Cell Death and Disease,
Journal Year:
2023,
Volume and Issue:
14(6)
Published: June 9, 2023
Abstract
Globally,
colorectal
cancer
(CRC)
is
the
third
most
prevalent
and
second
leading
cause
of
cancer-related
deaths.
Circular
RNAs
(circRNAs)
are
single-stranded
RNA
with
covalently
closed-loop
structures
highly
stable,
conserved,
abundantly
expressed
in
various
organs
tissues.
Recent
research
found
abnormal
circRNA
expression
CRC
patients’
blood/serum,
cells,
tissues,
exosomes.
Furthermore,
mounting
data
demonstrated
that
circRNAs
crucial
to
development
CRC.
CircRNAs
have
been
shown
exert
biological
functions
by
acting
as
microRNA
sponges,
RNA-binding
protein
regulators
gene
splicing
transcription,
protein/peptide
translators.
These
characteristics
make
potential
markers
for
diagnosis
prognosis,
therapeutic
targets,
circRNA-based
therapies.
However,
further
studies
still
necessary
improve
understanding
roles
mechanisms
In
this
review,
up-to-date
on
role
was
examined,
focusing
their
application
targeted
therapy,
which
would
advance
knowledge
progression
Frontiers in Pharmacology,
Journal Year:
2022,
Volume and Issue:
13
Published: Dec. 14, 2022
It
is
well
known
that
tumor
cells
rely
mainly
on
aerobic
glycolysis
for
energy
production
even
in
the
presence
of
oxygen,
and
a
modulator
tumorigenesis
development.
The
microenvironment
(TME)
composed
cells,
various
immune
cytokines,
extracellular
matrix,
among
other
factors,
complex
niche
supporting
survival
development
through
which
they
interact
co-evolve
with
cells.
In
recent
years,
there
has
been
renewed
interest
TME.
Many
studies
have
found
promotes
growth,
metastasis,
chemoresistance,
as
inhibiting
apoptosis
addition,
lactic
acid,
metabolite
glycolysis,
can
also
accumulate
TME,
leading
to
reduced
pH
immunosuppression,
affecting
This
review
discusses
significance
development,
its
association
potential
glycolysis-targeted
therapies,
provide
new
ideas
clinical
treatment
tumors.
Advanced Science,
Journal Year:
2022,
Volume and Issue:
9(34)
Published: Oct. 17, 2022
Abstract
Extracellular
vesicles
(EVs)
are
cell‐derived
nanosized
that
mediate
cell‐to‐cell
communication
via
transporting
bioactive
molecules
and
thus
critically
involved
in
various
physiological
pathological
conditions.
EVs
contribute
to
different
aspects
of
cancer
progression,
such
as
growth,
angiogenesis,
metastasis,
immune
evasion,
drug
resistance.
induce
the
resistance
cells
chemotherapy,
radiotherapy,
targeted
therapy,
antiangiogenesis
immunotherapy
by
transferring
specific
cargos
affect
efflux
regulate
signaling
pathways
associated
with
epithelial‐mesenchymal
transition,
autophagy,
metabolism,
stemness.
In
addition,
modulate
reciprocal
interaction
between
noncancer
tumor
microenvironment
(TME)
develop
therapy
detectable
many
biofluids
patients,
regarded
novel
biomarkers
for
monitoring
response
predicting
prognosis.
Moreover,
suggested
promising
targets
engineered
nanovehicles
deliver
drugs
overcoming
therapy.
this
review,
biological
roles
their
mechanisms
action
summarized.
The
preclinical
studies
on
using
also
discussed.
Advanced Science,
Journal Year:
2022,
Volume and Issue:
9(35)
Published: Oct. 26, 2022
Oxaliplatin
is
commonly
used
in
chemotherapeutic
regimens
for
colorectal
cancer
(CRC)
after
surgical
resection.
However,
acquired
chemoresistance
seriously
affects
the
curative
effect
CRC
patients,
and
mechanism
still
unclear.
Here,
a
circular
RNA,
circATG4B
identified,
which
plays
an
important
role
oxaliplatin
resistance
CRC.
expression
found
to
be
increased
exosomes
secreted
by
oxaliplatin-resistant
cells.
In
addition,
results
suggest
that
induces
promoting
autophagy.
Further
vivo
vitro
studies
indicate
of
attributed
its
potential
encode
novel
protein,
circATG4B-222aa.
Next,
circATG4B-222aa
function
as
decoy
competitively
interact
with
TMED10
prevent
from
binding
ATG4B,
leads
autophagy
followed
induction
chemoresistance.
Therefore,
this
study
reveals
exosomal
participates
decreased
chemosensitivity
cells,
providing
new
rationale
therapeutic
target
Cell Death and Disease,
Journal Year:
2023,
Volume and Issue:
14(6)
Published: June 9, 2023
Abstract
Globally,
colorectal
cancer
(CRC)
is
the
third
most
prevalent
and
second
leading
cause
of
cancer-related
deaths.
Circular
RNAs
(circRNAs)
are
single-stranded
RNA
with
covalently
closed-loop
structures
highly
stable,
conserved,
abundantly
expressed
in
various
organs
tissues.
Recent
research
found
abnormal
circRNA
expression
CRC
patients’
blood/serum,
cells,
tissues,
exosomes.
Furthermore,
mounting
data
demonstrated
that
circRNAs
crucial
to
development
CRC.
CircRNAs
have
been
shown
exert
biological
functions
by
acting
as
microRNA
sponges,
RNA-binding
protein
regulators
gene
splicing
transcription,
protein/peptide
translators.
These
characteristics
make
potential
markers
for
diagnosis
prognosis,
therapeutic
targets,
circRNA-based
therapies.
However,
further
studies
still
necessary
improve
understanding
roles
mechanisms
In
this
review,
up-to-date
on
role
was
examined,
focusing
their
application
targeted
therapy,
which
would
advance
knowledge
progression
