3D printing of PLA/n-HA composite scaffolds with customized mechanical properties and biological functions for bone tissue engineering

Composites Part B Engineering, Journal Year: 2021, Volume and Issue: 224, P. 109192 - 109192

Published: Aug. 3, 2021

Language: Английский

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Recent advances in 3D-printed polylactide and polycaprolactone-based biomaterials for tissue engineering applications

International Journal of Biological Macromolecules, Journal Year: 2022, Volume and Issue: 218, P. 930 - 968

Published: July 24, 2022

Language: Английский

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Unraveling of Advances in 3D-Printed Polymer-Based Bone Scaffolds

Polymers, Journal Year: 2022, Volume and Issue: 14(3), P. 566 - 566

Published: Jan. 30, 2022

The repair of large-area irregular bone defects is one the complex problems in orthopedic clinical treatment. scaffolds currently studied include electrospun membrane, hydrogel, cement, 3D printed tissue scaffolds, etc., among which polymer-based Bone are most promising for applications. This because printing modeled based on im-aging results actual so that can perfectly fit defect, and components be adjusted to promote Osteogenesis. review introduces a variety technologies healing processes, reviews previous studies characteristics commonly used natural or synthetic polymers, applications analyzes elaborates ideal from t he progress were summarized many aspects. challenges potential prospects this direction discussed.

Language: Английский

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Polymeric biomaterials for 3D printing in medicine: An overview

Annals of 3D Printed Medicine, Journal Year: 2021, Volume and Issue: 2, P. 100011 - 100011

Published: April 9, 2021

Three-dimensional (3D) printing is becoming a booming technology to fabricate scaffolds, orthoses, and prosthetic devices for tissue engineering, regenerative medicine, rehabilitation patients with disabling neurological diseases (such as amyotrophic lateral sclerosis, traumatic brain injuries, spinal cord injuries). This due the potential of 3D provide patient-specific designs, high structural complexity, rapid on-demand fabrication at low-cost. However, one major bottlenecks that limits widespread acceptance biomedical manufacturing lack polymers, biomaterials, hydrogels, bioinks functional printing, biocompatible, more performing from biomechanical point view meet different needs. As matter fact field still struggling processing such materials into self-supporting tunable biomechanics, optimal structures, degradation, bioactivity. Here, will be highlighted all recent advances have been made in biomedicine, analyzing bioinks, according their printability, ease processability, cost, properties mechanics, biocompatibility, degradation rate. Finally, future considerations bio-fabrication discussed.

Language: Английский

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Nano-Hydroxyapatite Composite Scaffolds Loaded with Bioactive Factors and Drugs for Bone Tissue Engineering

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(2), P. 1291 - 1291

Published: Jan. 9, 2023

Nano-hydroxyapatite (n-HAp) is similar to human bone mineral in structure and biochemistry is, therefore, widely used as biomaterial a drug carrier. Further, n-HAp composite scaffolds have great potential role regeneration. Loading bioactive factors drugs onto composites has emerged promising strategy for defect repair tissue engineering. With local delivery of agents drugs, biological materials may be provided with the activity they lack improve This review summarizes classification composites, application loaded engineering loading methods scaffolds, research direction future prospected.

Language: Английский

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Design, printing, and engineering of regenerative biomaterials for personalized bone healthcare

Progress in Materials Science, Journal Year: 2023, Volume and Issue: 134, P. 101072 - 101072

Published: Jan. 16, 2023

Language: Английский

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Recent Advances in the Additive Manufacturing of Stimuli‐Responsive Soft Polymers

Advanced Engineering Materials, Journal Year: 2023, Volume and Issue: 25(21)

Published: Aug. 29, 2023

Stimuli‐responsive polymers (SRPs) are special types of soft materials, which have been extensively used for developing flexible actuators, robots, wearable devices, sensors, self‐expanding structures, and biomedical thanks to their ability change shapes functional properties in response external stimuli including light, humidity, heat, pH, electric field, solvent, magnetic field or combinations two more these stimuli. In recent years, additive manufacturing (AM) aka 3D printing technology SRPs, also known as 4D printing, has gained phenomenal attention different engineering fields, its unique develop complex, personalized, innovative undergo twisting, elongating, swelling, rolling, shrinking, bending, spiraling, other complex morphological transformations. Herein, an effort made provide insightful information about the AM techniques, type applications including, but not limited tissue engineering, bionics, construction, smart textiles. This article incorporates current challenges prospects, hoping basis utilization this fields. It is expected that amalgamation with SRPs would unparalleled advantages arenas.

Language: Английский

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3D printing of magneto-active smart materials for advanced actuators and soft robotics applications

European Polymer Journal, Journal Year: 2024, Volume and Issue: 205, P. 112718 - 112718

Published: Jan. 2, 2024

In the contemporary era, novel manufacturing technologies like additive (AM) have revolutionized different engineering sectors including biomedical, aerospace, electronics, etc. Four-dimensional (4D) printing aka AM of smart materials is gaining popularity among scientific community, which has excellent ability to make soft structures such as robots, actuators, and grippers. These are developed by applying various stimuli pH, temperature, magnetic field, many combinations onto materials. Stimuli in 3D permit shape-morphing behaviors bending, twisting, folding, swelling, rolling, shrinking, origami, or locomotion. A wide variety can be fabricated through incorporation hard particles into resulting magneto-active (MASMs). With this integration, magneto-thermal coupling actuation allows diverse magneto-deformations, facilitating development personalized devices that capable enhanced deformation. review, guidelines provided on for MASMs polymers (MAPs), composites, hydrogels (MAHs) booming flexible wearable biomimetic devices. Moreover, 3D-printed robotics an outstanding capacity adapt complicated situations advanced actuating applications. Finally, some current challenges emerging areas exciting technology been proposed. Lastly, it anticipated technological advancements developing intelligent will a significant impact design real-world

Language: Английский

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3D/4D printing of cellulose nanocrystals-based biomaterials: Additives for sustainable applications

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 251, P. 126287 - 126287

Published: Aug. 11, 2023

Cellulose nanocrystals (CNCs) have gained significant attraction from both industrial and academic sectors, thanks to their biodegradability, non-toxicity, renewability with remarkable mechanical characteristics. Desirable characteristics of CNCs include high stiffness, strength, excellent flexibility, large surface-to-volume ratio. Additionally, the properties can be tailored through chemical modifications for high-end applications including tissue engineering, actuating, biomedical. Modern manufacturing methods 3D/4D printing are highly advantageous developing sophisticated intricate geometries. This review highlights major developments additive manufactured CNCs, which promote sustainable solutions across a wide range applications. this contribution also presents current challenges future research directions CNC-based composites developed techniques myriad engineering sectors wound healing, wearable electronics, robotics, anti-counterfeiting Overall, will greatly help scientists chemistry, materials, biomedicine, other disciplines comprehend underlying principles, properties, additively structures.

Language: Английский

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3D printing of stimuli-responsive hydrogel materials: Literature review and emerging applications

Giant, Journal Year: 2023, Volume and Issue: 17, P. 100209 - 100209

Published: Nov. 15, 2023

Additive manufacturing (AM) aka three-dimensional (3D) printing has been a well-established and unparalleled technology, which is expanding the boundaries of materials science exhibiting an enormous potential to fabricate intricate geometries for healthcare, electronics, construction sectors. In contemporary era, combination AM technology stimuli-responsive hydrogels (SRHs) helps create dynamic functional structures with extreme accuracy, are capable changing their shape, functional, or mechanical properties in response environmental cues such as humidity, heat, light, pH, magnetic field, electric etc. 3D SRHs permits creation on-demand dynamically controllable shapes excellent control over various self-repair, self-assembly, multi-functionality, These accelerate researchers think unthinkable applications. Additively manufactured objects have shown applications like tissue engineering, drug delivery, soft robots, sensors, other biomedical devices. The current review provides recent progress SRHs, more focus on techniques, stimuli mechanisms, shape morphing behaviors, Finally, trends future roadmap additively smart different also presented, will be helpful research. This holds great promise providing fundamental knowledge about diverse

Language: Английский

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