Gynecological Endocrinology, Journal Year: 2024, Volume and Issue: 40(1)
Published: Dec. 23, 2024
Background Previous studies on the impact of mitochondrial DNA (mtDNA) copy number female infertility were limited and inconsistent.
Language: Английский
Seminars in Reproductive Medicine, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 29, 2025
Female reproductive aging often affects women's emotional, physical, and physiological well-being. Ovarian is characterized by fluctuations in hormones determines the age at which menopause occurs. Understanding potentially modifiable factors that influence this process essential for addressing health disparities, improving quality of life, informing relevant public strategies. This review synthesizes vivo, vitro, epidemiological findings about effects endocrine-disrupting chemicals (EDCs), specifically heavy metals perfluoroalkyl polyfluoroalkyl substances (PFAS) on female aging. Most vivo vitro studies have demonstrated alter ovarian morphology, folliculogenesis, steroidogenesis. Evidence regarding PFAS limited inconsistent. Epidemiological consistently shown are associated with a higher risk diminished reserve (indicated decreased anti-Müllerian hormone) earlier menopause, hormone changes. exposure has been estradiol but not significantly reserve. Gaps literature require more comprehensive research EDCs aging, including reserve, vasomotor symptoms, to inform future interventions reduce hazardous exposures improve health.
Language: Английский
Citations
0
Reproduction Fertility and Development, Journal Year: 2025, Volume and Issue: 37(4)
Published: Feb. 2, 2025
Context Subfertility has a negative impact on the productivity of beef cow herds; thus, it is relevant to unravel mechanisms. Aims To study follicular development, body composition, concentrations progesterone and metabolic hormones their gene expression in endometrium during oestrus cycle. Methods Fertile subfertile Hereford cows were classified at 25 (n =84) 60 =25) months old, as (1) fertile, pregnant first insemination 25months, that became pregnantmore than three five times 60months =5), or (2) subfertile, i.e. failed inseminations fewer two opportunities =6). Key results had greater insuling-like growth factor 1 (IGF-1), leptin adiponectin (P P Conclusions Differences plasma fluid endometrial are associated with success pregnancy cows. Implications Strategies improve follicle microenvironments needed herds.
Language: Английский
Citations
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Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217569 - 217569
Published: Feb. 1, 2025
Language: Английский
Citations
0
Cells, Journal Year: 2025, Volume and Issue: 14(6), P. 444 - 444
Published: March 17, 2025
Increasing evidence has suggested that dihydrolipoamide S-acetyltransferase (DLAT), a subunit of the pyruvate dehydrogenase complex, is crucial for metabolism and regulation cell death. The excessive death granulosa cells (GCs) hinders progression follicular growth. However, relationship between DLAT growth poorly understood. Here, we found significantly shortened age pubertal initiation in mice promoted by promoting proliferation GCs. In addition, up-regulated expression high level was observed large follicles, which were associated with Mechanistically, increased mRNA protein levels pathways such as PCNA MCL1 to promote GC proliferation. Additionally, bound CASP3 CASP9 proteins inhibit apoptosis Taken together, these results reveal mechanism regulated growth, represents promising target supports new strategies improving follicles.
Language: Английский
Citations
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Reproductive Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 108901 - 108901
Published: April 1, 2025
Disinfection of drinking water is a critical measure for ensuring safety and controlling waterborne infectious diseases. However, during the disinfection process, variety by-products (DBPs), some which exhibit reproductive toxicity, are generated. This study aimed to assess whether DBP exposure contributes risk diminished ovarian reserve (DOR) explored underlying metabolic mechanisms. A total 182 participants, including 91 healthy women with DOR, were recruited case-control conducted between October 2023 February 2024. Serum concentrations DBPs, dibromoacetic acid (DBAA), monochloroacetic (MCAA), dichloroacetic (DCAA), trichloroacetic (TCAA), chlorate, perchlorate, measured evaluate exposure. Key indicators evaluating DOR included antral follicle count (AFC), anti-Mullerian hormone (AMH), follicle-stimulating (FSH). All six DBPs higher in patients (all p < 0.05). After covariates, all showed negative correlations AMH AFC, positive basal FSH, significant association To further investigate mechanisms, we an vitro using human granulosa cell line (KGN). KGN cells exposed DBAA perchlorate 48hours, metabolomic analysis was performed identify altered pathways. Metabolomics data suggested that might have contributed by disrupting arginine biosynthesis purine metabolism, respectively. In conclusion, (GC) metabolism.
Language: Английский
Citations
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International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 3951 - 3951
Published: April 22, 2025
Preeclampsia (PE), a pregnancy complication characterized by high blood pressure and organ damage, has been suggested to be associated with mitochondrial dysfunction, although evidence remains limited. This study aimed investigate the activity of oxidative phosphorylation (OXPHOS) enzymes expression related proteins in placental tissues from women diagnosed early-onset preeclampsia (eoPE, <34 weeks gestation), late-onset (loPE, ≥34 normotensive controls. Placental samples were analyzed using immunohistochemistry, western blotting, enzymatic assays assess OXPHOS complexes. Complex I was increased 80% eoPE 56% loPE, positive correlations between normalized complex expression, gestational age at delivery (r = 0.85, p 0.01), birth weight 0.88, 0.004) loPE. Relative II loPE showed duration 0.76, 0.03) 0.77, 0.03), while controls, correlated 0.64, 0.03). Additionally, IV enzyme negatively maternal −0.69, The observed highlight metabolism as promising biomarker for predicting disease progression guiding therapeutic interventions preeclampsia. Unraveling its precise role PE pathogenesis is critical advancing diagnostic precision improving maternal-fetal outcomes.
Language: Английский
Citations
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Artificial Intelligence in Medicine, Journal Year: 2024, Volume and Issue: 157, P. 102997 - 102997
Published: Oct. 8, 2024
Nowadays, the most adopted technique to address infertility problems is in vitro fertilisation (IVF). However, its success rate limited, and associated procedures, known as assisted reproduction technology (ART), suffer from a lack of objectivity at laboratory level clinical practice. This paper deals with applications Artificial Intelligence (AI) techniques IVF procedures. intelligence considered promising tool for ascertaining quality embryos, critical step IVF. Since oocyte influences final embryo quality, we present systematic review literature on AI-based used assess quality; analyse results discuss several research directions. In particular, highlight how can support process examine their current presented literature. Then, challenges must face fully deploying solutions medical Among them, availability high-quality data sets well standardised imaging protocols formats, use physics-informed simulation machine learning techniques, study informative, descriptive yet observable features, and, above all, studies oocytes specifically about live birth potential. An improved understanding determinants improve rates while reducing costs, risks long-term cultures, bioethical concerns.
Language: Английский
Citations
2
Reproductive Biology and Endocrinology, Journal Year: 2024, Volume and Issue: 22(1)
Published: Nov. 8, 2024
Advanced maternal age is associated with decreased oocyte quantity and quality in vitro fertilization (IVF) success rates. This study aimed to investigate whether melatonin supplementation can improve IVF outcomes women of advanced by modulating cuproptosis ferroptosis.
Language: Английский
Citations
1
Journal of Ovarian Research, Journal Year: 2024, Volume and Issue: 17(1)
Published: July 15, 2024
The relationship between leukocyte telomere length (LTL) and female reproductive endocrine diseases has gained significant attention research interest in recent years. However, there is still limited understanding of the exact impacts LTL on these diseases. Therefore, primary objective this study was to investigate genetic causal association by employing Mendelian randomization (MR) analysis.
Language: Английский
Citations
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Russian Pediatric Journal, Journal Year: 2024, Volume and Issue: 27(4), P. 283 - 290
Published: Sept. 16, 2024
Introduction. All current methods of hemostasis used in ovarian surgery inevitably lead to damage healthy follicles. Significant loss reserve childhood can the development premature insufficiency future. Therefore, choice a method that is most gentle on tissue becomes particularly important pediatric gynecology. Materials and methods. Paper search analysis was completed using PubMed, Embase, Cochrane Library Google Scholar databases. This literature review includes systematic reviews, cohort studies, case series, randomized controlled trials (RCTs) from 1989 2024. Results. modern decrease reserve. The rate potential repair depends as well technique hemostasis. According presented data, there no unambiguous opinion between coagulation ligature when working with tissue. Coagulation technically easier less time-consuming than suturing, especially for an inexperienced surgeon. Complications associated technical errors during significant deterioration long-term perspective. Thus, appropriate each clinical situation determined according capabilities, skills, preferences surgeon operation plan. Conclusion. Careful preservation practice paramount importance future reproductive health female patients. When choosing hemostasis, it take into account capabilities skills Further study needed assess impact
Language: Английский
Citations
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