Functional Hydrogels as Wound Dressing to Enhance Wound Healing

ACS Nano, Journal Year: 2021, Volume and Issue: 15(8), P. 12687 - 12722

Published: Aug. 10, 2021

Hydrogels, due to their excellent biochemical and mechnical property, have shown attractive advantages in the field of wound dressings. However, a comprehensive review functional hydrogel as dressing is still lacking. This work first summarizes skin healing process relates evaluation parameters then reviews advanced functions dressings such antimicrobial adhesion hemostasis, anti-inflammatory anti-oxidation, substance delivery, self-healing, stimulus response, conductivity, recently emerged monitoring feature, strategies adopted achieve these are all classified discussed. Furthermore, applications for treatment different types wounds incisional excisional summarized. Chronic also mentioned, focus attention on infected wounds, burn diabetic Finally, future directions further proposed.

Language: Английский

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Smart wound dressings for wound healing

Nano Today, Journal Year: 2021, Volume and Issue: 41, P. 101290 - 101290

Published: Sept. 22, 2021

Language: Английский

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Conductive Biomaterials as Bioactive Wound Dressing for Wound Healing and Skin Tissue Engineering

Nano-Micro Letters, Journal Year: 2021, Volume and Issue: 14(1)

Published: Dec. 2, 2021

Abstract Conductive biomaterials based on conductive polymers, carbon nanomaterials, or inorganic nanomaterials demonstrate great potential in wound healing and skin tissue engineering, owing to the similar conductivity human skin, good antioxidant antibacterial activities, electrically controlled drug delivery, photothermal effect. However, a review highlights design application of for engineering is lacking. In this review, fabrication methods with various structural forms including film, nanofiber, membrane, hydrogel, sponge, foam, acellular dermal matrix applications corresponding mechanism promoting process were summarized. The approaches that realize their value wounds via three main strategies (electrotherapy, dressing, assessment) reviewed. as dressing when facing different acute chronic (infected diabetic wound) monitoring discussed detail. challenges perspectives designing developing multifunctional are proposed well.

Language: Английский

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Green Tea Derivative Driven Smart Hydrogels with Desired Functions for Chronic Diabetic Wound Treatment

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(18)

Published: Feb. 1, 2021

Abstract Current treatments for chronic diabetic wounds remain unsatisfactory due to the lack of ideal wound dressings that can integrate matching mechanical strength, fast self‐healability, facile dressing change, and multiple therapeutic effects into one system. In this work, benefiting from catechol groups effect epigallocatechin‐3‐gallate (EGCG, green tea derivative), a smart hydrogel be conveniently obtained through copolymerization complex formed by EGCG 3‐acrylamido phenylboronic acid (APBA) (the formation boronate ester bond) acrylamide. The resulting features adequate properties, self‐healing capability, tissue adhesiveness. Otherwise, substantial release not only realize anti‐oxidation, antibacterial, anti‐inflammatory proangiogenic effect, modulation macrophage polarization accelerate healing, but also facilitate easy change. This advanced provides effective way management may extended therapy other complicated healings.

Language: Английский

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Engineering Robust Ag‐Decorated Polydopamine Nano‐Photothermal Platforms to Combat Bacterial Infection and Prompt Wound Healing

Advanced Science, Journal Year: 2022, Volume and Issue: 9(11)

Published: Feb. 22, 2022

Polydopamine (PDA) nanoparticles have emerged as an attractive biomimetic photothermal agent in antibacterial therapy due to their ease of synthesis, good biodegradability, long-term safety, and excellent photostability. However, the therapeutic effects PDA are generally limited by low conversion efficiency (PCE). Herein, PDA@Ag synthesized via growing Ag on surface then encapsulated into a cationic guar gum (CG) hydrogel network. The optimized CG/PDA@Ag platform exhibits high PCE (38.2%), which is more than two times higher that pure (16.6%). More importantly, formulated with many active groups can capture kill bacteria through effective interactions between bacteria, thereby benefiting effect. As anticipated, designed system combined advantages (high PCE) (preventing aggregation possessing inherent ability) demonstrated superior efficacy both vitro vivo. This study develops facile approach boost for therapy, providing significant step forward advancing application nano-photothermal agents.

Language: Английский

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Wound microenvironment self-adaptive hydrogel with efficient angiogenesis for promoting diabetic wound healing

Bioactive Materials, Journal Year: 2022, Volume and Issue: 20, P. 561 - 573

Published: July 1, 2022

Neovascularization is critical to improve the diabetic microenvironment, deliver abundant nutrients wound and promote closure. However, excess of oxidative stress impedes healing process. Herein, a self-adaptive multifunctional hydrogel with self-healing property injectability fabricated through boronic ester-based reaction between phenylboronic acid groups 3-carboxyl-4-fluorophenylboronic -grafted quaternized chitosan hydroxyl polyvinyl alcohol, in which pro-angiogenic drug desferrioxamine (DFO) loaded form gelatin microspheres (DFO@G). The ester bonds can self-adaptively react hyperglycemic hydrogen peroxide alleviate release DFO@G early phase healing. A sustained DFO then realized by responding overexpressed matrix metalloproteinases. In full-thickness model, accelerates angiogenesis upregulating expression hypoxia-inducible factor-1 angiogenic growth factors, resulting collagen deposition rapid This not only change microenvironment pro-healing state decreasing stress, but also respond metalloproteinases DFO. has potential for treating wounds.

Language: Английский

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Multifunctional Injectable Hydrogel Dressings for Effectively Accelerating Wound Healing: Enhancing Biomineralization Strategy

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(23)

Published: March 31, 2021

Abstract Bacterial infection can cause chronic nonhealing wounds, which may be a great threat to public health. It is highly desirable develop an injectable wound dressing hydrogel with multifunctions including self‐healing, remodeling, antibacterial, radical scavenging ability, and excellent photothermal properties promote the regeneration of damaged tissues in clinical practice. In this work, dopamine‐modified gelatin (Gel‐DA) employed for first time as biotemplate enhancing biomineralization ability synthesize gelatin@Ag nanoparticles (Gel‐DA@Ag NPs). Further, prepared Gel‐DA@Ag NPs antioxidant activity near‐infrared (NIR) laser irradiation synergistic antibacterial behavior are fixed guar gum based hydrogels through formation borate/didiol bonds possess remolding, injectable, self‐healing performance. addition, multifunctional completely cover irregular shape prevent secondary injury. More importantly, these platforms under NIR significantly accelerate healing more skin appendages like hair follicles blood vessels appearing. Therefore, it expected that serve competitive dressings biomedical field, bacteria‐derived other tissue repair related reactive oxygen species overexpression.

Language: Английский

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Research status of self-healing hydrogel for wound management: A review

International Journal of Biological Macromolecules, Journal Year: 2020, Volume and Issue: 164, P. 2108 - 2123

Published: Aug. 13, 2020

Language: Английский

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Noncompressible Hemostasis and Bone Regeneration Induced by an Absorbable Bioadhesive Self‐Healing Hydrogel

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(22)

Published: Feb. 28, 2021

Bone bleeding and bone defects arising from trauma or tumor resection pose a great threat to patients they are challenging problems orthopedic surgeons. Traditional hemostatic materials not suitable for fractures where compression cannot be applied, neither effective during surgeries large amounts of body fluids prevent them adhering the irregular wound sites. This research introduces catechol-conjugated chitosan (CHI-C) multi-functional hydrogel with adhesion, self-healing, cytocompatibility, hemocompatibility, blood cell coagulation capacity. The can injected into internal sites defective areas, then rapidly self-heals (within 2 min) an integrated that fully fills strongly sticks areas in presence surgery. In vivo experiments using rabbit ilium defect model demonstrate quick hemostasis after is applied loss only ¼ compared untreated injuries. addition, regeneration interfered by no longer visible disappearance 4 weeks. potentially valuable clinical applications towards tissue hemostasis, regeneration.

Language: Английский

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Flexible Bicolorimetric Polyacrylamide/Chitosan Hydrogels for Smart Real‐Time Monitoring and Promotion of Wound Healing

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(34)

Published: June 17, 2021

Abstract Real‐time monitoring of wound healing remains a major challenge in clinical tissue regeneration, calling the need for development biomaterial‐guided on‐site technology. In this study, multifunctional double colorimetry‐integrated polyacrylamide‐quaternary ammonium chitosan‐carbon quantum dots (CQDs)‐phenol red hydrogels are presented, aiming to simultaneously detect pH level, reduce bacterial infection, and promote healing. The hybridization CQDs indicator (phenol red) with enables their high responsiveness, reversibility, accurate indication variability reflect dynamic status context both ultraviolet visible light. Furthermore, these visual images can be collected by smartphones converted into signals, allowing real‐time evaluation conditions remote approach. Notably, exhibit excellent hemostatic adhesive properties, maintain sufficient moisture, via antibacterial activity (against Staphylococcus Aureus , Escherichia Coli ) skin repair function. Overall, resulting have potential as novel smart flexible dressing platform theranostic regeneration.

Language: Английский

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