Natural Products as Sources of New Drugs from 1981 to 2014

Journal of Natural Products, Journal Year: 2016, Volume and Issue: 79(3), P. 629 - 661

Published: Feb. 7, 2016

This contribution is a completely updated and expanded version of the four prior analogous reviews that were published in this journal 1997, 2003, 2007, 2012. In case all approved therapeutic agents, time frame has been extended to cover 34 years from January 1, 1981, December 31, 2014, for diseases worldwide, 1950 (earliest so far identified) 2014 antitumor drugs worldwide. As mentioned 2012 review, we have continued utilize our secondary subdivision "natural product mimic", or "NM", join original primary divisions designation botanical", "NB", those botanical "defined mixtures" now recognized as drug entities by U.S. FDA (and similar organizations). From data presented utilization natural products and/or their novel structures, order discover develop final entity, still alive well. For example, area cancer, over around 1940s end 175 small molecules approved, 131, 75%, are other than "S" (synthetic), with 85, 49%, actually being either directly derived therefrom. areas, influence structures quite marked, with, expected information, anti-infective dependent on structures. We wish draw attention readers rapidly evolving recognition significant number drugs/leads produced microbes microbial interactions "host whence it was isolated", therefore considered research should be significantly.

Language: Английский

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The Essential Medicinal Chemistry of Curcumin

Journal of Medicinal Chemistry, Journal Year: 2017, Volume and Issue: 60(5), P. 1620 - 1637

Published: Jan. 11, 2017

Curcumin is a constituent (up to ∼5%) of the traditional medicine known as turmeric. Interest in therapeutic use turmeric and relative ease isolation curcuminoids has led their extensive investigation. recently been classified both PAINS (pan-assay interference compounds) an IMPS (invalid metabolic panaceas) candidate. The likely false activity curcumin vitro vivo resulted >120 clinical trials against several diseases. No double-blinded, placebo controlled trial successful. This manuscript reviews essential medicinal chemistry provides evidence that unstable, reactive, nonbioavailable compound and, therefore, highly improbable lead. On basis this in-depth evaluation, potential new directions for research on are discussed.

Language: Английский

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Natural Deep Eutectic Solvents: Properties, Applications, and Perspectives

Journal of Natural Products, Journal Year: 2018, Volume and Issue: 81(3), P. 679 - 690

Published: March 7, 2018

As functional liquid media, natural deep eutectic solvent (NADES) species can dissolve or synthetic chemicals of low water solubility. Moreover, the special properties NADES, such as biodegradability and biocompatibility, suggest that they are alternative candidates for concepts applications involving some organic solvents ionic liquids. Owing to growing comprehension mechanisms advancing interest in phenomenon, many NADES have been developed past several years. However, unlike solvents, basic structural unit media primarily depends on intermolecular interactions among their components. This makes matrices readily influenced by various factors, content, temperature, component ratio and, thus, extends metabolomic challenge products (NPs). To enhance understanding importance biological systems, this review focuses NP research. The present thorough chronological statistical analysis existing report adds recognition distinctiveness (NA)DES, involves a discussion NADES-related observations research, reportes these mixtures. work identifies potential areas future studies (NA)DES evaluating relevant applications, including use extraction chromatographic well biomedical relevance. chemical diversity metabolites generate participate formation highlights insight biosynthetically primordial (PRIMs) essential function bioactivity unrefined more highly evolutionary (HEVOs) be isolated from crude

Language: Английский

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Synergy and antagonism in natural product extracts: when 1 + 1 does not equal 2

Natural Product Reports, Journal Year: 2019, Volume and Issue: 36(6), P. 869 - 888

Published: Jan. 1, 2019

This report documents the cellular, molecular, and analytical methods used to identify combination effects in complex natural product mixtures.

Language: Английский

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Feeling Nature’s PAINS: Natural Products, Natural Product Drugs, and Pan Assay Interference Compounds (PAINS)

Journal of Natural Products, Journal Year: 2016, Volume and Issue: 79(3), P. 616 - 628

Published: Feb. 22, 2016

We have previously reported on classes of compounds that can interfere with bioassays via a number different mechanisms and termed such Pan Assay INterference compoundS, or PAINS. These were defined the basis high-throughput data derived from vendor-supplied synthetics. The question therefore arises whether concept PAINS is relevant to natural origin. Here, it shown this indeed case, but context biological readout an important factor must be brought into consideration.

Language: Английский

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Rule of five in 2015 and beyond: Target and ligand structural limitations, ligand chemistry structure and drug discovery project decisions

Advanced Drug Delivery Reviews, Journal Year: 2016, Volume and Issue: 101, P. 34 - 41

Published: May 3, 2016

Language: Английский

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Natural Products as a Source for Novel Antibiotics

Trends in Pharmacological Sciences, Journal Year: 2016, Volume and Issue: 37(8), P. 689 - 701

Published: June 5, 2016

Language: Английский

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Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress‐ and aging‐related diseases

Medicinal Research Reviews, Journal Year: 2020, Volume and Issue: 41(1), P. 630 - 703

Published: Oct. 25, 2020

Abstract Adaptogens comprise a category of herbal medicinal and nutritional products promoting adaptability, resilience, survival living organisms in stress. The aim this review was to summarize the growing knowledge about common adaptogenic plants used various traditional medical systems (TMS) conventional medicine provide modern rationale for their use treatment stress‐induced aging‐related disorders. have pharmacologically pleiotropic effects on neuroendocrine‐immune system, which explain wide range conditions. They exhibit biphasic dose‐effect response: at low doses they function as mild stress‐mimetics, activate adaptive stress‐response signaling pathways cope with severe That is line preventing premature aging maintain good health vitality. However, potential adaptogens remains poorly explored. Treatment stress diseases require novel approaches. Some combinations unique due synergistic interactions not obtainable by any ingredient independently. Further progress field needs focus discovering new based concepts. Robust rigorous approaches including network pharmacology could help analyzing and, more broadly, future uses adaptogens. In conclusion, evolution concept has led back basics TMS level understanding holistic approach. It provides diseases.

Language: Английский

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The LOTUS initiative for open knowledge management in natural products research

eLife, Journal Year: 2022, Volume and Issue: 11

Published: May 26, 2022

Contemporary bioinformatic and chemoinformatic capabilities hold promise to reshape knowledge management, analysis interpretation of data in natural products research. Currently, reliance on a disparate set non-standardized, insular, specialized databases presents series challenges for access, both within the discipline integration interoperability between related fields. The fundamental elements exchange are referenced structure-organism pairs that establish relationships distinct molecular structures living organisms from which they were identified. Consolidating sharing such information via an open platform has strong transformative potential research beyond. This is ultimate goal newly established LOTUS initiative, now completed first steps toward harmonization, curation, validation dissemination 750,000+ pairs. hosted Wikidata regularly mirrored https://lotus.naturalproducts.net . Data framework broadens access interoperability, opening new possibilities community curation evolving publication models. Furthermore, embedding into vast graph will facilitate biological chemical insights. initiative represents important advancement design deployment comprehensive collaborative base.

Language: Английский

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Berry Phenolic Antioxidants – Implications for Human Health?

Frontiers in Pharmacology, Journal Year: 2018, Volume and Issue: 9

Published: March 26, 2018

Antioxidants present in the diet may have a significant effect on prophylaxis and progression of various diseases associated with oxidative stress. Berries contain range chemical compounds antioxidant properties, including phenolic compounds. The aim this review article is to provide an overview current knowledge such antioxidants, discuss whether these always be natural gifts for human health, based both vitro vivo studies. It describes properties fresh berries (including aronia berries, grapes, blueberries, sea buckthorn strawberries other berries) their products, especially juices wines. Some papers report that sometimes behave like prooxidants, demonstrate prooxidant activity, while others note they do not same way vivo. However, no unwanted or toxic effects (i.e. chemical, hematological urinary effect) been consumption berry extracts, products vivo, vitro, which suggest antioxidants found are health. compound content well described, further studies required determine therapeutic doses different use future clinical Moreover, experiments needed understand beneficial reported so far from mechanistic point view. Therefore, greater attention should paid development well-controlled high-quality area.

Language: Английский

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