Smart Materials in Medicine,
Journal Year:
2024,
Volume and Issue:
5(3), P. 359 - 372
Published: July 31, 2024
Diabetes
mellitus
(DM)
is
a
chronic
metabolic
disorder
that
can
affect
the
balance
of
bone
metabolism
and
microenvironment,
leading
to
impaired
fracture
healing.
There
are
several
underlying
mechanisms
which
contributing
diabetic
microenvironment
such
as
hyperglycemia,
production
advanced
glycation
end
products
(AGEs),
inflammation,
oxidative
stress,
etc.
Recent
studies
have
achieved
great
progress
in
developing
novel
smart
biomaterials
improving
promote
In
this
paper,
we
reviewed
on
DM-induced
Meanwhile,
also
summarized
used
improve
local
fractures
healing,
provides
perspective
for
future
treatment
patients.
Bioactive Materials,
Journal Year:
2024,
Volume and Issue:
38, P. 438 - 454
Published: May 12, 2024
Spinal
cord
injury
(SCI)
is
a
traumatic
condition
that
results
in
impaired
motor
and
sensory
function.
Ferroptosis
one
of
the
main
causes
neural
cell
death
loss
neurological
function
spinal
cord,
ferroptosis
inhibitors
are
effective
reducing
inflammation
repairing
SCI.
Although
human
umbilical
mesenchymal
stem
cells
(Huc-MSCs)
can
ameliorate
inflammatory
microenvironments
promote
regeneration
SCI,
their
efficacy
greatly
limited
by
local
microenvironment
after
Therefore,
this
study,
we
constructed
drug-release
nanoparticle
system
with
synergistic
Huc-MSCs
inhibitor,
which
anchored
Tz-A6
peptide
based
on
CD44-targeting
sequence,
combined
reactive
oxygen
species
(ROS)-responsive
drug
nanocarrier
mPEG-b-Lys-BECI-TCO
at
other
end
for
SCI
repair.
Meanwhile,
also
modified
classic
inhibitor
Ferrostatin-1
(Fer-1)
synthesized
new
prodrug
Feborastatin-1
(Feb-1).
The
showed
treatment
regimen
significantly
inhibited
response
promoted
recovery
rats
This
study
developed
combination
therapy
provides
strategy
construction
drug-coordinated
system.
Theranostics,
Journal Year:
2024,
Volume and Issue:
14(11), P. 4198 - 4217
Published: Jan. 1, 2024
The
utilization
of
extracellular
vesicles
(EVs)
in
wound
healing
has
been
well-documented.However,
the
direct
administration
free
EVs
via
subcutaneous
injection
at
sites
may
result
rapid
dissipation
bioactive
components
and
diminished
therapeutic
efficacy.Functionalized
hydrogels
provide
effective
protection,
as
well
ensure
sustained
release
bioactivity
during
process,
making
them
an
ideal
candidate
material
for
delivering
EVs.In
this
review,
we
introduce
mechanisms
by
which
accelerate
healing,
then
elaborate
on
construction
strategies
engineered
EVs.Subsequently,
discuss
synthesis
application
delivery
systems
to
enhance
complicated
healing.Furthermore,
face
wounds,
functionalized
with
specific
microenvironment
regulation
capabilities,
such
antimicrobial,
anti-inflammatory,
immune
regulation,
used
loading
EVs,
potential
approaches
addressing
these
challenges.Ultimately,
deliberate
future
trajectories
outlooks,
offering
a
fresh
viewpoint
advancement
artificial
intelligence
(AI)-energized
materials
3D
bio-printed
multifunctional
hydrogel-based
dressings
biomedical
applications.
Bioactive Materials,
Journal Year:
2024,
Volume and Issue:
35, P. 495 - 516
Published: Feb. 21, 2024
During
skin
aging,
the
degeneration
of
epidermal
stem
cells
(EpiSCs)
leads
to
diminished
wound
healing
capabilities
and
disintegration.
This
study
tackles
this
issue
through
a
comprehensive
analysis
combining
transcriptomics
untargeted
metabolomics,
revealing
age-dependent
alterations
in
Small,
Journal Year:
2024,
Volume and Issue:
20(45)
Published: July 25, 2024
Abstract
Diabetic
wounds
pose
a
persistent
challenge
due
to
their
slow
healing
nature,
primarily
caused
by
bacterial
infection
and
excessive
reactive
oxygen
species
(ROS)‐induced
inflammation.
In
this
study,
carbon
dots
with
synergistic
antibacterial
antioxidant
properties,
referred
as
AA‐CDs,
are
developed
specifically
for
diabetic
wound
using
straightforward
solvothermal
method.
By
utilizing
cost‐effective
precursors
like
citric
acid
ascorbic
acid,
AA‐CDs
engineered
possess
tailored
functions
of
photothermal
sterilization
ROS
scavenging.
The
resulting
demonstrats
broad‐spectrum
activity,
particularly
against
multidrug‐resistant
strains,
along
efficient
scavenging
both
in
solution
within
cells.
Additionally,
exhibits
protective
effect
oxidative
stress‐induced
damage.
Notably,
high
conversion
efficiency
(41.18%),
displays
heat‐enhanced
performance,
providing
not
only
augmented
but
also
additional
protection
stress,
yielding
true
“1
+
1
>
2”
effect.
To
facilitate
use
vivo,
incorporated
into
thermally
responsive
hydrogel,
which
evident
anti‐inflammatory
properties
modulating
inflammatory
factors
significantly
promots
the
wounds.
This
study
underscores
value
integrated
platforms
highlights
potential
versatile
CDs
promising
therapeutic
agents
biomedical
applications.
Materials Horizons,
Journal Year:
2024,
Volume and Issue:
11(18), P. 4367 - 4377
Published: Jan. 1, 2024
The
degradability
of
hydrogels
plays
a
pivotal
role
in
bone
regeneration,
yet
its
precise
effects
on
the
repair
process
remain
poorly
understood.
Traditional
studies
have
been
limited
by
use
with
insufficient
variation
degradation
properties
for
thorough
comparative
analysis.
Addressing
this
gap,
our
study
introduces
development
matrix
metalloproteinase
(MMP)-responsive
engineered
tunable
rate,
specifically
designed
regeneration
applications.
These
innovative
are
synthesized
integrating
MMP-sensitive
peptides,
which
exhibit
chirality-transferred
amino
acids,
norbornene
(NB)-modified
8-arm
polyethylene
glycol
(PEG)
macromers
to
form
hydrogel
network.
behavior
these
is
manipulated
through
chirality
incorporated
resulting
classification
into
L,
LD,
and
D
hydrogels.
Remarkably,
L
variant
shows
significantly
enhanced
both
Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
31, P. 101502 - 101502
Published: Jan. 19, 2025
DNA-based
hydrogels
stand
out
for
bone
regeneration
due
to
their
exceptional
biocompatibility
and
programmability.
These
facilitate
the
formation
of
spatial
structures
through
bulk
hydrogel
fabricating,
microsphere
formatting,
3D
printing.
Furthermore,
microenvironment
can
be
finely
tuned
by
leveraging
degradation
products,
nanostructure,
targeting,
delivery
capabilities
inherent
materials.
In
this
review,
we
underscore
advantages
hydrogels,
detailing
composition,
gelation
techniques,
structure
optimization.
We
then
delineate
three
critical
elements
in
promotion
using
hydrogels:
(i)
osteogenesis
driven
phosphate
ions,
plasmids,
oligodeoxynucleotides
(ODNs)
that
enhance
mineralization
promote
gene
protein
expression;
(ii)
vascularization
facilitated
tetrahedral
DNA
nanostructures
(TDNs)
aptamers,
which
boosts
expression
targeted
release;
(iii)
immunomodulation
achieved
loaded
factors,
TDNs,
bound
ions
stimulate
macrophage
polarization
exhibit
antibacterial
properties.
With
these
properties,
used
construct
organoids,
providing
an
innovative
tool
disease
modeling
therapeutic
applications
tissue
engineering.
Finally,
discuss
current
challenges
future
prospects,
emphasizing
potential
impacts
regenerative
medicine.
