Materials Today Bio,
Journal Year:
2024,
Volume and Issue:
28, P. 101217 - 101217
Published: Aug. 24, 2024
Cold
exposure
therapy
(CE),
as
an
inexpensive
method,
has
shown
great
potential
in
cancer
therapy.
Exploring
the
combined
anti-tumor
mechanism
of
CE
and
traditional
therapies
(such
photodynamic
(PDT))
is
exciting
promising.
Here,
a
bionic
aggregation-induced
emission
photosensitizer
system
(named
THL)
designed
for
to
enhance
immunotherapy.
THL
inherits
homologous
targeting
ability
tumor
derived
exosomes,
promoting
enrichment
at
site.
Under
external
illumination,
generates
hydroxyl
radicals
superoxide
anions
through
type
I
PDT.
In
addition,
mice
are
pretreated
with
cold
exposure,
which
promotes
mediated
PDT
reactive
oxygen
species
(ROS)
generation
by
reducing
production
ATP
GSH
tissue.
This
combination
increases
ROS
within
tumor,
inhibits
growth
distant
tumors,
recurrent
rechallenged
tumors
number
cytotoxic
CD8+T
cells
memory
T
cells.
Compared
alone,
shows
greater
advantages
The
strategy
provides
new
ideas
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(15), P. 14347 - 14405
Published: July 24, 2023
Light
has
profoundly
impacted
modern
medicine
and
healthcare,
with
numerous
luminescent
agents
imaging
techniques
currently
being
used
to
assess
health
treat
diseases.
As
an
emerging
concept
in
luminescence,
aggregation-induced
emission
(AIE)
shown
great
potential
biological
applications
due
its
advantages
terms
of
brightness,
biocompatibility,
photostability,
positive
correlation
concentration.
This
review
provides
a
comprehensive
summary
AIE
luminogens
applied
structure
dynamic
physiological
processes,
disease
diagnosis
treatment,
detection
monitoring
specific
analytes,
followed
by
representative
works.
Discussions
on
critical
issues
perspectives
future
directions
are
also
included.
aims
stimulate
the
interest
researchers
from
different
fields,
including
chemistry,
biology,
materials
science,
medicine,
etc.,
thus
promoting
development
fields
life
health.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(12)
Published: Jan. 11, 2023
Phototheranostics
have
emerged
and
flourished
as
a
promising
pattern
for
cancer
theranostics
owing
to
their
precise
photoinduced
diagnosis
therapeutic
meet
the
demands
of
precision
medicine.
The
information
effect
are
directly
determined
by
fluorescence
imaging
ability
photothermal
conversion
efficiency
(PCE)
phototheranostic
agents.
Hence,
how
balance
competitive
radiative
nonradiative
processes
agents
is
key
factor
evaluate
effect.
Herein,
molecules
named
ICRs
with
high
photostaibility
rationally
designed,
exhibiting
emission
in
second
near-infrared
window
(NIR-II,
1000-1700
nm)
PCE,
which
related
strong
donor-acceptor
(D-A)
interaction
reorganization
energy
Noteworthily,
ICR-Qu
stronger
D-A
large-sized
conjugated
unit
encapsulated
nanoparticles
exhibits
PCE
(81.1%).
In
addition,
ICR-QuNPs
used
(FLI),
photoacoustic
(PAI),
(PTI)
guide
deep-tissue
photonic
hyperthermia,
achieving
removal
inhibition
breast
cancer.
Furthermore,
combined
α-PD-1,
show
huge
potential
be
facile
efficient
tool
photo-immunotherapy.
More
importantly,
this
study
not
only
reports
an
"all-in-one"
polymethine-based
agent,
but
also
sheds
light
on
exploration
versatile
organic
future
practical
applications.
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
33(42)
Published: June 24, 2023
Abstract
Induction
of
immunogenic
cell
death
(ICD)
represents
a
robust
therapeutic
strategy
for
cancer
treatment.
However,
only
few
ICD
inducers
are
currently
available
and
many
them
take
effect
based
on
traditional
endoplasmic
reticulum
(ER)
stress
rather
than
mitochondrial
stress.
Besides,
mitochondrion
is
closely
related
to
ER
drug
delivery
via
targeting
usually
shows
higher
efficiency
cytotoxicity
that
targeting,
which
inspires
explore
the
cells
through
Herein,
mito‐missile
can
realize
not
mitochondria‐targeted
photodynamic
therapy
(PDT)/mild‐temperature
photothermal
(MTPTT)
but
also
ICD‐induced
immunotherapy
constructed.
The
(termed
DIH)
prepared
by
coating
dc‐IR825
(a
mitochondrion‐targeting
cyanine
dye)‐loaded
polyamidoamine
dendrimer
with
hyaluronic
acid.
precisely
target
mitochondria
produce
reactive
oxygen
species
(ROS)
mild
heat
upon
near‐infrared
(NIR)
light
irradiation,
inducing
damage
stress‐caused
enhanced
ICD.
By
combining
PDT,
MTPTT,
immunotherapy,
DIH
efficiently
inhibit
tumor
growth
even
eradicate
tumors.
This
study
develops
dendrimer‐based
nanoplatform
realizing
mitochondrion‐acting
PDT/MTPTT
as
well
stress‐induced
potentiated
ICD,
may
provide
guideline
designing
effective
in
future.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(28)
Published: April 25, 2024
Abstract
Photosensitizers
(PSs)
with
aggregation‐induced
emission
(AIE)
characteristics
are
competitive
candidates
for
bioimaging
and
therapeutic
applications.
However,
their
short
wavelength
nonspecific
organelle
targeting
hinder
effectiveness.
Herein,
a
donor–acceptor
modulation
approach
is
reported
to
construct
series
of
ionic
AIE
photosensitizers
enhanced
photodynamic
therapy
(PDT)
outcomes
fluorescent
in
the
second
near‐infrared
(NIR‐II)
window.
By
employing
dithieno[3,2‐b:2′,3′‐d]pyrrole
(DTP)
indolium
(In)
as
strong
donor
acceptor,
respectively,
compound
DTP‐In
exhibits
substantial
redshift
absorption
reach
NIR‐II
region.
The
reduced
energy
gap
between
singlet
triplet
states
also
increases
reactive
oxygen
species
(ROS)
generation
rate.
Further,
can
self‐assemble
aqueous
solutions,
forming
positively
charged
nanoaggregates,
which
superior
conventional
encapsulated
nanoparticles
cellular
uptake
mitochondrial
targeting.
Consequently,
aggregates
show
efficient
ablation
4T1
cancer
cells
outstanding
tumor
theranostic
vivo
under
660
nm
laser
irradiation.
This
work
highlights
potential
molecular
engineering
PSs
multiple
functionalities,
thereby
facilitating
development
more
effective
strategies
therapy.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(37), P. 25671 - 25684
Published: Sept. 3, 2024
Combined
photodynamic
and
photothermal
therapy
(PDT
PTT)
can
achieve
more
superior
therapeutic
effects
than
the
sole
mode
by
maximizing
photon
utilization,
but
there
remains
a
significant
challenge
in
development
of
related
single-molecule
photosensitizers
(PSs),
particularly
those
with
type
I
photosensitization.
In
this
study,
self-assembly
squaraine
dyes
(SQs)
is
shown
to
be
promising
strategy
for
designing
PSs
combined
PDT
PTT,
supramolecular
PS
(TPE-SQ7)
has
been
successfully
developed
through
subtle
molecular
design
an
indolenine
SQ,
which
self-assemble
into
highly
ordered
H-aggregates
aqueous
solution
as
well
nanoparticles
(NPs).
contrast
typical
quenching
effect
on
reactive
oxygen
species
(ROS)
generation,
our
results
encouragingly
manifest
that
enhance
ROS
(
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 10, 2025
Abstract
Photodynamic
therapy
(PDT)
and
photothermal
(PTT)
have
emerged
as
promising
treatment
options,
showcasing
immense
potential
in
addressing
both
oncologic
nononcologic
diseases.
Single‐component
organic
phototherapeutic
agents
(SCOPAs)
offer
advantages
compared
to
inorganic
or
multicomponent
nanomedicine,
including
better
biosafety,
lower
toxicity,
simpler
synthesis,
enhanced
reproducibility.
Nonetheless,
how
further
improve
the
therapeutic
effectiveness
of
SCOPAs
remains
a
challenging
research
area.
This
review
delves
deeply
into
strategies
performance
PDT
PTT
by
optimizing
structural
design
SCOPAs.
These
encompass
augmenting
reactive
oxygen
species
(ROS)
generation,
mitigating
dependence,
elevating
light
absorption
capacity,
broadening
region,
enhancing
conversion
efficiency
(PCE).
Additionally,
this
also
underscores
ideal
for
developing
with
balanced
PTT.
Furthermore,
synergies
are
highlighted
between
other
modalities
such
ferroptosis,
gas
therapy,
chemotherapy,
immunotherapy.
By
providing
comprehensive
analysis
these
strategies,
aspires
serve
valuable
resource
clinicians
researchers,
facilitating
wider
application
advancement
SCOPAs‐mediated
Nature Communications,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Jan. 2, 2025
The
discovery
of
tertiary
lymphoid
structures
(TLS)
within
tumor
tissues
provides
a
promising
avenue
to
promote
the
efficacy
cancer
immunotherapy.
Yet,
lack
effective
strategies
induce
TLS
formation
poses
substantial
obstacle.
Thus,
exploration
potential
inducers
for
is
great
interest
but
remains
challenging.
Here,
inspired
by
mechanism
artificially
cultivated
pearls,
covalent
organic
framework
(COF)
employed
formation.
Single-cell
sequencing
analysis
reveals
that
this
achieved
promotion
cytokine
hypersecretion,
which
facilitates
maturation,
proliferation,
and
migration
T
B
cells,
critical
triggering
Furthermore,
COF-mediated
phototherapy
in
inducing
validated
both
MC38
4MOSC1
female
models.
Notably,
strong
synergistic
effect
between
αCTLA-4
observed,
resulting
eradication
primary
distant
tumors,
while
also
inhibiting
recurrence.
boosting
immunotherapy,
it
challenging
develop
authors
report
able
trigger
