Nano based drug delivery systems: recent developments and future prospects

Journal of Nanobiotechnology, Journal Year: 2018, Volume and Issue: 16(1)

Published: Sept. 19, 2018

Nanomedicine and nano delivery systems are a relatively new but rapidly developing science where materials in the nanoscale range employed to serve as means of diagnostic tools or deliver therapeutic agents specific targeted sites controlled manner. Nanotechnology offers multiple benefits treating chronic human diseases by site-specific, target-oriented precise medicines. Recently, there number outstanding applications nanomedicine (chemotherapeutic agents, biological immunotherapeutic etc.) treatment various diseases. The current review, presents an updated summary recent advances field nanomedicines based drug through comprehensive scrutiny discovery application nanomaterials improving both efficacy novel old drugs (e.g., natural products) selective diagnosis disease marker molecules. opportunities challenges from synthetic/natural sources their clinical also discussed. In addition, we have included information regarding trends perspectives area.

Language: Английский

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Discovery and resupply of pharmacologically active plant-derived natural products: A review

Biotechnology Advances, Journal Year: 2015, Volume and Issue: 33(8), P. 1582 - 1614

Published: Aug. 15, 2015

Medicinal plants have historically proven their value as a source of molecules with therapeutic potential, and nowadays still represent an important pool for the identification novel drug leads. In past decades, pharmaceutical industry focused mainly on libraries synthetic compounds discovery source. They are comparably easy to produce resupply, demonstrate good compatibility established high throughput screening (HTS) platforms. However, at same time there has been declining trend in number new drugs reaching market, raising renewed scientific interest from natural sources, despite its known challenges. this survey, brief outline historical development is provided together comprehensive overview used approaches recent developments relevant plant-derived product discovery. Associated challenges major strengths product-based critically discussed. A snapshot advanced products that currently actively recruiting clinical trials also presented. Importantly, transition compound “screening hit” through “drug lead” “marketed drug” associated increasingly challenging demands amount, which often cannot be met by re-isolation respective plant sources. regard, existing alternatives resupply discussed, including different biotechnology total organic synthesis. While intrinsic complexity necessitates highly integrated interdisciplinary approaches, reviewed developments, technological advances, research trends clearly indicate will among most sources future.

Language: Английский

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Antibacterial Activity of Silver Nanoparticles: Structural Effects

Advanced Healthcare Materials, Journal Year: 2018, Volume and Issue: 7(13)

Published: May 29, 2018

Abstract The increase of antibiotic resistance in bacteria has become a major concern for successful diagnosis and treatment infectious diseases. Over the past few decades, significant progress been achieved on development nanotechnology‐based medicines combating multidrug microorganisms. Among this, silver nanoparticles (AgNPs) hold great promise addressing this challenge due to their broad‐spectrum robust antimicrobial properties. This review illustrates antibacterial mechanisms further elucidates how different structural factors including surface chemistry, size, shape, impact activities, which are expected promote future more potent nanoparticle‐based agents.

Language: Английский

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Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review

Biochemical Pharmacology, Journal Year: 2014, Volume and Issue: 92(1), P. 73 - 89

Published: July 29, 2014

Agonists of the nuclear receptor PPARγ are therapeutically used to combat hyperglycaemia associated with metabolic syndrome and type 2 diabetes. In spite being effective in normalization blood glucose levels, currently agonists from thiazolidinedione have serious side effects, making discovery novel ligands highly relevant. Natural products proven historically be a promising pool structures for drug discovery, significant research effort has recently been undertaken explore PPARγ-activating potential wide range natural originating traditionally medicinal plants or dietary sources. The majority identified compounds selective modulators (SPPARMs), transactivating expression PPARγ-dependent reporter genes as partial agonists. Those different binding modes comparison full agonists, on some occasions activate addition PPARα (e.g. genistein, biochanin A, sargaquinoic acid, sargahydroquinoic resveratrol, amorphastilbol) PPARγ-dimer partner retinoid X (RXR; e.g. neolignans magnolol honokiol). A number vivo studies suggest that product activators honokiol, amorfrutin 1, B, improve parameters diabetic animal models, partly reduced effects bioactivity pattern well use several active plant extracts warrants future regarding their therapeutic possibility modulate activation by interventions food supplements.

Language: Английский

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The pharmaceutical industry and natural products: historical status and new trends

Phytochemistry Reviews, Journal Year: 2014, Volume and Issue: 14(2), P. 299 - 315

Published: June 2, 2014

Language: Английский

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Marketed Marine Natural Products in the Pharmaceutical and Cosmeceutical Industries: Tips for Success

Marine Drugs, Journal Year: 2014, Volume and Issue: 12(2), P. 1066 - 1101

Published: Feb. 17, 2014

The marine environment harbors a number of macro and micro organisms that have developed unique metabolic abilities to ensure their survival in diverse hostile habitats, resulting the biosynthesis an array secondary metabolites with specific activities. Several these are high-value commercial products for pharmaceutical cosmeceutical industries. aim this review is outline paths natural discovery development, special focus on compounds successfully reached market particularly looking at approaches tackled by cosmetic companies succeeded marketing those products. main challenges faced during bioactives development programs were analyzed grouped three categories: biodiversity (accessibility resources efficient screening), supply technical (sustainable production knowledge mechanism action) (processes, costs, partnerships marketing). Tips surpass given order improve entry success rates highly promising current pipelines, highlighting what can be learned from successful unsuccessful stories applied novel and/or ongoing programs.

Language: Английский

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Importance of ethnopharmacological studies in drug discovery: role of medicinal plants

Phytochemistry Reviews, Journal Year: 2019, Volume and Issue: 19(5), P. 1199 - 1209

Published: July 8, 2019

Language: Английский

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Recent advances in leishmaniasis treatment

International Journal of Infectious Diseases, Journal Year: 2011, Volume and Issue: 15(8), P. e525 - e532

Published: May 26, 2011

About 1.5 million new cases of cutaneous leishmaniasis and 500,000 visceral occur each year around the world. For over half a century, clinical forms disease have been treated almost exclusively with pentavalent antimonial compounds. In this review, we describe arsenal available for treating Leishmania infections, as well recent advances from research on plants synthetic compounds source drugs disease. We also review some drug-delivery systems development novel chemotherapeutics. observe that pharmaceutical industry should employ its modern technologies, which could lead to better use their extracts, semi-synthetic New studies highlighted biopharmaceutical technologies in design delivery strategy, such nanoparticles, liposomes, cochleates, non-specific lipid transfer proteins. These observations serve basis indicate routes effective anti-Leishmania drugs.

Language: Английский

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Natural products for human health: an historical overview of the drug discovery approaches

Natural Product Research, Journal Year: 2017, Volume and Issue: 32(16), P. 1926 - 1950

Published: July 27, 2017

Natural products (NPs) are secondary metabolites produced and used by organisms for defending or adapting purposes. These molecules were naturally selected during thousands of years to improve the specificity cover a very wide range functions, depending on origin, habitat specific activity carried out in organism origin. Due these intrinsic features, NPs have been as healing agents since still today continue be most important source new potential therapeutic preparations.The purpose this review is provide information about historical evolution investigation methods, focusing attention relative benefit/problems emerged after improvement scientific investigations them, especially over last two centuries. Taken together, reported lead central role future drug development human needs.

Language: Английский

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Can Invalid Bioactives Undermine Natural Product-Based Drug Discovery?

Journal of Medicinal Chemistry, Journal Year: 2015, Volume and Issue: 59(5), P. 1671 - 1690

Published: Oct. 27, 2015

High-throughput biology has contributed a wealth of data on chemicals, including natural products (NPs). Recently, attention was drawn to certain, predominantly synthetic, compounds that are responsible for disproportionate percentages hits but false actives. Spurious bioassay interference led their designation as pan-assay (PAINS). NPs lack comparable scrutiny, which this study aims rectify. Systematic mining 80+ years the phytochemistry and literature, using NAPRALERT database, revealed only 39 represent most reported by occurrence, activity, distinct activity. Over 50% not explained phenomena known synthetic libraries, all had manifold ascribed bioactivities, designating them invalid metabolic panaceas (IMPs). Cumulative distributions ∼200,000 uncovered NP research follows power-law characteristics typical behavioral phenomena. Projection into occurrence–bioactivity–effort space produces hyperbolic black hole NPs, where IMPs populate high-effort base.

Language: Английский

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