Silk fibroin-based biomaterials for cartilage/osteochondral repair

Theranostics, Journal Year: 2022, Volume and Issue: 12(11), P. 5103 - 5124

Published: Jan. 1, 2022

Osteoarthritis (OA) is a common joint disease with high disability rate.In addition, OA not only causes great physiological and psychological harm to patients, but also puts pressure on the social healthcare system.Pathologically, disintegration of cartilage lesions subchondral bone are related OA.Currently, tissue engineering, which expected overcome defects existing treatment methods, had lot research in field cartilage/osteochondral repair.Silk fibroin (SF), as natural macromolecular material good biocompatibility, unique mechanical properties, excellent processability degradability, holds potential engineering.Nowadays, SF been prepared into various materials adapt demands repair.SF-based biomaterials can be functionally modified enhance repair performance further.In this review, preparation types, structures, functional modifications SF-based used for summarized discussed.We hope that review will provide reference design development field.

Language: Английский

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Bone Repair Biomaterials: A Perspective from Immunomodulation

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(51)

Published: Oct. 9, 2022

Abstract With an increasingly aging society, bone defects and fractures have become significant threats to human health quality of life. Currently, autologous allogeneic grafts remain the “gold standard” for clinical treatment repair. However, transplantation is still clinically insufficient, owing its substantial limitations, such as graft rejection, donor functional defects, risk infection. Therefore, a variety biomaterials been developed facilitate advancement tissue engineering, focus research has transitioned from bioinert bioactive biomaterials. many not achieved satisfactory therapeutic effects. In recent years, advancements in osteoimmunology revealed that immune system, which macrophages are critical components, plays essential regulatory role regeneration. this review, healing explored developments promote regeneration by modulating macrophage polarization improving osteoimmune microenvironment reviewed. This review provides reference development application repair immunomodulation perspective.

Language: Английский

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Bioinspired Mild Photothermal Effect-Reinforced Multifunctional Fiber Scaffolds Promote Bone Regeneration

ACS Nano, Journal Year: 2023, Volume and Issue: 17(7), P. 6466 - 6479

Published: March 30, 2023

Bone fractures are often companied with poor bone healing and high rates of infection. Early recruitment mesenchymal stem cells (MSCs) is critical for initiating efficient repair, mild thermal stimulation can accelerate the recovery chronic diseases. Here, a bioinspired, staged photothermal effect-reinforced multifunctional scaffold was fabricated repair. Uniaxially aligned electrospun polycaprolactone nanofibers were doped black phosphorus nanosheets (BP NSs) to endow excellent near-infrared (NIR) responsive capability. Apt19S then decorated on surface selectively recruit MSCs toward injured site. Afterward, microparticles phase change materials loaded antibacterial drugs also deposited scaffold, which could undergo solid-to-liquid transition above 39 °C, triggering release payload eliminate bacteria prevent Under NIR irradiation, photothermal-mediated up-regulation heat shock proteins accelerated biodegradation BP NSs promote osteogenic differentiation biomineralization. Overall, this strategy shows ability elimination, recruitment, regeneration promotion assistance effect in vitro vivo, emphasizes design bioinspired its potential tissue engineering.

Language: Английский

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Recent advances in biopolymer-based hydrogels and their potential biomedical applications

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 323, P. 121408 - 121408

Published: Sept. 17, 2023

Language: Английский

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Mild Photothermal‐Stimulation Based on Injectable and Photocurable Hydrogels Orchestrates Immunomodulation and Osteogenesis for High‐Performance Bone Regeneration

Small, Journal Year: 2023, Volume and Issue: 19(28)

Published: May 16, 2023

Abstract A photoactivated bone scaffold integrated with minimally invasive implantation and mild thermal‐stimulation capability shows great promise in the repair regeneration of irregularly damaged tissues. Developing multifunctional photothermal biomaterials that can simultaneously serve as both controllable thermal stimulators biodegradable engineering scaffolds for immunomodulation, infection therapy, impaired remains an enormous challenge. Herein, injectable photocurable hydrogel therapeutic platform (AMAD/MP) based on alginate methacrylate, alginate‐graft‐dopamine, polydopamine (PDA)‐functionalized Ti3C2 MXene (MXene@PDA) nanosheets is rationally designed near‐infrared (NIR)‐mediated synergistic osteogenesis, bacterial elimination. The optimized AMAD/MP exhibits favorable biocompatibility, osteogenic activity, immunomodulatory functions vitro. proper immune microenvironment provided by could further modulate balance M1/M2 phenotypes macrophages, thereby suppressing reactive oxygen species‐induced inflammatory status. Significantly, this stimulation efficiently attenuates local reactions promotes new formation without addition exogenous cells, cytokines, or growth factors. This work highlights potential application advanced providing on‐demand cues tissue regenerative medicine.

Language: Английский

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Targeted and responsive biomaterials in osteoarthritis

Theranostics, Journal Year: 2023, Volume and Issue: 13(3), P. 931 - 954

Published: Jan. 1, 2023

Osteoarthritis (OA) is a degenerative disease characterized by loss of articular cartilage and chronic inflammation, involving multiple cellular dysfunctions tissue lesions.The non-vascular environment dense matrix in the joints tend to block drug penetration, resulting low bioavailability.There desire develop safer more effective OA therapies meet challenges an aging world population future.Biomaterials have achieved satisfactory results improving targeting, prolonging duration action, achieving precision therapy.This article reviews current basic understanding pathological mechanisms clinical treatment dilemmas OA, summarizes discusses advances for different kinds targeted responsive biomaterials seeking provide new perspectives OA.Subsequently, limitations translation biosafety are analyzed guide development future therapeutic strategies OA.As need medicine rises over time, emerging multifunctional based on targeting controlled release will become irreplaceable part management.

Language: Английский

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Smart Hydrogels for Bone Reconstruction via Modulating the Microenvironment

Research, Journal Year: 2023, Volume and Issue: 6

Published: Jan. 1, 2023

Rapid and effective repair of injured or diseased bone defects remains a major challenge due to shortages implants. Smart hydrogels that respond internal external stimuli achieve therapeutic actions in spatially temporally controlled manner have recently attracted much attention for therapy regeneration. These can be modified by introducing responsive moieties embedding nanoparticles increase their capacity repair. Under specific stimuli, smart variable, programmable, controllable changes on demand modulate the microenvironment promoting healing. In this review, we highlight advantages summarize materials, gelation methods, properties. Then, overview recent advances developing biochemical signals, electromagnetic energy, physical including single, dual, multiple types enable physiological pathological modulating microenvironment. discuss current challenges future perspectives regarding clinical translation hydrogels.

Language: Английский

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Boosting cartilage repair with silk fibroin-DNA hydrogel-based cartilage organoid precursor

Bioactive Materials, Journal Year: 2024, Volume and Issue: 35, P. 429 - 444

Published: Feb. 16, 2024

Osteoarthritis (OA), a common degenerative disease, is characterized by high disability and imposes substantial economic impacts on individuals society. Current clinical treatments remain inadequate for effectively managing OA. Organoids, miniature 3D tissue structures from directed differentiation of stem or progenitor cells, mimic native organ functions. They are useful drug testing serve as active grafts repair. However, organoid construction requires extracellular matrix-like scaffolds cellular growth. Hydrogel microspheres, with tunable physical chemical properties, show promise in cartilage engineering replicating the natural microenvironment. Building prior work SF-DNA dual-network hydrogels regeneration, we developed novel RGD-SF-DNA hydrogel microsphere (RSD-MS) via microfluidic system integrating photopolymerization self-assembly techniques then modified Pep-RGDfKA. The RSD-MSs exhibited uniform size, porous surface, optimal swelling degradation properties.

Language: Английский

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Advanced strategies of scaffolds design for bone regeneration

BMEMat, Journal Year: 2023, Volume and Issue: 1(4)

Published: Sept. 2, 2023

Abstract Bone defects are encountered substantially in clinical practice, and bionic scaffolds represent a promising solution for repairing bone defects. However, it is difficult to fabricate with structures reconstruct the microenvironment fulfill satisfying repair effects. In this review article, we first discuss various strategies design construction of promote defect repair, especially including structural scaffold integration bioactive substances together application external stimuli. We then roles artificial intelligence medical imaging aiding treatment. Finally, point out challenges future outlooks developing multifunctional scaffolds, aiming provide insights improving regeneration efficacy accelerating translation.

Language: Английский

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A Factor‐Free Hydrogel with ROS Scavenging and Responsive Degradation for Enhanced Diabetic Bone Healing

Small, Journal Year: 2024, Volume and Issue: 20(24)

Published: Jan. 2, 2024

Abstract In view of the increased levels reactive oxygen species (ROS) that disturb osteogenic differentiation bone marrow mesenchymal stem cells (BMSCs), repair diabetic defects remains a great challenge. Herein, factor‐free hydrogel is reported with ROS scavenging and responsive degradation properties for enhanced healing. These hydrogels contain ROS‐cleavable thioketal (TK) linkers ultraviolet (UV)‐responsive norbornene (NB) groups conjugated 8‐arm PEG macromers, which are formed via UV crosslinking‐mediated gelation. Upon reacting high in defect microenvironment, TK destroyed, allowing hydrogels, promotes migration BMSCs. Moreover, reduced through hydrogel‐mediated to reverse BMSC from adipogenic phenotype. As such, favorable microenvironment created after simultaneous degradation, leading effective mouse models, even without addition growth factors. Thus, this study presents platform regulates stromal engineering.

Language: Английский

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