Hydrogel‐Based Growth Factor Delivery Platforms: Strategies and Recent Advances

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(5)

Published: April 3, 2023

Growth factors play a crucial role in regulating broad variety of biological processes and are regarded as powerful therapeutic agents tissue engineering regenerative medicine the past decades. However, their application is limited by short half-lives potential side effects physiological environments. Hydrogels identified having promising to prolong growth mitigate adverse restricting them within matrix reduce rapid proteolysis, burst release, unwanted diffusion. This review discusses recent progress development factor-containing hydrogels for various biomedical applications, including wound healing, brain repair, cartilage bone regeneration, spinal cord injury repair. In addition, introduces strategies optimizing factor release affinity-based delivery, carrier-assisted stimuli-responsive spatial structure-based cellular system-based delivery. Finally, presents current limitations future research directions factor-delivering hydrogels.

Language: Английский

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Designing nanozymes for in vivo applications

Nature Reviews Bioengineering, Journal Year: 2024, Volume and Issue: 2(10), P. 849 - 868

Published: July 18, 2024

Language: Английский

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Stimulus‐Responsive Hydrogels as Drug Delivery Systems for Inflammation Targeted Therapy

Advanced Science, Journal Year: 2023, Volume and Issue: 11(1)

Published: Nov. 20, 2023

Abstract Deregulated inflammations induced by various factors are one of the most common diseases in people's daily life, while severe inflammation can even lead to death. Thus, efficient treatment has always been hot topic research medicine. In past decades, as a potential biomaterial, stimuli‐responsive hydrogels have focus attention for due their excellent biocompatibility and design flexibility. Recently, thanks rapid development nanotechnology material science, more efforts made develop safer, personal effective therapy some frequent but tough such sepsis, rheumatoid arthritis, osteoarthritis, periodontitis, ulcerative colitis. Herein, from recent studies articles, conventional emerging delivery anti‐inflammatory drugs summarized. And prospects clinical translation future also discussed further detail.

Language: Английский

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Injectable hydrogels as promising in situ therapeutic platform for cartilage tissue engineering

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 261, P. 129537 - 129537

Published: Jan. 25, 2024

Language: Английский

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Organic–inorganic composite hydrogels: compositions, properties, and applications in regenerative medicine

Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(5), P. 1079 - 1114

Published: Jan. 1, 2024

Hydrogels, formed from crosslinked hydrophilic macromolecules, provide a three-dimensional microenvironment that mimics the extracellular matrix. They served as scaffold materials in regenerative medicine with an ever-growing demand. However, hydrogels composed of only organic components may not fully meet performance and functionalization requirements for various tissue defects. Composite hydrogels, containing inorganic components, have attracted tremendous attention due to their unique compositions properties. Rigid particles, rods, fibers,

Language: Английский

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Surface-activated 3D-printed PEEK implant enhances anti-infection and osteogenesis

Composites Part B Engineering, Journal Year: 2024, Volume and Issue: 273, P. 111258 - 111258

Published: Feb. 1, 2024

Language: Английский

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Biomimetic lubricating COFs with donor–acceptor structure for osteoarthritis therapy

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 687, P. 85 - 94

Published: Feb. 5, 2025

Language: Английский

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Designing functional hyaluronic acid-based hydrogels for cartilage tissue engineering

Materials Today Bio, Journal Year: 2022, Volume and Issue: 17, P. 100495 - 100495

Published: Nov. 13, 2022

Language: Английский

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Temporomandibular Joint Osteoarthritis: Pathogenic Mechanisms Involving the Cartilage and Subchondral Bone, and Potential Therapeutic Strategies for Joint Regeneration

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 24(1), P. 171 - 171

Published: Dec. 22, 2022

The temporomandibular joint (TMJ) is a specialized synovial that crucial for the movement and function of jaw. TMJ osteoarthritis (TMJ OA) result disc dislocation, trauma, functional overburden, developmental anomalies. OA affects all structures, including articular cartilage, synovium, subchondral bone, capsule, ligaments, periarticular muscles, sensory nerves innervate tissues. present review aimed to illustrate main pathomechanisms involving cartilage bone changes in some therapeutic options have shown potential restorative properties regarding these structures vivo. Chondrocyte loss, extracellular matrix (ECM) degradation, remodeling are important factors OA. actively participates through an abnormal initially characterized by loss mass, followed reparative mechanisms lead stiffness thickening condylar osteochondral interface. In recent years, such therapies as intraarticular platelet-rich plasma (PRP), hyaluronic acid (HA), mesenchymal stem cell-based treatment (MSCs) promising results with respect regeneration or protection against further damage Nevertheless, PRP MSCs more frequently associated and/or repair than HA. According findings, latter could enhance other (PRP, MSCs) when used combination, rather itself. complex disease which degenerative develop intricate mechanisms. regenerative PRP, MSCs, HA (alone various combinations) remains matter research, studies sometimes obtaining discrepant results.

Language: Английский

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Metal‐Based Nanozymes with Multienzyme‐Like Activities as Therapeutic Candidates: Applications, Mechanisms, and Optimization Strategy

Small, Journal Year: 2022, Volume and Issue: 19(7)

Published: Dec. 13, 2022

Most nanozymes in development for medical applications only exhibit single-enzyme-like activity, and are thus limited by insufficient catalytic activity dysfunctionality complex pathological microenvironments. To overcome the impediments of substrate availabilities concentrations, some metal-based may mimic two or more activities natural enzymes to catalyze cascade reactions multiple substrates simultaneously, thereby amplifying catalysis. Metal-based with multienzyme-like (MNMs) adapt dissimilar conditions exert different enzyme-like effects. These can synergize realize "self-provision substrate," which upstream catalysts produce downstream limitation microenvironment. Consequently, MNMs potent antitumor, antibacterial, anti-inflammatory effects preclinical models. This review summarizes cellular underlying mechanisms MNMs. Their potential utility optimization strategy from perspective clinical requirements also discussed, aim provide a theoretical reference design, development, therapeutic application their

Language: Английский

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