Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
12(25)
Published: June 19, 2023
First-aid
for
severe
traumatic
injuries
in
the
battlefield
or
pre-hospital
environment,
especially
skin
defects
visceral
rupture,
remains
a
substantial
medical
challenge
even
context
of
rapidly
evolving
modern
technology.
Hydrogel-based
biomaterials
are
highly
anticipated
excellent
biocompatibility
and
bio-functional
designability.
Yet,
inadequate
mechanical
bio-adhesion
properties
limit
their
clinical
application.
To
address
these
challenges,
kind
multifunctional
hydrogel
wound
dressing
is
developed
with
collective
multi-crosslinking
advantages
dynamic
covalent
bonds,
metal-catechol
chelation,
hydrogen
bonds.
The
mussel-inspired
design
zinc
oxide-enhanced
cohesion
strategy
collaboratively
reinforce
hydrogel's
bloody
humoral
environments.
pH-sensitive
coordinate
Zn2+
-catechol
bond
Schiff
base
reversible
breakage
reformation
equip
self-healing
on-demand
removal
properties.
In
vivo
evaluation
rat
ventricular
perforation
model
Methicillin-resistant
Staphylococcus
aureus
(MRSA)-infected
full-thickness
defect
reveal
hemostatic,
antibacterial
pro-healing
effectiveness
dressing,
demonstrating
its
great
potential
dealing
bleeding
infected
wounds.
Bioactive Materials,
Journal Year:
2021,
Volume and Issue:
12, P. 327 - 339
Published: Oct. 26, 2021
Bone
tissue
engineering
has
emerged
as
a
significant
research
area
that
provides
promising
novel
tools
for
the
preparation
of
biomimetic
hydrogels
applied
in
bone-related
diseases
(e.g.,
bone
defects,
cartilage
damage,
osteoarthritis,
etc.).
Herein,
thermal
sensitive
polymers
PNIPAAm,
Soluplus,
etc.)
were
introduced
into
main
chains
to
fabricate
with
injectability
and
compatibility
those
defect
need
minimally
invasive
surgery.
Mineral
ions
calcium,
copper,
zinc,
magnesium),
an
indispensable
role
maintaining
balance
organism,
linked
polymer
form
functional
accelerating
regeneration.
In
chemically
triggered
hydrogel
section,
advanced
crosslinked
by
different
molecular
agents
genipin,
dopamine,
caffeic
acid,
tannic
acid)
possess
many
advantages,
including
extensive
selectivity,
rapid
gel-forming
capacity
tunable
mechanical
property.
Additionally,
photo
crosslinking
response
mild
condition
can
be
photoinitiators
I2959,
LAP,
eosin
Y,
riboflavin,
under
specific
wavelength
light.
Moreover,
enzyme
also
utilized
regeneration
due
its
excellent
biocompatibility.
Particularly,
some
key
factors
determine
therapy
effect
mentioned.
Finally,
brief
summaries
remaining
issues
on
how
properly
design
clinical-oriented
provided
this
review.
Chemical Society Reviews,
Journal Year:
2022,
Volume and Issue:
51(10), P. 4175 - 4198
Published: Jan. 1, 2022
Polyphenolic
materials
are
a
class
of
fascinating
and
versatile
bioinspired
for
biointerfacial
engineering.
In
particular,
due
to
the
presence
active
chemical
groups,
series
unique
physicochemical
properties
become
accessible
tunable
as-prepared
polyphenolic
platforms,
which
could
delicately
regulate
cell
activities
via
cell-material
contact-dependent
interactions.
More
interestingly,
polyphenols
also
affect
behaviors
contact-independent
manner,
arise
their
intrinsically
functional
characteristics
(e.g.,
antioxidant
photothermal
behaviors).
As
such,
comprehensive
understanding
on
relationship
between
material
desired
biomedical
applications,
as
well
underlying
mechanism
at
cellular
molecular
level
would
provide
design
principles
accelerate
lab-to-clinic
translation
platforms.
this
review,
we
firstly
give
brief
overview
hallmarks
governed
by
surrounding
cues,
followed
introduction
engineering
strategies.
Subsequently,
detailed
discussion
cell-polyphenols
interfacial
interaction
was
carefully
provided.
Lastly,
applications
were
elaborated.
We
believe
that
review
guidances
rational
multifunctional
extend
application
window.
Nano-Micro Letters,
Journal Year:
2023,
Volume and Issue:
15(1)
Published: Oct. 31, 2023
Abstract
Blood
vessels
are
essential
for
nutrient
and
oxygen
delivery
waste
removal.
Scaffold-repairing
materials
with
functional
vascular
networks
widely
used
in
bone
tissue
engineering.
Additive
manufacturing
is
a
technology
that
creates
three-dimensional
solids
by
stacking
substances
layer
layer,
mainly
including
but
not
limited
to
3D
printing,
also
4D
5D
printing
6D
printing.
It
can
be
effectively
combined
vascularization
meet
the
needs
of
vascularized
scaffolds
precisely
tuning
mechanical
structure
biological
properties
smart
scaffolds.
Herein,
development
neovascularization
engineering
systematically
discussed
terms
importance
tissue.
Additionally,
research
progress
future
prospects
printed
scaffold
highlighted
presented
four
categories:
scaffolds,
cell-based
loaded
specific
carriers
bionic
Finally,
brief
review
additive
manufacturing-tissue
related
tissues
such
as
engineering,
cardiovascular
system,
skeletal
muscle,
soft
discussion
challenges
efforts
leading
significant
advances
intelligent
regeneration
presented.
Gels,
Journal Year:
2023,
Volume and Issue:
9(7), P. 588 - 588
Published: July 21, 2023
Hydrogel-based
bone
tissue
engineering
is
a
potential
strategy
for
treating
abnormalities
and
fractures.
Hyaluronic
acid
(HA)
natural
polymer
that
widely
distributed
in
the
human
body
plays
significant
role
numerous
physiological
processes
such
as
cell
migration,
hydration,
wound
healing.
Hydrogels
based
on
HA
its
derivatives
have
gained
popularity
treatments
bone-related
diseases.
HA-based
hydrogels
been
extensively
studied
their
ability
to
mimic
extracellular
matrix
of
provide
suitable
microenvironment
support
regeneration.
The
physical
chemical
properties
can
be
modified
improve
mechanical
strength,
biocompatibility,
osteogenic
potential.
Moreover,
combined
with
other
biomaterials
presence
or
absence
bioactive
agents
investigated
means
improving
bioactivity
hydrogel
scaffold.
Therefore,
shown
great
promise
due
activity,
tissue.
Overall,
this
review
provides
comprehensive
overview
current
state
art
engineering,
highlighting
key
advances,
challenges,
future
directions
rapidly
evolving
field.
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
53(3), P. 1167 - 1315
Published: Jan. 1, 2024
Silicon-based
biomaterials
have
been
extensively
developed
in
the
past
decades.
The
classification,
characteristics,
multi-dimensional
design,
and
biomedical
applications
of
silicon-containing
are
comprehensively
elaborated.
Advanced Science,
Journal Year:
2021,
Volume and Issue:
8(20)
Published: Aug. 16, 2021
As
a
chronic
metabolic
disease,
diabetes
mellitus
(DM)
creates
hyperglycemic
micromilieu
around
implants,
resulting
inthe
high
complication
and
failure
rate
of
implantation
because
mitochondrial
dysfunction
in
hyperglycemia.
To
address
the
daunting
issue,
authors
innovatively
devised
developed
mitochondria-targeted
orthopedic
implants
consisted
nutrient
element
coatings
polyetheretherketone
(PEEK).
Dual
elements,
modality
ZnO
Sr(OH)2
,
are
assembled
onto
sulfonated
PEEK
surface
(Zn&Sr-SPEEK).
The
results
indicate
synergistic
liberation
Zn2+
Sr2+
from
coating
massacres
pathogenic
bacteria
dramatically
facilitates
cyto-activity
osteoblasts
upon
niche.
Intriguingly,
Zn&Sr-SPEEK
demonstrated
to
have
robust
ability
recuperate
hyperglycemia-induced
dynamic
disequilibrium
by
means
Dynamin-related
protein
1
(Drp1)
gene
down-regulation,
membrane
potential
(MMP)
resurgence,
reactive
oxygen
species
(ROS)
elimination,
ultimately
enhancing
osteogenicity
osteoblasts.
In
vivo
evaluations
utilizing
diabetic
rat
femoral/tibia
defect
model
at
4
8
weeks
further
confirm
that
substantially
augment
bone
remodeling
osseointegration.
Altogether,
this
study
not
only
reveals
importance
modulation
on
dynamics
contributes
formation
osseointegration,
but
also
provides
novel
implant
for
patients
with
capability.
