Eating disorder symptoms and emotional arousal modulate food biases during reward learning in females DOI Creative Commons
Nina Rouhani, Cooper D. Grossman, Jamie D. Feusner

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 26, 2025

Food seeking and avoidance engage primary reward systems to drive behavior. It is nevertheless unclear whether innate or learned food biases interact with general processing interfere goal-directed choice. To this end, we recruited a large non-clinical sample of females high eating-disorder symptoms ('HED') matched low ('LED') complete reward-learning task where the calorie content stimuli was incidental goal maximizing monetary reward. We find replicate low-calorie bias in HED high-calorie LED, reflecting strength pre-experimental food-reward associations. An emotional arousal manipulation shifts group-dependent across individual differences, interoceptive awareness predicting change. Reinforcement-learning models further identify distinct cognitive components supporting these group-specific biases. Our results highlight influence reinforcement-based mechanisms eliciting potentially maladaptive Disordered eating can disrupt rewarding value food. Here, authors show female that disorder symptoms, arousal, modulate goal-irrelevant during reinforcement learning.

Language: Английский

From compulsivity to compulsion: the neural basis of compulsive disorders DOI
Trevor W. Robbins, Paula Banca, David Belin

et al.

Nature reviews. Neuroscience, Journal Year: 2024, Volume and Issue: 25(5), P. 313 - 333

Published: April 9, 2024

Language: Английский

Citations

33
Personalized and Circuit-Based Transcranial Magnetic Stimulation: Evidence, Controversies, and Opportunities DOI Creative Commons
Robin Cash, Andrew Zalesky

Biological Psychiatry, Journal Year: 2023, Volume and Issue: 95(6), P. 510 - 522

Published: Nov. 29, 2023

The development of neuroimaging methodologies to map brain connectivity has transformed our understanding psychiatric disorders, the distributed effects stimulation, and how transcranial magnetic stimulation can be best employed target ameliorate symptoms. In parallel, research revealed that higher-order regions such as prefrontal cortex, which represent most common therapeutic targets for show some highest levels interindividual variation in connectivity. These findings provide rationale personalized site selection based on person-specific network architecture. Recent advances have made it possible determine reproducible with millimeter precision clinically tractable acquisition times. enable potential advantages spatially targeting evaluated translated basic clinical applications. this review, we outline motivation personalization, preliminary support (mostly depression), convergent evidence from other modalities, generalizability beyond depression cortex. We end by detailing methodological recommendations, controversies, notable alternatives. Overall, while area appears highly promising, value remains unclear, dedicated large prospective randomized trials using validated methodology are critical.

Language: Английский

Citations

44
Psilocybin-induced changes in neural reactivity to alcohol and emotional cues in patients with alcohol use disorder: an fMRI pilot study DOI Creative Commons
Broc A. Pagni, Petros Petridis,

Samantha K. Podrebarac

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Feb. 7, 2024

Abstract This pilot study investigated psilocybin-induced changes in neural reactivity to alcohol and emotional cues patients with use disorder (AUD). Participants were recruited from a phase II, randomized, double-blind, placebo-controlled clinical trial investigating psilocybin-assisted therapy (PAT) for the treatment of AUD (NCT02061293). Eleven adult completed task-based blood oxygen dependent functional magnetic resonance imaging (fMRI) approximately 3 days before 2 after receiving 25 mg psilocybin (n = 5) or 50 diphenhydramine 6). Visual emotionally valanced (positive, negative, neutral) stimuli presented block design. Across both cues, increased activity medial lateral prefrontal cortex (PFC) left caudate, decreased insular, motor, temporal, parietal, occipital cortices, cerebellum. Unique negative supramarginal gyrus activity; unique positive right hippocampus activity. Greater PFC caudate engagement concomitant insula, cerebellar disengagement suggests enhanced goal-directed action, improved regulation, diminished craving. The robust brain observed this warrant larger neuroimaging studies elucidate mechanisms PAT. Trial registration : NCT02061293.

Language: Английский

Citations

14
Parameter Space and Potential for Biomarker Development in 25 Years of fMRI Drug Cue Reactivity DOI
Arshiya Sangchooli, Mehran Zare-Bidoky, Ali Fathi Jouzdani

et al.

JAMA Psychiatry, Journal Year: 2024, Volume and Issue: 81(4), P. 414 - 414

Published: Feb. 7, 2024

Importance In the last 25 years, functional magnetic resonance imaging drug cue reactivity (FDCR) studies have characterized some core aspects in neurobiology of addiction. However, no FDCR-derived biomarkers been approved for treatment development or clinical adoption. Traversing this translational gap requires a systematic assessment FDCR literature evidence, its heterogeneity, and an evaluation possible uses biomarkers. Objective To summarize state field FDCR, assess their potential biomarker development, outline clear process qualification to guide future research validation efforts. Evidence Review The PubMed Medline databases were searched every original investigation published from database inception until December 2022. Collected data covered study design, participant characteristics, task whether each provided evidence that might potentially help develop susceptibility, diagnostic, response, prognostic, predictive, severity 1 more addictive disorders. Findings There 415 between 1998 Most focused on nicotine (122 [29.6%]), alcohol (120 [29.2%]), cocaine (46 [11.1%]), most used visual cues (354 [85.3%]). Together, these recruited 19 311 participants, including 13 812 individuals with past current substance use could support diagnostic (143 [32.7%]), response (141 [32.3%]), (84 [19.2%]), prognostic (30 [6.9%]), predictive (25 [5.7%]), monitoring (12 [2.7%]), susceptibility (2 [0.5%]) A total 155 interventional mostly investigate pharmacological (67 [43.2%]) cognitive/behavioral (51 [32.9%]) interventions; 141 as measure, which 125 (88.7%) reported significant alterations; intervention outcome predictor, 24 (96%) finding associations markers outcomes. Conclusions Relevance Based review proposed framework, there is pathway regulatory FDCR-based addiction recovery. Further measures, accelerating improving judgments.

Language: Английский

Citations

13
Neural Correlates of Stress and Alcohol Cue-Induced Alcohol Craving and of Future Heavy Drinking: Evidence of Sex Differences DOI
Milena Radoman, Nia Fogelman, Cheryl Lacadie

et al.

American Journal of Psychiatry, Journal Year: 2024, Volume and Issue: 181(5), P. 412 - 422

Published: May 1, 2024

Objective: Stress and alcohol cue reactivity are associated with poor treatment outcomes in use disorder (AUD), but sex-specific neural correlates of stress cue–induced craving compared neutral heavy drinking AUD have not been examined. Thus, this study prospectively examined these associations assessed sex differences. Methods: Treatment-seeking adults (N=77; 46 men 31 women) completed a functional MRI task involving stress, alcohol, exposure repeated assessments craving. Most participants (N=72; 43 29 then participated an 8-week standardized behavioral program, during which the percentage days was assessed. Results: Significant increases both relative to were observed, greater alcohol-neutral contrast stress-neutral among equivalent contrasts women. Whole-brain voxel-based regression analyses showed craving-associated hyperactivation condition, hypoactive prefrontal (ventromedial lateral prefrontal, supplementary motor, anterior cingulate regions) striatal responses stressful images (stress-neutral contrast) cues (alcohol-neutral contrast), significant Additionally, higher hypoactivation subgenual cortex bed nucleus stria terminalis women, hypothalamus men, hippocampus men. Conclusions: Sex differences stress- cue-induced cortico-striatal-limbic network related subjective indicated that distinct brain circuits underlie women These findings underscore need for therapeutics address dysfunction effectively.

Language: Английский

Citations

12
Efficacy and Neural Mechanisms of Mindfulness Meditation Among Adults With Internet Gaming Disorder DOI Creative Commons

Haosen Ni,

Huabin Wang,

Xuefeng Ma

et al.

JAMA Network Open, Journal Year: 2024, Volume and Issue: 7(6), P. e2416684 - e2416684

Published: June 18, 2024

Importance The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision ( DSM-5-TR ), recently identified internet gaming disorder (IGD) as a condition warranting more research, few empirically validated treatments exist. Mindfulness meditation (MM) has multiple health benefits; however, its efficacy in treating IGD potential neural mechanisms underlying MM treatment the remain largely unknown. Objective To explore used to treat adults with identify MM. Design, Setting, Participants This randomized clinical trial was performed from October 1 November 30, 2023, at Hangzhou Normal University Hangzhou, China. Adults (aged ≥18 years) who met least 6 9 proposed criteria for were recruited receive either or progressive muscle relaxation (PMR). Data analysis on December 1, 2023. Intervention underwent training (an 8-session program that focuses attention acceptance) PMR 8-time body relaxation) delivered groups 2 times each week 4 weeks. Main Outcomes Measures per-protocol included only participants finished pretest assessment, 8 sessions, posttest assessment. main outcomes addiction severity (measured Internet Addiction Test scores), craving Questionnaire Gaming Urges blood oxygen level–dependent signals assessed cue-craving tasks fMRI. Behavioral brain measurements compared using variance. Functional connectivity (FC) among regions measured test changes associated Results study 64 IGD. A total 32 received (mean [SD] age, 20.3 [1.9] years; 17 women [53%]) 20.2 [1.5] 16 [50%]). decreased group (pretest vs posttest: mean [SD], 7.0 [1.1] 3.6 [0.8]; P < .001) 7.1 [0.9] 6.0 [0.9]; = .04). had greater decrease than score change group, −3.6 [0.3] −1.1 [0.2]; .001). activation bilateral lentiform nuclei r 0.40; 95% CI, 0.19 0.60; .02), insula 0.35; 0.09 .047), medial frontal gyrus (MFG; 0.43; 0.16 0.70; .01). Increased MFG-lentiform FC 58.8 [15.7] 33.6 [12.0]; t −8.66; ƞ 0.30; observed after MM, mediated relationship between increased mindfulness (mediate effect, −0.17; −0.32 −0.08; .03). Conclusions Relevance In this study, effective decreasing cravings PMR. These findings indicate may be an exert effects by altering frontopallidal pathways. Trial Registration Chinese Clinical Registry Identifier: ChiCTR2300075869

Language: Английский

Citations

8
Dysfunctional decision-making in binge-eating disorder: A meta-analysis and systematic review DOI Creative Commons
Emily Colton, Kira-Elise Wilson, Trevor T.‐J. Chong

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 152, P. 105250 - 105250

Published: May 30, 2023

Binge-Eating Disorder (BED) involves anticipatory craving and urges, subjective loss-of-control during binge-eating episodes, post-feeding psychological distress guilt. Evidence indicates neurocognitive dysfunctions contribute to BED onset, maintenance, treatment response. However, an integrated understanding of how cognitive processes underpin symptomology is lacking. We utilised a multi-stage decision-making model defining ten underpinning Preference Formation, Choice Implementation, Feedback Processing, Flexibility/Shifting, comprehensively review research published since 2013. used preregistered PICOS criteria assess 1966 articles identified from PubMed, PsycInfo, Scopus database searches. This yielded 50 studies reporting behavioural tasks outcomes, comparing individuals with controls normal higher weight. Meta-analyses revealed unique profile that spanned all stages. Significant deficits were evident in Uncertainty Evaluation, Attentional Inhibition, Consistency, Cognitive Flexibility/Set-shifting. propose novel dysfunctional describe their role behaviour. further highlight the potential for interventions target these address significant gap BED.

Language: Английский

Citations

14
Multimodal frontal neuroimaging markers predict longitudinal craving reduction in abstinent individuals with heroin use disorder DOI

Xinwen Wen,

Wenhan Yang,

Zhe Du

et al.

Journal of Psychiatric Research, Journal Year: 2024, Volume and Issue: 177, P. 1 - 10

Published: June 26, 2024

Language: Английский

Citations

6
The affective gradient hypothesis: an affect-centered account of motivated behavior DOI
Amitai Shenhav

Trends in Cognitive Sciences, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

6
Neural signatures of emotion regulation DOI Creative Commons

Jared Rieck,

Julia Wrobel, Antonio R. Porras

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 20, 2024

Language: Английский

Citations

5