Differential effects of acute and prolonged morphine withdrawal on motivational and goal‐directed control over reward‐seeking behaviour DOI Creative Commons
Briac Halbout,

Collin Hutson,

Stuti Agrawal

et al.

Addiction Biology, Journal Year: 2024, Volume and Issue: 29(5)

Published: May 1, 2024

Abstract Opioid addiction is a relapsing disorder marked by uncontrolled drug use and reduced interest in normally rewarding activities. The current study investigated the impact of spontaneous withdrawal from chronic morphine exposure on emotional, motivational cognitive processes involved regulating pursuit consumption food rewards male rats. In Experiment 1, rats experiencing acute lost weight displayed somatic signs dependence. However, hedonically driven sucrose was significantly elevated, suggesting intact potentially heightened reward processing. 2, undergoing motivation when performing an effortful response for palatable reward. Subsequent devaluation testing revealed that disrupted their ability to exert flexible goal‐directed control over seeking. Specifically, morphine‐withdrawn were impaired using value select actions both relying prior action‐outcome learning given direct feedback about consequences actions. 3, tested after prolonged rather than diminished retained engage action selection. brief re‐exposure sufficient impair disrupt selection, though this case, only presence morphine‐paired context cues absence response‐contingent feedback. We suggest these opioid‐withdrawal induced deficits may contribute interfering with adaptive alternatives use.

Language: Английский

A neuromarker for drug and food craving distinguishes drug users from non-users DOI
Leonie Koban, Tor D. Wager, Hedy Kober

et al.

Nature Neuroscience, Journal Year: 2022, Volume and Issue: 26(2), P. 316 - 325

Published: Dec. 19, 2022

Language: Английский

Citations

93
The centrality of craving in network analysis of five substance use disorders DOI Creative Commons
Christophe Gauld, Emmanuelle Baillet,

Jean-Arthur Micoulaud-Franchi

et al.

Drug and Alcohol Dependence, Journal Year: 2023, Volume and Issue: 245, P. 109828 - 109828

Published: Feb. 26, 2023

Language: Английский

Citations

26
Neural Correlates of Stress and Alcohol Cue-Induced Alcohol Craving and of Future Heavy Drinking: Evidence of Sex Differences DOI
Milena Radoman, Nia Fogelman, Cheryl Lacadie

et al.

American Journal of Psychiatry, Journal Year: 2024, Volume and Issue: 181(5), P. 412 - 422

Published: May 1, 2024

Objective: Stress and alcohol cue reactivity are associated with poor treatment outcomes in use disorder (AUD), but sex-specific neural correlates of stress cue–induced craving compared neutral heavy drinking AUD have not been examined. Thus, this study prospectively examined these associations assessed sex differences. Methods: Treatment-seeking adults (N=77; 46 men 31 women) completed a functional MRI task involving stress, alcohol, exposure repeated assessments craving. Most participants (N=72; 43 29 then participated an 8-week standardized behavioral program, during which the percentage days was assessed. Results: Significant increases both relative to were observed, greater alcohol-neutral contrast stress-neutral among equivalent contrasts women. Whole-brain voxel-based regression analyses showed craving-associated hyperactivation condition, hypoactive prefrontal (ventromedial lateral prefrontal, supplementary motor, anterior cingulate regions) striatal responses stressful images (stress-neutral contrast) cues (alcohol-neutral contrast), significant Additionally, higher hypoactivation subgenual cortex bed nucleus stria terminalis women, hypothalamus men, hippocampus men. Conclusions: Sex differences stress- cue-induced cortico-striatal-limbic network related subjective indicated that distinct brain circuits underlie women These findings underscore need for therapeutics address dysfunction effectively.

Language: Английский

Citations

11
Climate Change and Substance-Use Behaviors: A Risk-Pathways Framework DOI
Francis Vergunst, Helen Berry, Kelton Minor

et al.

Perspectives on Psychological Science, Journal Year: 2022, Volume and Issue: 18(4), P. 936 - 954

Published: Nov. 28, 2022

Climate change is undermining the mental and physical health of global populations, but question how it affecting substance-use behaviors has not been systematically examined. In this narrative synthesis, we find that climate could increase harmful substance use worldwide through at least five pathways: psychosocial stress arising from destabilization social, environmental, economic, geopolitical support systems; increased rates disorders; physical-health burden; incremental changes to established behavior patterns; worry about dangers unchecked change. These pathways operate independently, additively, interactively, cumulatively vulnerability. Young people face disproportionate risks because their high vulnerability mental-health problems disorders greater number life years ahead in which be exposed current worsening We suggest systems thinking developmental life-course approaches provide practical frameworks for conceptualizing relationship. Further conceptual, methodological, empirical work urgently needed evaluate nature scope burden so effective adaptive preventive action can taken.

Language: Английский

Citations

33
IUPHAR Review: New strategies for medications to treat substance use disorders DOI Creative Commons
Iván D. Montoya, Nora D. Volkow

Pharmacological Research, Journal Year: 2024, Volume and Issue: 200, P. 107078 - 107078

Published: Jan. 21, 2024

Substance use disorders (SUDs) and drug overdose are a public health emergency safe effective treatments urgently needed. Developing new medications to treat them is expensive, time-consuming, the probability of compound progressing clinical trials obtaining FDA-approval low. The small number FDA-approved for SUDs reflects low interest pharmaceutical companies invest in this area due market forces, characteristics population (e.g., stigma, socio-economic legal disadvantages), high bar regulatory agencies set medication approval. In consequence, most research on funded by government agencies, such as National Institute Drug Abuse (NIDA). Multiple scientific opportunities emerging that can accelerate discovery development SUDs. These include fast efficient tools screen molecules, discover targets, big data explore large sets artificial intelligence (AI) applications make predictions, precision medicine individualize optimize treatments. This review provides general description these strategies with emphasis gaps opportunities. It includes brief overview rising toll SUDs; justification, challenges, develop medications; discussion treatment endpoints being evaluated support from NIDA.

Language: Английский

Citations

9
Opioid craving does not incubate over time in inpatient or outpatient treatment studies: Is the preclinical incubation of craving model lost in translation? DOI Creative Commons
Cecilia L. Bergeria, Cassandra D. Gipson, Kirsten E. Smith

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 160, P. 105618 - 105618

Published: March 15, 2024

Language: Английский

Citations

7
An electroencephalography connectome predictive model of craving for methamphetamine DOI Creative Commons
Hang-Bin Zhang, Quanhao Yu, Xinyuan Zhang

et al.

International Journal of Clinical and Health Psychology, Journal Year: 2025, Volume and Issue: 25(1), P. 100551 - 100551

Published: Jan. 1, 2025

Methamphetamine use disorder (MUD) is characterized by prominent psychological craving and its relapsing nature. Previous studies have linked trait impulsivity abstinence duration to drug use, but the neural substrates of cue-induced relationship with these traits remain unclear in MUD. We acquired high-density resting-state electroencephalography (EEG) after participants watched a five-minute video demonstrating methamphetamine use. Combining precise source imaging reconstruct brain activities connectome predictive modeling (CPM), we built craving-specific network within beta band activity from two independent MUD cohorts (N=144 for model development N=47 validation). This reveals unified signature MUD, spanning multiple networks including medial prefrontal, frontal parietal, subcortical networks. Our findings underscored mediating role this profile modulating between intensity. Moreover, mediated EEG-derived craving. study presents novel that utilizes sourced connectivity EEG recording successfully predict abstinent individuals These results shed light on cognitive organization involved craving, involving control, attention, reward reactivity. A comprehensive analysis data's capacity decipher craving's complex dynamics, facilitating improved understanding targeted treatments substance disorders.

Language: Английский

Citations

1
N-acetylcysteine reduces prefrontal reactivity to cocaine cues in individuals with cocaine use disorder DOI Creative Commons
Etna Engeli, Katrin H. Preller, Nathalie M. Rieser

et al.

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 27, 2025

Individuals with cocaine use disorder experience heightened motivation to pursue rewards tied cocaine, often triggered by associated cues. Cue reactivity and subsequent craving significantly elevate the risk of substance use, creating a pressing need for treatments that can help alleviate cravings. However, no pharmaceutical therapies treating have been approved. Preclinical findings reveal dysfunctions in glutamatergic pathway connecting prefrontal regions nucleus accumbens, which are correlated cue-induced substance-seeking behaviour. These alterations, at both molecular behavioural levels, be reversed rodents N-acetylcysteine, modulator signalling. In contrast, therapeutic potential humans remains uncertain. Here, we assessed impact short-term challenge N-acetylcysteine on neural responses cues randomised, placebo-controlled cross-over trial using fMRI cue paradigm. total, 44 scans 22 individuals were recorded-once after administration 2,400 mg N-acetylcysteine/day 2 days once placebo intake. condition, participants showed increased towards pictures, accompanied higher cravings as compared neutral images. accordance recent meta-analyses, was evident parietal such posterior cingulate precuneus, temporal like hippocampus, bilateral insula, medial regions, namely inferior, middle, superior frontal gyrus. Cue-induced activity gyrus strongly predicted individual duration use. While subjectively rated craving, decreased under placebo. Our show reduced even brief pharmacological N-acetylcysteine. Since drug has shown precursor relapse behaviour, N-acetylcysteine's should further investigated future studies extending treatment periods. https://clinicaltrials.gov, identifier NCT02626494.

Language: Английский

Citations

1
Comparing neuromodulation targets to reduce cigarette craving and withdrawal: a randomized clinical trial DOI Creative Commons
Nicole Petersen, Michael Apostol, Timothy R. Jordan

et al.

Neuropsychopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Abstract Cigarette smoking remains the leading preventable cause of death, emphasizing need for new therapeutics, such as repetitive transcranial magnetic stimulation (TMS). We tested hypothesis that TMS to three targets would reduce cigarette craving and withdrawal by modulating connectivity within between canonical networks in a randomized clinical trial (ClinicalTrials.gov: NCT03827265). Participants ( N = 72; DSM-5 tobacco use disorder, ≥1 year daily smoking) received one session hubs resting-state networks: dorsolateral prefrontal cortex (dlPFC), superior frontal gyrus (SFG), posterior parietal (PPC), area v5 (control). Self-reports (craving, withdrawal, negative affect) functional were measured before after stimulation. SFG significantly reduced (95% CI, 0.0476–7.9559) 0.9225–8.1063) versus control, with larger effects men D 0.59) than women 0.30). did not change network connectivity, whereas dlPFC increased somatomotor, default mode, dorsal attention connectivity. No severe or unexpected treatment-related adverse events occurred. These findings suggest shows promise target smoking-cessation treatment, especially men. Further trials are warranted confirm efficacy develop imaging biomarkers precision neuromodulation.

Language: Английский

Citations

1
Connectome-based prediction of craving in gambling disorder and cocaine use disorder DOI Creative Commons
Stephanie Antons, Sarah W. Yip, Cheryl Lacadie

et al.

Dialogues in Clinical Neuroscience, Journal Year: 2023, Volume and Issue: 25(1), P. 33 - 42

Published: May 16, 2023

Introduction Craving, involving intense and urgent desires to engage in specific behaviours, is a feature of addictions. Multiple studies implicate regions salience/limbic networks basal ganglia, fronto-parietal, medial frontal craving However, prior have not identified common neural that reliably predict across substance behavioural addictions.Methods Functional magnetic resonance imaging during an audiovisual cue-reactivity task connectome-based predictive modelling (CPM), data-driven method for generating brain-behavioural models, were used study individuals with cocaine-use disorder gambling disorder. Functions nodes relevant interpreted based on meta-analytic data.Results Craving was predicted by connectivity disorders. The highest degree mostly located the prefrontal cortex. Overall, prediction model included complex including motor/sensory, default-mode networks. decoding revealed high functional associations components memory, valence ratings, physiological responses, finger movement/motor imagery.Conclusions could be may reflect general mechanisms despite specificities individual Prefrontal associated working memory autobiographical seem important predicting craving. For further validation, should tested diverse samples contexts.

Language: Английский

Citations

15