Advanced Fiber Materials, Journal Year: 2022, Volume and Issue: 4(4), P. 807 - 819
Published: Feb. 9, 2022
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)
Published: May 11, 2023
Abstract Angiogenesis, the formation of new blood vessels, is a complex and dynamic process regulated by various pro- anti-angiogenic molecules, which plays crucial role in tumor growth, invasion, metastasis. With advances molecular cellular biology, biomolecules such as growth factors, chemokines, adhesion factors involved angiogenesis has gradually been elucidated. Targeted therapeutic research based on these molecules driven treatment to become promising strategy anti-tumor therapy. The most widely used agents include monoclonal antibodies tyrosine kinase inhibitors (TKIs) targeting vascular endothelial factor (VEGF) pathway. However, clinical benefit this modality still limited due several defects adverse events, acquired drug resistance, recurrence, lack validated biomarkers, impel further mechanisms angiogenesis, development multiple drugs combination therapy figure out how improve efficacy. Here, we broadly summarize signaling pathways discuss current challenges We also propose approaches efficacy provide perspective for
Language: Английский
Citations
543
Acta Pharmaceutica Sinica B, Journal Year: 2022, Volume and Issue: 12(7), P. 3028 - 3048
Published: March 1, 2022
Compared with traditional drug therapy, nanomedicines exhibit intriguing biological features to increase therapeutic efficiency, reduce toxicity and achieve targeting delivery. This review provides a snapshot of that have been currently launched or in the clinical trials, which manifests diversified trend carrier types, applied indications mechanisms action. From perspective indications, this article presents an overview applications involving prevention, diagnosis treatment various diseases, include cancer, infections, blood disorders, cardiovascular immuno-associated diseases nervous system etc. Moreover, some considerations perspectives research development facilitate their translations clinic.
Language: Английский
Citations
212
Biomaterials, Journal Year: 2019, Volume and Issue: 228, P. 119578 - 119578
Published: Oct. 29, 2019
Language: Английский
Citations
190
Advanced Science, Journal Year: 2020, Volume and Issue: 8(1)
Published: Nov. 27, 2020
The impermeable barrier of solid tumors due to the complexity their components limits treatment effect nanomedicine and hinders its clinical translation. Several methods are available increase penetrability nanomedicine, yet they too complex be effective, operational, or practical. Surface modification employs characteristics direct contact between multiphase surfaces achieve most efficient penetration tumors. Furthermore, simple operation makes use feasible. In this review, latest surface strategies for into summarized classified "bulldozer strategies" "mouse strategies." Additionally, evaluation methods, existing problems, development prospects these technologies discussed.
Language: Английский
Citations
186
Nano Today, Journal Year: 2020, Volume and Issue: 35, P. 100960 - 100960
Published: Sept. 14, 2020
Language: Английский
Citations
155
Journal of Materials Chemistry B, Journal Year: 2020, Volume and Issue: 8(31), P. 6765 - 6781
Published: Jan. 1, 2020
The strategies and obstacles for overcoming the barriers in tumor microenvironment are presented.
Language: Английский
Citations
145
Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 162, P. 114643 - 114643
Published: April 7, 2023
Multi-drug resistance (MDR) in cancer cells, either intrinsic or acquired through various mechanisms, significantly hinders the therapeutic efficacy of drugs. Typically, reduced performance drugs is predominantly due to inherent over expression ATP-binding cassette (ABC) transporter proteins on cell membrane, resulting deprived uptake drugs, augmenting drug detoxification, and DNA repair. In addition physiological abnormalities extensive blood flow, MDR phenotypes exhibit improved apoptotic threshold efflux efficiency. These severe consequences have substantially directed researchers fabrication advanced strategies, such as co-delivery along with generations inhibitors, augmented dosage regimens frequency administration, well combinatorial treatment options, among others. this review, we emphasize different reasons mechanisms responsible for cancer, including but not limited known mediated by permeability glycoprotein (P-gp) other pumps, uptake, altered repair, targets, Further, an emphasis specific cancers that share pathogenesis executing effluxed common provided. Then, aspects related nanomaterials-based supramolecular programmable designs (organic- inorganic-based materials), physical approaches (light- ultrasound-based therapies), are discussed, highlighting unsolved issues future advancements. Finally, summarize review interesting perspectives trends, exploring further opportunities overcome MDR.
Language: Английский
Citations
139
Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)
Published: May 16, 2022
Abstract Inhibited immune response and low levels of delivery restrict starvation cancer therapy efficacy. Here, we report on the co-delivery glucose oxidase (GOx) indoleamine 2,3-dioxygenase (IDO) inhibitor 1-methyltryptophan using a metal-organic framework (MOF)-based nanoreactor, showing an amplified release for tumor starvation/oxidation immunotherapy. The nanosystem significantly overcomes biobarriers associated with penetration improves cargo bioavailability owing to weakly acidic microenvironment-activated charge reversal size reduction strategy. rapidly disassembles releases cargoes in intracellular reactive oxygen species (ROS). GOx competitively consumes generates ROS, further inducing self-amplifiable MOF disassembly drug release. combined IDO-blockade immunotherapy not only strengthens stimulates memory through GOx-activated recruitment effector T cells, but also effectively relieves tolerance by IDO blocking, remarkably inhibiting growth metastasis vivo.
Language: Английский
Citations
129
Applied Physics Reviews, Journal Year: 2021, Volume and Issue: 8(4)
Published: Dec. 1, 2021
The physical morphologies of nanoparticles, especially size and shape, always significantly influence their biological behaviors. In the past, nanoparticles with constant have been widely investigated applied in tumor theranostics. With increased in-depth knowledge tumors physiological microenvironments, are required to self-adjust during circulation varying microenvironments when reaching site that possess distinct microenvironments. Therefore, smart transformable nanomaterials, which can alter under different conditions, show great potential advanced This review summarizes nanoparticles' on behaviors highlights designs serving as a guideline for construction, intensively discusses recent biomedical applications these theranostics, also proposes future challenges perspectives development
Language: Английский
Citations
110
Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)
Published: Sept. 2, 2023
Tumor metastases are considered the leading cause of cancer-associated deaths. While clinically applied drugs have demonstrated to efficiently remove primary tumor, remain poorly accessible. To overcome this limitation, herein, development a theranostic nanomaterial by incorporating chromophore for imaging and photosensitizer treatment metastatic tumor sites is presented. The mechanism action reveals that nanoparticles able intervene local generation cellular damage through photodynamic therapy as well systemic induction an immune response immunotherapy upon inhibition mTOR signaling pathway which crucial importance onset, progression spreading. strongly reduce volume eradicates in breast cancer multi-drug resistant patient-derived hepatocellular carcinoma models female mice.
Language: Английский
Citations
66