Conductive Biomaterials as Bioactive Wound Dressing for Wound Healing and Skin Tissue Engineering

Nano-Micro Letters, Journal Year: 2021, Volume and Issue: 14(1)

Published: Dec. 2, 2021

Abstract Conductive biomaterials based on conductive polymers, carbon nanomaterials, or inorganic nanomaterials demonstrate great potential in wound healing and skin tissue engineering, owing to the similar conductivity human skin, good antioxidant antibacterial activities, electrically controlled drug delivery, photothermal effect. However, a review highlights design application of for engineering is lacking. In this review, fabrication methods with various structural forms including film, nanofiber, membrane, hydrogel, sponge, foam, acellular dermal matrix applications corresponding mechanism promoting process were summarized. The approaches that realize their value wounds via three main strategies (electrotherapy, dressing, assessment) reviewed. as dressing when facing different acute chronic (infected diabetic wound) monitoring discussed detail. challenges perspectives designing developing multifunctional are proposed well.

Language: Английский

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pH/Glucose Dual Responsive Metformin Release Hydrogel Dressings with Adhesion and Self-Healing via Dual-Dynamic Bonding for Athletic Diabetic Foot Wound Healing

ACS Nano, Journal Year: 2022, Volume and Issue: 16(2), P. 3194 - 3207

Published: Jan. 31, 2022

In view of the lack a specific drug-sustained release system that is responsive to chronic wounds type II diabetic foot, and demands for frequent movement at foot wound, pH/glucose dual-responsive metformin-released adhesion-enhanced self-healing easy-removable antibacterial antioxidant conductive hemostasis multifunctional phenylboronic acid benzaldehyde bifunctional polyethylene glycol-co-poly(glycerol sebacic acid)/dihydrocaffeic l-arginine cografted chitosan (PEGS-PBA-BA/CS-DA-LAG, denoted as PC) hydrogel dressings were constructed based on double dynamic bond Schiff-base phenylboronate ester. It was further demonstrated PC promotes wound healing by reducing inflammation enhancing angiogenesis in rat model. addition, addition metformin (Met) graphene oxide (GO), well their synergy, confirmed better promote repair vivo. summary, PC/GO/Met hydrogels with stimuli-responsive ability easy removability have shown promoting effect athletic provide local-specific drug dual-response strategy treatment feet.

Language: Английский

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Multifunctional Photoactive Hydrogels for Wound Healing Acceleration

ACS Nano, Journal Year: 2021, Volume and Issue: 15(12), P. 18895 - 18930

Published: Dec. 6, 2021

Light is an attractive tool that has a profound impact on modern medicine. Particularly, light-based photothermal therapy (PTT) and photodynamic (PDT) show great application prospects in the prevention of wound infection promoting healing. In addition, hydrogels have shown advantages field dressings due to their excellent biochemical effects. Therefore, multifunctional photoresponsive (MPRHs) integrate light are increasingly used biomedicine, especially repair. However, comprehensive review MPRHs for regeneration still lacking. This first focuses various types prepared by diverse photosensitizers, agents (PHTAs) including transition metal sulfide/oxides nanomaterials, nanostructure-based PHTAs, carbon-based conjugated polymer or complex-based and/or (PHDAs) such as ZnO-based, black-phosphorus-based, TiO2-based, small organic molecule-based PHDAs. We also then discuss how PTT, PDT, photothermal/photodynamic synergistic can modulate microenvironments bacteria inhibit infection. Overall, with both therapeutic tissue capabilities been discussed existing challenges, well future research directions management argued.

Language: Английский

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Wound Dressing: From Nanomaterials to Diagnostic Dressings and Healing Evaluations

ACS Nano, Journal Year: 2022, Volume and Issue: 16(2), P. 1708 - 1733

Published: Jan. 20, 2022

Wound dressings based on nanomaterials play a crucial role in wound treatment and are widely used whole range of medical settings, from minor to life-threatening tissue injuries. This article presents an educational review the accumulating knowledge this multidisciplinary area lay out challenges opportunities that lie ahead ignite further faster development clinically valuable technologies. The analyzes functional advantages nanomaterial-based gauzes hydrogels as well hybrid structures thereof. On basis, state-of-the-art advances transfer (semi)blind approaches evaluation state smart enable real-time monitoring diagnostic functions could help during healing. explores translation related aspects into real-world use. ongoing future associated with clinical decisions presented reviewed.

Language: Английский

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Antibacterial biomaterials for skin wound dressing

Asian Journal of Pharmaceutical Sciences, Journal Year: 2022, Volume and Issue: 17(3), P. 353 - 384

Published: Jan. 24, 2022

Bacterial infection and the ever-increasing bacterial resistance have imposed severe threat to human health. And contamination could significantly menace wound healing process. Considering sophisticated process, novel strategies for skin tissue engineering are focused on integration of bioactive ingredients, antibacterial agents included, into biomaterials with different morphologies improve cell behaviors promote healing. However, a comprehensive review anti-bacterial dressing enhance has not been reported. In this review, various as dressings will be discussed. Different kinds agents, including antibiotics, nanoparticles (metal metallic oxides, light-induced agents), cationic organic others, their recent advances summarized. Biomaterial selection fabrication structures forms, films, hydrogel, electrospun nanofibers, sponge, foam three-dimension (3D) printed scaffold regeneration, elaborated Current challenges future perspectives presented in multidisciplinary field. We envision that provide general insight elegant design further refinement dressing.

Language: Английский

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Antibacterial adhesive self-healing hydrogels to promote diabetic wound healing

Acta Biomaterialia, Journal Year: 2022, Volume and Issue: 146, P. 119 - 130

Published: April 25, 2022

Language: Английский

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Bioinspired Injectable Self-Healing Hydrogel Sealant with Fault-Tolerant and Repeated Thermo-Responsive Adhesion for Sutureless Post-Wound-Closure and Wound Healing

Nano-Micro Letters, Journal Year: 2022, Volume and Issue: 14(1)

Published: Sept. 13, 2022

Hydrogels with multifunctionalities, including sufficient bonding strength, injectability and self-healing capacity, responsive-adhesive ability, fault-tolerant repeated tissue adhesion, are urgently demanded for invasive wound closure healing. Motivated by the adhesive mechanism of mussel brown algae, bioinspired dynamic bonds cross-linked multifunctional hydrogel is designed based on sodium alginate (SA), gelatin (GT) protocatechualdehyde, ferric ions added, sutureless post-wound-closure. The through Schiff base bond, catechol-Fe coordinate bond strong interaction between GT temperature-dependent phase transition SA, endows resulting mechanical strength efficient closure, reopened wounds. Moreover, properties endowed mispositioning to be removed/repositioned, which conducive adhesion adhesives during surgery. Besides, hydrogels present good biocompatibility, near-infrared-assisted photothermal antibacterial activity, antioxidation thermo-responsive reversible hemostatic effect. in vivo incision evaluation demonstrated their capability promote post-wound-closure healing incisions, indicating that developed dressing could serve as versatile sealant.

Language: Английский

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All-in-one: Harnessing multifunctional injectable natural hydrogels for ordered therapy of bacteria-infected diabetic wounds

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 439, P. 135691 - 135691

Published: March 9, 2022

Language: Английский

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A stretchable wireless wearable bioelectronic system for multiplexed monitoring and combination treatment of infected chronic wounds

Science Advances, Journal Year: 2023, Volume and Issue: 9(12)

Published: March 24, 2023

Chronic nonhealing wounds are one of the major and rapidly growing clinical complications all over world. Current therapies frequently require emergent surgical interventions, while abuse misapplication therapeutic drugs often lead to an increased morbidity mortality rate. Here, we introduce a wearable bioelectronic system that wirelessly continuously monitors physiological conditions wound bed via custom-developed multiplexed multimodal electrochemical biosensor array performs noninvasive combination therapy through controlled anti-inflammatory antimicrobial treatment electrically stimulated tissue regeneration. The patch is fully biocompatible, mechanically flexible, stretchable, can conformally adhere skin throughout entire healing process. Real-time metabolic inflammatory monitoring in series preclinical vivo experiments showed high accuracy stability for spatial temporal biomarker analysis. enabled substantially accelerated cutaneous chronic rodent model.

Language: Английский

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Recent Advances in the Development and Antimicrobial Applications of Metal–Phenolic Networks

Advanced Science, Journal Year: 2022, Volume and Issue: 9(27)

Published: July 25, 2022

Due to the abuse of antibiotics and emergence multidrug resistant microorganisms, medical devices, related biomaterials are at high risk microbial infection during use, placing a heavy burden on patients healthcare systems. Metal-phenolic networks (MPNs), an emerging organic-inorganic hybrid network system developed gradually in recent years, have exhibited excellent multifunctional properties such as anti-inflammatory, antioxidant, antibacterial by making use coordination between phenolic ligands metal ions. Further, MPNs received widespread attention antimicrobial infections due their facile synthesis process, biocompatibility, brought about polyphenols In this review, different categories based (nanoparticles, coatings, capsules, hydrogels) fabrication strategies summarized, research advances applications biomedical fields (e.g., skin repair, bone regeneration, etc.) highlighted.

Language: Английский

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