Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(35)
Published: May 26, 2023
Cationic
photosensitizers
have
good
binding
ability
with
negatively
charged
bacteria
and
fungi,
exhibiting
broad
applications
potential
in
antimicrobial
photodynamic
therapy
(aPDT).
However,
cationic
often
display
unsatisfactory
transkingdom
selectivity
between
mammalian
cells
pathogens,
especially
for
eukaryotic
fungi.
It
is
unclear
which
biomolecular
sites
are
more
efficient
damage,
owing
to
the
lack
of
systematic
research
same
photosensitizer
system.
Herein,
a
series
aggregation-induced
emission
(AIE)
derivatives
(CABs)
(using
berberine
(BBR)
as
core)
different
length
alkyl
chains
successfully
designed
synthesized
flexible
modulation
cellular
activities.
The
BBR
core
can
efficiently
produce
reactive
oxygen
species
(ROS)
achieve
high-performance
aPDT
.
Through
precise
regulation
chain
length,
bindings,
localizations,
killing
effects
CABs
achieved
investigated
systematically
among
bacteria,
cells.
found
that
intracellular
active
substances,
not
membranes,
damage
aPDT.
Moderate
enable
effectively
kill
Gram-negative
fungi
light,
while
still
maintaining
excellent
cell
blood
compatibility.
This
study
expected
provide
theoretical
strategic
guidance
construction
selectivity.
Biomaterials Science,
Journal Year:
2022,
Volume and Issue:
10(15), P. 4058 - 4076
Published: Jan. 1, 2022
Multifunctional
wound
dressings
or
smart
with
pro-angiogenic
function,
antibacterial
properties,
anti-inflammatory/antioxidant
activity
and
tissue
adhesion
for
chronic
repair.
ACS Applied Bio Materials,
Journal Year:
2022,
Volume and Issue:
5(9), P. 4055 - 4085
Published: Aug. 18, 2022
Currently,
the
clinic's
treatment
of
acute/chronic
wounds
is
still
unsatisfactory
due
to
lack
functional
and
appropriate
wound
dressings.
Intelligent
multifunctional
dressings
are
considered
most
advanced
modalities.
It
essential
design
develop
with
required
functions
according
microenvironment
in
clinical
treatment.
This
work
summarizes
characteristics
various
common
wounds,
such
as
acute
wound,
diabetic
burns
scalded
mucosal
ulcers
wound.
Furthermore,
factors
transformation
from
chronic
were
analyzed.
Then
we
focused
on
summarizing
how
researchers
fully
thoroughly
combined
complex
modern
technology
ensure
usability
value
dressing,
photothermal-sensitive
dressings,
dressing
(pH-sensitive
ROS-sensitive
osmotic
pressure
dressings),
hemostatic
guiding
tissue
regeneration
microneedle
3D/4D
printing
Finally,
revolutionary
development
transform
existing
into
needs
soon
possible
have
carried
out
a
reasonable
meaningful
outlook.
ACS Applied Materials & Interfaces,
Journal Year:
2023,
Volume and Issue:
15(13), P. 16515 - 16525
Published: March 23, 2023
Antibacterial
hydrogel
wound
dressings
with
adhesive
and
antioxidant
activity
are
desirable
for
treating
skin
injuries
in
clinical
care.
Hereby,
a
series
of
multifunctional
high
adhesive,
self-healing,
antioxidant,
antibacterial
were
designed
fabricated
using
dopamine
(DA)
quercetin
(QT).
The
hydrogels
constructed
by
the
interpenetrated
quaternized
chitosan
chain
segments
polyacrylamide
network.
catechol
groups
on
DA,
QT,
quaternary
ammonium
system
endow
strength,
excellent
adhesion,
self-healing
ability.
results
confirmed
admirable
hemocompatibility
remarkable
multifunction
against
Staphylococcus
aureus
Escherichia
coli.
Consequently,
satisfactory
appropriate
alternative
materials
fields
tissue
dressing
applications.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(17)
Published: April 19, 2023
Chronic
wounds
in
diabetic
patients
are
challenging
because
their
prolonged
inflammation
makes
healing
difficult,
thus
burdening
patients,
society,
and
health
care
systems.
Customized
dressing
materials
needed
to
effectively
treat
such
that
vary
shape
depth.
The
continuous
development
of
3D-printing
technology
along
with
artificial
intelligence
has
increased
the
precision,
versatility,
compatibility
various
materials,
providing
considerable
potential
meet
abovementioned
needs.
Herein,
functional
inks
comprising
DNA
from
salmon
sperm
DNA-induced
biosilica
inspired
by
marine
sponges,
developed
for
machine
learning-based
wound
dressings.
biomineralized
silica
incorporated
into
hydrogel
a
fast,
facile
manner.
3D-printed
generates
provided
appropriate
porosity,
characterized
effective
exudate
blood
absorption
at
sites,
mechanical
tunability
indicated
good
fidelity
printability
during
optimized
3D
printing.
Moreover,
act
as
nanotherapeutics,
enhancing
biological
activity
dressings
terms
reactive
oxygen
species
scavenging,
angiogenesis,
anti-inflammation
activity,
thereby
accelerating
acute
healing.
These
bioinspired
hydrogels
produce
using
biomineralization
strategy
an
excellent
platform
clinical
applications
chronic
repair.
ACS Applied Materials & Interfaces,
Journal Year:
2022,
Volume and Issue:
14(28), P. 31737 - 31750
Published: July 8, 2022
Chronic
wounds
cannot
proceed
through
the
normal,
orderly,
and
timely
sequence
of
repair.
The
adverse
cycle
between
excess
reactive
oxide
species
(ROS)
a
persistent
inflammatory
response
is
an
important
mechanism
impaired
wound
healing.
Herein,
by
combining
intrinsic
bioactivities
natural
polysaccharides
drugs,
glycosaminoglycan-based
hydrogel
delivery
system
proposed
to
regulate
microenvironment.
Dynamic
supramolecular
cross-linking
enables
easily
encapsulate
drug
fully
fill
area.
As
backbone
hydrogel,
heparin
captures
chemokines
at
site,
while
hyaluronic
acid
mimics
function
ECM.
hydrophobic
curcumin
has
been
ingeniously
encapsulated
in
micellization,
thereby
exerting
good
ROS
scavenging
ability
anti-inflammatory
activity.
Evaluations
diabetic
mice
showed
that
this
antioxidant
was
effective
reducing
influx
immune
cells
site
down-regulating
response.
Accelerated
healing
also
observed,
as
evidenced
faster
re-epithelialization
better
ECM
remodeling.
can
microenvironment
from
multiple
aspects
achieve
regression
repair,
which
may
provide
new
therapeutic
strategy
for
chronic
wounds.
ACS Applied Materials & Interfaces,
Journal Year:
2023,
Volume and Issue:
15(14), P. 17562 - 17576
Published: March 6, 2023
Bioactive
hydrogels
self-assembled
from
naturally
occurring
herbal
small
molecules
are
attracting
growing
interest
for
applications
in
wound
healing,
due
to
their
versatile
intrinsic
biological
activities,
excellent
biocompatibility,
as
well
facile,
sustainable,
and
eco-friendly
processes.
However,
the
development
of
supramolecular
herb
with
sufficient
strength
multifunctionality
an
ideal
dressing
clinical
practice
remains
a
challenge.
In
this
work,
inspired
by
efficient
clinic
therapy
directed
self-assembly
natural
saponin
glycyrrhizic
acid
(GA),
we
create
novel
GA-based
hybrid
hydrogel
promote
full-thickness
healing
bacterial-infected
healing.
This
possesses
stability
mechanical
performance
multifunctional
properties,
including
injectable,
shape-adaptation
remodeling,
self-healing,
adhesive
abilities.
is
attributed
hierarchical
dual-network
that
comprises
hydrogen-bond
fibrillar
network
aldehyde-contained
GA
(AGA)
dynamic
covalent
through
Schiff
base
reaction
between
AGA
biopolymer
carboxymethyl
chitosan
(CMC).
Notably,
benefiting
inherent
strong
activity
GA,
AGA-CMC
exhibits
unique
significant
anti-inflammation
effects
antibacterial
ability,
especially
toward
Gram-positive
Staphylococcus
aureus
(S.
aureus).
vivo
experiments
demonstrate
promotes
uninfected
skin
S.
aureus-infected
enhancing
formation
granulation
tissue,
facilitating
collagen
deposition,
reducing
bacterial
infection,
downregulating
inflammatory
response.
study
highlights
design
new
bioactive
drug-food
homologous
molecules,
which
can
serve
promising
wound-healing
biomedical
applications.
