Journal Year:
2023,
Volume and Issue:
20(4), P. 353 - 370
Published: Dec. 12, 2023
Abstract
Background
Optimising
the
immunogenicity
of
COVID-19
vaccines
to
improve
their
protection
against
disease
is
necessary.
Fractional
dosing
by
intradermal
(ID)
administration
has
been
shown
be
equally
immunogenic
as
intramuscular
(IM)
for
several
vaccines,
but
ID
inactivated
whole
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
at
full
dose
unknown.
This
study
(NCT04800133)
investigated
superiority
antibody
and
T-cell
responses
full-dose
CoronaVac
over
IM
in
adolescents.
Methods
Participants
aged
11–17
years
received
two
doses
or
vaccine,
followed
3rd
13–42
days
later.
Humoral
cellular
outcomes
were
measured
post-dose
(IM-CC
versus
ID-CC)
3
(IM-CCC
ID-CCC).
Doses
administered
173
104
adolescents,
respectively.
Results
Spike
protein
(S)
immunoglobulin
G
(IgG),
S-receptor-binding
domain
(RBD)
IgG,
S
IgG
Fcγ
receptor
IIIa
(FcγRIIIa)-binding,
SNM
[sum
individual
(S),
nucleocapsid
(N),
membrane
(M)
peptide
pool]-specific
interleukin-2
(IL-2)
+
CD4
,
SNM-specific
IL-2
CD8
S-specific
N-specific
M-specific
fulfilled
superior
non-inferior
criteria
ID-CC
compared
IM-CC,
whereas
avidity
was
inferior.
For
ID-CCC,
S-RBD
surrogate
virus
neutralisation
test,
90%
plaque
reduction
titre
(PRNT90),
PRNT50,
avidity,
FcγRIIIa-binding,
interferon-γ
IM-CCC.
The
estimated
vaccine
efficacies
49%,
52%,
66%
79%
ID-CC,
IM-CCC
groups
reported
more
local,
mild
adverse
reactions.
Conclusion
first
demonstrate
SARS-CoV-2
vaccination
serves
basis
future
research
vaccines.
Graphical
abstract