First‐Aid Hydrogel Wound Dressing with Reliable Hemostatic and Antibacterial Capability for Traumatic Injuries DOI

Junyao Cheng,

Hufei Wang, Jianpeng Gao

et al.

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(25)

Published: June 19, 2023

First-aid for severe traumatic injuries in the battlefield or pre-hospital environment, especially skin defects visceral rupture, remains a substantial medical challenge even context of rapidly evolving modern technology. Hydrogel-based biomaterials are highly anticipated excellent biocompatibility and bio-functional designability. Yet, inadequate mechanical bio-adhesion properties limit their clinical application. To address these challenges, kind multifunctional hydrogel wound dressing is developed with collective multi-crosslinking advantages dynamic covalent bonds, metal-catechol chelation, hydrogen bonds. The mussel-inspired design zinc oxide-enhanced cohesion strategy collaboratively reinforce hydrogel's bloody humoral environments. pH-sensitive coordinate Zn2+ -catechol bond Schiff base reversible breakage reformation equip self-healing on-demand removal properties. In vivo evaluation rat ventricular perforation model Methicillin-resistant Staphylococcus aureus (MRSA)-infected full-thickness defect reveal hemostatic, antibacterial pro-healing effectiveness dressing, demonstrating its great potential dealing bleeding infected wounds.

Language: Английский

Fabrication of physical and chemical crosslinked hydrogels for bone tissue engineering DOI Creative Commons
Xue Xu, Yan Hu, Sicheng Wang

et al.

Bioactive Materials, Journal Year: 2021, Volume and Issue: 12, P. 327 - 339

Published: Oct. 26, 2021

Bone tissue engineering has emerged as a significant research area that provides promising novel tools for the preparation of biomimetic hydrogels applied in bone-related diseases (e.g., bone defects, cartilage damage, osteoarthritis, etc.). Herein, thermal sensitive polymers PNIPAAm, Soluplus, etc.) were introduced into main chains to fabricate with injectability and compatibility those defect need minimally invasive surgery. Mineral ions calcium, copper, zinc, magnesium), an indispensable role maintaining balance organism, linked polymer form functional accelerating regeneration. In chemically triggered hydrogel section, advanced crosslinked by different molecular agents genipin, dopamine, caffeic acid, tannic acid) possess many advantages, including extensive selectivity, rapid gel-forming capacity tunable mechanical property. Additionally, photo crosslinking response mild condition can be photoinitiators I2959, LAP, eosin Y, riboflavin, under specific wavelength light. Moreover, enzyme also utilized regeneration due its excellent biocompatibility. Particularly, some key factors determine therapy effect mentioned. Finally, brief summaries remaining issues on how properly design clinical-oriented provided this review.

Language: Английский

Citations

351

Versatile polyphenolic platforms in regulating cell biology DOI
Huấn Cao, Lei Yang,

Rong Tian

et al.

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(10), P. 4175 - 4198

Published: Jan. 1, 2022

Polyphenolic materials are a class of fascinating and versatile bioinspired for biointerfacial engineering. In particular, due to the presence active chemical groups, series unique physicochemical properties become accessible tunable as-prepared polyphenolic platforms, which could delicately regulate cell activities via cell-material contact-dependent interactions. More interestingly, polyphenols also affect behaviors contact-independent manner, arise their intrinsically functional characteristics (e.g., antioxidant photothermal behaviors). As such, comprehensive understanding on relationship between material desired biomedical applications, as well underlying mechanism at cellular molecular level would provide design principles accelerate lab-to-clinic translation platforms. this review, we firstly give brief overview hallmarks governed by surrounding cues, followed introduction engineering strategies. Subsequently, detailed discussion cell-polyphenols interfacial interaction was carefully provided. Lastly, applications were elaborated. We believe that review guidances rational multifunctional extend application window.

Language: Английский

Citations

133

A review of the properties and applications of bioadhesive hydrogels DOI
Yingshuo Xiong, Xiaoran Zhang, Xintao Ma

et al.

Polymer Chemistry, Journal Year: 2021, Volume and Issue: 12(26), P. 3721 - 3739

Published: Jan. 1, 2021

Due to their outstanding properties, bioadhesive hydrogels have been extensively studied by researchers in recent years.

Language: Английский

Citations

126

Smart/stimuli-responsive hydrogels: State-of-the-art platforms for bone tissue engineering DOI

Hussein M. El‐Husseiny,

Eman A. Mady, Walaa A. El‐Dakroury

et al.

Applied Materials Today, Journal Year: 2022, Volume and Issue: 29, P. 101560 - 101560

Published: June 22, 2022

Language: Английский

Citations

88

Intelligent Vascularized 3D/4D/5D/6D-Printed Tissue Scaffolds DOI Creative Commons
Xiaoyu Han, Qimanguli Saiding,

Xiaolu Cai

et al.

Nano-Micro Letters, Journal Year: 2023, Volume and Issue: 15(1)

Published: Oct. 31, 2023

Abstract Blood vessels are essential for nutrient and oxygen delivery waste removal. Scaffold-repairing materials with functional vascular networks widely used in bone tissue engineering. Additive manufacturing is a technology that creates three-dimensional solids by stacking substances layer layer, mainly including but not limited to 3D printing, also 4D 5D printing 6D printing. It can be effectively combined vascularization meet the needs of vascularized scaffolds precisely tuning mechanical structure biological properties smart scaffolds. Herein, development neovascularization engineering systematically discussed terms importance tissue. Additionally, research progress future prospects printed scaffold highlighted presented four categories: scaffolds, cell-based loaded specific carriers bionic Finally, brief review additive manufacturing-tissue related tissues such as engineering, cardiovascular system, skeletal muscle, soft discussion challenges efforts leading significant advances intelligent regeneration presented.

Language: Английский

Citations

56

Recent Progress in Hyaluronic-Acid-Based Hydrogels for Bone Tissue Engineering DOI Creative Commons

Hee Sook Hwang,

Chung‐Sung Lee

Gels, Journal Year: 2023, Volume and Issue: 9(7), P. 588 - 588

Published: July 21, 2023

Hydrogel-based bone tissue engineering is a potential strategy for treating abnormalities and fractures. Hyaluronic acid (HA) natural polymer that widely distributed in the human body plays significant role numerous physiological processes such as cell migration, hydration, wound healing. Hydrogels based on HA its derivatives have gained popularity treatments bone-related diseases. HA-based hydrogels been extensively studied their ability to mimic extracellular matrix of provide suitable microenvironment support regeneration. The physical chemical properties can be modified improve mechanical strength, biocompatibility, osteogenic potential. Moreover, combined with other biomaterials presence or absence bioactive agents investigated means improving bioactivity hydrogel scaffold. Therefore, shown great promise due activity, tissue. Overall, this review provides comprehensive overview current state art engineering, highlighting key advances, challenges, future directions rapidly evolving field.

Language: Английский

Citations

52

Silicon-containing nanomedicine and biomaterials: materials chemistry, multi-dimensional design, and biomedical application DOI
Liang Chen, Shanshan Zhang,

Yanqiu Duan

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(3), P. 1167 - 1315

Published: Jan. 1, 2024

Silicon-based biomaterials have been extensively developed in the past decades. The classification, characteristics, multi-dimensional design, and biomedical applications of silicon-containing are comprehensively elaborated.

Language: Английский

Citations

39

Physical strategies to engineer supramolecular composite hydrogels for advanced biomedical applications DOI

Sravan Baddi,

Auphedeous Y. Dang-i,

Fengli Gao

et al.

Progress in Materials Science, Journal Year: 2025, Volume and Issue: 151, P. 101428 - 101428

Published: Jan. 9, 2025

Language: Английский

Citations

4

Nutrient Element Decorated Polyetheretherketone Implants Steer Mitochondrial Dynamics for Boosted Diabetic Osseointegration DOI
Hao Wang,

Xinliang Fu,

Jiacheng Shi

et al.

Advanced Science, Journal Year: 2021, Volume and Issue: 8(20)

Published: Aug. 16, 2021

As a chronic metabolic disease, diabetes mellitus (DM) creates hyperglycemic micromilieu around implants, resulting inthe high complication and failure rate of implantation because mitochondrial dysfunction in hyperglycemia. To address the daunting issue, authors innovatively devised developed mitochondria-targeted orthopedic implants consisted nutrient element coatings polyetheretherketone (PEEK). Dual elements, modality ZnO Sr(OH)2 , are assembled onto sulfonated PEEK surface (Zn&Sr-SPEEK). The results indicate synergistic liberation Zn2+ Sr2+ from coating massacres pathogenic bacteria dramatically facilitates cyto-activity osteoblasts upon niche. Intriguingly, Zn&Sr-SPEEK demonstrated to have robust ability recuperate hyperglycemia-induced dynamic disequilibrium by means Dynamin-related protein 1 (Drp1) gene down-regulation, membrane potential (MMP) resurgence, reactive oxygen species (ROS) elimination, ultimately enhancing osteogenicity osteoblasts. In vivo evaluations utilizing diabetic rat femoral/tibia defect model at 4 8 weeks further confirm that substantially augment bone remodeling osseointegration. Altogether, this study not only reveals importance modulation on dynamics contributes formation osseointegration, but also provides novel implant for patients with capability.

Language: Английский

Citations

96

Advanced PLGA hybrid scaffold with a bioactive PDRN/BMP2 nanocomplex for angiogenesis and bone regeneration using human fetal MSCs DOI Creative Commons
Da‐Seul Kim, Jun‐Kyu Lee,

Jun Hyuk Kim

et al.

Science Advances, Journal Year: 2021, Volume and Issue: 7(50)

Published: Dec. 8, 2021

Nanocomplex immobilized scaffold effects on anti-inflammation, antibacterial activity, angiogenesis, and bone regeneration.

Language: Английский

Citations

81