Exosomal circular RNAs: A chief culprit in cancer chemotherapy resistance

Drug Resistance Updates, Journal Year: 2023, Volume and Issue: 67, P. 100937 - 100937

Published: Feb. 2, 2023

Language: Английский

---

Unveiling the mechanisms and challenges of cancer drug resistance

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: Feb. 12, 2024

Abstract Cancer treatment faces many hurdles and resistance is one among them. Anti-cancer strategies are evolving due to innate acquired capacity, governed by genetic, epigenetic, proteomic, metabolic, or microenvironmental cues that ultimately enable selected cancer cells survive progress under unfavorable conditions. Although the mechanism of drug being widely studied generate new target-based drugs with better potency than existing ones. However, broader flexibility in resistance, advanced therapeutic options efficacy need be explored. Combination therapy an alternative a success rate though risk amplified side effects commonplace. Moreover, recent groundbreaking precision immune ways overcome has revolutionized anticancer greater extent only limitation individual-specific needs further attention. This review will focus on challenges opted withstand current therapies at molecular level also highlights emerging -like immunological, stem cell-based may prove have potential challenge problem resistance.

Language: Английский

---

Extracellular Vesicles in Cancer Drug Resistance: Roles, Mechanisms, and Implications

Advanced Science, Journal Year: 2022, Volume and Issue: 9(34)

Published: Oct. 17, 2022

Abstract Extracellular vesicles (EVs) are cell‐derived nanosized that mediate cell‐to‐cell communication via transporting bioactive molecules and thus critically involved in various physiological pathological conditions. EVs contribute to different aspects of cancer progression, such as growth, angiogenesis, metastasis, immune evasion, drug resistance. induce the resistance cells chemotherapy, radiotherapy, targeted therapy, antiangiogenesis immunotherapy by transferring specific cargos affect efflux regulate signaling pathways associated with epithelial‐mesenchymal transition, autophagy, metabolism, stemness. In addition, modulate reciprocal interaction between noncancer tumor microenvironment (TME) develop therapy detectable many biofluids patients, regarded novel biomarkers for monitoring response predicting prognosis. Moreover, suggested promising targets engineered nanovehicles deliver drugs overcoming therapy. this review, biological roles their mechanisms action summarized. The preclinical studies on using also discussed.

Language: Английский

---

NK cell-based tumor immunotherapy

Bioactive Materials, Journal Year: 2023, Volume and Issue: 31, P. 63 - 86

Published: Aug. 9, 2023

Natural killer (NK) cells display a unique inherent ability to identify and eliminate virus-infected tumor cells. They are particularly powerful for elimination of hematological cancers, have attracted considerable interests therapy solid tumors. However, the treatment tumors with NK less effective, which can be attributed very complicated immunosuppressive microenvironment that may lead inactivation, insufficient expansion, short life, poor infiltration Fortunately, development advanced nanotechnology has provided potential solutions these issues, could improve immunotherapy efficacy In this review, we summarize activation inhibition mechanisms in tumors, recent advances cell-based boosted by diverse nanomaterials. We also propose challenges opportunities clinical application immunotherapy.

Language: Английский

---

Delivering metal ions by nanomaterials: Turning metal ions into drug-like cancer theranostic agents

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 494, P. 215332 - 215332

Published: July 17, 2023

Language: Английский

---

SIRT1 is a regulator of autophagy: Implications for the progression and treatment of myocardial ischemia-reperfusion

Pharmacological Research, Journal Year: 2023, Volume and Issue: 199, P. 106957 - 106957

Published: Oct. 10, 2023

SIRT1 is a highly conserved nicotinamide adenine dinucleotide (NAD

Language: Английский

---

Anticancer Therapy Targeting Cancer-Derived Extracellular Vesicles

ACS Nano, Journal Year: 2024, Volume and Issue: 18(9), P. 6748 - 6765

Published: Feb. 23, 2024

Extracellular vesicles (EVs) are natural lipid nanoparticles secreted by most types of cells. In malignant cancer, EVs derived from cancer cells contribute to its progression and metastasis facilitating tumor growth invasion, interfering with anticancer immunity, establishing premetastasis niches in distant organs. recent years, multiple strategies targeting cancer-derived have been proposed improve patient outcomes, including inhibiting EV generation, disrupting during trafficking, blocking uptake recipient Developments engineering also show promising results harnessing as agents. Here, we summarize the current understanding origin functions review progress therapy these EVs.

Language: Английский

---

Hypoxia-induced SHMT2 protein lactylation facilitates glycolysis and stemness of esophageal cancer cells

Molecular and Cellular Biochemistry, Journal Year: 2024, Volume and Issue: 479(11), P. 3063 - 3076

Published: Jan. 4, 2024

Language: Английский

---

Writers, readers, and erasers RNA modifications and drug resistance in cancer

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Aug. 30, 2024

Drug resistance in cancer cells significantly diminishes treatment efficacy, leading to recurrence and metastasis. A critical factor contributing this is the epigenetic alteration of gene expression via RNA modifications, such as N6-methyladenosine (m6A), N1-methyladenosine (m1A), 5-methylcytosine (m5C), 7-methylguanosine (m7G), pseudouridine (Ψ), adenosine-to-inosine (A-to-I) editing. These modifications are pivotal regulating splicing, translation, transport, degradation, stability. Governed by "writers," "readers," "erasers," impact numerous biological processes progression, including cell proliferation, stemness, autophagy, invasion, apoptosis. Aberrant can lead drug adverse outcomes various cancers. Thus, targeting modification regulators offers a promising strategy for overcoming enhancing efficacy. This review consolidates recent research on role prevalent resistance, with focus m6A, m1A, m5C, m7G, Ψ, A-to-I Additionally, it examines regulatory mechanisms linked underscores existing limitations field.

Language: Английский

---

Extracellular Vesicles as Mediators and Potential Targets in Combating Cancer Drug Resistance

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 498 - 498

Published: Jan. 23, 2025

Extracellular vesicles (EVs) are key mediators in the communication between cancer cells and their microenvironment, significantly influencing drug resistance. This review provides a comprehensive analysis of roles EVs promoting resistance through mechanisms such as efflux, apoptosis resistance, autophagy imbalance, tumor microenvironment modulation. Despite extensive research, details biogenesis, cargo selection, specific pathways EVs-mediated not fully understood. critically examines recent advancements, highlighting studies that elucidate molecular functions. Additionally, innovative therapeutic strategies targeting explored, including inhibiting engineering for delivery, identifying resistance-inhibiting molecules within EVs. By integrating insights from primary research proposing new directions future studies, this aims to advance understanding biology foster effective interventions mitigate therapy.

Language: Английский

---