Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 413, P. 135917 - 135917
Published: May 3, 2024
Language: Английский
Advanced Healthcare Materials, Journal Year: 2022, Volume and Issue: 11(13)
Published: April 9, 2022
Abstract Peripheral nerve regeneration and functional recovery is a major challenge in clinical practice. Nerve conduit an effective treatment for peripheral repair, but the traditional hollow not satisfactory repair due to limitation of cell migration nutrient transport. Herein, double cross‐linked hydrogels with injectable, self‐healing, conductive properties are synthesized by Schiff base reaction between polyaniline‐modified carboxymethyl chitosan aldehyde‐modified Pluronic F‐127 (F127‐CHO), hydrophobic interaction F127‐CHO. The hydrogel injected into cavity prepared electrodeposition. inner outer formed whole through obtain double‐layer composite conduit. neural loaded 7,8‐dihydroxyflavone (DHF) has excellent degradability, biocompatibility, antioxidant activity, Schwann proliferation activity. In rat sciatic defect model, significantly promotes compared Surprisingly, ability double‐layered DHF comparable that autologous transplantation. Therefore, this multifunctional great potential repairing.
Language: Английский
Citations
78
Nano Energy, Journal Year: 2023, Volume and Issue: 119, P. 109051 - 109051
Published: Nov. 3, 2023
Language: Английский
Citations
70
Science Advances, Journal Year: 2024, Volume and Issue: 10(1)
Published: Jan. 5, 2024
Electrical stimulation can effectively accelerate bone healing. However, the substantial size and weight of electrical devices result in reduced patient benefits compliance. It remains a challenge to establish flexible lightweight implantable microelectronic stimulator for regeneration. Here, we use self-powered technology develop an electric pulse without circuits batteries, which removes problems weight, volume, necessary rigid packaging. The fully defect (BD-ES) system combines hybrid tribo/piezoelectric nanogenerator provide biphasic pulses response rehabilitation exercise with conductive bioactive hydrogel. BD-ES enhance multiple osteogenesis-related biological processes, including calcium ion import osteogenic differentiation. In rat model critical-sized femoral defects, was reversed by therapy subsequent mineralization, femur completely healed within 6 weeks. This work is expected advance development symbiotic batteries circuits.
Language: Английский
Citations
59
Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(8)
Published: Jan. 10, 2023
Abstract Advances in implantable bioelectronics for the nervous system are reinventing stimulation, inhibition, and sensing of neuronal activity. These efforts promise not just breakthrough treatments several neurological psychiatric conditions but also signal beginning a new era computer‐controlled human therapeutics. Batteries remain major power source all implanted electrical neuromodulation devices, which impairs miniaturization necessitates replacement surgery when battery is drained. Triboelectric nanogenerators (TENGs) have recently emerged as an innovative solution self‐powered, closed loop neurostimulation devices. TENGs can leverage biomechanical activities different body organs to sustainably generate electricity neurostimulation. This review features advances they pave way self‐sustainable A comprehensive TENG research brain, autonomic, somatic systems provided. The direction growth this field, publication trends, modes discussed. Finally, insightful outlook into challenges facing neuromodulators reach clinical practice provided, solutions maladies proposed.
Language: Английский
Citations
50
Nano Energy, Journal Year: 2023, Volume and Issue: 116, P. 108787 - 108787
Published: Aug. 15, 2023
Language: Английский
Citations
43
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(29)
Published: May 15, 2024
Electronic stethoscope used to detect cardiac sounds that contain essential clinical information is a primary tool for diagnosis of various disorders. However, the linear electromechanical constitutive relation makes conventional piezoelectric sensors rather ineffective low-intensity, low-frequency heart acoustic signal without assistance complex filtering and amplification circuits. Herein, it found triboelectric sensor features superior advantages over one microquantity sensing originated from fast saturated characteristic. As result, shows ultrahigh sensitivity (1215 mV Pa
Language: Английский
Citations
26
Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(17), P. 8632 - 8712
Published: Jan. 1, 2024
Bioelectronics is a hot research topic, yet an important tool, as it facilitates the creation of advanced medical devices that interact with biological systems to effectively diagnose, monitor and treat broad spectrum health conditions. Electrical stimulation (ES) pivotal technique in bioelectronics, offering precise, non-pharmacological means modulate control processes across molecular, cellular, tissue, organ levels. This method holds potential restore or enhance physiological functions compromised by diseases injuries integrating sophisticated electrical signals, device interfaces, designs tailored specific mechanisms. review explains mechanisms which ES influences cellular behaviors, introduces essential principles, discusses performance requirements for optimal systems, highlights representative applications. From this review, we can realize based bioelectronics therapy, regenerative medicine rehabilitation engineering technologies, ranging from tissue neurological modulation cardiovascular cognitive functions. underscores versatility various biomedical contexts emphasizes need adapt complex clinical landscapes addresses.
Language: Английский
Citations
24
Advanced Composites and Hybrid Materials, Journal Year: 2024, Volume and Issue: 7(3)
Published: June 1, 2024
Language: Английский
Citations
17
Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(38)
Published: July 8, 2022
Abstract Exploring efficient energy systems with integrated harvesting and storage toward sustainable power sources is an extremely promising solution for alleviating the crisis but nevertheless remains arduous challenge. Here, a high‐efficient self‐charging system (SCPS) by integrating solid‐state asymmetric supercapacitors device (SASD) rotational triboelectric nanogenerator (RTENG) to achieve reported. Dual redox active sites Ni 2 P/NiSe heterostructure homogeneously inlaid on N‐C (N‐C@Ni ) via in situ phosphoselenization, which achieves maximum exposure of prevents aggregation nanoparticles. The ingeniously designed N‐C@Ni features high activity dual sites, well‐defined heterointerface, stable superhighway conductive support, facilitates electrochemical reaction efficiency, accelerated kinetics, enhanced stability, thus achieving capacitance excellent stability. Meanwhile, SASD delivers density long lifespan. Furthermore, RTENG exhibits output performance, enabling harvesting. SCPS can reach voltage 3.8 V within 40 s, continuously electronics. It believed that proposed survey based design integration will offer new prospect next‐generation sources.
Language: Английский
Citations
51
Nano Energy, Journal Year: 2022, Volume and Issue: 99, P. 107420 - 107420
Published: May 25, 2022
Language: Английский
Citations
40