Antimicrobial Activity of the Peptide C14R Against Ab Initio Growing and Preformed Biofilms of Candida albicans, Candidaparapsilosis and Candidozyma auris DOI Creative Commons

John B. Walter,

Ann‐Kathrin Kissmann,

DORINNE KAN GRUBER

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(3), P. 322 - 322

Published: Feb. 21, 2025

Biofilms are the predominant lifeforms of microorganisms, contributing to over 80% infections, including those caused by Candida species like C. albicans, parapsilosis and Candidozyma auris. These form biofilms on medical devices, making infections challenging treat, especially with rise in drug-resistant strains. particularly hospital-acquired ones, a significant health threat due their resistance antifungals risk developing systemic (i.e., sepsis). We have previously shown that C14R reduces viability albicans auris, but not parapsilosis. Here, we show only inhibits pore formation, resazurin reduction assay, fluorescence-based permeabilization it also halts biofilm maturation significantly biomass preformed 70%. findings suggest could be an effective option for treating severe fungal offering potential new treatment approach biofilm-related diseases. Further research is needed fully understand its dispersal optimize use future applications as antifungal clinical settings.

Language: Английский

Antimicrobial Activity of the Peptide C14R Against Ab Initio Growing and Preformed Biofilms of Candida albicans, Candidaparapsilosis and Candidozyma auris DOI Creative Commons

John B. Walter,

Ann‐Kathrin Kissmann,

DORINNE KAN GRUBER

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(3), P. 322 - 322

Published: Feb. 21, 2025

Biofilms are the predominant lifeforms of microorganisms, contributing to over 80% infections, including those caused by Candida species like C. albicans, parapsilosis and Candidozyma auris. These form biofilms on medical devices, making infections challenging treat, especially with rise in drug-resistant strains. particularly hospital-acquired ones, a significant health threat due their resistance antifungals risk developing systemic (i.e., sepsis). We have previously shown that C14R reduces viability albicans auris, but not parapsilosis. Here, we show only inhibits pore formation, resazurin reduction assay, fluorescence-based permeabilization it also halts biofilm maturation significantly biomass preformed 70%. findings suggest could be an effective option for treating severe fungal offering potential new treatment approach biofilm-related diseases. Further research is needed fully understand its dispersal optimize use future applications as antifungal clinical settings.

Language: Английский

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