Targeting natural antioxidant polyphenols to protect neuroinflammation and neurodegenerative diseases: a comprehensive review

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 24, 2025

Polyphenols, naturally occurring phytonutrients found in plant-based foods, have attracted significant attention for their potential therapeutic effects neurological diseases and neuroinflammation. These compounds possess diverse neuroprotective capabilities, including antioxidant, anti-inflammatory, anti-amyloid properties, which contribute to mitigating the progression of neurodegenerative conditions such as Alzheimer's Disease (AD), Parkinson's (PD), Dementia, Multiple Sclerosis (MS), Stroke, Huntington's (HD). Polyphenols been extensively studied ability regulate inflammatory responses by modulating activity pro-inflammatory genes influencing signal transduction pathways, thereby reducing neuroinflammation neuronal death. Additionally, polyphenols shown promise various cellular signaling pathways associated with viability, synaptic plasticity, cognitive function. Epidemiological clinical studies highlight polyphenol-rich diets decrease risk alleviate symptoms disorders Furthermore, demonstrated through regulation key Akt, Nrf2, STAT, MAPK, play critical roles neuroprotection body's immune response. This review emphasizes growing body evidence supporting combating neurodegeneration neuroinflammation, well enhancing brain health. Despite substantial promising hypotheses, further research investigations are necessary fully understand role establish them advanced targets age-related neuroinflammatory conditions.

Language: Английский

Transformation of Quality Attributes of Fruit Leathers Using Diverse Hydrocolloids: Recent Application and Future Perspective

Journal of Food Process Engineering, Journal Year: 2024, Volume and Issue: 47(11)

Published: Nov. 1, 2024

ABSTRACT This study provides a comprehensive review of recent advancements in the application diverse hydrocolloids formulation fruit‐based leathers. It highlights significant impact improving techno‐functional properties these fruit leathers to align with consumer preferences. The extends beyond traditional attributes, exploring specific effects on leather formulations. Key factors such as selection, processing methods, type and concentration hydrocolloids, their synergistic interactions are thoroughly evaluated. also importance controlling parameters like pH, sugar content, total soluble solids (TSS), drying temperature, time which crucial for maintaining quality attributes By addressing aspects, offers understanding role play developing superior products. Moreover, textural, sensory retention anti‐oxidant activity significantly improved use hydrocolloids. enhancement not only demands better texture taste but promotes creation healthier food Overall, this underscores potential transforming formulations, leading more appealing health‐conscious options.

Language: Английский

Polyphenol metabolomics reveals the applications and prospects of polyphenol-rich plants in natural dyes

Forestry Research, Journal Year: 2024, Volume and Issue: 4(1), P. 0 - 0

Published: Jan. 1, 2024

Polyphenols, as one of the primary compounds produced by plant secondary metabolism, have garnered considerable attention because their non-toxic, environmentally friendly, and biodegradable properties, well notable medicinal value. This study presents a metabolomic analysis polyphenols from 11 woody plants, including Camellia oleifera, Quercus acutissima, Punica granatum, investigating total 40 polyphenolic metabolites. A differential metabolite dynamics map highlighted five most differentiated substances among vitexin, dihydromyricetin, genistin, resveratrol, isorhamnetin. To evaluate application polyphenol-rich plants natural dyes, dye performance tests, color fastness evaluations were conducted, focusing on specific role in dyeing cotton fabrics. The composition had minor effect dyed fabrics, typically imparting only black or brown tones to fabric. However, is notable, with ratio absorption coefficient (k) scattering (s) (K/S) ranging 1 20, lightness varying 26 78. addition mordants not improved dye's but also expanded range. Furthermore, this identified four key that influence naringenin, epicatechin, catechin, discovered novel compound, naringenin. Importantly, six dyes selected are derived waste, thus providing theoretical basis for advancing friendly sustainable technologies.

Language: Английский