ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 31, 2024
Floxuridine
is
a
potential
clinical
anticancer
drug
for
the
treatment
of
various
cancers.
However,
floxuridine
typically
causes
unfavorable
side
effects
due
to
its
very
poor
tumor
selectivity,
and,
hence,
there
high
demand
development
novel
approaches
that
permit
targeted
delivery
into
cancerous
cells.
Herein,
design
and
synthesis
an
esterase-responsive
multifunctional
nanoformulation
in
esterase-overexpressed
cancer
cells
reported.
Photopolymerization
floxuridine-tethered
lipoic
acid
results
formation
amphiphilic
poly(disulfide).
Self-assembly
polymer
nanoparticles
with
decorated
on
surfaces
particles.
Integration
aptamer
DNA
nucleolin
onto
surface
nanoparticle
demonstrated
by
exploring
base-pairing
interaction
adenine.
Targeted
internalization
aptamer-decorated
nucleolin-expressed
demonstrated.
Esterase
triggered
cleavage
ester
bond
connecting
backbone,
subsequent
also
shown.
Excellent
therapeutic
efficacy
observed
both
vitro
3D
spheroid
model.
This
noncovalent
strategy
provides
simple
yet
effective
less
laborious
fashion.
Small,
Journal Year:
2024,
Volume and Issue:
20(25)
Published: Jan. 25, 2024
Abstract
The
growth
state
of
tumor
cells
is
strictly
affected
by
the
specific
abnormal
redox
status
microenvironment
(TME).
Moreover,
reactions
at
biological
level
are
also
central
and
fundamental
to
essential
energy
metabolism
in
tumors.
Accordingly,
anti‐tumor
nanodrugs
targeting
disruption
this
homeostasis
have
become
one
hot
spots
field
research
due
effectiveness
TME
modulation
efficiency
mediated
interference.
This
review
discusses
latest
results
therapy,
which
regulate
levels
oxidants
or
reductants
through
a
variety
therapeutic
strategies,
ultimately
breaking
original
“stable”
promoting
cell
death.
With
gradual
deepening
study
on
vigorous
development
nanomaterials,
it
expected
that
more
nano
drugs
based
regulation
will
be
designed
even
applied
clinically.
Metabolites,
Journal Year:
2025,
Volume and Issue:
15(3), P. 201 - 201
Published: March 13, 2025
Background:
Tumor
cells
engage
in
continuous
self-replication
by
utilizing
a
large
number
of
resources
and
capabilities,
typically
within
an
aberrant
metabolic
regulatory
network
to
meet
their
own
demands.
This
dysregulation
leads
the
formation
tumor
microenvironment
(TME)
most
solid
tumors.
Nanomedicines,
due
unique
physicochemical
properties,
can
achieve
passive
targeting
certain
tumors
through
enhanced
permeability
retention
(EPR)
effect,
or
active
deliberate
design
optimization,
resulting
accumulation
TME.
The
use
nanomedicines
target
critical
pathways
holds
significant
promise.
However,
requires
careful
selection
relevant
drugs
materials,
taking
into
account
multiple
factors.
traditional
trial-and-error
process
is
relatively
inefficient.
Artificial
intelligence
(AI)
integrate
big
data
evaluate
delivery
efficiency
nanomedicines,
thereby
assisting
nanodrugs.
Methods:
We
have
conducted
detailed
review
key
papers
from
databases,
such
as
ScienceDirect,
Scopus,
Wiley,
Web
Science,
PubMed,
focusing
on
reprogramming,
mechanisms
action
development
metabolism,
application
AI
empowering
nanomedicines.
integrated
content
present
current
status
research
metabolism
potential
future
directions
this
field.
Results:
Nanomedicines
possess
excellent
TME
which
be
utilized
disrupt
cells,
including
glycolysis,
lipid
amino
acid
nucleotide
metabolism.
disruption
selective
killing
disturbance
Extensive
has
demonstrated
that
AI-driven
methodologies
revolutionized
nanomedicine
development,
while
concurrently
enabling
precise
identification
molecular
regulators
involved
oncogenic
reprogramming
pathways,
catalyzing
transformative
innovations
targeted
cancer
therapeutics.
Conclusions:
great
Additionally,
will
accelerate
discovery
metabolism-related
targets,
empower
optimization
help
minimize
toxicity,
providing
new
paradigm
for
development.
Nanoscale Horizons,
Journal Year:
2023,
Volume and Issue:
9(2), P. 186 - 214
Published: Nov. 29, 2023
Silica
nanoparticles
have
emerged
as
promising
candidates
in
the
field
of
nanomedicine
due
to
their
remarkable
versatility
and
customizable
properties.
However,
concerns
about
potential
toxicity
healthy
tissues
organs
hindered
widespread
clinical
translation.
To
address
this
challenge,
significant
attention
has
been
directed
toward
a
specific
subset
silica
nanoparticles,
namely
degradable
primarily
because
excellent
biocompatibility
responsive
biodegradability.
In
review,
we
provide
comprehensive
understanding
categorizing
them
into
two
distinct
groups:
inorganic
species-doped
organic
moiety-doped
based
on
framework
components.
Next,
recent
progress
tumor
microenvironment
(TME)-responsive
for
precision
theranostic
applications
is
summarized
detail.
Finally,
current
bottlenecks
future
opportunities
nanomedicines
are
also
outlined
discussed.
The
aim
review
shed
light
addressing
challenges
nanomedicine,
offering
insights
design,
diagnosis
treatment,
paving
way
advancements
nanomedicines.
Personalized Medicine,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 23
Published: Feb. 9, 2025
Colorectal
cancer
is
a
common
and
fatal
disease
that
affects
many
people
globally.
CRC
classified
as
the
third
most
prevalent
among
males
second
frequent
females
worldwide.
The
purpose
of
this
article
to
examine
how
personalized
medicine
might
be
used
treat
colorectal
cancer.
classification
based
on
molecular
profiling,
including
detection
significant
gene
mutations,
genomic
instability,
dysregulation,
main
topic
discussion.
Advanced
technologies
biomarkers
are
methods
explored,
demonstrating
their
potential
for
early
diagnosis
precise
prognosis.
In
addition,
essay
explores
world
treatment
possibilities
by
providing
light
FDA-approved
solutions
provide
individualized
interventions
patient
characteristics.
This
assesses
targeted
treatments
like
cetuximab
nivolumab,
looks
at
therapeutic
usefulness
microsatellite
instability
(MSI)
circulating
tumor
DNA
(ctDNA),
investigates
new
approaches
combat
resistance.
Through
this,
our
review
provides
thorough
overview
in
context
cancer,
ultimately
highlighting
its
revolutionize
field
improve
care.
