Tricarboxylic Acid Cycle Intermediates and Individual Ageing

Biomolecules, Journal Year: 2024, Volume and Issue: 14(3), P. 260 - 260

Published: Feb. 22, 2024

Anti-ageing biology and medicine programmes are a focus of genetics, molecular biology, immunology, endocrinology, nutrition, therapy. This paper discusses metabolic therapies aimed at prolonging longevity and/or health. Individual components these effects postulated to be related the energy supply by tricarboxylic acid (TCA) cycle intermediates free radical production processes. article presents several theories ageing clinical descriptions top markers ageing, which define in different categories; additionally, their interactions with age-related changes diseases α-ketoglutarate (AKG) succinate SC formation metabolism pathological states explained. review describes convincingly differences mitochondrial characteristics animals, levels (high low) physiological reactivity functional systems state regulatory providing oxygen-dependent Much attention is given crucial role AKG cells amino synthesis, epigenetic regulation, cell stemness, differentiation, as well associated development conditions and, particular, cancer cells. Another goal was address issue terms individual reactivity. also demonstrated Krebs key component cellular closely various pathologies, such cancer, type 2 diabetes, cardiovascular or neurodegenerative where mTOR pathway plays role. provides postulates postischaemic phenomena an organism demonstrates dependence accelerated pathology on studies species (roundworm Caenorhabditis elegans, Drosophila, mice, humans used models). The findings suggest that this approach may useful show metabolites involved abnormalities thus induce reprogramming contributes senile phenotype degenerative diseases. compounds particularly important when considering mechanisms connected initial able initiate programmed depending intensity oxygen consumption, peculiarities, behavioural reactions.

Language: Английский

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Ovarian aging: energy metabolism of oocytes

Journal of Ovarian Research, Journal Year: 2024, Volume and Issue: 17(1)

Published: May 31, 2024

Abstract In women who are getting older, the quantity and quality of their follicles or oocytes decline. This is characterized by decreased ovarian reserve function (DOR), fewer remaining oocytes, lower oocytes. As more choose to delay childbirth, decline in fertility associated with age has become a significant concern for modern women. The oocyte key indicator aging. Many studies suggest that age-related changes energy metabolism may impact quality. Changes affect adenosine 5'-triphosphate (ATP) production, but how related products proteins influence remains largely unknown. review focuses on aging its potential quality, as well therapeutic strategies partially metabolism. research aims enhance our understanding metabolism, identification biomarkers treatment methods.

Language: Английский

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Investigating the bidirectional interactions between senotherepeutic agents and human gut microbiota

European Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 107098 - 107098

Published: April 1, 2025

Biological ageing is a time-dependent process that has implications for health and disease. Cellular senescence key driver in age-related diseases. Senotherapeutic agents have been shown to slow biological by eliminating senescent mammalian cells. Given the increasing awareness of gut microbiome regulating human health, this study aimed investigate effects senotherapeutic as pharmacological interventions on microbiota. In study, bidirectional four agents, quercetin, fisetin, dasatinib, sirolimus, with microbiota sourced from healthy donors were investigated. The results revealed quercetin was completely biotransformed within six hours, while dasatinib most stable compounds. Additionally, metagenomic analysis confirmed all compounds increased abundance bacterial species associated (e.g., Bacteroides fragilis, Bifidobacterium longum, Veillonella parvula), decreased pathogenic bacteria primarily diseases Enterococcus faecalis Streptococcus spp.). findings provide comprehensive understanding pharmacobiomics interventions, highlighting potential microbiome-targeted senolytics promoting ageing.

Language: Английский

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Glucosinolates from Seed-Press Cake of Camelina sativa (L.) Crantz Extend Yeast Chronological Lifespan by Modulating Carbon Metabolism and Respiration

Antioxidants, Journal Year: 2025, Volume and Issue: 14(1), P. 80 - 80

Published: Jan. 11, 2025

Glucosinolates (GSLs) are nitrogen/sulfur-containing glycosides widely present in the order of Brassicales, particularly Brassicaceae family. Camelina (Camelina sativa (L.) Crantz) is an oilseed plant belonging to this Its seeds, addition a distinctive fatty acid composition, contain three aliphatic GSLs: glucoarabin, glucocamelinin, and homoglucocamelinin. Our study explored impact these GSLs purified from press cake, by-product oil production, on yeast chronological aging, which established model for simulating aging post-mitotic quiescent mammalian cells. Supplementing cells with extends lifespan (CLS) dose-dependent manner. This enhancement relies improved mitochondrial respiration efficiency, resulting drastic decrease superoxide anion levels increase ATP production. Furthermore, GSL supplementation affects carbon metabolism. In particular, support pro-longevity preservation TCA cycle enzymatic activities enhanced glycerol catabolism. These changes contribute positively phosphorylating trehalose storage: both longevity-promoting prerequisites.

Language: Английский

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Phytic Acid Extraction from Rice Bran with Acetic Acid : Optimization, Antioxidant Capacity and Mechanism Based on Cellular Metabolomics

LWT, Journal Year: 2025, Volume and Issue: unknown, P. 117394 - 117394

Published: Jan. 1, 2025

Language: Английский

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Amelioratory Role of Lactobacillus paracasei N1115 on Blood Glucose, Inflammation, Cognitive Function, and Gut Microbiota Composition in Type 2 Diabetes Mellitus Rats

Journal of Food Biochemistry, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

This study aims to investigate the effect of probiotic Lactobacillus paracasei N1115 on Type 2 diabetes mellitus (T2DM) rats. SD rats were randomly divided into 5 groups, including control group (ND), (DM) group, and high (10 9 CFU/mL), medium 8 or low 7 CFU/mL) doses probiotics intervention groups. The ND fed a normal diet, others high‐fat diet injected with streptozotocin (STZ) build T2DM model. In three given high, medium, L. by gavage for 12 weeks. Results indicated that could prevent weight loss decrease blood glucose levels rats, in dose‐dependent manner. A dose also led significant decline inflammatory response regulating TLR4/NF‐κB pathway reducing proinflammatory cytokines, such as tumor necrosis factor‐ α (TNF‐α), interleukin‐1β (IL‐1β), lipopolysaccharide (LPS) ( p < 0.05). Besides, memory factor cAMP cognitive regulatory BDNF/TrkB increased treatment 0.05), revealing an enhanced competence. addition, analysis gut microbiome showed L.paracasei decreased Firmicutes/Bacteroidota ratio relative abundance beneficial bacteria, unclassified_Lachnospiraceae, Ligilactobacillus, Lachnospiraceae_NK4A136_group. microbial gene contents associated metabolic pathways, nicotinate nicotinamide metabolism, glycine, serine, threonine metabolism citrate cycle upregulated under treatment. summary, this elucidated effects revealed promising dietary supplement T2DM.

Language: Английский

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The imidazoline I2 receptor agonist 2-BFI enhances cytotoxic activity of hydroxychloroquine by modulating oxidative stress , energy-related metabolism and autophagic influx in human colorectal adenocarcinoma cell lines

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177590 - 177590

Published: April 1, 2025

Language: Английский

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Oxidant-Based Cytotoxic Agents During Aging: From Disturbed Energy Metabolism to Chronic Inflammation and Disease Progression

Biomolecules, Journal Year: 2025, Volume and Issue: 15(4), P. 547 - 547

Published: April 9, 2025

In humans, aging is an inevitable consequence of diminished growth processes after reaching maturity. The high order biomolecules in cells and tissues continuously disturbed by numerous physical chemical destructive impacts. Host-derived oxidant-based cytotoxic agents (reactive species, transition free metal ions, heme) contribute considerably to this damage. These are under the control immediately acting antagonizing principles, which important ensure cell tissue homeostasis. review, I apply concept host-derived their interplay with principles process. During aging, energy metabolism supply dioxygen nutrients increasingly disturbed. addition, a chronic inflammatory state develops, condition known as inflammaging. balance between protective mechanisms analyzed depending on age-based physiological alterations ATP production. Disturbances associated development age-related diseases comorbidities. An enhanced production reactive species from dysfunctional mitochondria, cellular redox homeostasis, adaptations hypoxia highlighted. Examples how disturbances pathogenesis persons advanced age given.

Language: Английский

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Amino acid metabolism-related genes as potential biomarkers and the role of MATN3 in stomach adenocarcinoma: A bioinformatics, mendelian randomization and experimental validation study

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 143, P. 113253 - 113253

Published: Sept. 30, 2024

Language: Английский

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From Genomics to Metabolomics: Molecular Insights into Osteoporosis for Enhanced Diagnostic and Therapeutic Approaches

Biomedicines, Journal Year: 2024, Volume and Issue: 12(10), P. 2389 - 2389

Published: Oct. 18, 2024

Osteoporosis (OP) is a prevalent skeletal disorder characterized by decreased bone mineral density (BMD) and increased fracture risk. The advancements in omics technologies—genomics, transcriptomics, proteomics, metabolomics—have provided significant insights into the molecular mechanisms driving OP. These technologies offer critical perspectives on genetic predispositions, gene expression regulation, protein signatures, metabolic alterations, enabling identification of novel biomarkers for diagnosis therapeutic targets. This review underscores potential these multi-omics approaches to bridge gap between basic research clinical applications, paving way precision medicine OP management. By integrating technologies, researchers can contribute improved diagnostics, preventative strategies, treatments patients suffering from related conditions.

Language: Английский

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