Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
53(16), P. 8306 - 8378
Published: Jan. 1, 2024
As
natural
living
substances,
microorganisms
have
emerged
as
useful
resources
in
medicine
for
creating
microbe-material
hybrids
ranging
from
nano
to
macro
dimensions.
The
engineering
of
microbe-involved
nanomedicine
capitalizes
on
the
distinctive
physiological
attributes
microbes,
particularly
their
intrinsic
"living"
properties
such
hypoxia
tendency
and
oxygen
production
capabilities.
Exploiting
these
remarkable
characteristics
combination
with
other
functional
materials
or
molecules
enables
synergistic
enhancements
that
hold
tremendous
promise
improved
drug
delivery,
site-specific
therapy,
enhanced
monitoring
treatment
outcomes,
presenting
substantial
opportunities
amplifying
efficacy
disease
treatments.
This
comprehensive
review
outlines
microbial
derivatives
used
biomedicine
specific
advantages
therapeutic
application.
In
addition,
we
delineate
fundamental
strategies
mechanisms
employed
constructing
hybrids.
diverse
biomedical
applications
constructed
hybrids,
encompassing
bioimaging,
anti-tumor,
anti-bacteria,
anti-inflammation
diseases
therapy
are
exhaustively
illustrated.
We
also
discuss
current
challenges
prospects
associated
clinical
translation
hybrid
platforms.
Therefore,
unique
versatility
potential
exhibited
by
position
them
promising
candidates
development
next-generation
biomaterials
theranostic
functionalities.
Smart Medicine,
Journal Year:
2023,
Volume and Issue:
2(4)
Published: July 20, 2023
As
a
kind
of
intestinal
flora
regulator,
probiotics
show
great
potential
in
the
treatment
many
diseases.
However,
orally
delivered
are
often
vulnerable
to
unfriendly
gastrointestinal
environments,
resulting
low
survival
rate
and
decreased
therapeutic
efficacy.
Decorating
or
encapsulating
with
functional
biomaterials
has
become
facile
yet
useful
strategy,
can
be
given
different
functions
by
wearing
armors.
This
review
systematically
discusses
challenges
faced
oral
research
progress
armored
delivery
systems.
We
focus
on
how
various
armors
help
overcome
obstacles
achieve
efficient
delivery.
also
introduce
applications
armor
disease
analyze
future
trends
developing
advanced
probiotics-based
therapies.
Engineering,
Journal Year:
2023,
Volume and Issue:
34, P. 187 - 194
Published: Sept. 22, 2023
Transplantation
of
probiotics
to
the
intestine
can
positively
regulate
gut
microbiota,
thereby
promoting
immune
system
and
treating
various
diseases.
However,
harsh
gastrointestinal
environment
short
retention
time
in
tract
significantly
limit
bioavailability
intestinal
colonization
probiotics.
Herein,
we
present
a
double-layer
polysaccharide
hydrogel
(DPH)
form
structure
composed
carboxymethyl
cellulose
(CMCL)
supramolecular
inner
layer
dialdehyde
alginate
(DAA)
cross-linked
chitosan
(CMCS)
outer
layer.
This
allows
DPH
encapsulate
deliver
targeted
manner
within
body.
In
stomach,
cage
is
closed,
absorbs
surrounding
liquids
barrier
protect
from
gastric
fluids.
intestine,
opens
disintegrates,
releasing
Thus,
endows
with
excellent
intestine-targeted
delivery,
improved
oral
bioavailability,
enhanced
tolerance,
robust
mucoadhesion
capacity.
The
encapsulated
exhibit
almost
unchanged
bioactivity
before
release,
as
well
delivery.
particular,
by
100.1
times
higher
10.6
than
free
an
animal
model
48
h
post-treatment.
addition,
remarkable
ability
survive
be
retained
show
vitro
vivo
competition
pathogens.
Notably,
DAA-mediated
dynamic
crosslinking
not
only
maintains
overall
integrity
hydrogels
but
also
controls
release
timing
it
expected
that
substances
(probiotics,
proteins,
etc.)
delivered
specific
sites
means
DPH,
controlling
covalent
crosslinking.
Comprehensive Reviews in Food Science and Food Safety,
Journal Year:
2024,
Volume and Issue:
23(3)
Published: April 10, 2024
Abstract
Adequate
intake
of
live
probiotics
is
beneficial
to
human
health
and
wellbeing
because
they
can
help
treat
or
prevent
a
variety
conditions.
However,
the
viability
reduced
by
harsh
environments
experience
during
passage
through
gastrointestinal
tract
(GIT).
Consequently,
oral
delivery
viable
significant
challenge.
Probiotic
encapsulation
provides
potential
solution
this
problem.
production
methods
used
create
conventional
technologies
often
damage
probiotics.
Moreover,
systems
produced
do
not
have
required
physicochemical
attributes
robustness
for
food
applications.
Single‐cell
based
on
forming
protective
coating
around
single
probiotic
cell.
These
coatings
may
be
biofilms
biopolymer
layers
designed
protect
from
environment,
enhance
their
colonization,
introduce
additional
functions.
This
article
reviews
factors
affecting
probiotics,
analyses
shortcomings
existing
technologies,
highlights
advantages
single‐cell
encapsulation.
It
also
various
approaches
available
including
implementation
characteristics
produce.
In
addition,
mechanisms
which
improve
bioavailability
benefits
are
described.
benefits,
limitations,
safety
issues
technology
applications
in
beverages
analyzed.
Finally,
future
directions
challenges
widespread
adoption
highlighted.
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
53(16), P. 8306 - 8378
Published: Jan. 1, 2024
As
natural
living
substances,
microorganisms
have
emerged
as
useful
resources
in
medicine
for
creating
microbe-material
hybrids
ranging
from
nano
to
macro
dimensions.
The
engineering
of
microbe-involved
nanomedicine
capitalizes
on
the
distinctive
physiological
attributes
microbes,
particularly
their
intrinsic
"living"
properties
such
hypoxia
tendency
and
oxygen
production
capabilities.
Exploiting
these
remarkable
characteristics
combination
with
other
functional
materials
or
molecules
enables
synergistic
enhancements
that
hold
tremendous
promise
improved
drug
delivery,
site-specific
therapy,
enhanced
monitoring
treatment
outcomes,
presenting
substantial
opportunities
amplifying
efficacy
disease
treatments.
This
comprehensive
review
outlines
microbial
derivatives
used
biomedicine
specific
advantages
therapeutic
application.
In
addition,
we
delineate
fundamental
strategies
mechanisms
employed
constructing
hybrids.
diverse
biomedical
applications
constructed
hybrids,
encompassing
bioimaging,
anti-tumor,
anti-bacteria,
anti-inflammation
diseases
therapy
are
exhaustively
illustrated.
We
also
discuss
current
challenges
prospects
associated
clinical
translation
hybrid
platforms.
Therefore,
unique
versatility
potential
exhibited
by
position
them
promising
candidates
development
next-generation
biomaterials
theranostic
functionalities.
