Biological Psychiatry Global Open Science, Journal Year: 2025, Volume and Issue: unknown, P. 100499 - 100499
Published: April 1, 2025
Language: Английский
Child Abuse & Neglect, Journal Year: 2025, Volume and Issue: 160, P. 107238 - 107238
Published: Jan. 5, 2025
Language: Английский
Citations
1
Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
Language: Английский
Citations
1
Schizophrenia, Journal Year: 2025, Volume and Issue: 11(1)
Published: Feb. 20, 2025
Adverse childhood experiences (ACEs) are common in people at clinical high-risk for psychosis (CHR), however, the relationship between ACEs and long-term outcomes is still unclear. This study examined associations CHR individuals. 344 individuals 67 healthy controls (HC) were assessed using Childhood Trauma Questionnaire (CTQ), Bullying Experience of Care Abuse (CECA). followed up to 5 years. Remission from state, transition (both defined with Comprehensive Assessment an At Risk Mental State), level functioning (assessed Global Functioning) assessed. Stepwise multilevel logistic regression models used investigate outcomes. significantly more prevalent than HC. Within cohort, physical abuse was associated a reduced likelihood remission (OR = 3.64, p 0.025). Separation parent linked increased both 0.32, 0.011) higher 1.77, 0.040). Death 1.87, 0.037) risk transitioning psychosis. Physical death related adverse CHR. The counter-intuitive association separation may reflect removal child environment. Future studies should whether interventions targeting effect specific might help improve this population.
Language: Английский
Citations
1
medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: July 5, 2024
Abstract The major anxiety disorders (ANX; including generalized disorder, panic and phobias ) are highly prevalent, often onset early, persist throughout life, cause substantial global disability. Although distinct in their clinical presentations, they likely represent differential expressions of a dysregulated threat-response system. Here we present genome-wide association meta-analysis comprising 122,341 European ancestry ANX cases 729,881 controls. We identified 58 independent significant risk variants 66 genes with robust biological support. In an sample 1,175,012 self-report 1,956,379 controls, 51 the associated were replicated. As predicted by twin studies, found genetic correlation between depression, neuroticism, other internalizing phenotypes. Follow-up analyses demonstrated enrichment all brain regions highlighted GABAergic signaling as one potential mechanism underlying risk. These results advance our understanding architecture prioritize for functional follow-up studies.
Language: Английский
Citations
7
The Lancet Psychiatry, Journal Year: 2024, Volume and Issue: 11(9), P. 720 - 730
Published: Aug. 13, 2024
Cognitive deficits might contribute to the elevated risk of life-course psychopathology observed in maltreated children. Leading theories about links between childhood maltreatment and cognitive focus on documented exposures (objective experience), but empirical research has largely relied retrospective self-reports these experiences (subjective two measures identify non-overlapping groups. We aimed test associations objective subjective with abilities within same individuals.
Language: Английский
Citations
7
Journal of Child Psychology and Psychiatry, Journal Year: 2024, Volume and Issue: 65(12), P. 1662 - 1677
Published: Aug. 16, 2024
Background Childhood maltreatment contributes to a large mental health burden worldwide. Different measures of childhood are not equivalent and may capture meaningful differences. In particular, prospective retrospective identify different groups individuals differentially associated with psychopathology. However, the reasons behind these discrepancies have yet been comprehensively mapped. Methods this review, we draw on multi‐disciplinary research present an integrated framework explain measurement disagreement. Results We identified three interrelated domains. First, methodological issues related data collection methods. Second, role memory in influencing reports maltreatment. Finally, motivations disclose, withhold, or fabricate information about Conclusions A greater understanding disagreement point new ways conceptualise assess Furthermore, it help uncover mechanisms underlying maltreatment‐related psychopathology targets for novel interventions.
Language: Английский
Citations
6
Frontiers in Psychology, Journal Year: 2024, Volume and Issue: 15
Published: Nov. 7, 2024
Background Latin American youth have a high prevalence of mental health disorders and face major socioeconomic public safety problems. This study assesses the association between stressful life events (SLEs) depression, anxiety, quality among adolescents young adults from deprived neighbourhoods America. Methods The sample consisted 2,402 participants, (15–16 years) (20–24 years), Bogotá (Colombia), Buenos Aires (Argentina), Lima (Peru), assessed in 2021–2022 recruited education community settings social media. We evaluated most frequent recent distant SLEs (occurred previous year more than ago, respectively), relationship severity depression (PHQ-8), anxiety (GAD-7), (MANSA), we tested for differences by gender age group. Results common were related to issues financial distress. Accidents school suspensions men, sexual harassment bullying women. Every additional reported SLE increased odds mild, moderate, severe (18, 17, 25%, respectively) (10, 21%, symptoms. Similar trends found with (8, 9, 11% symptoms, (9, 11, 12%, respectively). Furthermore, higher number associated lower ( β = −0.05, p < 0.001, 95% CI [−0.06, −0.04] −0.04, [−0.05, −0.03], distress seems stronger one SLEs, may impact on adolescents’ compared adults. Conclusion Both are life. Policies programmes should aim enhance safety, as well improve individual, family, protective factors that could mitigate effect youth.
Language: Английский
Citations
5
European journal of psychotraumatology, Journal Year: 2025, Volume and Issue: 16(1)
Published: Jan. 7, 2025
Background: The body is the medium through which humans experience world, and key to most suffering, healing, clinical mental diagnoses. Body attitude refers affective, cognitive, behavioural aspects of embodiment, typically more negative in samples.
Language: Английский
Citations
0
eLife, Journal Year: 2025, Volume and Issue: 12
Published: Feb. 20, 2025
Childhood adversity is a strong predictor of developing psychopathological conditions. Multiple theories on the mechanisms underlying this association have been suggested which, however, differ in operationalization ‘exposure.’ Altered (threat) learning represent central by which environmental inputs shape emotional and cognitive processes ultimately behavior. 1402 healthy participants underwent fear conditioning paradigm (acquisition training, generalization), while acquiring skin conductance responses (SCRs) ratings (arousal, valence, contingency). was operationalized as (1) dichotomization, following (2) specificity model, (3) cumulative risk (4) dimensional model. Individuals exposed to childhood showed blunted physiological reactivity SCRs, but not ratings, reduced CS+/CS- discrimination during both phases, mainly driven attenuated CS+ responding. The latter evident across different operationalizations ‘exposure’ theories. None tested clear explanatory superiority. Notably, remarkably pattern increased responding CS- reported literature for anxiety patients, suggesting that individuals may specific sub-sample. We highlight linking (vulnerability to) psychopathology need refinement.
Language: Английский
Citations
0
Australian & New Zealand Journal of Psychiatry, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 24, 2025
Language: Английский
Citations
0