Risk of adverse pregnancy, delivery and neonatal outcomes associated with bipolar disorder and prenatal use of mood stabilizers: A population-based cohort study

Psychiatry Research, Journal Year: 2024, Volume and Issue: 339, P. 116050 - 116050

Published: June 21, 2024

Language: Английский

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Maternal Risk Factors for Congenital Vertebral Anomalies

Journal of Bone and Joint Surgery, Journal Year: 2023, Volume and Issue: 105(14), P. 1087 - 1092

Published: May 22, 2023

The spectrum of congenital vertebral defects varies from benign lesions to severe, life-threatening conditions. etiology and maternal risk factors remain mainly unclear in isolated cases. Hence, we aimed assess identify potential for these anomalies. Based on previous studies, hypothesized that diabetes, smoking, advanced age, obesity, chronic diseases, medication used during the first trimester pregnancy might increase malformations.We performed a nationwide register-based case-control study. All cases with anomalies (including live births, stillbirths, terminations fetal anomaly) were identified Finnish Register Congenital Malformations 1997 2016. Five matched controls same geographic region randomly selected each case. Analyzed included body mass index (BMI), parity, history miscarriages, prescription drugs dispensed pregnancy.In total, 256 diagnosed identified. After excluding 66 malformations associated known syndromes, 190 nonsyndromic malformation included. These compared 950 controls. Maternal pregestational diabetes was significant factor (adjusted odds ratio [OR], 7.30 [95% confidence interval (CI), 2.53 21.09). Also, rheumatoid arthritis OR, 22.91 CI, 2.67 196.40]), estrogens 5.30 1.57 17.8]), heparins 8.94 1.38 57.9]) elevated risk. In sensitivity analysis using imputation, smoking also significantly an 1.05 2.34]).Maternal increased heparins, both which are frequently assisted reproductive technologies, Sensitivity suggested warranting further studies.Prognostic Level III . See Instructions Authors complete description levels evidence.

Language: Английский

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Outcomes of long-acting injectable antipsychotics use in pregnancy: A literature review

World Journal of Psychiatry, Journal Year: 2024, Volume and Issue: 14(4), P. 582 - 599

Published: April 16, 2024

Women with a history of serious psychotic disorders are at increased risk disease relapse during pregnancy. Long-acting injectable (LAI) antipsychotics have been widely used to improve adherence and prevent in patients various severe disorders, but there is lack high-quality data from previous research on the safety LAI

Language: Английский

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Mood stabilizers for treatment of bipolar disorder in pregnancy and impact on neonatal outcomes

Bipolar Disorders, Journal Year: 2024, Volume and Issue: 26(8), P. 779 - 784

Published: Aug. 22, 2024

Abstract Introduction Untreated bipolar disorder in pregnancy is associated with adverse maternal and neonatal outcomes. Despite advances clinical management, there concern among obstetric providers patients about the safety of pharmacological agents for treatment pregnancy. Recent studies have shown atypical antipsychotics lamotrigine to a favorable profile; however, little information published on lurasidone. Objectives The objective this retrospective chart review was evaluate outcomes who are untreated, compared those treated lurasidone, other antipsychotics, at tertiary teaching institution. Methods This cohort study included neonates whose mothers had diagnosis were referred Maternal & Fetal Care Clinic two documented visits after January 1, 2014, delivery by October 31, 2017, within an SSM health‐system hospital. Results In study, women untreated (not any mood stabilizer) significantly higher rates premature low birth weight stabilizers lamotrigine, antipsychotics. No difference observed or between taking stabilizers. Conclusions suggests that use better than

Language: Английский

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Risk of congenital anomalies associated with psychotropic medications: a review of neonatal reports in the FDA adverse event reporting System (FAERS)

Archives of Women s Mental Health, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 23, 2024

Language: Английский

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