Small Methods,
Journal Year:
2022,
Volume and Issue:
7(5)
Published: Nov. 29, 2022
Abstract
Pancreatic
ductal
adenocarcinoma
(PDAC)
is
highly
lethal
and
resistant
to
conventional
therapies,
including
chemo‐,
radio‐,
immunotherapy.
In
this
study,
it
first
determined
that
a
combination
of
dihydroartemisinin
(DHA)
RSL‐3
(a
glutathione
peroxidase
4
(GPX4)
inhibitor)
markedly
induced
ferroptosis
PDAC
tumor
cells.
A
mechanistic
study
revealed
DHA
can
react
with
iron
ions
generate
carbon
radicals
deplete
intracellular
glutathione,
thereby
cumulatively
triggering
the
lipid
peroxidation
cells
RSL‐3‐mediated
GPX4
inhibition.
DHA‐conjugated
amphiphilic
copolymer
subsequently
synthesized,
acidity
oxidation
dual‐responsive
nanoparticles
are
further
engineered
for
tumor‐specific
co‐delivery
RSL‐3.
The
resultant
(PDBA@RSL‐3)
efficiently
induce
in
Panc02
tumor‐bearing
immune‐deficient
mouse
model,
elicit
T‐cell‐based
antitumor
immunity
immune‐competent
model.
PDBA@RSL‐3
programmed
death
ligand
1
blockade
therapy
inhibits
growth
models.
This
may
provide
novel
insights
treatment
ferroptosis‐based
ACS Applied Materials & Interfaces,
Journal Year:
2023,
Volume and Issue:
15(17), P. 20697 - 20711
Published: April 21, 2023
Conventional
chemotherapy
usually
fails
to
achieve
its
intended
effect
because
of
the
poor
water
solubility,
tumor
selectivity,
and
low
accumulation
drugs.
The
systemic
toxicity
agents
is
also
a
problem
that
cannot
be
ignored.
It
expected
smart
nano-drug
delivery
systems
are
able
respond
microenvironments
will
provide
better
therapeutic
outcomes
with
decreased
side
effects
chemotherapeutics.
Nano-drug
capable
breaking
redox
balance
can
increase
sensitivity
cells
In
this
study,
using
polymer-containing
disulfide
bonds,
ester
d-α-tocopherol
polyethylene
glycol
succinate
(TPGS),
which
amplify
reactive
oxygen
species
(ROS)
in
cells,
we
have
successfully
prepared
glutathione
(GSH)
esterase
dual-responsive
system
(DTX@PAMBE-SS-TPGS
NPs)
ability
deplete
GSH
as
well
ROS
effectively
release
an
encapsulated
drug
(DTX)
cells.
potential
DTX@PAMBE-SS-TPGS
NPs
for
enhanced
antitumor
was
thoroughly
evaluated
vitro
vivo
experiments.
Our
research
offers
promising
strategy
maximizing
efficacy
therapy.
Ultrasonics Sonochemistry,
Journal Year:
2024,
Volume and Issue:
103, P. 106798 - 106798
Published: Feb. 1, 2024
Non-invasive
and
high
spatiotemporal
resolution
mythologies
for
the
diagnosis
treatment
of
disease
in
clinical
medicine
promote
development
modern
medicine.
Ultrasound
(US)
technology
provides
a
non-invasive,
real-time,
cost-effective
imaging
modality,
which
plays
significant
role
chemical
synthesis
translation,
especially
vivo
cancer
therapy.
On
one
hand,
US
is
usually
accompanied
by
cavitation,
leading
to
temperature
pressure,
so-called
"hot
spot",
playing
sonochemical-based
colloidal
synthesis.
Compared
with
classical
nucleation
synthetic
method,
sonochemical
strategy
presents
efficiency
fabrication
nanocrystals
due
its
fast
growth
procedure.
other
attractive
medical
treatment,
applications
increasing
novel
contrast
agents,
such
as
micro
nano
bubbles,
are
widely
used
neuromodulation,
can
breach
blood–brain
barrier
temporarily
safely,
opening
new
door
neuromodulation
In
terms
sonodynamic
therapy
US-assisted
synergetic
show
great
effects
against
immunotherapy
present
unparalleled
potentiality
compared
therapies.
Further
ultrasound
revolutionize
both
translation
improving
efficiency,
precision,
accessibility
while
reducing
environmental
impact
enhancing
patient
care.
this
paper,
we
review
biological
applications,
next
generation
technology-assisted
applications.
ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 2, 2024
Ultrasound
has
gained
prominence
in
biomedical
applications
due
to
its
noninvasive
nature
and
ability
penetrate
deep
tissue
with
spatial
temporal
resolution.
The
burgeoning
field
of
ultrasound-responsive
prodrug
systems
exploits
the
mechanical
chemical
effects
ultrasonication
for
controlled
activation
prodrugs.
In
polymer
mechanochemistry,
materials
scientists
exploit
sonomechanical
effect
acoustic
cavitation
mechanochemically
activate
force-sensitive
On
other
hand,
researchers
sonodynamic
therapy
adopt
fundamentally
distinct
methodologies,
utilizing
sonochemical
(e.g.,
generation
reactive
oxygen
species)
ultrasound
presence
sonosensitizers
induce
transformations
that
This
cross-disciplinary
review
comprehensively
examines
these
two
divergent
yet
interrelated
approaches,
both
which
originated
from
cavitation.
It
highlights
molecular
design
strategies
potential
diverse
therapeutic
contexts,
chemotherapy
immunotherapy
gene
methods,
discusses
future
directions
this
rapidly
advancing
domain.
Small Methods,
Journal Year:
2022,
Volume and Issue:
7(5)
Published: Nov. 29, 2022
Abstract
Pancreatic
ductal
adenocarcinoma
(PDAC)
is
highly
lethal
and
resistant
to
conventional
therapies,
including
chemo‐,
radio‐,
immunotherapy.
In
this
study,
it
first
determined
that
a
combination
of
dihydroartemisinin
(DHA)
RSL‐3
(a
glutathione
peroxidase
4
(GPX4)
inhibitor)
markedly
induced
ferroptosis
PDAC
tumor
cells.
A
mechanistic
study
revealed
DHA
can
react
with
iron
ions
generate
carbon
radicals
deplete
intracellular
glutathione,
thereby
cumulatively
triggering
the
lipid
peroxidation
cells
RSL‐3‐mediated
GPX4
inhibition.
DHA‐conjugated
amphiphilic
copolymer
subsequently
synthesized,
acidity
oxidation
dual‐responsive
nanoparticles
are
further
engineered
for
tumor‐specific
co‐delivery
RSL‐3.
The
resultant
(PDBA@RSL‐3)
efficiently
induce
in
Panc02
tumor‐bearing
immune‐deficient
mouse
model,
elicit
T‐cell‐based
antitumor
immunity
immune‐competent
model.
PDBA@RSL‐3
programmed
death
ligand
1
blockade
therapy
inhibits
growth
models.
This
may
provide
novel
insights
treatment
ferroptosis‐based
