Polydopamine antibacterial materials

Materials Horizons, Journal Year: 2021, Volume and Issue: 8(6), P. 1618 - 1633

Published: Jan. 1, 2021

This review focuses on the recent progress in polydopamine antibacterial materials, including their structural and functional features, preparation strategies, mechanisms, biomedical applications.

Language: Английский

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PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application

Drug Delivery, Journal Year: 2021, Volume and Issue: 28(1), P. 1397 - 1418

Published: Jan. 1, 2021

Biodegradable microspheres have been widely used in the field of medicine due to their ability deliver drug molecules various properties through multiple pathways and advantages low dose side effects. Poly (lactic-co-glycolic acid) copolymer (PLGA) is one most biodegradable material currently has good biocompatibility. In application, PLGA with a specific monomer ratio (lactic acid glycolic can be selected according requirements release rate. PLGA-based studied delivery, including delivery anticancer drugs, protein or peptide bacterial viral DNA, etc. This review describes basic knowledge current situation discusses selection polymer materials. Then, preparation methods are introduced, emulsification, microfluidic technology, electrospray, spray drying. Finally, this summarizes application treatment pulmonary ocular-related diseases.

Language: Английский

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Applications of nanotechnology in medical field: a brief review

Global Health Journal, Journal Year: 2023, Volume and Issue: 7(2), P. 70 - 77

Published: Feb. 25, 2023

Nanotechnology has extensive application as nanomedicine in the medical field. Some nanoparticles have possible applications novel diagnostic instruments, imagery and methodologies, targeted medicinal products, pharmaceutical biomedical implants, tissue engineering. Today treatments of high toxicity can be administered with improved safety using nanotechnology, such chemotherapeutic cancer drugs. Further, wearable gadgets detect crucial changes vital signs, cell conditions, infections that are genuinely happening body. We anticipate these technologies to provide doctors considerably much better direct access critical data on reasons for signs life or illness because technological presence at source problem. Biomedicine utilised therapies predictive analytics artificial intelligence. For carrying out this study, relevant papers field from Scopus, Google scholar, ResearchGate, other research platforms identified studied. The study discusses different types Nanoparticles used This paper nanotechnology class, features, characteristics medicine also briefed. Scientists, governments, civil society organisations, general public will need collaborate across sectors assess significance guide its advancement various fields. current includes several uses As a result, provides brief well-organised report should valuable researchers, engineers, scientists future projects.

Language: Английский

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Nanozyme for tumor therapy: Surface modification matters

Exploration, Journal Year: 2021, Volume and Issue: 1(1), P. 75 - 89

Published: Aug. 1, 2021

As the next generation of artificial enzymes, nanozymes have shown unique properties compared to its natural counterparts, such as stability in harsh environment, low cost, and ease production modification, paving way for biomedical applications. Among them, tumor catalytic therapy mediated by reactive oxygen species (ROS) has made great progress mainly from peroxidase-like activity nanozymes. Fe

Language: Английский

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Applications of Surface Modification Technologies in Nanomedicine for Deep Tumor Penetration

Advanced Science, Journal Year: 2020, Volume and Issue: 8(1)

Published: Nov. 27, 2020

The impermeable barrier of solid tumors due to the complexity their components limits treatment effect nanomedicine and hinders its clinical translation. Several methods are available increase penetrability nanomedicine, yet they too complex be effective, operational, or practical. Surface modification employs characteristics direct contact between multiphase surfaces achieve most efficient penetration tumors. Furthermore, simple operation makes use feasible. In this review, latest surface strategies for into summarized classified "bulldozer strategies" "mouse strategies." Additionally, evaluation methods, existing problems, development prospects these technologies discussed.

Language: Английский

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Charge-reversal biodegradable MSNs for tumor synergetic chemo/photothermal and visualized therapy

Journal of Controlled Release, Journal Year: 2021, Volume and Issue: 338, P. 719 - 730

Published: Sept. 10, 2021

Language: Английский

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Polyphenol-based hydrogels: Pyramid evolution from crosslinked structures to biomedical applications and the reverse design

Bioactive Materials, Journal Year: 2022, Volume and Issue: 17, P. 49 - 70

Published: Feb. 1, 2022

As a kind of nature-derived bioactive materials, polyphenol-based hydrogels possess many unique and outstanding properties such as adhesion, toughness, self-healing due to their specific crosslinking structures, which have been widely used in biomedical fields including wound healing, antitumor, treatment motor system injury, digestive disease, oculopathy, bioelectronics. In this review, starting with the classification common hydrogels, pyramid evolution process from structures derived then applications is elaborated, well efficient reverse design considerations hydrogel systems are proposed. Finally, existing problems development prospects these materials discussed. It hoped that perspective review can promote further innovation breakthroughs future.

Language: Английский

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Chemically engineered mesoporous silica nanoparticles-based intelligent delivery systems for theranostic applications in multiple cancerous/non-cancerous diseases

Coordination Chemistry Reviews, Journal Year: 2021, Volume and Issue: 452, P. 214309 - 214309

Published: Nov. 15, 2021

Language: Английский

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A photo-triggered self-accelerated nanoplatform for multifunctional image-guided combination cancer immunotherapy

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Aug. 25, 2023

Precise and efficient image-guided immunotherapy holds great promise for cancer treatment. Here, we report a self-accelerated nanoplatform combining an aggregation-induced emission luminogen (AIEgen) hypoxia-responsive prodrug multifunctional combination immunotherapy. The near-infrared AIEgen with methoxy substitution simultaneously possesses boosted fluorescence photoacoustic (PA) brightness the strong light absorption ability, as well amplified type I II photodynamic therapy (PDT) properties via enhanced intersystem crossing process. By formulating high-performance paclitaxel (PTX) into nanoparticles, further camouflaging macrophage cell membrane, tumor-targeting theranostic agent is built. integration of PA imaging helps to delineate tumor site sensitively, providing accurate guidance light-induced PDT effect could consume local oxygen lead severer hypoxia, accelerating release PTX drug. As result, chemotherapy induces immunogenic death, which not only elicit antitumor immunity suppress primary tumor, but also inhibit growth distant in 4T1 tumor-bearing female mice. strategy develop agents rational molecular design boosting

Language: Английский

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Nanoarchitectured prototypes of mesoporous silica nanoparticles for innovative biomedical applications

Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)

Published: March 12, 2022

Despite exceptional morphological and physicochemical attributes, mesoporous silica nanoparticles (MSNs) are often employed as carriers or vectors. Moreover, these conventional MSNs suffer from various limitations in biomedicine, such reduced drug encapsulation efficacy, deprived compatibility, poor degradability, resulting therapeutic outcomes. To address limitations, several modifications have been corroborated to fabricating hierarchically-engineered terms of tuning the pore sizes, modifying surfaces, engineering siliceous networks. Interestingly, further advancements engineered lead generation highly complex nature-mimicking structures, Janus-type, multi-podal, flower-like architectures, well streamlined tadpole-like nanomotors. In this review, we present explicit discussions relevant advanced hierarchical architectures different fields including delivery, bioimaging, tissue engineering, miscellaneous applications, photoluminescence, artificial enzymes, peptide enrichment, DNA detection, biosensing, among others. Initially, give a brief overview diverse, innovative stimuli-responsive (pH, light, ultrasound, thermos)- targeted delivery strategies, along with on recent cancer immune therapy applicability other ailments related cardiac, vascular, nervous systems, diabetes. Then, provide initiatives taken so far clinical translation silica-based materials their scope towards translation. Finally, summarize review interesting perspectives lessons learned exploring biomedical applications requirements be explored.

Language: Английский

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